Small Ionization Chamber Research Articles

Small ion pulse ionization chamber for radon measurement in underground space

Radon, prevalent in underground spaces, requires continuous monitoring due to health risks. Traditional detectors are often expensive, bulky, and ill-suited for humid environments in underground spaces. This study presents a compact, cost-effective radon detector designed for long-term, online monitoring. It uses a small ionization chamber with natural airflow, avoiding the need for fans or pumps, and includes noise filtering and humidity mitigation. Featuring multi-point networking and easy integration capabilities, this detector significantly enhances radon monitoring in challenging, underground conditions.

Simulation of radon detection efficiency with small pulse ionization chamber based on Geant4

Radon measurement is crucial in assessing the damage to the human body caused by natural radiation. Pulsed ionization chambers are effective for real-time radon measurement and have widespread applications in other radiation techniques. However, due to practical constraints such as limited space and portability concerns, it becomes imperative to consider not only the detection efficiency but also their ease of transportation. This work utilizes the Geant4 Monte Carlo simulation toolkit to characterize the detection models of small cylindrical and flat plate-type pulsed ionization chambers, and carry out a simulation study to analyze the three crucial factors that influence detection efficiency, including the geometry of the chamber, electrode size, and operating temperature. The results indicate that the cylindrical pulse ionization chamber, with a length of 8 cm and radius of 2 cm, has the best detection efficiency and portability in terms of geometric dimensions, achieving a detection efficiency of (58 ± 4)%. Meanwhile, the flat plate pulse ionization chamber, with dimensions of 7 cm in length and 3 cm in width, achieves the best detection efficiency and portability, with a detection efficiency of (54 ± 3)%. In terms of electrode wire size, the cylindrical ionization chamber electrode wire with a length of 7 cm and a radius of 2.5 mm was optimal with a detection efficiency of (59 ± 4)%. In terms of operating temperature, the detection efficiency of the flat-plate pulsed ionization chamber was the highest at 30 °C, which was (58 ± 4)%, and that of the cylindrical pulsed ionization chamber was the highest at 20 °C, which was (63 ± 4)%. By analyzing the influencing factors of the detection efficiency of the pulsed ionization chamber, it has a certain reference value and guiding significance for the research and design of small pulsed ionization chamber detectors for radon measuring instruments.

Implementation of a Patient Specific QA Protocol for a Novel Dedicated Stereotactic Radiosurgery Linear Accelerator

To describe the patient specific QA (Quality Assurance) protocol implemented for plan integrity verification, in stereotactic radiosurgery (SRS) and radiotherapy (SRT) treatments performed on a novel dedicated frameless image guided radiosurgery system using conical collimator, and a combination of yoked gimbals to cover near2pi solid angle. Startup and commissioning results obtained for planned vs measured dose distributions with several detectors are presented. The patient specific QA protocol includes: A) Review of the approved plan based on AAPM TG 275 report recommendations B) 1D verification using small volume ionization chambers inside an anthropomorphic head phantom C) 2D dose verification of a coronal and sagittal dose plan performed with high resolution 2D Array and respective phantom apparatus D) In-house independent MU (Monitor Unit) calculation using the same formalism of the vendor TPS (Treatment Planning Systems) RayTracing dose-calculation algorithm E) Monte Carlo based secondary dose check & plan QA. A retrospective analysis of the results of the first 15 patients treated is presented, focusing on plan complexity vs QA results. The 1D results obtained for the 15 SRS plans were within ±5% for all reported cases, with a mean percent difference of -1,25%, confirming an overall good agreement and, as expected, a partial volume effect in plans with smaller collimators. For the 2D dose verifications, with a 10% dose threshold, gamma passing rates of 97,5% (coronal) and 96,78 (sagittal) with 3% 1mm criteria, 95,1% (coronal) and 94,3% (sagittal) for 2% 1 mm criteria and 90,7% (coronal) and 90,0% (sagittal) for 1% 1mm criteria were obtained. Moreover, the results showed a correlation between lesion volume or number of collimators used with gamma passing rates. All MU verification results were within ±0,3% and provides an efficient risk mitigation approach for this new delivery technique. The verification results of the first 15 treated SRS plans confirmed point dose and planar measurements in agreement with TPS calculations, with superior results for planes with smaller lesions and fewer collimators. This also represents an integral validation of the image-based alignment system and fine treatment couch movements, as treatments are intrinsically multi-isocentric.

