Social Unit Research Articles

Unpacking Taiwan’s ‘People-Centred’ New Southbound Policy in Indonesia: A Transnational Perspective

Almost eight years since the start of Taiwan’s people-centred New Southbound Policy (NSP) in 2016, various discussions have arisen regarding the policy’s efficacy in enhancing Taiwan’s external relations with targeted countries in the Indo-Pacific region. Most scholars have primarily addressed this policy from a state-centric perspective, focusing on the impact of the policy on bilateral interstate relations. Contrary to the existing approach, this article employs a transnational perspective by looking at the practice and success of the policy from both state and non-state level analysis. The use of this approach gives a comprehensive understanding of the nature of the NSP and offers an alternative view on the study of foreign policy by focusing on the transnational level of interactions. Drawing on the case study of the talent exchange program between Indonesia and Taiwan, this article argues that while the NSP has improved the number of student, worker and academic exchanges between Taiwan and Indonesia, the policy has not achieved its aim of extending ‘genuine two-way’ exchanges, resulting in asymmetrical relations that present challenges to the overall achievement of the NSP. Keywords: New Southbound Policy, transnational politics, foreign policy, Taiwan, Indonesia. *

What are the determinants of variation in caretaker satisfaction with sick child consultations? A cross-sectional analysis in five low-income and middle-income countries

ObjectivesThe objective of this study was to explore determinants of variation in overall caretaker satisfaction with curative care for sick children under the age of 5 in five low-income and...

Abstract A045: Adhering to a culturally responsive framework: Integrating kinship into a multilevel community-based intervention for American Indian adults with comorbid type 2 diabetes and cancer

Abstract The prolific disparities of type 2 diabetes (T2D) and cancer in tribal communities is well documented. American Indian (AI) adults living with T2D are at greater risk of not only developing cancer, but also dying from it, with cooccurrence becoming increasingly prevalent. On rural tribal reservations, common environmental diabetogenic factors (e.g., obesity, lack of physical activity, poor diet, and stress) are considered as sources of elevated risk for both T2D and cancer. Critically important in improving both diabetes and cancer-related health behaviors and outcomes, particularly for AI people, is psychosocial support from family and community ties (e.g., kinship). Despite supporting evidence, few interventions include kinship as a key factor to promote best outcomes for T2D management among AI adults with a dual diagnosis of cancer. To address this growing issue, there is an urgent need for culturally and contextually adapted interventions aiming to address the cooccurrence of T2D and cancer that are, ideally, led by tribal communities. In this session, healthcare professional Early-Stage Investigators (ESIs), some of whom also identify as AI, will present community-based participatory research (CBPR) principles used to develop a multilevel Tribally tailored intervention, with kinship as a moderating factor, for AI adults living with both T2D and cancer. The ESIs represent a unique pool of providers invested in the community within which they work by co-creating an intervention which utilizes pre-existing strong community and familial norms. The ESIs further look to break away from the common trend in research to overgeneralize interventions and findings to all AI Tribal communities by tailoring the intervention to each specific Tribal Community engaged in the research intervention. To foster innovative research methods by emphasizing important historic and socio-cultural influences relevant to understanding the holistic context of health disparities in tribal communities, the guiding framework is the NIMHD Minority Health and Health Disparities Research Framework adapted for AI and Alaska Native Nations. In this research, individuals are viewed within the context of the broader social system where they function daily, while families and community are key stakeholders and leaders in the successful management of T2D and cancer. The approach focuses on diabetes-related barriers by providing family and social units with skills for successful T2D and cancer management, healthy communication, and shared commitment. In addition to these domains of influence, involving community systems is critical for a sustainable intervention that effectively addresses health disparities for T2D and cancer. Citation Format: Sheila L. Hammer, Timian M. Godfrey. Adhering to a culturally responsive framework: Integrating kinship into a multilevel community-based intervention for American Indian adults with comorbid type 2 diabetes and cancer [abstract]. In: Proceedings of the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2023 Sep 29-Oct 2;Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(12 Suppl):Abstract nr A045.

