Small Families Research Articles

Antenatal socioeconomic status of childhood family and the risk of pain spreading (ROPS) in early and mid-adulthood - a descriptive study from the northern Finland birth cohort 1966.

The Risk of Pain Spreading (ROPS) is a six-item tool capturing key data-driven prognostic factors for chronic pain and its spreading. Higher values on the ROPS indicate a higher risk. Early factors potentially associated with the ROPS are unknown. We aimed to examine the associations between antenatal socioeconomic status of childhood family (antenatal SES) and ROPS at ages 31 and 46years. The study was based on the Northern Finland Birth Cohort 1966 and previously formulated latent clusters of antenatal family SES: Highest status (the reference), Small, Larger, Average wealth, and Rural families. The ROPS ranged from zero (the reference) to two or more points out of six. A multinomial regression model was used to identify antenatal SES clusters associated with ROPS. At 31years (n=8252), only the Larger families cluster was associated with having accumulated points (two or more) (Odds ratio [OR]: 1.46, 95% Confidence Interval [CI]: 1.14-1.87) on the ROPS compared to the Highest status families cluster. Corresponding finding was observed at 46years (n=6245), but the Small families and Average wealth families clusters were also associated with this outcome. The association of Larger families cluster was, however, the strongest (OR 1.48, 95% CI 1.16-1.89). Offspring born into families with ≥5 members are likely to accumulate higher sums of key data-driven prognostic factors for worse pain across the life course until middle age. In future, associations between antenatal SES and pain would be important to be examined in a light of the ROPS.

Household Food Insecurity and Its Association with Nutritional Status of Children 6–59 Months of Age in Kebridehar City

Malnutrition, characterized by an imbalance in the intake of calories, proteins, or other nutrients, includes undernutrition and overnutrition. This study aimed to assess the impact of household food insecurity on the nutritional status of children aged 6 to 59 months in Kebridehar town using a community-based cross-sectional approach. The city of Kebridehar was divided into 12 kebeles and the study targeted families with children in the specified age group. A proportional sample of 344 households was randomly selected from each kebele. Data were collected through surveys and analyzed to determine the prevalence of food insecurity and its effects on children's nutrition.Results: The study revealed significant disparities in food security: 11.6% of households were food secure, while 88.4% were food insecure. Female-headed homes had a lower percentage of impoverished children and the mother's education had a vital influence. Low- and middle-income households had a larger risk of childhood loss than higher-income ones. Smaller families were 15.76 times more likely to suffer food insecurity and homes without health services were 3.27 times higher potential to be food insecure. Children from insecure food families have poorer health outcomes, being 4.95 times more likely to be underweight, 1.30 times more likely to be stunted, and 1.45 times more likely to be wasted.Conclusion: The study highlights an important problem of food insecurity that affects the health of children. Factors such as the woman's family, the mother's education level, low income and family size are crucial. Urgent interventions are necessary to improve food security and nutritional outcomes, especially for families with low income, less education, and poor sanitation.

Abstract 4134792: SIRTUIN5 Modulates Na + /Ca 2+ Handling Via Oxidative Stress Dependent Manner In Mouse Heart

