Sneak Peek Research Articles

RTKs in pathobiology of head and neck cancers.

Non-communicable diseases contribute to 71% of the deaths worldwide, of which cancers rank second after cardiovascular diseases. Among all the cancers, head and neck cancers (HNC) are consequential in augmenting the global cancer incidence as well as mortality. Receptor tyrosine kinases (RTKs) are emphatic for the matter that they serve as biomarkers aiding the analysis of tumor progression and metastasis as well as diagnosis, prognosis and therapeutic progression in the patients. The extensive researches on HNC have made significant furtherance in numerous targeted therapies, but for the escalating therapeutic resistance. This review explicates RTKs in HNC, their signaling pathways involved in tumorigenesis, metastasis and stemness induction, the association of non-coding RNAs with RTKs, an overview of RTK based therapy and associated resistance in HNC, as well as a sneak peek into the HPV positive HNC and its therapy. The review extrapolates the cardinal role of RTKs and RTK based therapy as superior to other existing therapeutic interventions for HNC.

A sneak peek into the curriculum on disaster management medicine in India for health professionals: A mixed-methods approach.

INTRODUCTION:India being a disaster-prone country necessitates us to be able to act proactively for any sort of preparedness and prevention. This necessitates a curriculum which can bring all the aspects related to disaster under one umbrella and thus impart training.AIM:The aim of the study was to assess the responses of students about the importance of disaster management (DM) in their MBBS course, take up suggestions about the important inclusions to be made in their curriculum, and get an insight of the higher education and research of DM domain in the Indian context.METHODOLOGY:A cross-sectional study with a batch of 100 MBBS students purposively sampled were part of the questionnaire. Besides, a thorough Internet search for institutes providing training on DM was done, and relevant details were noted down. Later on, the students were given guest lectures and demonstrations by certified trainers and experts along with a know-how of where to go for getting a hands-on training and whom to respond to.RESULTS:Seventy-two percent of the students felt the portion of DM being taught to them to be insufficient, and 95% never got any training or demonstration for DM although 22% felt that it is not so important for them as a doctor. Only 23% of them knew about any sort of DM courses or certifications in India, and almost 16% of the students were confident enough to tackle any incidence of public health emergency.CONCLUSION:Making an earlier start will impart seriousness and accountability in the mindset of budding physicians.

Sliding Sign and Gel Sonovaginography: A Sneak Peek Prior to Laparoscopy in Patients with Endometriosis.

Context:The rising incidence of endometriosis may be due to improvisation in the diagnostic techniques. Transvaginal sonography has proven to be very useful in the diagnosis of complexity of the disease and in turn to predict the intraoperative findings on laparoscopy.Aims:The aim was to study the use of sliding sign for detecting the status of the pouch of Douglas (POD) and to check for the presence of bowel and nonbowel deep infiltrating endometriosis (DIE) by gel sonovaginography.Settings and Design:This is a prospective observational study carried out patient division of Department of OBG in Kasturba Hospital Manipal.Methods:The study was carried out over a period of 2 years and included 136 women. After written informed consent, a detailed history and clinical examination was done. A detailed transvaginal sonography was done for each of the patients by a single observer on the Philips HD11XE machine two-dimensional transvaginal probe which included gel sonovaginography and real-time dynamic test called sliding sign.Statistical Analysis:Chi-square test was used in this study.Results:Sliding sign is highly specific, sensitive, and accurate for the detection of POD obliteration. It is 96.6% sensitive and 89.5% specific. It is 94.1% accurate and 94.5% positively predictive for the same. Transvaginal sonography is >92% specific for the detection of bowel and nonbowel DIE. The accuracy is over 91%. The negative predictability is 93.6% and 94.6%, respectively.Conclusions:Sliding sign is a useful, easy-to-perform, reproducible, and noninvasive modality for assessing the status of POD. Gel sonovaginography is also useful in accurately detecting the presence of deep infiltrating endometriotic deposits.

