New guidelines implemented by the U.S. Department of Health and Human Services exempt broad categories of social science research from regulation by university review boards. The analysis examines how exemption from regulation will change the way researchers manage ethical matters in the future. Social scientists will wish to protect the rights of research subjects and, at the same time, study sensitive social issues by scientific designs. As in the past, these goals will be incompatible in various ways. The analysis examines the parameters within which researchers will deal with several ethical and methodological dilemmas.