Background: The cardiac Na + channel Na V 1.5 (encoded by SCN5A ) governs cardiac inward Na + current (I Na ) and the fast upstroke and plateau phases of the cardiac action potential. Mutations in Na V 1.5 can cause acquired or inherited arrhythmias and conduction diseases, including ~20% of cases of Brugada Syndrome (BrS). Changes in I Na can impact Ca 2+ handling and cardiac excitation-contraction coupling. We have previously shown that SIRT1-mediated deacetylation of Na V 1.5 increased I Na . Recently, potential mutations (including P114T) in SIRT5, another NAD + -dependent deACYLase in the Sirtuin family localized to mitochondria, were identified in small families with BrS. Hypothesis: Sirt5 dysfunction evokes arrhythmias via Na + and Ca 2+ mishandling in an oxidative stress-dependent manner in mouse hearts. Aims: To explore the potential role of SIRT5 in BrS using heterologous expression systems and homozygous P114T-Sirt5 knock-in (P114T-KI) mice. Methods: Protein expression and physical interactions were detected by immunoprecipitation and immunoblot. The effects of SIRT5 on Na + current was measured using patch clamp in HEK cells and mouse cardiac myocytes. Confocal microscopy was used to measure reactive oxygen species (ROS) and for Ca 2+ imaging. Results: Both WT and P114T-SIRT5 co-immunoprecipitate with Na V 1.5, but WT increased peak I Na in HEK cells while P114T did not (Fig A,B). Live-cell staining using DCFDA or mitoSOX showed that P114T-KI hearts had increased basal ROS and were more sensitive to oxidative stress induced by H 2 O 2 than WT littermates. P114T-KI hearts had increased Na + /Ca 2+ exchange protein 1 (NCX1) expression, and Langendorff-perfused hearts displayed abnormal Ca 2+ handling and arrhythmias (Fig C). Notably, treatment with the mitochondrial ROS scavenger mitotempo mitigated the aberrant Ca 2+ handling and arrhythmias. Conclusion: These findings suggest that the P114T-SIRT5 causes abnormal Na + and Ca 2+ handling and arrhythmias in a ROS-dependent manner, highlighting potential mechanisms underlying BrS. This finding may pave the way for the use of SIRT5 or its activators as novel anti-arrhythmic therapies in the future.

Exploring determinants of basic childhood vaccination coverage in Bangladesh: a generalized Poisson regression analysis

IntroductionChildhood vaccination is crucial for safeguarding children against potentially life-threatening diseases. This study aims to investigate the significant factors influencing vaccination coverage among children aged 12–59 months in Bangladesh.MethodsThe study utilizes cross-sectional data from the 2017–18 Bangladesh Demographic and Health Survey. A Kruskal–Wallis test is employed in bivariate analysis to identify significant predictors associated with childhood immunizations. A generalized Poisson regression model is applied to assess the impact of various risk factors on children’s incomplete vaccination status.ResultsChildren born in the Sylhet division show lower chances of receiving immunizations. Additionally, children whose mothers are younger, have no education or only primary education, and are unemployed, are less likely to be fully vaccinated. Furthermore, children born into smaller families, first birth, those whose mothers had access to media, and those who received more than four antenatal visits during pregnancy are more likely to have received all recommended vaccines.ConclusionImplementing targeted interventions to improve childhood vaccination coverage, particularly among vulnerable populations such as young and uneducated mothers with middle-income status, is crucial. Enhancing media access, promoting the utilization of antenatal care at health care facilities, and raising awareness about the benefits of vaccination can help ensure optimal vaccination coverage among children in Bangladesh.

Время новых налоговых решений

The author considers the processes and phenomena occurring and emerging in the Russian tax reality amid foreign sanctions. The concept of tax capital has confirmed its relevance and viability. The historical excursion and the demographic crisis enable to return to the discussion of the tax on small families. The current VAT calculation procedure actually encourages late payment and needs to be changed. The harsh environment threatens to erode universally recognised principles of taxation.

From Family to Community: A Preliminary Discussion on Strengthening the Sence of the Chinese National Community through the Integration of Family and Country

The Chinese nation shares the same culture and ancestry, and the traditional values of the unity and homogeneity of the family and the country in Chinese civilization indicate the development prospects and process of various ethnic groups on the road of rejuvenation, which is characterized by unity and solidarity, and has become an endogenous driving force for strengthening the sense of community of the Chinese nation. At a new historical starting point, with the focus and support on the unity of family and country, we aim to strengthen the sense of community among the Chinese nation, providing important value guidance and spiritual support for consolidating the shared spiritual home of the Chinese nation and consolidating its centripetal force. We should promote the construction of modern civilization of the Chinese nation and enhance the cultural subjectivity of the Chinese nation; Focusing on "small families", melting millions of "family dreams" into the "Chinese Dream" of the great rejuvenation of the Chinese nation; Focusing on "everyone", inheriting and innovating excellent traditional Chinese culture, and enhancing the subjectivity of Chinese national culture; Looking at the world, we should enhance the conscious identification of various ethnic groups with the sense of community of the Chinese nation through cultural exchange and mutual learning.

