Social Isolation Research Articles

Social Support Domains Associated with Social Isolation in MCI

ABSTRACT The millions of older adults who are affected by social isolation report less social support, which has been shown to benefit well-being and decrease risk for cognitive decline. Social support is measured in different ways, including emotional, informational, and instrumental support. As an exploratory study, this secondary data analysis of 30 older adults living with Mild Cognitive Impairment examined what social support subtype is associated with social isolation. Social isolation was measured using the Patient Reported Outcomes Measurement Information System (PROMIS®) Social Isolation Computer Adaptive Test (CAT). Social support subtypes were measured using the PROMIS Informational, Emotional, and Instrumental Support CATs. We found that informational support was significantly associated with decreased self-reported social isolation. This finding increases our understanding of informational support’s potential and can inform future strategies for older adults with MCI facing social isolation.

Evaluating the potential effects of apigenin on memory, anxiety, and social interaction amelioration after social isolation stress.

Vigorous research confirmed the anti-inflammatory, antioxidant, and antidementia effects of apigenin (Api). The present study evaluated the beneficial impacts of Api administration on behaviour, brain-derived neurotrophic factor (BDNF), Interleukin 6 (IL-6), oxidative stress, and inflammation induced by social isolation (SI) stress in rats. For this purpose, rats underwent a 28-day SI period followed by a 4-week oral Api treatment (50 mg/kg/day, PO). On Day 56, behaviour tests were performed, including an elevated plus maze (EPM), Morris water maze (MWM), and three-chamber social tests. The oxidative stress markers, IL-6, and BDNF levels were measured in the hippocampus. Our results showed that SI stress caused an increase in anxiety and a decrease in spatial memory, sociability, and social preference index. In addition, SI stress increased hippocampal levels of IL-6 and malondialdehyde (MDA) content, whereas it reduced the hippocampal BDNF level and superoxide dismutase (SOD) activities. Our study indicated that Api attenuates anxiety and causes improvements in spatial memory and social interaction. These desirable effects of Api might be related to amelioration in the BDNF level, IL-6, and oxidative stress biomarkers in the hippocampus.

A Technology-Supported Psychoeducational Intervention for Older Adults and Their Families to Improve Social Isolation, Loneliness, and Intergenerational Connectedness-A Randomized Controlled Study.

Information and communication technologies (ICT) provide digital tools to support and facilitate social engagement. However, the extent to which new ICTs, such as instant messaging, and training on its use, enhance intergenerational family interactions and reduce social isolation and loneliness needs further exploration. In the present study, we developed a brief psychoeducational intervention to promote older adults and their family members (N = 64) to use new technologies to increase communication with each other. With a randomized controlled trial design, we evaluated the effectiveness of the intervention in changing primarily participants' intergenerational interactions, perceived social isolation, and loneliness. Through repeated-measures analysis of variance, an overall condition by time effect was found in younger family members such that contact frequency improved in the intervention condition compared with the waitlist control condition. Using a dyadic framework, we further investigated the role of the intervention in fostering interactions among family members. Dyadic analyses showed a partner effect with contact frequency in younger adults at pre-assessment predicting contact frequency of older adults at post-assessment. This suggests that support and encouragement from younger family members could increase intergenerational interactions and technology adoption among older adults. Moreover, online phone calls served as a promising tool to enhance intergenerational communication; higher user satisfaction was associated with increased ICT use, perceived usefulness, and fewer barriers to technology. This study provides preliminary findings on the effectiveness of ICT-based interventions for engaging older adults and their family members in the use of newer technologies to promote intergenerational interactions and reduce social isolation.

N-Pep-Zn Improves Cognitive Functions and Acute Stress Response Affected by Chronic Social Isolation in Aged Spontaneously Hypertensive Rats (SHRs)

N-Pep-Zn Improves Cognitive Functions and Acute Stress Response Affected by Chronic Social Isolation in Aged Spontaneously Hypertensive Rats (SHRs)

The association between social isolation and incident dementia among older adults: Evidence from National Health and Aging Trend Study

The association between social isolation and incident dementia among older adults: Evidence from National Health and Aging Trend Study

Exploring the association between multidimensional social isolation and heterogeneous cognitive trajectories among older adults: evidence from China

Exploring the association between multidimensional social isolation and heterogeneous cognitive trajectories among older adults: evidence from China

Help-Seeking Behaviors and Associated Factors Among Chinese Immigrant Women Experiencing Intimate Partner Violence