A Review on Medicinal Properties of Mangosteen (Garcinia mangostana L.)

Indonesia is rich in medicinal plants where its population has used them traditionally from generation to generation in curing diseases. Traditional medicine and medicinal plants from Indonesia may lead to the discovery of the novel drugs. The mangosteen or Garcinia mangostana L. is a well-known to cure several diseases and applied in various folk medicinal stockpile. In recent decades, scientist has discovered the phytochemical composition in the whole plant of mangosteen as well as the pharmacological activities. These studies established the therapeutic potential of mangosteen for the drug's discovery. Therefore, the present review gives a sneak peek view on mangosteen's ethnobotany, toxicology, pharmacology, and phytochemistry.

A Sneak Peek at Planned K 2019 Introductions

A Sneak Peek at Planned K 2019 Introductions

Introduction to the inaugural volume of Indiana Working Papers in South Asian Languages and Cultures (IWPSALC)

Welcome to the inaugural volume of IWPSALC. In creating this publication—inspired by progress reports like those published from 1965 through 1995 as the Haskins Laboratories Status Report on Speech Research—we seek to encourage scholars to publish discrete portions of their research while they work towards full papers. The papers included herein are a small sampling of the work that began in Spring 2018, work which will be presented at future conferences, be expanded for other publications, and serve as the basis for future dissertations. Since much of the research is still ongoing, in a sense this volume provides a sneak peek at things yet to come. Topics touched on range from the phonetic to the syntactic to the descriptive. Thank you for picking up this volume and showing interest. We hope the contents are of interest and we look forward to future conversations.

Mammary cancer: Sneak peek to thyroid nodules

Mammary cancer: Sneak peek to thyroid nodules

A Rendezvous with the Ghosh Brothers: a sneak peek into Bengal’s homegrown exploitation cinema

ABSTRACTThe article is part of a broader research project that considers the low budget sector of contemporary Bengali cinema and its relationship to the regional popular culture. I intend to draw critical attention towards a recent and unique development in Bengali popular cinema that stages a bizarre encounter between high art and low-brow sensibilities in the regional culture. This previously uncharted terrain also testifies to Bengali cinema’s new found kinship with certain established practices of exploitation cinema prevalent in the West as well as many Asian countries, which complicate conventional generic classifications, as well as prevalent taste cultures. The article uses the author’s in-depth interview with the Ghosh Brothers, a significant directorial duo working in this field, to chart the economic and cultural networks that sustain such a fringe phenomenon. The larger aim of the project is to unravel the socio-political contexts overseeing such precarious developments in a regional popular culture and to understand their relevance in the context of widely expanding studies of marginal cinematic cultures

Products on Display at Display Week 2019

AbstractDisplay Week shines a spotlight on new and developing displays, display components, and display systems from the industry’s top manufacturers and best ground‐floor start‐ups. Use the pages ahead to get a sneak peek at this year’s exhibition and look for these products and more on the show floor in San Jose.

Circulating Tumor DNA Provides a Sneak Peek into Treatment Responses in Non-Small Cell Lung Cancer.

Circulating tumor DNA (ctDNA) holds great promise as a noninvasive diagnostic tool to guide treatment for patients with lung cancer. Two studies by Phallen and colleagues and Anagnostou and colleagues correlated sensitive measures of ctDNA with clinical responses to tyrosine kinase inhibitors (TKI) and immune checkpoint inhibitors, respectively, in patients with non-small cell lung cancer (NSCLC). Together, these studies further highlight the potential clinical utility of serial ctDNA monitoring in patients with NSCLC undergoing treatment with both targeted therapies and immunotherapies.See related articles by Phallen et al., p. 1204, and Anagnostou et al., p. 1214.

A First Look at Display Week 2019

AbstractWhat can you expect from Display Week, the Society for Information Display's annual conference? Now in its 56th year, it offers many of the signature features that the display community has come to expect, as well as new presentation tracks, new programs, and new opportunities to network. Here's a sneak peek at the event.

