SummaryThe size of the Tilapia nilotica population in Lake George was determined using purse seines. Production, mortality rate, size at maturity, and other parameters of the population were also determined. In Lake George, the factors that regulate the population of T. nilotica are both natural and artificial. The restricted size of nursery zones, strong fish‐killing storms, predation and old age are some of the natural regulators. For the adult population, mortality due to these factors is low (natural mortality coefficient, M=0.1). However, commercial fishing appears to have a stronger controlling force. Since the intensification of commercial fishing in 1950, the size of the fish caught has been decreasing, whereas the number of fish caught has been increasing yearly, probably as a result of increasing effort and the use of small mesh nets. These two trends may be the cause for T. nilotica to mature at a smaller size than they did 15 years ago.