ABSTRACT Chinese immigrants are underrepresented in research on intimate partner violence (IPV). There is a lack of quantitative research on help-seeking behaviors and patterns among Chinese immigrant women experiencing IPV. In this study, using a cross-sectional design, we examine patterns of help-seeking behaviors among Chinese immigrant survivors of IPV, as well as associated factors. Participants were recruited through the WeChat and Prolific platforms to complete an online survey. A total of 139 women who reported IPV while residing in the U.S. participated. The survey’s questions addressed five forms of informal help and eight forms of formal help, as well as reasons for not seeking help. The survey also included measures of social isolation, loneliness, preferences for the ethnicity of people at social gatherings, depression, anxiety, sociodemographic characteristics, and immigration-related factors. Latent class analysis revealed two distinct help-seeking patterns. The majority either refrained from seeking help or solely relied on family and friends, while a smaller group sought support from a wider range of sources, but still primarily relied on family and friends. Factors associated with Chinese immigrant women’s use of broad sources for support included older age; being single, separated, divorced, or widowed; U.S. citizenship or permanent residency; attending social gatherings primarily with Americans; depression symptoms; and lower loneliness levels. The study’s findings underscore the importance of interventions to promote help-seeking behaviors among Chinese immigrant survivors by expanding social networks, fostering collaborations between mainstream IPV services and Chinese community organizations to implement community outreach, offering interventions that are empowerment-based, and training bilingual and bicultural service providers.

Temporary sensory separation of ewes from lambs effects stress-related behaviours and hormones of Small-tailed Han ewes

Context Different individuals within a group can form strong links through auditory, visual, and tactile senses. Temporarily separating sheep into subflocks, although not involving complete social isolation of individuals, can be stressful, especially when ewes are separated from lambs. Aims This study aimed to explore the effects of 1-h temporary ewe–lamb sensory separations on stress-related behaviours during separation, as well as its effect on stress-related hormones of ewes. Methods Small-tailed Han ewes were randomly assigned to the following four groups (six each): the auditory + visual + tactile separation (A + V + T group), visual + tactile separation (V + T group), tactile separation (T group), and the control (C group). Then, the ewes were separated from their lambs for 1 h on Postnatal Days 14, 21, 28, 35 and 42. Ewe behaviours during the separations were observed using focal animal-sampling methods. Key results Results showed that the separated ewes (A + V + T, V + T, and T groups) spent more time looking and exploring and less time lying (P < 0.05). Ewes showed more exploring behaviour in T group (P < 0.05). Ewes that gave birth to two lambs showed more urinating behaviour (P < 0.05). There was no significant difference in the level of stress-related hormones in ewes among the four different separation-method groups (A + V + T, V + T, T, and C groups). Conclusions One hour ewe-lamb sensory separation affected the stress related behaviours of Small-tailed Han ewes during separation, but it did not cause differences in stress-related hormones in ewes after the separation. Ewes showed increased exploring or urinating behaviour when they were separated through lack of tactile contact only with lambs, or when ewes give birth to two lambs. Implications Ewes temporarily separated from their lambs are less stressed if they are unable to hear or see the lambs, thereby improving ewe welfare. These effects appear more pronounced in ewes with multiple lambs and provides new perspectives for further studies on the effect of litter size on ewe-lamb bonding.

Psychological impacts of AI use on school students: a systematic scoping review of the empirical literature

This systematic scoping review aimed to collate evidence assessing associations between AI use and psychological outcomes (including cognitive, emotional, and behavioural responses to these intelligent systems) for school students from preschool (age <5 years), primary school (age 5–11 years), middle school (age 12–14 years), to high school (age 15–18 years). Original empirical studies were identified in seven reliable databases (Scopus, Web of Science, PubMed, PsycINFO, ScienceDirect, IEEE, and ERIC), resulting in 189 eligible studies. From these, we have identified 24 relevant studies reporting students’ hands-on experiential learning outcomes on AI use. Findings revealed that the use of AI in schools can have both positive and negative impacts on the psychological well-being of students. Increased engagement, cognitive achievement, self-efficacy, learning autonomy, and decreased frustration are among the benefits of this strategy; nevertheless, over reliance, anxiety, stress, social isolation, unstable mental health, and moral dilemmas including privacy, bias, and justice are among its drawbacks. Overall, the psychological impacts of AI use among school students are multifaceted, context-dependent and across grades. By carefully considering the design, implementation, and ethical decorum of AI in school education, teachers and policymakers can maximise its benefits by mitigating potential risks in practicing technology enhanced learning.