Re-analysis and meta-analysis of summary statistics from gene-environment interaction studies.

statistics from genome-wide association studies enable many valuable downstream analyses that are more efficient than individual-level data analysis while also reducing privacy concerns. As growing sample sizes enable better-powered analysis of gene-environment interactions, there is a need for gene-environment interaction-specific methods that manipulate and use summary statistics. We introduce two tools to facilitate such analysis, with a focus on statistical models containing multiple gene-exposure and/or gene-covariate interaction terms. REGEM (RE-analysis of GEM summary statistics) uses summary statistics from a single, multi-exposure genome-wide interaction study to derive analogous sets of summary statistics with arbitrary sets of exposures and interaction covariate adjustments. METAGEM (META-analysis of GEM summary statistics) extends current fixed-effects meta-analysis models to incorporate multiple exposures from multiple studies. We demonstrate the value and efficiency of these tools by exploring alternative methods of accounting for ancestry-related population stratification in genome-wide interaction study in the UK Biobank as well as by conducting a multi-exposure genome-wide interaction study meta-analysis in cohorts from the diabetes-focused ProDiGY consortium. These programs help to maximize the value of summary statistics from diverse and complex gene-environment interaction studies. REGEM and METAGEM are open-source projects freely available at https://github.com/large-scale-gxe-methods/REGEM and https://github.com/large-scale-gxe-methods/METAGEM.

EE368 Would Initiating Colorectal Cancer Screening from Age of 45 Be Cost-Effective in Germany? An Individual-Level Simulation Analysis

EE368 Would Initiating Colorectal Cancer Screening from Age of 45 Be Cost-Effective in Germany? An Individual-Level Simulation Analysis

Social Housing - A Key Part of Past and Pandemic Impacts

This Social housing represents a crucial facet of social welfare policy and affordable housing provision, constituting over 28 million residences, accounting for approximately 6% of the total housing inventory in OECD and non-OECD EU nations. Considerable variations exist among countries regarding the definition, scale, extent, target demographic, and provider types within the realm of social housing. Although social mixing remains a primary goal in many countries' social housing sectors, there's a growing concentration of lower- income and vulnerable occupants, leading to a diminished diversity of income levels. This trend poses challenges to the economic viability of the sector, fostering an increased spatial clustering of poverty and disadvantage. The size of the social housing sector has dwindled in recent years in nearly all countries with available data, except for six, while the absolute count of social housing units has declined in just four countries with available data. This decline can be attributed, in part, to reduced public investment in housing stock. The pandemic has significantly disrupted construction, rendering it challenging for numerous households to afford shelter and adversely impacting the housing sector. Many countries have initiated substantial revitalization projects to enhance the quality of social dwellings and their surrounding neighborhoods, aiming to address persistent challenges associated with social housing, such as segregation. Policymakers must ensure that renovation efforts do not displace low-income households. Key Words: Social housing, OECD, crisis, response, Finance, Pandemic.

Exploring The Cultural Barrier of Indonesian Pre-Service English Teachers During Their Teaching Practice at Primary School in Thailand

Understanding cultural barriers is crucial in the context of increasing global collaboration in education. This research addresses a gap in the literature by focusing on the cultural barriers hindering the Indonesian pre-service English teacher’s learning process and the strategies to deal with it in a cross-cultural context which is in Thailand primary school. Through qualitative research, involving semi-structured interviews that allowed participants to share their unique challenges and perspectives, three types of cultural barriers are identified; 1) Communication barriers due to language differences, English knowledge and skills of the Thai students; 2) Knowledge about the education of the host country which involves unfamiliarity with the Thai curriculum and Thai primary school learning routines; 3) The integration of technology as there is no facilitate to integrate technology and students’ misbehaviour. Thus, nine types of strategies to overcome these cultural barriers employed include harnessing various tools, asking for help from local people, utilizing verbal and non-verbal language, employing instructional strategy, applying a social approach, planning lessons and units, grouping students for instruction, using verbal intervention, and resorting to logical consequence. These findings emphasize the importance of training for future educators to thrive in cross-cultural contexts, highlighting the need for further research in policy and program development for pre-abroad training of aspiring teachers.