Sneak peek of Hypericum perforatum L.: phytochemistry, phytochemical efficacy and biotechnological interventions

The phytochemistry of Hypericum perforatum (St. John’s wort) has been elaborated extensively owing to its immense application in medicinal chemistry. Illustrated pharmacological activities like antidepressant, antiviral, and antibacterial effects demonstrated its substantiation for numerous of the conventional purposes reported for St John’s wort. St. John’s wort is herbal remedy extensively used in mild to moderate depression. Most of pharmacological activities were assigned to presence of photosensitive naphthodianthrone; hypericin and other allied flavonoid constituents. Escalating demands of hyperforin as antidepressant added more lure to H. perforatum L. The crude extracts of H. perforatum containing phloroglucinols were used for free radical scavenging and against DNA damage. To meet increasing demands of this drug, researchers need to tailor out the biosynthetic pathways to improve secondary metabolite. This necessitated advancement in biotechnological intervention to improve phytochemical potential of this growing herb. This review will brief out ecology, chemistry and phytochemical efficacy with respective phytoconstituents. Further, review will emphasize biotechnological interventions including both conventional and modern contrivances that have been implemented to augment the glory of this species.

Financial Crisis in Germany: A Sneak Peek

Financial Crisis in Germany: A Sneak Peek

A sneak peek into channelopathies

A sneak peek into channelopathies

'Sanctifying sex': exploring 'indecent' sexual imagery in pentecostal liturgical practices

Pentecostalism, like many other church traditions, is well known for its fixation with doctrinal dualisms which enforce a separation of body and spirit, and a Puritan sexual ethic. These conservative sexual norms have led to the policing of bodies and sexual practices. As a result, instead of encouraging safer sexual practices, the churches have been known to enforce abstinence outside of marriage, or sexual restrictions within it, thus marking sex in general as ‘inde-cent’. Some of the consequences of this repression of sexuality are young people being forced into early marriages to avoid ‘living in sin’, teenage pregnancies as a consequence of not wanting to disobey the church’s teaching on sex and contraceptives, as well as more serious consequences of unbridled sexual expressions resulting in sexually transmitted viruses. The consequences of a repressed sexuality are indeed serious. However, what if this ‘repressive hypothesis’ can be challenged within Pentecostal spaces? What if, like Foucault suggests, a deeper engagement with the subject matter would show, not sexual censorship, but rather a re-channeling of sexuality? Drawing on Foucault’s challenge to the repressive hypothesis, where he suggests that so-called repressed sexuality finds ‘appropriate’ outlets in spaces such as psychi-atry and prostitution, this essay suggests a third outlet, namely Pentecostalism. While particular sexual discourses may be constructed as indecent and conta-minated as ‘sin’, liturgical and deliverance practices ironically signify erotic relationships between the divine and the believer. Proceeding with an ‘in-decent’ theological lens, as proposed by Marcella Althaus-Reid, we argue that Pentecostalism’s liturgical practices ironically and unconsciously open up possibilities for more embodied, real, and sexed experiences of the divine. This consideration not only expands the interpretive possibilities for how we mark relationships with the divine, but also how sexual relationships between humans are shaped and possibly destigmatized. In taking a sneak peek ‘under God’s skirt’, in Althaus-Reid’s words, we reimagine the indecent as sacred. Through an analysis of how bodies and rituals are marked by discursive prac-tices within the songs and performances in these churches and an examination of a blasphemy case, this essay lays bare the critical spaces available for more embodied theologies – ‘sexual healing’ that perhaps even the worshipers them-selves have unconsciously ignored.Keywords: Pentecostalism, sexuality, indecent theologies, embodiment, Foucault

