YBa 2Cu 3−xCo xO 7−δ goes through a metal-insulator transition near x = 0.4. When these doped YBCO materials are used as barriers in SNS junctions, a clean interface can be formed due to their excellent match of lattice constants and thermal expansion coefficients. By using three doping levels, x = 0.12, 0.21 and 0.42, we have estimated the effects of the dopant from the temperature and thickness dependences of I c and R n. In the framework of conventional de Gennes proximity effect theory, we have observed a crossover from the clean limit to the dirty limit as the doping level approaches the metal-insulator transition. In the case of x = 0.42, which no longer superconducts on its own, we had to invoke a pair-breaking mechanism by a cutoff scattering rate in order to explain the slower increase of the critical currents at low temperatures than the standard proximity effect would predict. Several ideas on the possible origins of such a cutoff scattering rate will be discussed. By adding Pr dopants in the Co-doped barrier, we were able to deduce the elastic scattering effect of Pr dopants, which results in smaller diffusion constants. The interfaces YBCO forms with other barriers such as (CaSr)RuO 3 and (LaSr)CoO 3 have been investigated in detail. The defect states on the surface of YBCO seem responsible for the observed zero bias conductance anomaly.