Connections between eating psychopathology, loneliness, and quality of life: insights from a multi-center study

BackgroundEating disorders (ED) involve dysfunctional attitudes towards food intake, affecting physical and psychosocial well-being. These disorders significantly impact various domains of life and can lead to a decrease in health-related quality of life (HRQoL). Recent studies emphasize the importance of addressing HRQoL in ED treatment, particularly in the context of social isolation and loneliness, but this aspect is currently poorly evaluated.MethodsA sample of 220 people with an ED was enrolled for the study from different centers specialized in the treatment of ED and compared to 151 people from the general population. Different validated questionnaires were used to evaluate eating psychopathology, HRQoL, and loneliness. Partial correlation analyzes adjusted for marital status and regressions were used to evaluate the relationships between constructs and the differences between groups.ResultsHigher feelings of loneliness were associated with a poorer HRQoL in patients and controls. In the ED group, both loneliness and eating psychopathology were significant predictors of HRQoL. Meanwhile, the duration of the disorder predicted HRQoL specifically in underweight patients, and BMI was a predictor of HRQoL in individuals with normal or above-normal weight.ConclusionsThese findings highlight the importance of considering both HRQoL and loneliness in EDs, particularly among younger individuals. This approach aligns with the increasing focus on the role of interpersonal relationships in the recovery process. Additionally, the data confirm a link between weight and loneliness, suggesting that this connection, especially the differences between underweight patients and those of other weights, deserves further investigation.

The temporal sequence and reciprocal relationships of frailty, social isolation and loneliness in older adults across 21years.

It is unclear whether social isolation and loneliness may precede frailty status or whether frailty may precipitate social isolation and loneliness. We investigated the reciprocal and temporal sequence of social isolation, loneliness, and frailty among older adults across 21years. We used seven waves of the Longitudinal Aging Study Amsterdam from 2302 Dutch older adults (M = 72.6years, SD = 8.6, 52.1% female) ages 55 or older. Using random intercept cross-lagged panel models, we investigated between- and within-person associations of social isolation and loneliness with frailty. Frailty was measured using the Frailty Index. Loneliness was measured using the 11-item De Jong Gierveld Loneliness Scale. Social isolation was measured using a multi-domain 6-item scale. Social isolation and loneliness were weakly correlated across waves. At the between-person level, individuals with higher levels of frailty tended to have higher levels of social isolation but not loneliness. At the within-person level, the cross-lagged paths indicated that earlier frailty status predicted future social isolation and loneliness over time. However, prior social isolation was not associated with subsequent frailty except at time point 5 (T5). Loneliness at specific time points (T1, T4 and T6) predicted greater frailty at later time points (T2, T5 and T7). The results also supported reciprocal and contemporaneous relations between social isolation, loneliness and frailty. Social isolation and loneliness are potential outcomes of frailty. Public health policies and health practitioners should prioritise interventions targeting social connection among older adults with pre-frailty or frailty.

Living With and Beyond Cancer With Comorbid Conditions: Qualitative Insights to Understand Psychosocial Support Needs.

There is a pressing need to understand and explore the complex experiences and psychosocial support needs of people LWBC-CM and their informal caregivers, to inform survivorship and supportive care interventions. In-depth qualitative interviews were conducted with people LWBC-CM and their informal caregivers in Scotland, invited via primary care. One-to-one, face-to-face interviews were conducted with informed consent exploring experiences of symptoms, psychosocial support needs and interactions with health services. Interviews were transcribed and analysed using a thematic approach. Forty-one people LWBC-CM and twenty-three informal caregivers were interviewed. Four themes were identified: the Physical and Psychological Impact of Cancer and Comorbidity, Dominant Storie-Prioritising Conditions and Making Sense of Illness, Navigating Health Services and Treatments and Caring for People with Complex Health Conditions. Type and severity of conditions mediated people's experiences and daily living. Complex fatigue-fatigue arising from a number of health conditions-dominated symptomology. Participants navigated multiple appointments and complex medication regimes. Patients identified the need for acknowledgement of other chronic conditions and for streamlined care provision. Mutual caring and social isolation were also identified as part of the caring relationship. There is a mandate to address the psychosocial support needs of people LWBC-CM, and their informal carers, given the burden of treatment for cancer survivors with moderate to severe complex conditions as they navigate health services. A patient representative has been involved in all stages of the study from development of the application through study design, commenting on documentation, analysis of transcripts and writing the manuscript. They are included as an author on the manuscript.

Development and validation of a natural language processing algorithm using electronic health record data to identify patients with breast cancer with low social support.

