Traditional access control system is relatively simple, low efficiency, small storage capacity, which can not meet the initiative, timeliness, and flexibility requirements of security technology in the Internet of Things. To solve this problem, this paper researches and designs the intelligent access control system based on Radio Frequency Identification (RFID) technology. The system consists of an access control management system and an access controller. The system can not only be used as the import and export of safety management, but also contribute to the internal order management, achieve effective control and management of access control region.