Technological Changes, Investments, and Unemployment Pre and Post Covid 19 in the United States A State-Level Analysis

Breaking the intractable cycle of poverty in a country requires effective resolution of the unemployment problem by the government. One approach to mitigate unemployment is to foster investment in various sectors, and in the era of the industrial revolution, technological innovation should also be considered. The correlation between technology and unemployment has been extensively debated, and this study seeks to examine the connections between technological progress, physical investment, education, inflation, and unemployment in the United States. We utilized panel data from the 51 states from 2015 to 2021 and found that technological advancements resulted in a decline in the unemployment rate, while inflation had an inverse relationship with it, as predicted by the Phillips curve. However, investments in education increased the unemployment rate, indicating that highly educated individuals experienced notable employment difficulties. Our study had two distinct parts: the initial phase analyzed the statistical explanations for the outcomes, while the latter phase introduced initiatives that focused on government intervention to halt the rising unemployment rate.

Unpaid Work by Women: A State-level Analysis of Evidence from Time-use Survey

Low and declining female labour force participation in India over the past two decades has turned attention to the high unpaid work time spent by women. The question, however, remains whether women spend more time on unpaid work because there are not enough jobs or whether it is time spent on unpaid work that is holding them back from participation in the labour force. Against this backdrop, the present article explores India’s nationally representative time-use survey conducted by National Sample Survey Office (NSSO) to estimate factors that explain variations in time spent by women in unpaid work at the state level. The results show that structural transformation, entailing a reduction in employment in agriculture and an increase in the share of industries in state GDP, does not necessarily entail any reduction in unpaid time spent by women if the technology embodied in industrialisation is not gender-friendly. Worryingly, progress in female literacy recorded by states is no guarantee of a reduction in unpaid work by women. However, a gender-friendly atmosphere does make a difference in the reduction in unpaid work reported by women. Similarly, targeted public policy intervention does relax the constraints that women face at home, with a positive effect on unpaid work time.

Smartphone sensor data estimate alcohol craving in a cohort of patients with alcohol-associated liver disease and alcohol use disorder.

Sensors within smartphones, such as accelerometer and location, can describe longitudinal markers of behavior as represented through devices in a method called digital phenotyping. This study aimed to assess the feasibility of digital phenotyping for patients with alcohol-associated liver disease and alcohol use disorder, determine correlations between smartphone data and alcohol craving, and establish power assessment for future studies to prognosticate clinical outcomes. A total of 24 individuals with alcohol-associated liver disease and alcohol use disorder were instructed to download the AWARE application to collect continuous sensor data and complete daily ecological momentary assessments on alcohol craving and mood for up to 30 days. Data from sensor streams were processed into features like accelerometer magnitude, number of calls, and location entropy, which were used for statistical analysis. We used repeated measures correlation for longitudinal data to evaluate associations between sensors and ecological momentary assessments and standard Pearson correlation to evaluate within-individual relationships between sensors and craving. Alcohol craving significantly correlated with mood obtained from ecological momentary assessments. Across all sensors, features associated with craving were also significantly correlated with all moods (eg, loneliness and stress) except boredom. Individual-level analysis revealed significant relationships between craving and features of location entropy and average accelerometer magnitude. Smartphone sensors may serve as markers for alcohol craving and mood in alcohol-associated liver disease and alcohol use disorder. Findings suggest that location-based and accelerometer-based features may be associated with alcohol craving. However, data missingness and low participant retention remain challenges. Future studies are needed for further digital phenotyping of relapse risk and progression of liver disease.