Językowa kreacja rodziny w polskojęzycznych wypracowaniach uczniów z doświadczeniem migracyjnym

The article presents the linguistic creation of a family reconstructed on the basis of the works of Polish and foreign students from families with migration experience studying in Polish schools in Poland and abroad. In the collected corpus of over 200 works, the young authors created, apart from parents, many other family members, creating images of small and large families functioning in everyday life and during holidays. When creating an image of a family, the young authors used primarily the lexical resources of general Polish, and the analyzed material reflects the joy that comes with writing about family.

Assessing the Potential of 1,2,3-Triazole-Dihydropyrimidinone Hybrids Against Cholinesterases: In Silico, In Vitro, and In Vivo Studies.

Combining the pharmacological properties of the 1,2,3-triazole and dihydropyrimidinone classes of compounds, two small families of mono- and di(1,2,3-triazole)-dihydropyrimidinone hybrids, A and B, were previously synthesized. The main objective of this work was to investigate the potential anti-Alzheimer effects of these hybrids. The inhibitory activities of cholinesterases (AChE and BuChE), antioxidant activity, and the inhibitory mechanism through in silico (molecular docking) and in solution (STD-NMR) experiments were evaluated. The 1,2,3-triazole-dihydropyrimidinone hybrids (A and B) showed moderate in vitro inhibitory activity on eqBuChE (IC50 values between 1 and 58.4 μM). The best inhibitor was the hybrid B4, featuring two 1,2,3-triazole cores, which exhibited stronger inhibition than galantamine, with an IC50 of 1 ± 0.1 μM for eqBuChE, through a mixed inhibition mechanism. Among the hybrids A, the most promising inhibitor was A1, exhibiting an IC50 of 12 ± 2 µM, similar to that of galantamine. Molecular docking and STD-NMR experiments revealed the key binding interactions of these promising inhibitors with BuChE. Hybrids A and B did not display Artemia salina toxicity below 100 μM.

Current status and the future trajectory of geriatric services in Nigeria

The world population of people aged 65 and above, termed as older persons, is increasing rapidly. The number of people aged 65 years or older worldwide is projected to more than double, rising from 761 million in 2021 to 1.6 billion in 2050. The number of people aged 80 years or older is growing even faster. Population ageing is an irreversible global trend. It is the inevitable result of the demographic transition – the trend toward longer lives and smaller families – that is taking place even in countries with relatively youthful populations. In 2021, one in 10 people worldwide were aged 65 or above. In 2050, this age group is projected to account for one in six people globally [1]. People are living longer because of better nutrition, sanitation, healthcare, education, and economic well-being. With increasing age, older adults become at greater risk for diseases, disability, and side effects of medications. The common geriatric syndromes suffered by older persons include degenerative joint diseases, falls and mobility issues, sensory impairments (visual and hearing), dementia, sleep disturbances, frailty, and urinary incontinence. These syndromes are described as ‘Giants of Geriatrics’ on account of the impact on quality of life, and functional status of older persons. Geriatricians provide person-centered holistic care that attempts to preserve function and maintain a good quality of life by deploying the comprehensive geriatrics assessment and management approach which involves a multidisciplinary team (MDT). Nigeria has an increasing ageing population that will benefit from a healthcare system that is aligned to their peculiar care needs in the different settings care will be sought. This can be achieved by building capacity in the various disciplines involved in providing comprehensive care to older persons, and including geriatric medicine in the training curriculum for medical students, nurses and all allied health workers.

Mining human microbiomes reveals an untapped source of peptide antibiotics

Drug-resistant bacteria are outpacing traditional antibiotic discovery efforts. Here, we computationally screened 444,054 previously reported putative small protein families from 1,773 human metagenomes for antimicrobial properties, identifying 323 candidates encoded in small open reading frames (smORFs). To test our computational predictions, 78 peptides were synthesized and screened for antimicrobial activity invitro, with 70.5% displaying antimicrobial activity. As these compounds were different compared with previously reported antimicrobial peptides, we termed them smORF-encoded peptides (SEPs). SEPs killed bacteria by targeting their membrane, synergizing with each other, and modulating gut commensals, indicating a potential role in reconfiguring microbiome communities in addition to counteracting pathogens. The lead candidates were anti-infective in both murine skin abscess and deep thigh infection models. Notably, prevotellin-2 from Prevotella copri presented activity comparable to the commonly used antibiotic polymyxin B. Our report supports the existence of hundreds of antimicrobials in the human microbiome amenable to clinical translation.

