Patients face many Social, economic and Psychological problems faced in hospitals. The primary caregivers of people with various mental illnesses, such as early psychosis, chronic schizophrenia, depressive disorders, anxiety disorders, and others, were the focus of this study, which sought to examine their psychological, economic, social and quality of life. Patients face social problems in hospitals. They face many difficulties while living in the hospital. The present study is designed to examine hospitalized patients' social, psychological and economic issues and their effects on their quality of life in the Muzaffargarh District. Government hospital patients are participating in the study as respondents. Data collection made use of the multistage sampling technique. First, the Hospital Muzaffargarh is deliberately chosen. The sampling data was collected from 375 respondents. The second stage used the hospital record to create a list of attendants. In the third stage, three hundred seventy-five data are randomly selected from the list. In light of the research objectives, an interviewing schedule was created for the data collection. The ten respondents as a pretest population evaluated the questionnaire's acceptability. Using Social science statistical software, data was examined using descriptive regression methods (SPSS).