421 Background: Social support is important to the management of breast cancer treatment. Our team has developed data from electronic health record (EHR) data into structured ‘concept groups’ that will form the basis for the development of EHRsupport, a computable, EHR-based measure of social support. We report the evaluation of these concept groups against chart review as a part of our validation. Methods: We built a natural language processing (NLP) algorithm on clinical notes in 7,989 women diagnosed from January 2006 to September 2021 with invasive breast cancer. We identified and developed 10 concept groups from unstructured data: 1) living situation, 2) marital/partner status, 3) parenthood status, 4) visit support (accompanied patient to ≥1 visit, patient attended alone at ≥1 visit), 5) friends/other support, 6) explicit positive or negative mentions of social support, 7) mention of a deceased person, 8) transportation issues, 9) relationship conflict or stress, and 10) social isolation. We validated concept groups against the charts of 100 patients randomly drawn from the broader patient population (nonoverlapping with the training data set) also around the time (-1 to +3 months) of diagnosis. Results: Concept group data availability ranged from 1.3% social isolation to 98.3% for living situation. Specificity and negative predictive values were moderate to high for all concept groups. Sensitivity and positive predictive values were moderate to high for concept groups with high data availability (Table) and lower for concept groups with low data availability. Conclusions: Data on social support have been available since the advent of Epic in 2006 and our NLP-based algorithm accurately captured data within the EHR that were systematically collected supporting the development of a clinical tool that can be used to identify patients at risk of low social support. EHRsupport concept groups, data availability (n=7,989), and evaluation vs. chart review. Availability (%) Sensitivity Specificity PPV NPV Living situation (e.g., alone or not) 98.3 100 92 61 100 Partner/spouse 92.0 85 100 100 81 Parenthood status 88.8 95 80 93 83 Visit support 82.9 92 77 96 59 Positive mentions social support *46.9 75 100 100 70 Negative mentions social support 33 99 67 96 Friend/other support 46.8 81 81 79 83 Deceased person 39.9 86 97 95 90 Transportation issues 14.6 80 85 22 99 Relationship conflict/stress 7.7 25 95 29 94 *Availability of positive and negative mentions of social support.

Development and Validation of the Perceived Interpersonal Relevancy Scales: A New Measure of Perceived Threat, Opportunity, and Invisibility Appraisals for Use Across the Adult Life-Course.

Interpersonal relevancy appraisals are a dynamic and understudied aspect of human social cognition. Despite their importance, there are no existing measures. This study developed and validated a new measure of self-perceived interpersonal threat, opportunity, and invisibility appraisals among a life-course sample of adults. We also explored the relationships between relevance appraisals, social connectedness, loneliness, age, and sex-assigned-at-birth. Items were developed based on a theoretical model of multi-domain interpersonal relevance appraisals and refined following feedback from five experts in social psychology. Cross-sectional data were obtained online from a sample of 1,079 adults (age 18-90 years), recruited from the general population of Australia. Data were split into two pseudo-random samples used for 1) scale development and evaluation, and 2) assessment of internal consistency, construct validity, convergent validity with social connectedness and loneliness, and exploratory analysis with age and sex. Results support the factor structure and internal consistency of 17- and 9-item versions of the Perceived Interpersonal Relevancy Scales (PIRS) and measurement invariance across younger and older age groups. Higher self-perceived threat and invisibility appraisals were associated with decreased social network size, increased loneliness, younger age, and male sex. Higher self-perceived opportunity appraisals were associated with increased social network size and decreased loneliness. Results support this new measure of perceived interpersonal relevance appraisals, which shows relationships between the way we believe others perceive us, loneliness, and social isolation. The PIRS likely has wide utility for studies that seek to understand the intersections between human social cognition, well-being, and health across the lifespan.

Associations Between Social Media Use, Social Isolation, and Nutrition-related Chronic Disease: An Exploratory Cross-sectional Analysis of Health Information National Trends Survey (HINTS) Data

Associations Between Social Media Use, Social Isolation, and Nutrition-related Chronic Disease: An Exploratory Cross-sectional Analysis of Health Information National Trends Survey (HINTS) Data