Anxiety and its associated factors Among Undergraduate Nursing Students During Psychiatry Clinical Placement: A Cross-sectional Study in MARDAN Khyber Pakhtunkhwa

The clinical education setting is a complex social unit that affects student skills within the clinical setting. Anxiety influences the student's performance in the clinical setting since it initiates the fight-or-flight response, leading to a positive or negative outcome. Objective: This study evaluates anxiety among students when they start rotation in the clinical area. Methods: An analytical cross-sectional survey was conducted to determine the anxiety level among undergraduate nursing students during psychiatry/mental health nursing clinical rotations in the psychiatry unit. Participants were recruited through the probability sample method. The sample of the study consists of 93 students of undergraduate level. A self-adapted questionnaire was distributed manually to collect data. Results: According to the survey result, 67.7% of students have a normal range of anxiety, whereas 32.3% of students have mild to moderate levels of anxiety during psychiatry clinical rotation. Conclusions: The study identifies a significant link between anxiety levels and semester, notably higher in the 6th semester and a marginal association with race. With majority in the normal range and few with mild to moderate anxiety, it suggests targeted support programs for students, especially in high-anxiety semesters.

Patient-Reported Outcomes (PROs) from the Phase 2 TRANSCEND FL Study of Lisocabtagene Maraleucel (liso-cel) in Patients (pts) with Relapsed or Refractory Follicular Lymphoma (FL)

Background: In TRANSCEND FL (NCT04245839), a global, phase 2, open-label, single-arm, multicohort, pivotal study, the CAR T cell therapy liso-cel showed promising efficacy and safety in pts with R/R FL (Morschhauser F, et al. Hematol Oncol 2023;41[S2]:877-880). Here, we present corresponding data for PROs. Methods: Adults with R/R FL after ≥ 1 prior (2L+) line of therapy (LOT) were enrolled in cohorts with 1 (2L), 2 (3L), or ≥ 3 (4L+) prior LOTs. After leukapheresis and lymphodepleting chemotherapy (LDC), pts received 1 infusion of liso-cel (100 × 10 6 CAR + T cells). Pts completed the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-30 items (EORTC QLQ-C30), Functional Assessment of Cancer Therapy-Lymphoma “Additional Concerns” Scale (FACT-LymS), and the EQ-5D-5L on the following schedule: pretreatment (≤ 7 days before LDC; baseline); before infusion on the day of liso-cel infusion (Day 1); on Days 15, 29, 60, 90, 180, 270, 365, 545, and 730 after infusion; and at the end of study assessment. PROs were evaluated using 6 EORTC QLQ-C30 primary domains of interest preselected for relevance to FL, including global health status/quality of life, physical functioning, role functioning, cognitive functioning, fatigue, and pain, and the FACT-LymS subscale assessing lymphoma-specific symptoms. EORTC QLQ-C30 remaining domains, EQ-5D-5L utility index, and EQ-VAS were examined in exploratory analyses. Unless otherwise stated, analyses were performed in all liso-cel-treated pts with assessments at baseline and ≥ 1 postbaseline visit. Separate analyses were done for pts receiving liso-cel as 2L and 3L+ therapy. Linear mixed-effects models for repeated measures were used to calculate least squares (LS) mean change from baseline for visits with ≥ 10 pts. In individual-level analyses, proportions of pts with clinically meaningful changes over time were calculated using published responder definitions. Time to confirmed deterioration or improvement in PROs was assessed in all PRO-evaluable liso-cel-treated pts by the Kaplan-Meier method. Results: Of 130 liso-cel-treated pts with 2L+ R/R FL, 116 were included in the EORTC QLQ-C30 analysis (median age, 60 years; 63% male; 55% White). Among them, 19 (16%) had received 1 prior line of systemic therapy and 97 (84%) had received ≥ 2 prior LOTs (3L, 44 [38%]; 4L+, 53 [46%]). Assessment completion rates were > 80% across visits. For EORTC QLQ-C30, mean baseline scores in study pts were comparable to EU and US population averages, with a few domains slightly worse than the EU general population. After liso-cel infusion, transient deterioration was observed in physical and role functioning and fatigue up to Day 15. Thereafter, PROs were maintained or showed meaningful improvements relative to baseline that approached or exceeded minimally important difference thresholds at some visits. Overall LS mean changes from baseline showed statistically significant improvements in most primary and some secondary domains of interest (Table 1). In individual-level analyses, from Day 29 onward, most pts (65%‒100% across domains and visits) experienced improvements or no changes in primary domains of interest. For all domains, median time to confirmed deterioration was longer than median time to confirmed improvement, indicating that liso-cel-treated pts had a greater chance of achieving improvement in PROs than of experiencing deterioration. More than half of pts achieved meaningful improvements in fatigue, pain, and FACT-LymS at 26, 5, and 15 weeks post infusion, respectively (Table 2). Across PROs, results were comparable between pts receiving liso-cel as 2L or 3L+ therapy, although those receiving liso-cel as 2L therapy generally demonstrated greater/faster meaningful improvements in most primary domains, including role and cognitive functioning, fatigue, pain, and FACT-LymS scores. Conclusions:In TRANSCEND FL, most pts with 2L or 3L+ R/R FL experienced statistically and clinically significant improvements in PROs after liso-cel treatment, including in quality of life, disease symptoms, and functioning. These data, which include the first report of PROs in pts with 2L FL treated with CAR T cell therapy, represent the direct patient experience with liso-cel treatment and complement liso-cel treatment outcomes demonstrating clinical benefit and manageable safety in pts with R/R FL.