Sums of multidimensional Kloosterman sums

AbstractWe obtain a new bound on certain multiple sums with multidimensional Kloosterman sums. In particular, these bounds show the existence of nontrivial cancellations between such sums in very small families.

Diversity of jack fruit germplasm in Pudukkottai district of Tamil Nadu

The present investigation was undertaken to develop a variety of jackfruit. Hence, the research was conducted on the bearing trees of different jackfruit genotypes in the Pudukkottai District of Tamil Nadu, India, during the year 2016-2019. Fifty-five jackfruit genotypes, viz., KDM-AhJ-01 to KDM-AhJ-55, were selected for the study to identify superior ones. The season of fruiting in each genotype was recorded and classified into early (March-April), mid-season (May-June), and late (July-August). The genotype 46 was found to be mid-season bearing (May-June, 2016-2019). Meanwhile, KDM-AhJ -08, KDM-AhJ -10, and KDM-AhJ -35 were found to have late season bearing (July to August 2016-2019). The genotypes KDM-AhJ 31 and KDM-AhJ 32 were produced during the main season (March-April, 2016-2019) and also during the off-season (September -November 2016-2019) production of jackfruit. The highest number of fruits per plant (43.33.00) was obtained from 08, followed by 31 (33.33). Maximum individual fruit weight was gained from 46 (16.33 kg) followed by 10 (14.33 kg), and a minimum of (4.67 kg) was observed that genotype 08 was suitable for small families. Yield varied from 62.67 kg/tree to 458.33. Yield was recorded from 10. The highest number of flakes per fruit was obtained from 10 (210.00). The highest Flakes: Seed ratio was obtained from 10 (5.30). Upper limit TSS content recorded to 08 (29.17° brix). The highest total sugar (25.20%), highest protein, lowest acidity (0.10%), and lowest ascorbic acid content were found to be 8. Maximum carotene content was recorded on KDM-AhJ- 46, followed by 8 and 10. Maximum color and appearance of 9.00 were obtained from the genotypes KDM-AhJ- 10. A maximum overall acceptability of 9.75 was observed by genotype 08, followed by 10 (9.00). Genotype 51, recorded for the TSS content of (6° brix) followed by the genotypes viz.,6, 18, 20, 21, 22, 24, 25, and 26 (7° brix), was found to have low TSS content, hence it is suitable for diabetic patients. Genotype 37 was identified for vegetable purposes in the immature stage, and ripened fruits were more suitable for table purposes. KDM-AhJ- 31 and 39 identified for thousand fruited jackfruit genotype. Flake color varied from white, yellow, whitish yellow, light yellow, bright yellow, and senthuram/deep orange. The genotypes KDM-AhJ-01, 4, 7, and 10 showed good deep orange (Senthuram color) flakes. Genotype 45 recorded pure white flakes that were very sweet in taste. The owner of this jackfruit farmer, S.Karthick, said this is for Seeni pala. Genotypes 17, 18, and 19 were identified for Tharaipala. The shelf life of flakes varied distinctly among the fifty-five jackfruit germplasms. The genotypes KDM-AhJ -08 and KDM-Ah -10 record for five days. Among the 55 genotypes, diversity was recorded for every genotype. Based on overall performance concerning vegetative growth, yield, and quality, characters were recorded to identify the superior genotypes.

Cherished sons and considerate daughters? Claims to resettlement housing in the urbanizing Eastern China

China’s urbanization has led to massive demolition and resettlement projects on the edge of the expanding cities, moving affected villagers into resettlement housing. This study examines the consequent changes in family property structures, focusing on how resettlement housing was redistributed between sons and daughters. This study draws on fieldwork in the suburban area of an expanding city in Shandong, Eastern China, and analyzes in-depth interviews about how resettlement housing was divided in families that had (1) both sons and daughters, (2) sons only, and (3) daughters only. The findings suggest that the sons’ privilege in receiving housing properties was more salient in families with more children (three children or above) and with both sons and daughters. In small families (with one or two children) or daughter-only families, it was more likely for siblings’ needs and daughters’ contributions to be mentioned in the division of properties; when daughters adjusted their family roles, such as assuming the role of the ‘heir,’ their negotiation for inheritance rights changed. Built on studies about how local governments and rural communities have ignored or reproduced gender inequality in property structures in urbanization, this study illustrates how gendered access to housing varies across family structures.