Social Risk Factor Domains and Preventive Care Services in US Adults

Growing evidence suggests that social determinants of health are associated with low uptake of preventive care services. To examine the independent associations of social risk factor domains with preventive care services among US adults. This cross-sectional study used National Health Interview Survey data on 82 432 unweighted individuals (239 055 950 weighted) from 2016 to 2018. Subpopulations were created for each of the primary outcomes: routine mammography (women aged 40-74 years), Papanicolaou test (women aged 21-65 years), colonoscopy (adults aged 45-75 years), influenza vaccine (adults aged ≥18 years), and pneumococcal vaccine (adults aged ≥65 years). Statistical analysis was performed from July to December 2023. Six social risk domains (economic instability, lack of community, education deficit, food insecurity, social isolation, and lack of access to care) and a count of domains. Logistic regression models were used to examine the independent association between each primary outcome (mammography, Papanicolaou test, colonoscopy, influenza vaccine, and pneumococcal vaccine) and social risk factor domains, while controlling for covariates (age, sex, race and ethnicity, health insurance, and comorbidities). A total of 82 432 unweighted US individuals (239 055 950 weighted individuals) were analyzed. A total of 54.3% were younger than 50 years, and 51.7% were female. All 5 screening outcomes were associated with educational deficit (mammography: odds ratio [OR], 0.73 [95% CI, 0.67-0.80]; Papanicolaou test: OR, 0.78 [95% CI, 0.72-0.85]; influenza vaccine: OR, 0.71 [95% CI, 0.67-0.74]; pneumococcal vaccine: OR, 0.68 [95% CI, 0.63-0.75]; colonoscopy: OR, 0.82 [95% CI, 0.77-0.87]) and a lack of access to care (mammography: OR, 0.32 [95% CI, 0.27-0.38]; Papanicolaou test: OR, 0.49 [95% CI, 0.44-0.54]; influenza vaccine: OR, 0.44 [95% CI, 0.41-0.47]; pneumococcal vaccine: OR, 0.30 [95% CI, 0.25-0.38]; colonoscopy: OR, 0.35 [95% CI, 0.30-0.41]). Fully adjusted models showed that every unit increase in social risk count was significantly associated with decreased odds of receiving a mammography (OR, 0.74 [95% CI, 0.71-0.77]), Papanicolaou test (OR, 0.84 [95% CI, 0.81-0.87]), influenza vaccine (OR, 0.81 [95% CI, 0.80-0.83]), pneumococcal vaccine (OR, 0.80 [95% CI, 0.77-0.83]), and colonoscopy (OR, 0.88 [95% CI, 0.86-0.90]). This cross-sectional study of US adults suggests that social risk factor domains were associated with decreased odds of receiving preventive services; this association was cumulative. There is a need to address social risk factors to optimize receipt of recommended preventive services.

The prevalence of lifetime trauma and association with physical and psychosocial health among adults at the end of life.

National guidelines recognize lifetime trauma as relevant to clinical care for adults nearing the end of life. We determined the prevalence of early life and cumulative trauma among persons at the end of life by gender and birth cohort, and the association of lifetime trauma with end-of-life physical, mental, and social well-being. We used nationally representative Health and Retirement Study data (2006-2020), including adults age > 50 who died while enrolled (N = 6495). Early life and cumulative traumatic events were measured using an 11-item traumatic events scale (cumulative trauma: 0-5+ events over the lifespan). We included six birth cohorts (born <1924; children of depression [1924-1930]; HRS cohort [1931-1941]; war babies [1942-1947]; early baby-boomers [1948-1953]; mid-baby boomers [1954-1959]). End-of-life outcomes included validated measures of physical (pain, fatigue, dyspnea), mental (depression, life satisfaction), and social (loneliness, social isolation) needs. We report the prevalence of lifetime trauma by gender and birth cohort and the adjusted probability of each end-of-life outcome by trauma using multivariable logistic regression. The mean age at death was 78 years (SD = 11.1) and 52% were female. Lifetime trauma was common (0 events: 19%; 1-2: 47%; 3-4: 25%; 5+: 9%), with variation in individual events (e.g., death of a child, weapons in combat) by gender and birth cohort. After adjustment, increasing cumulative trauma was significantly associated (p-value<0.001) with higher reports of end-of-life moderate-to-severe pain (0 events: 46%; 1-2 events: 50%; 3-4 events: 57%; 5+ events: 60%), fatigue (58%; 60%; 66%; 69%), dyspnea (46%; 51%; 56%; 58%), depression (24%; 33%; 37%; 40%), loneliness (12%; 17%; 19%; 22%), and lower life satisfaction (73%; 63%; 58%; 54%). Older adults in the last years of life report a high prevalence of lifetime traumatic events which are associated with worse end-of-life physical and psychosocial health. A trauma-informed approach to end-of-life care and management of physical and psychosocial needs may improve a patient's quality of life.

