The first data on the composition and quantitative development of meiobenthos in the small tropical Cai River (Central Vietnam) at the end of the “small rainy season” (early June) have been obtained. In the community composition, 101 taxa out of 15 systematic groups have been documented. Specimens which are new for science (Acari), new for the fauna of Vietnam (Nematoda, etc.), and rare representatives of surface waters (Syncarida) are found. The largest part of taxonomic diversity is formed by Nematoda (38 taxa), Annelida (18), and Chironomidae (22). The same groups dominated in abundance. The taxonomic richness, abundance, and biomass of the community varied within 4–45 taxa, 3.8–161.9 thousand ind/m2, and 0.05–2.2 g/m2. In general, the type of changes of all parameters along the river profile was classical: the values increased from the upper mountain sections to the lower plain parts. The revealed pattern testifies to the important role that hydrodynamics play in the macroscale distribution of meiobenthos in the river during the period under study. The dependence that the community characteristics have on the local features of biotopes (microdistribution) is not as definite and requires an additional study of more extensive material.