Working for the Saints

This article presents some of the main dynamics of the social reproduction of an Italian community through an ethnographic study of the Feast of the Three Saints in Silkwood, North Queensland. It has been celebrated annually there since being imported from the Sicilian village of St Alfio in 1950. As a celebration of Italian sociality and the Italian way of life, the Feast offers a particular opportunity to study the relationship between popular religion, food production and consumption, the senses, memory and materiality. From this perspective, I argue that the Feast as ‘lived religion’ should be understood not only as an expression of Catholic devotion, but also in terms of the construction of a ‘domus’, defined as a social unit and a community based on shared values and practices enacted and continually renewed by the preparation of food and the sensorial aspects of commensality. In the ‘sacred street theatre’ of the Feast, it is by means of these food practices that a community comes into being by sharing knowledge, memories and feelings. [A religious feast in Sicily] is, above all, an existential explosion. (Sciascia 1965: 30)1 This completely irreligious way of understanding and professing a religion … has its roots in a profound materialism, a total rejection of all that entails mystery, invisible revelation, metaphysics. (Sciascia 1965: 21)

On religious ambiguity: Childhood family religiosity and adult flourishing in a twin sample

Ambiguity is an important notion in sociology, denoting situations where social actors and groups carry on without shared meaning. The current article applies this concept to the context of religiosity during people's upbringing, recognizing that multiple factors make family-level religion a complex experience. Indeed, though recent research portrays household religiosity in childhood as a sociocultural exposure with long-term implications for well-being, existing studies have yet to incorporate multiple inputs to consider the cohesiveness of that exposure. Using twin data from a national sample, we investigate whether consistency in recalled household religiosity is associated with mid-life flourishing. Multi-level linear regression models reveal that similarity in twin reports matter, above and beyond the actual level of religiosity individuals report and net of dis/similarity across other childhood recollections. We conclude that coherence in religious upbringing—whether religion was understood to be important or not—is a key ingredient for thriving later in life and then reflect more broadly on manifestations of sociocultural ambiguity in families and in larger social units.

Infertility Burden Across Indian States: Insights from a Nationally Representative Survey Conducted During 2019-21.