Digital image approach to tool path generation for surface machining

Conventional tool path generation algorithms are usually dependent to the surface geometry and thus case-sensitive. A specific tool path planning method for regular parametric surfaces cannot directly handle a triangular mesh surface, and vice versa. Presented in this paper is a unified digital image representation of a surface, along with a general process of tool path generation and optimization directly based on such representation. Regarding different objectives and utilities, three typical digital images are introduced to represent a projectable surface. Each digital image induces a uniform discrete scalar/vector field indicating the surface geometric property, which can be further applied to the cutter contact curve generation, tool orientation determination, and the cutting simulation tasks. Preliminary examples give a sneak peek of the capability of the proposed method. It is observed that, instead of utilizing geometry-based algorithm, some global optimization task of the tool path is transformed into finding a proper convolutional kernel and its parameter for the image processing. Though more investigation is worth spending in the future, the proposed approach inaugurates a standard and effective way to facilitate the tool path generation and optimization task for surface machining.

An Improvised Feature-Based Method for Sentiment Analysis of Product Reviews

In today’s society, sentiment analysis has gained due importance as it provides useful information about products that are used by variety of users. It gives a sneak peek of users’ reactions towards the products that are available in the market at an early stage. It thus intimates users’ perception and charts out a path that is beneficial for the market to grow as a whole. Although a lot of research is done to exploit the product based sentiment analysis but due to increase demand of the detailed components based products and their associated features, a novel method is desired to meet these criteria. So far, no such method is explored that analyses the product’s components and their features simultaneously, on the basis of sentiments of the users. This paper proposes an improvised Feature Based Algorithm (FBA) for the sentiment analysis of product reviews while formulating a tree structure of product, components, and associated features. In addition, evaluation of double negative sentences, detecting questions and emotions from the review sentences are measured which increases efficiency of the FBA method. The comparison of product’s components reviews is done with other existing algorithmsTF, TF-IDF and Naive Bayes to demonstrate that the proposed FBA is coherent and auspicious.

A delve into the exploration of potential bacterial extremophiles used for metal recovery

A multitude of microbes are involved in the solubilisation of minerals and metals as this approach offers numerous advantages over traditional methods. This strategy is preferred as it is eco-friendly and economical, thus overcoming the drawbacks of the traditional approach of pyrometallurgy. Many different types of bacteria are employed in the process of Bioleaching, which are collectively grouped under chemolithotrophs, as they derive their energy from inorganic compounds. Bioleaching is the mobilization of metal cations from insoluble ores by microorganisms. All chemolithotropic bacteria are extremophiles since they have the ability to survive in extreme conditions. They carry out the process of Bioleaching through three mechanisms: Indirect, contact/ direct and cooperative bioleaching. This review gives a sneak peek into the different strains of chemolithotrophs which are used in bioleaching, and some recent work in the field. It also gives an insight into the general process and mechanism of Bioleaching, the study of which will pave way for developing better and efficient industrial bioleaching operations.

A Sneak Peek into 5G Communications

The world of mobile communications is poised for yet another disruptive transformation – the introduction of 5G. It will change the way mobile phones communicate. New technologies at the device level and novel network architectures to manage them will be soon seen everywhere. This article explores what 5G is all about. It also talks briefly about the preparations underway across the globe to deploy 5G by 2020.

Constrained optimization framework for interface-aware sub-scale dynamics models for voids closure in Lagrangian hydrodynamics

In hydrocodes, voids are used to represent vacuum and model free boundaries between vacuum and real materials. We give a systematic description of a new treatment of void closure in the framework of the multimaterial arbitrary Lagrangian–Eulerian (ALE) methods. This includes a new formulation of the interface-aware sub-scale-dynamics (IA-SSD) closure model for multimaterial cells with voids, which is used in the Lagrangian stage of our indirect ALE scheme.The results of the comprehensive testing of the new model are presented for one- and two-dimensional multimaterial calculations in the presence of voids. We also present a sneak peek of a realistic shaped charge calculation in the presence of voids and solids.