Application of OSL strips in CT dosimetry according to the AAPM methodology

Computed tomography (CT) images contribute to high-quality medical diagnosis, but radiation dose can be quite high, requiring accurate assessment. CT dose index (CTDI) was developed for dosimetric purposes, but for scanners operated exclusively in axial mode. Nowadays, CTDI underestimate patient dose in helical CT exams. AAPM report TG111 (2010) suggested a new metric in which the patient's radiation dose is obtained from dose profiles constructed from several measurements made with a small ionization chamber. It is also possible to obtain dose profiles using properly calibrated OSL (optically stimulated luminescence) strips. The main objective of the present work is to contribute to optimizing CT dosimetry, comparing dose profiles obtained with OSL strips with measurements obtained by other authors. In this work, a “pencil” ionization chamber and 20 cm x 0.3 cm OSL strips were X-ray-irradiated, in air and in the holes of two cylindrical CT phantoms, using 100, 120, 140 kV peak voltages, both in lab and in a clinical CT scanner. Irradiated strips were read using an OSL reader built in the GDRFM. OSL profiles were calibrated against ionization chamber. From them, CTDIw and CTDIvol values were determined, differing approximately 3.9% from those of the CT scanner. From the profiles, also the planar equilibrium dose Deq,p (TG111) was evaluated in some CT protocols; Deq,p exceeded the CTDI values from the CT scanner in every case. E.g.: The percentage difference between Deq,p and CTDIvol for the head phantom ranged between 33-25%. Thus, in some cases, it could be advantageous to use calibrated OSL dosimeters instead of ionization chambers to obtain the profiles, saving time, because it is possible to obtain five OSL profiles from a single phantom irradiation.

Correction factors for commissioning and patient specific quality assurance of stereotactic fields in a Monte Carlo based treatment planning system

Validation of small field dosimetry is crucial for stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). Accurate and considered measurement of linear accelerator dose must be compared to precise and accurate calculation by the treatment planning system (TPS). Monte Carlo calculated distributions contain statistical noise, reducing the reliance that should be given to single voxel doses. The average dose to a small volume of interest (VOI) can minimise the influence of noise, but for small fields introduces significant volume averaging. Similar challenges present during measurement of composite dose from clinical plans when a small volume ionisation chamber is used. This study derived correction factors for VOI averaged TPS doses calculated for small fields, allowing correction to an isocentre dose following account for statistical noise. These factors were used to determine an optimal VOI to represent small volume ionisation chambers during patient specific quality assurance (PSQA). A retrospective comparison of 82 SRS and 28 SBRT PSQA measurements to TPS calculated doses from varying VOI was completed to evaluate the determined volumes. Small field commissioning correction factors of under 5% were obtained for field sizes of 8 mm and larger. Optimal spherical VOI with radius between 1.5 and 1.8 mm and 2.5 to 2.9 mm were determined for IBA CC01 and CC04 ionisation chambers respectively. Review of PSQA confirmed an optimal agreement between CC01 measured doses and a volume of 1.5 to 1.8 mm while CC04 measured doses showed no variation with VOI.

Transition of Standard Dosimetry of Absorbed Dose to Water in External Beam Radiotherapy [Part 1]

The radiotherapy is performed with the aim of delivering the optimal dose to the target volume with minimal side effect of surrounding normal tissue. For this purpose, quality assurance is essential to ensure that the target volume is correctly irradiated in the optimal geometrical arrangement, and the absorbed dose evaluation is essential to ensure that the prescribed dose is correctly delivered. The absorbed doses are generally evaluated using a small cavity ionization chamber that utilizes gas ionization. For the evaluation of absorbed dose to water using ionization chambers, the national dose and charge standards, ionization chambers and electrometer calibration systems are required. And it is also required standard dosimetry protocol that recommend conditions such as fields, depths, and optimal ionization chambers for the measurement, as well as reliable physical data. This manuscript reviews the transition of standard dosimetry of absorbed dose to water in external beam radiotherapy, including the background of dose standards, ionization chamber calibration systems, units, and physical constants.