Infertility is an escalating global concern, impacting approximately one-sixth of the reproductive age population worldwide. Employing data from the National Family Health Survey-5 (NFHS-5, 2019-21), this study assessed the prevalence of primary infertility at both national and state levels in India. The data of the study was extracted from the National Family Health Survey and Individual file (women file) of the fifth round of NFHS encompassing a sample of 491,484 currently married women in the age group of 15-49 years. The findings showed that the prevalence of infertility is 18.7 per 1,000 women among those married for at least five years and currently in union. This prevalence increases as the duration of marriage decreases. On a state-level analysis, regions such as Goa, Lakshadweep, and Chhattisgarh exhibit the highest burdens. These findings underscore the growing challenge posed by primary infertility in India, calling for targeted interventions and policy measures. The establishment of a national infertility surveillance system is of pivotal importance in addressing this pressing public health issue.

Correlation between Commitment and Organizational Performance

Organizations are basically social units that are intentionally formed and may be reformed by taking into account the effectiveness and efficiency of achieving a particular goal. In addition, the role of the workforce of a company is essential because it is the main driver in running a smooth business and the company's performance; hence, it is considered as one of the assets of the company that must be maintained by fulfilling its needs and desires. However, the recent phenomenon indicates that the organizational performance of the company is still low, and there are numerous employees that are lack of competitiveness and productivity in carrying out their duties. Due to this reason, the researchers are interested in analyzing the correlation between commitment and organizational performance. The researchers utilized a causal research design to empirically test the correlation between commitment and organizational performance. One of the factors that is perceived to affect the employee performance is the organizational capabilities. The primary data of the study were collected by administering the questionnaire to the employees who work in manufacturing and service companies. The questionnaire was spread through e-mail to 100 respondents, and of the 100 respondents, 34 returned the answers. The data were then analyzed by using SPSS 25 through which the t-value test of the simple linear regression was determined. The results indicated that the commitment has a positive and significant correlation with the organizational performance. Every time there is a strengthening of commitment, there will be an increase in the organizational performance. This study shares similar findings with the previous studies. The implications of this research can be applied managerially by manufacturing and service companies. This finding is what distinguishes the present study from the previous research in which the latter is only applied for the service sector.

Hydrological sustainability of international virtual water trade

International virtual water (VW) trade helps to balance water stress across regions. However, it can be questioned whether such trade can remain sustainable as water resources are redistributed across regions resulting from changes in our climate. A conceptual framework to compare VW trade volumes with water fluxes within the water cycle is introduced. We evaluate the distribution of traded water surpluses and deficits associated with crop, animal, and industrial products over 157 countries and 182 global watersheds. About 7% of the countries are identified to conduct VW trade unsustainably. Regions within Africa, North America, central Asia, and Europe exhibit unfeasible VW trading resulting from higher appropriation of freshwater resources than availability influenced by precipitation and evaporation. Assessment at the watershed scale captures overexploitation at finer resolution, generally overlooked in country level analysis. An evaluation into the future reveals more watersheds becoming vulnerable to water storage depletion under future climate trends.

A System That Allows Users to Have a Job Interview Experience

Today, corporate companies spend a lot of time on and attach importance to job interviews in recruitment. In job interviews, they select or eliminate many of the candidates using interview techniques. This poses a serious problem, especially for candidates who have not had job interview experience, even though they meet sufficient requirements. Because these candidates do not have previous interview experience, they experience more difficulties in this process. In this regard, the study is about a system created in a virtual environment that allows a job interview experience through a user interface. The system subject of the study is a model consisting of a user interface unit, server, interview information database, language processing unit, behavior analysis unit, virtual interview unit, reporting unit, and social media integration unit. This proposed model has been detailed modularly through the web-based system.

Gender-Affirming Voice Training for Trans Women: Effectiveness of Training on Patient-Reported Outcomes and Listener Perceptions of Voice.

