The centrifugal pump with high rotation speed is the key component in the cooling system of an aircraft. Because of the high rotation speed, the impeller inlet is very prone to cavitation. Two impellers with different types of blades (cylindrical and splitter) are designed, and the numerical models of the pumps are built. The authenticity of the numerical models is validated with the corresponding experiments in terms of both the hydraulic and cavitation characteristics. Then, the effects of different coolants and working temperatures on the hydraulic and cavitation performances of the prototype models are studied based on the numerical simulations. The results show that the head and efficiency of the pump for conveying water are higher than those for conveying ethylene glycol (EG) aqueous solution and propylene glycol (PG) aqueous solution (EGaq and PGaq are defined to represent the EG aqueous solution and the PG aqueous solution, respectively). The hydraulic performance in the EGaq is slightly better than that in the PGaq. The cavitation performance of water is far less than that of the EGaq and PGaq under high working temperature. The volume of cavitation in EGaq is smaller than that in PGaq, and the volume of cavitation in the splitter blades is slightly smaller than that in the cylindrical blades. It is suggested that EGaq be used as the first option. The splitter blades can improve the cavitation performance somehow while the improvement by using the splitter blades is very limited at high rotation speeds, and the design of the short blades should be careful in order to obtain a smooth internal flow field.