Validating a double Gaussian source model for small proton fields in a commercial Monte-Carlo dose calculation engine

PurposeThe primary fluence of a proton pencil beam exiting the accelerator is enveloped by a region of secondaries, commonly called “spray”. Although small in magnitude, this spray may affect dose distributions in pencil beam scanning mode e.g., in the calculation of the small field output, if not modelled properly in a treatment planning system (TPS). The purpose of this study was to dosimetrically benchmark the Monte Carlo (MC) dose engine of the RayStation TPS (v.10A) in small proton fields and systematically compare single Gaussian (SG) and double Gaussian (DG) modeling of initial proton fluence providing a more accurate representation of the nozzle spray. MethodsThe initial proton fluence distribution for SG/DG beam modeling was deduced from two-dimensional measurements in air with a scintillation screen with electronic readout. The DG model was either based on direct fits of the two Gaussians to the measured profiles, or by an iterative optimization procedure, which uses the measured profiles to mimic in-air scan-field factor (SF) measurements. To validate the DG beam models SFs, i.e. relative doses to a 10 × 10 cm2 field, were measured in water for three different initial proton energies (100MeV, 160MeV, 226.7MeV) and square field sizes from 1×1cm2 to 10×10cm2 using a small field ionization chamber (IBA CC01) and an IBA ProteusPlus system (universal nozzle). Furthermore, the dose to the center of spherical target volumes (diameters: 1cm to 10cm) was determined using the same small volume ionization chamber (IC). A comprehensive uncertainty analysis was performed, including estimates of influence factors typical for small field dosimetry deduced from a simple two-dimensional analytical model of the relative fluence distribution. Measurements were compared to the predictions of the RayStation TPS. ResultsSFs deviated by more than 2% from TPS predictions in all fields <4×4cm2 with a maximum deviation of 5.8% for SG modeling. In contrast, deviations were smaller than 2% for all field-sizes and proton energies when using the directly fitted DG model. The optimized DG model performed similarly except for slightly larger deviations in the 1×1cm2 scan-fields. The uncertainty estimates showed a significant impact of pencil beam size variations (±5%) resulting in up to 5.0% standard uncertainty. The point doses within spherical irradiation volumes deviated from calculations by up to 3.3% for the SG model and 2.0% for the DG model. ConclusionProperly representing nozzle spray in RayStation’s MC-based dose engine using a DG beam model was found to reduce the deviation to measurements in small spherical targets to below 2%. A thorough uncertainty analysis shows a similar magnitude for the combined standard uncertainty of such measurements.

Quantitative evaluation of dosimetric uncertainties associated with small electron fields

IntroductionAlthough many studies have investigated small electron fields, there are several dosimetric issues that are not well understood. This includes lack of charged particle equilibrium, lateral scatter, source occlusion and volume averaging of the detectors used in the measurement of the commissioning data. High energy electron beams are also associated with bremsstrahlung production that contributes to dose deposition, which is not well investigated, particularly for small electron fields. The goal of this work has been to investigate dosimetric uncertainties associated with small electron fields using dose measurements with different detectors as well as calculations with eMC dose calculation algorithm. MethodsDifferent dosimetric parameters including output factors, depth dose curves and dose profiles from small electron field cutouts were investigated quantitatively. These dosimetric parameters were measured using different detectors that included small ion chambers and diodes for small electron cutouts with diameters ranging from 15-50mm mounted on a 6 × 6cm2 cone with beam energies from 6-20MeV. ResultsLarge deviations existed between the output factors calculated with the eMC algorithm and measured with small detectors for small electron fields up to 55% for 6MeV. The discrepancy between the calculated and measured doses increased 10%-55% with decreasing electron beam energy from 20 MeV to 6 MeV for 15mm circular field. For electron fields with cutouts 20mm and larger, the measured and calculated doses agreed within 5% for all electron energies from 6-20MeV. For small electron fields, the maximal depth dose shifted upstream and becomes more superficial as the electron beam energy increases from 6-20MeV as measured with small detectors. DiscussionLarge dose discrepancies were found between the measured and calculated doses for small electron fields where the eMC underestimated output factors by 55% for small circular electron fields with a diameter of 15 mm, particularly for low energy electron beams. The measured entrance doses and dmax of the depth dose curves did not agree with the corresponding values calculated by eMC. Furthermore, the measured dose profiles showed enhanced dose deposition in the umbra region and outside the small fields, which mostly resulted from dose deposition from the bremsstrahlung produced by high energy electrons that was not accounted for by the eMC algorithm due to inaccurate modeling of the lateral dose deposition from bremsstrahlung. ConclusionElectron small field dosimetry require more consideration of variations in beam quality, lack of charged particle equilibrium, lateral scatter loss and dose deposition from bremsstrahlung produced by energetic electron beams in a comprehensive approach similar to photon small field dosimetry. Furthermore, most of the commercially available electron dose calculation algorithms are commissioned with large electron fields; therefore, vendors should provide tools for the modeling of electron dose calculation algorithms for small electron fields.