Although speech-language pathologists have provided gender-affirming voice training for trans women since the 1970s, evidence for this training's effectiveness remains weak. Our study aimed to redress limitations of earlier studies and evaluate voice training effects on outcomes important to trans women. Seventy-four trans women (19-54 years old) who wanted a more female-sounding voice were recruited through two health facilities and provided with an eight- to 12-session voice training program based on contemporary literature, usual clinical practice, and client-centered care principles. Self-reported outcomes and an audio-recorded reading sample were collected 3 months before, immediately before and after, and 3 months after training. Forty cisgender speakers were audio-recorded reading the same sample material as comparison voices. Seventy-nine naive listeners made gender-related voice ratings of an extract from these audio recordings. Training effectiveness was evaluated using group-level analyses (linear mixed-effects models) and individual-level analyses to establish what proportion of participants improved to a predetermined relevant degree. Group-level analyses demonstrated positive training effects, maintained 3 months posttraining, for trans women's vocal satisfaction, perceptions of voice-related social participation, and self- and listener perceptions of their voices. Individual-level analyses also demonstrated positive effects. Two thirds of trans women increased vocal satisfaction to a relevant degree, one third who reported restricted social participation before training reduced this restriction to a relevant degree, and all were rated more female-sounding after training (although not all to a relevant degree). All trans women participants made progress toward their voice goals and maintained those gains at follow-up. These findings provide evidence that gender-affirming speech-language pathology services warrant prioritization. Further research is warranted to investigate factors predicting outcomes of voice training for trans women.

Effectiveness and safety of catheter-directed thrombolysis for pulmonary embolism in key patient subgroups: results of an individual patient level analysis

Abstract Background The effectiveness of catheter-directed thrombolysis (CDT) for acute pulmonary embolism (PE) has been rarely investigated in subgroups of patients at a higher risk of complications. Furthermore, this group of patients has been excluded from prior and ongoing phase 3 trials with CDT. Purpose To assess the efficacy and safety of catheter-directed thrombolysis for pulmonary embolism among specific patient subpopulations. Material and methods We conducted an individual patient-level analysis of patient data from 16 cohort studies and randomized trials of CDT for intermediate- and high-risk acute PE. Studies were identified on the basis of a systematic review of the literature. We focused on early clinical outcomes, including haemodynamic decompensation, intracranial bleeding, major bleeding, and death, as well as on the changes in the mean pulmonary artery pressure (mPAP) before and after CDT. We predefined three subgroups of at-risk patients: (i) older age (i.e. ≥75 years), (ii) active cancer, and (iii) surgery in the prior 4 weeks. Results We studied 1244 patients, of whom 586 (47.1%) were women. The median age was 61 (Q1-Q3; 50-71) years. There were 202 (16.3% of total available) patients aged 75 years or older, 101 (10%) with active cancer, and 108 (14.8%) with prior surgery. A total of 946 (89.3%) patients had intermediate-risk PE, and 113 (10.7%) were classified in the high-risk group. Patients aged ≥75 years more frequently suffered haemodynamic decompensation (7.5% vs 1.6% aged <75 years; p< 0.001), major bleeding (12.7% vs 4.5%; p<0.001), and death (9.2% vs 2.2%; p<0.001); Table 1. In a multivariable logistic regression model, age remained associated with death, major bleeding, and haemodynamic decompensation after adjustment for a key prognostic factor (high-risk PE). The same, except for decompensation, was observed after conditioning for sex, high-risk PE, and cancer status. Patients with active cancer showed a tendency to a higher 30-day case fatality when compared with patients with no active cancer, without reaching statistical significance; Table 1. Recent surgery did not appear to influence the outcome rate in this cohort. No differences were found among the three subgroups regarding the reduction of the mPAP following CDT ; Table 2. Conclusions Our results point to age as a strong predictor of early mortality and decompensation in patients undergoing CDT, even after adjusting for the higher rate of high-risk PE in the elderly. The clinical net benefit of CDT in the elderly when accounting for bleeding and the risk of haemodynamic decompensation remains unclear.Efficacy and safety outcomes of CDTmPAP values before and after CDT