Abstract In subway station fires, the most immediate threat to passengers’ life is not the direct exposure to fire, but the smoke inhalation with hot air and toxic gases. Thus, the study on efficient smoke control is of theoretical and practical significance. In this paper, the fire dynamics simulator (FDS) is used to study the effects of open mode of platform screen doors (PSDs) on mechanical smoke exhaust in subway station fire. The fires is located on the middle of the platform. And the results indicate that open platform screen doors on both sides of the platform, can not only reduce the gas temperature, but also improve the efficiency of mechanical smoke exhaust, which are beneficial to safety evacuation.