Evaluation of a micro ionization chamber for dosimetric measurements in image-guided preclinical irradiation platforms

Image-guided small animal irradiation platforms deliver small radiation fields in the medium energy x-ray range. Commissioning of such platforms, followed by dosimetric verification of treatment planning, are mostly performed with radiochromic film. There is a need for independent measurement methods, traceable to primary standards, with the added advantage of immediacy in obtaining results. This investigation characterizes a small volume ionization chamber in medium energy x-rays for reference dosimetry in preclinical irradiation research platforms. The detector was exposed to a set of reference x-ray beams (0.5–4 mm Cu HVL). Leakage, reproducibility, linearity, response to detector’s orientation, dose rate, and energy dependence were determined for a 3D PinPoint ionization chamber (PTW 31022). Polarity and ion recombination were also studied. Absorbed doses at 2 cm depth were compared, derived either by applying the experimentally determined cross-calibration coefficient at a typical small animal radiation platform ‘user’s’ quality (0.84 mm Cu HVL) or by interpolation from air kerma calibration coefficients in a set of reference beam qualities. In the range of reference x-ray beams, correction for ion recombination was less than 0.1%. The largest polarity correction was 1.4% (for 4 mm Cu HVL). Calibration and correction factors were experimentally determined. Measurements of absorbed dose with the PTW 31022, in conditions different from reference were successfully compared to measurements with a secondary standard ionization chamber. The implementation of an End-to-End test for delivery of image-targeted small field plans resulted in differences smaller than 3% between measured and treatment planning calculated doses. The investigation of the properties and response of a PTW 31022 small volume ionization chamber in medium energy x-rays and small fields can contribute to improve measurement uncertainties evaluation for reference and relative dosimetry of small fields delivered by preclinical irradiators while maintaining the traceability chain to primary standards.

PD-0937 Reference dosimetry in image guided preclinical irradiators with a small volume ionization chamber

PD-0937 Reference dosimetry in image guided preclinical irradiators with a small volume ionization chamber

Application of radiochromic gel dosimetry to commissioning of a megavoltage research linear accelerator for small-field animal irradiation studies.

To develop and implement an efficient and accurate commissioning procedure for small-field static beam animal irradiation studies on an MV research linear accelerator (Linatron-M9) using radiochromic gel dosimetry. The research linear accelerator (Linatron-M9) is a 9MV linac with a static fixed collimator opening of 5.08cm diameter. Lead collimators were manually placed to create smaller fields of 2×2cm2 , 1×1cm2 , and 0.5×0.5cm2 . Relative dosimetry measurements were performed, including profiles, percent depth dose (PDD) curves, beam divergence, and relative output factors using various dosimetry tools, including a small volume ionization chamber (A14), GAFCHROMIC™ EBT3 film, and Clearview gel dosimeters. The gel dosimeter was used to provide a 3D volumetric reference of the irradiated fields. The Linatron profiles and relative output factors were extracted at a reference depth of 2cm with the output factor measured relative to the 2×2cm2 reference field. Absolute dosimetry was performed using A14 ionization chamber measurements, which were verified using a national standards laboratory remote dosimetry service. Absolute dosimetry measurements were confirmed within 1.4% (k=2, 95% confidence=5%). The relative output factor of the small fields measured with films and gels agreed with a maximum relative percent error difference between the two methods of 1.1 % for the 1×1cm2 field and 4.3 % for the 0.5×0.5cm2 field. These relative errors were primarily due to the variability in the collimator positioning. The measured beam profiles demonstrated excellent agreement for beam size (measured as FWHM), within approximately 0.8mm (or less). Film measurements were more accurate in the penumbra region due to the film's finer resolution compared with the gel dosimeter. Following the van Dyk criteria, the PDD values of the film and gel measurements agree within 11% in the buildup region starting from 0.5cm depth and within 2.6 % beyond maximum dose and into the fall-off region for depths up to 5cm. The 2D beam profile isodose lines agree within 0.5mm in all regions for the 0.5×0.5cm2 and the 1×1cm2 fields and within 1mm for the larger field of 2×2cm2 . The 2D PDD curves agree within approximately 2% of the maximum in the typical therapy region (1-4cm) for the 1×1cm2 and 2×2cm2 and within 5% for the 0.5×0.5cm2 field. This work provides a commissioning process to measure the beam characteristics of a fixed beam MV accelerator with detailed dosimetric evaluation for its implementation in megavoltage small animal irradiation studies. Radiochromic gel dosimeters are efficient small-field relative dosimetry tools providing 3D dose measurements allowing for full representation of dose, dosimeter misalignment corrections and high reproducibility with low inter-dosimeter variability. Overall, radiochromic gels are valuable for fast, full relative dosimetry commissioning in comparison to films for application in high-energy small-field animal irradiation studies.

