This study researched on the smoke control system which is applicable for delay and prevention on fire spreading in the most common case of central core open intelligent building. Fire simulation program (FDS) was used to analyze the effect on the applicability of selected fire scenarios on each case. As a result, I confirmed that fire shutters blocked fire spreading by limiting fire zone, but the effect of blocking fire spreading of smoke control window installed on one surface was reduced after time has passed. The study found that the area ratio and the height of windows and installation on multiple surfaces shall be considered in order to improve the smoke exhaust effect of smoke control window. Air flow of ventilation shall be calculated with the consideration of fire load and the HRR of internal combustibles and the smoke outlet are determined to be effective with securing a sufficient size in square shape. Especially the result of this study can be maximized by mixed complex operations of smoke control system which is proposed through this study rather than the individual applications.