Mutual fund partial liquidation and future performance

AbstractWe examine the determinants of mutual fund partial liquidation and the effect of a negative shock to fund size on performance. We find that older funds from a smaller family with a large number of share classes are more likely to conduct partial liquidation. As fund size decreases after partial liquidation, its performance improves. This effect is more pronounced for funds with stronger pre‐event liquidity constraint and funds that subsequently experience a larger decrease in liquidity, suggesting that liquidity constraint is a contributing factor of fund performance. These findings are consistent with mutual funds having decreasing returns to scale.

Greywater heat recovery to the refill water of a dishwasher via paraffin wax and steel wool aided segmental baffle heat exchanger

In this study, the recovery of household dishwasher greywater thermal energy into dishwashing water using paraffin wax and steel wool supported segmental heat exchanger was experimentally investigated. The heat exchange performance was 40% in rapid, economy, and intensive modes and the heat recovery was 0.048, 0.031 and 0.082 kWh, respectively. Efficiency increased by 5.01%, 3.84%, and 6.5%. Time and energy were saved, and hygienic washing was accomplished by raising the washing temperature and reducing the cycle time nearly 97, 113, and 240 s. It is estimated that by using heat exchangers on 16,954,196 dishwashers in use in Turkey, small, medium, and large families can save an average of 127.366, 254.733 and 509.466 GWh per year, respectively, provided they use the three dishwasher modes equally. The annual economic size of the gain and its contribution to emission reduction in CO2 equivalents are $15.793 million, $31.586 million, $63.173 million and 112.974 kt, 225.948 kt, 451.897 kt, respectively. Energy efficiency index of dishwasher increased from 48.84 to 46.97.

Investigating the Prevalence of the Giardia lamblia Parasite in Children in Salah Al-Din Governorate

The research was conducted from June 2023 until December 2024 to detect the prevalence of infection with the Giardia lamblia parasite among children with diarrhea attending Tikrit Teaching Hospital in Salah al-Din Governorate. The study included collecting 400 stool samples for children whose ages ranged between (1-12) years. Direct wet swab to detect the presence of the parasite. The level of infection with the parasite reached 14.75%. The highest rate of infection was in males at 67.7% and lower in females at a rate of 32.2%. The highest rate of infection was at the age of (1-3) years at a rate of 38.9% and the lowest rate was 11.8% at the age of (9-12) years. The infection rate was 69.4%, high in families with 10 or more members, while in small families (4-5) individuals, the infection rate was 30.5%. The infection rate was highest in children who drank unfiltered river water, at 50.8%, and lowest in children who drank pure water, at 3.3%. The prevalence of this parasite in rural areas was higher than in urban areas, at a rate of 55.9% in all areas of the governorate. It was found that there were varying rates of infection in the different months of the year, reaching 28.8% in the summer, and the lowest infection rate in the winter.

Sustainable future food demand: Integrating social, health, and environmental considerations in forecasting

Predicting future food demand and understanding its environmental and dietary ramifications are vital for ensuring food system sustainability in an equitable manner. Existing forecasting methods often overlook societal diversity and do not connect projected food demand with its socio-environmental implications. This paper introduces a framework for forecasting a nation's future food demand with considerations for socio-demographics and dietary preferences, along with potential dietary and environmental implications. Israeli household expenditure surveys spanning two decades (1997–2017) representing over 120,000 households were used to explore a series of potential food purchase scenarios for the period up to 2030 and the nutritional and environmental footprints of subgroups. These subgroups included small and large families, young couples, the elderly, and wealthy adult households. Three dietary scenarios based on expected socio-demographic changes were then examined: “Environmental,” “Healthy,” and “Mediterranean” scenarios. All examined scenarios predicted a surge in food demand by 18 to 22 % for the period of 2018–2030. The “business-as-usual” (BAU) scenario emphasizes the expected rise in the consumption of meat, oil products, and food outside the home, leading to a 20 % rise in greenhouse gas emissions. In comparison, in the case of the Healthy scenario, emissions are expected to rise by 22 %, and according to the Environmental scenario by only 10 %. Significant differences were also discovered across various social groups in regard to the analyzed dietary and environmental indicators. Although the study focuses on Israel, the proposed framework's universality makes it adaptable to any country. This could empower policymakers and stakeholders to craft food security informed decisions and targeted interventions that address the needs of diverse social groups while considering socio-environmental implications both presently and in the future.