Experimental determination of magnetic field correction factors for ionization chambers in parallel and perpendicular orientations

Magnetic field correction factors are needed for absolute dosimetry in magnetic resonance (MR)-linacs. Currently experimental data for magnetic field correction factors, especially for small volume ionization chambers, are largely lacking. The purpose of this work is to establish, independent methods for the experimental determination of magnetic field correction factors in an orientation in which the ionization chamber is parallel to the magnetic field. The aim is to confirm previous experiments on the determination of Farmer type ionization chamber correction factors and to gather information about the usability of small-volume ionization chambers for absolute dosimetry in MR-linacs. The first approach to determine is based on a cross-calibration of measurements using a conventional linac with an electromagnet and an MR-linac. The absolute influence of the magnetic field in perpendicular orientation is quantified with the help of the conventional linac and the electromagnet. The correction factors for the parallel orientation are then derived by combining these measurements with relative measurements in the MR-linac. The second technique utilizes alanine electron paramagnetic resonance dosimetry. The alanine system as well as several ionization chambers were directly calibrated with the German primary standard for absorbed dose to water. Magnetic field correction factors for the ionization chambers were determined by a cross-calibration with the alanine in an MR-linac. Important quantities like for Farmer type ionization chambers in parallel orientation and the change of the dose to water due the magnetic field have been confirmed. In addition, magnetic field correction factors have been determined for small volume ionization chambers in parallel orientation. The electromagnet-based measurements of for MR-linacs and parallel ionization chamber orientations resulted in 0.9926(22), 0.9935(31) and 0.9841(27) for the PTW 30013, the PTW 31010 and the PTW 31021, respectively. The measurements based on the second technique resulted in values for of 0.9901(72), 0.9955(72), and 0.9885(71). Both methods show excellent accuracy and reproducibility and are therefore suitable for the determination of magnetic field correction factors. Small-volume ionization chambers showed a variation in the resulting values for and should be cross-calibrated instead of using tabulated values for correction factors.

Characterization of a modular microfluidic photoionization detector

Photoionization detectors with a small ionization chamber can contribute to overall gas analyser miniaturization. This work reports the characterization of a microfluidic photoionization detector prototype (μPID) which is constructed to be modular for easy replacement of the components and maintenance. The device is fabricated by micromilling and electrical discharge machining, dispensing clean room fabrication techniques. The μPID ionization chamber is a microchannel and four channel designs are presented and tested in experiments in order to evaluate the influence of the geometrical parameters on the detector performance. The chamber volumes of the channel designs range from 1.1 to 6.7 μL. Experimental characterization of the prototype is performed when it is used without and with a portable gas chromatograph (GC) for volatile organic compounds (VOCs) analysis. When a sample of 100 ppm toluene is injected directly into the μPID, it can generate a current signal up to ∼4 nA. When used without a GC, the device showed a linear response for an injection of toluene gas concentrations ranging from 1 to 100 ppm. A combination of high illumination area and electrode area resulted in the highest signal in the μPID with a detection limit of ∼40 ppb of toluene. When integrated to the portable GC, the detection limit reached for toluene is ∼140 ppb. The detection limit for toluene was further reduced to low ppb levels (∼5 ppb) when a preconcentrator was integrated into the sampling loop of the portable GC.

Detector response in the buildup region of small MV fields.

