This paper proposes the design of gray wolf optimizer (GWO) algorithm-based fractional order proportional integral (FOPI) controller for power factor correction (PFC) using interleaved dc–dc single ended primary inductance converter converter with improved performance characteristics such as speed, accuracy, and stability. The detailed analysis and modeling of the proposed converter are presented. The optimal parameters of FOPI controller are obtained using GWO algorithm to improve the speed of response of the system. FOPI controller provides better performance in terms of robustness and stability since it has one more adjustable parameter than the conventional proportional integral (PI) controller. The cascade control strategy is implemented for the proposed converter with GWO-based FOPI controller as inner current and outer voltage controllers for PFC and load voltage regulation. The performance characteristics of the proposed system are analyzed and compared with conventional and other optimization techniques using MATLAB/Simulink software. A prototype of the proposed converter controlled by TMS320C2000 microcontroller for an output power of 200 W is tested and validated with the simulation results. The proposed system is used for powering devices like robots in critical applications such as military, space craft, etc., where stability, speed, and accuracy are major concerns.