Water, Sanitation and Hygiene (WASH) Facilities in Sikkim: Findings from National Family Health Survey (NFHS) 5

ABSTRACT The UN General Assembly has recognized access to improved drinking water and sanitation as a fundamental right. Despite this, a significant portion of the global population lacked access to safely managed drinking water (around 25%) and improved sanitation (around 50%) in 2020. India, the second most populous country, has approximately 3.7% of its population without access to improved drinking water and 31% without access to improved sanitation. This article examines factors influencing household access to improved drinking water and sanitation in Sikkim, India, using National Family Health Survey (NFHS) 5 data. The findings reveal that urban households, older, unmarried, female-headed households, with smaller families, earning higher incomes, located in the North, West and South districts, were more likely to have access to improved drinking water. Similarly, households with unmarried heads, located in higher wealth quintiles, located in the East district, were more likely to have access to improved sanitation facilities. The study suggests subsidizing the cost of improved water and sanitation services for poor rural households and increasing public investment to make these facilities more affordable for them.

Factors associated with adolescent food Security and nutritional status in a selected rural area of the central region of Bangladesh

Food insecurity affects physical growth, health of adolescents and nutritional status while food insecurity is common in rural area of Bangladesh. During adolescence, individuals have gone through series of key transitions into adulthood which may be hindered by food insecurity and poor nutritional status. The present study aimed to identify the most relevant factors that may be associated with food security and nutritional status of adolescents. Additionally, this study also tried to explore the association between adolescent food security and their nutritional status. This Cross-sectional study was carried out among 317 unmarried adolescents aged 10 to 19 years in a selected rural area of central region of Bangladesh. Multistage cluster sampling and purposive sampling were followed to select households and enroll adolescents into the study. Other than descriptive statistics, chi-square test was performed to test the difference between groups as well as to evaluate expected associations between different predictors and outcome variables. Additionally, univariate logistic regression was carried out to estimate the effect of predictor variables on the outcome variable. Moreover, multivariate logistic regression analysis was conducted to control the potential confounder effects upon desired outcome variables. It is observed that around 32.5% adolescents were food secure whereas 67.5% adolescents were food insecure. Our study also reveals that two predictor variables such as family income and family size had significant association with food security where odds of becoming food secure were higher among the adolescents from higher income families (AOR=6.1; 95% CI=2.240-16.718) and smaller families (AOR=3.4; 95% CI=1.563, 7.495). Furthermore, prevalence of underweight, normal nutritional status and overweight was 13%, 83% and 4% respectively where adolescent educational qualification and occupation were significantly associated with normal nutritional status. Adolescents with higher educational qualification (AOR=12.3;95% CI=5.270,28.479) and involved in work (AOR=12.3;95% CI=5.270,28.479) were more likely to have normal nutritional status compared to those who were primarily educated and not involved in work. Further study is recommended to replicate the findings and to generate new knowledge about relevant factors associated with adolescent food security and nutritional status. Bioresearch Commu. 10(2): 1573-1582, 2024 (July)

Sibling Availability, Sibling Sorting, and Subjective Health Among Chinese Adults

Despite rising numbers of only children in China, little is known about their family dynamics and well-being in adulthood—for example, how often they marry other only children and whether those in siblingless families have worse or better health than others. Theoretical expectations produce opposing predictions: siblings might provide social and emotional support and reduce parental caregiving pressures, but only children might receive more support from parents and grandparents. Using the 2010 China Family Panel Study, we examine marital sorting on Chinese adults’ number of siblings and test whether sibling availability and sibling sorting are associated with subjective physical and mental health. Despite general perceptions that China has an exceedingly high prevalence of adults with no siblings that might produce very small families, results demonstrate a low prevalence of siblingless couples (i.e., both spouses are only children). Married adults with no siblings or siblings-in-law have better subjective physical health but similar levels of subjective mental health relative to their counterparts with siblings. The health advantages of siblingless marital unions are greater for rural and female adults. Declining sibling prevalence in China will shape future family demographic dynamics but appears less detrimental to population health than sometimes assumed.