Numerous solutions have been proposed for the emerging “Smart Hospital-Room”, however, there is little progress made yet. Interesting approaches include the Amplion Smart (er) Room of the Future, the IBM-UPMC (University of Pittsburgh Medical-Center), the NXT-Health-program of the US-Department of Defense and the EU-Agency for Network and Information Security. Nevertheless, a Hospital Smart-Room has to be cost-effective and it is the aim of this project, to pinpoint the most important catches. Crucial delay-factors and high-cost sources have been traced, by following the innovation trail, as reflected upon numerous Hospital-Technology related Patents and other research Publications, synopsizing the obstacles for achieving an acceptable and interoperable Electronic Medical Record and the enhanced Cognitive-computing based ways to harness, share, manage and trace big-data. On the other hand, increased Patient-interactivity and participation, is a cardinal challenge for the future’s Smart-Room and the Health-care providers need access to real-time, Point-of-care feedback, on a continuous basis. Finally, Technology supporting overloaded clinical-staff causes frequently complications and tension. Therefore, Clinical-workflow improvements require goal-oriented training, based on Patient-care-plans and supported by mature and cost-effective Technologies. Cost, lack of education and short-term focusing lead to cul-de-sac. The Hospital-leaders must realize that the world is changing dramatically; in order to survive, they have to offer Smart, innovative, efficient and above all affordable and cost-effective Health-care. Modern Photonics may improve dramatically the smooth operation of the “Smart Hospital-Room”, as it is proven in the detailed created “Patent mappings” relating Photonics Technology and Health-care.