Sex differences in fear expression and persistence in an animal model of Post-Traumatic Stress Disorder

Post-Traumatic Stress Disorder (PTSD) is a complex psychiatric condition arising from traumatic experiences, marked by abnormal fear memories. Despite women are twice as likely as men to develop PTSD, the biological mechanisms underlying this disparity remain inadequately explored, particularly in preclinical studies involving female subjects.Previous research shows that female rats exhibit active fear responses, while males display passive behaviors. Additionally, sex differences in ultrasonic vocalizations (USVs) during fear conditioning have been observed, indicating varying emotional responses.Here, we validated a traumatic stress model consisting of footshock exposure paired with social isolation − originally developed in male rats − on females for the first time, focusing on sex differences in fear memory expression, retention and extinction. Our findings reveal that only during trauma exposure, males predominantly exhibited passive responses, whereas females demonstrated more active responses, despite both sexes emitting similar numbers of alarm USVs. Females also showed lower levels of freezing and USV emissions throughout extinction sessions and displayed a higher extinction rate compared to males. Notably, only males displayed a conditioned fear response when triggered by a single mild stressor.These findings highlight sex differences in trauma responses and fear memory processes. The study emphasizes the importance of incorporating 22-kHz USV evaluations along with other behavioral metrics for a comprehensive understanding of fear memory. This research contributes to the existing literature on traumatic stress models as well as underscores the necessity of including female subjects in preclinical studies to better inform treatment and prevention strategies tailored to both sexes.

The impact of the COVID-19 pandemic on the incidence of sexual violence against children and adolescents in the home environment in Brazil

The scope of this article is to identify the impact of the COVID-19 pandemic on the incidence of sexual violence against children and adolescents in the home environment in Brazil. It involves an ecological time-series study using joinpoint regression based on data from the Notifiable Diseases Information System from 2009 to 2021. The relative frequency and crude incidence rates of sexual violence occurring in the home against the population group aged 0 to 19 years were analyzed, estimating the annual percentage change (APC) and average annual percentage change (AAPC), with a 95% confidence interval. The relative frequency of the problem was higher in 2020 (69.8%) and 2021 (71.7%), with an increase of 3.1% (p = 0.001) in 2017-2021. Girls were more affected, with rates rising in 2009-2012 (APC = 44.4; p = 0.010) and 2015-2019 (APC = 16.6; p=0.017) but falling in 2019-2021 (APC= -17.7; p = 0.042). All age groups showed a significant increase until 2019, and a reduction after this year for 5-9 years (APC = -18.6; p = 0.016), 10-14 years (APC = -14.1; p = 0.040) and 15-19 years (APC = -18.4; p = 0.021). The reduction in the incidence rates of this type of violence may have been influenced by the context of social isolation during the COVID-19 pandemic, which led to the underreporting of cases.

Associations between sensory impairment and functional limitations among older Chinese adults: mediating roles of social isolation and cognition

BackgroundThe high prevalence of sensory impairment and functional limitations in older adults is a significant concern, yet there is limited understanding of the relationship between these two conditions. Therefore, the objective of this study was to investigate the pathways connecting sensory impairment and functional limitations by examining serial multiple mediating effects of social isolation and cognition in older adults.MethodsUsing the China Health and Retirement Longitudinal Study dataset, a sample of 4871 older adults was selected. The study variables included sensory impairment, functional limitations, social isolation and cognition, and other covariates. A hierarchical multiple linear regression model was used to assess the association between sensory impairment and functional limitations. Mediation analysis was conducted to explore the sequential multiple mediating effects of social isolation and cognitive function in the relationship between sensory impairment and functional limitations.ResultsOur findings revealed a significant and positive association between sensory impairment and functional limitations (B = 0.615, 95% CI: 0.397, 0.834). After adjusting for social isolation and cognitive function, the impact of sensory impairment on functional limitations accounted for 87.19% of the total effect. Additionally, approximately 12.81% of the significant relationship between dual sensory impairment and functional limitations was mediated by social isolation and cognitive function. A serial multiple mediating pathway (sensory impairment → social isolation → cognition → functional limitations) was identified, with a coefficient of 0.013 (95% CI: 0.006, 0.020).ConclusionsOur study provides evidence for the mediating effects of social isolation and cognition in the relationship between sensory impairment and functional limitations. Given the prevalence of functional limitations among older adults with sensory impairment, it is crucial to consider social isolation and cognitive function in efforts to reduce the burden of disability care. Future validation of these findings through longitudinal studies is necessary.