The model used to calculate dose distributions in a radiotherapy treatment plan relies on the data entered during beam commissioning. The quality of these data heavily depends on the detector choice made, especially in small fields and in the buildup region. Therefore, it is necessary to identify suitable detectors for measurements in the buildup region of small fields. To aid the understanding of a detector's limitations, several factors that influence the detector signal are to be analyzed, for example, the volume effect due to the detector size, the response to electron contamination, the signal dependence on the polarity used, and the effective point of measurement chosen. We tested the suitability of different small field detectors for measurements of depth dose curves with a special focus on the surface-near area of dose buildup for fields sized between 10×10 and 0.6×0.6cm2 . Depth dose curves were measured with 14 different detectors including plane-parallel chambers, thimble chambers of different types and sizes, shielded and unshielded diodes as well as a diamond detector. Those curves were compared with depth dose curves acquired on Gafchromic film. Additionally, the magnitude of geometric volume corrections was estimated from film profiles in different depths. Furthermore, a lead foil was inserted into the beam to reduce contaminating electrons and to study the resulting changes of the detector response. The role of the effective point of measurement was investigated by quantifying the changes occurring when shifting depth dose curves. Last, measurements for the small ionization chambers taken at opposing biasing voltages were compared to study polarity effects. Depth-dependent correction factors for relative depth dose curves with different detectors were derived. Film, the Farmer chamber FC23, a 0.13cm3 scanning chamber CC13 and a plane-parallel chamber PPC05 agree very well in fields sized 4×4 and 10×10cm2 . For most detectors and in smaller fields, depth dose curves differ from the film. In general, shielded diodes require larger corrections than unshielded diodes. Neither the geometric volume effect nor the electron contamination can account for the detector differences. The biggest uncertainty arises from the positioning of a detector with respect to the water surface and from the choice of the detector's effective point of measurement. Depth dose curves acquired with small ionization chambers differ by over 15% in the buildup region depending on sign of the biasing voltage used. A scanning chamber or a PPC40 chamber is suitable for fields larger than 4×4cm2 . Below that field size, the microDiamond or small ionization chambers perform best requiring the smallest corrections at depth as well as in the buildup region. Diode response changes considerably between the different types of detectors. The position of the effective point of measurement has a huge effect on the resulting curves, therefore detector specific rather than general shifts of half the inner radius of cylindrical ionization chambers for the effective point of measurement should be used. For small ionization chambers, averaging between both polarities is necessary for data obtained near the surface.

Evaluation of a pixelated large format CMOS sensor for x-ray microbeam radiotherapy.

PurposeCurrent techniques and procedures for dosimetry in microbeams typically rely on radiochromic film or small volume ionization chambers for validation and quality assurance in 2D and 1D, respectively. Whilst well characterized for clinical and preclinical radiotherapy, these methods are noninstantaneous and do not provide real time profile information. The objective of this work is to determine the suitability of the newly developed vM1212 detector, a pixelated CMOS (complementary metal‐oxide‐semiconductor) imaging sensor, for in situ and in vivo verification of x‐ray microbeams.MethodsExperiments were carried out on the vM1212 detector using a 220 kVp small animal radiation research platform (SARRP) at the Helmholtz Centre Munich. A 3 x 3 cm2 square piece of EBT3 film was placed on top of a marked nonfibrous card overlaying the sensitive silicon of the sensor. One centimeter of water equivalent bolus material was placed on top of the film for build‐up. The response of the detector was compared to an Epson Expression 10000XL flatbed scanner using FilmQA Pro with triple channel dosimetry. This was also compared to a separate exposure using 450 µm of silicon as a surrogate for the detector and a Zeiss Axio Imager 2 microscope using an optical microscopy method of dosimetry. Microbeam collimator slits with range of nominal widths of 25, 50, 75, and 100 µm were used to compare beam profiles and determine sensitivity of the detector and both film measurements to different microbeams.ResultsThe detector was able to measure peak and valley profiles in real‐time, a significant reduction from the 24 hr self‐development required by the EBT3 film. Observed full width at half maximum (FWHM) values were larger than the nominal slit widths, ranging from 130 to 190 µm due to divergence. Agreement between the methods was found for peak‐to‐valley dose ratio (PVDR), peak to peak separation and FWHM, but a difference in relative intensity of the microbeams was observed between the detectors.ConclusionsThe investigation demonstrated that pixelated CMOS sensors could be applied to microbeam radiotherapy for real‐time dosimetry in the future, however the relatively large pixel pitch of the vM1212 detector limit the immediate application of the results.

Output correction factors for small static fields in megavoltage photon beams for seven ionization chambers in two orientations - perpendicular and parallel.

PurposeThe goal of the present work was to provide a large set of detector‐specific output correction factors for seven small volume ionization chambers on two linear accelerators in four megavoltage photon beams utilizing perpendicular and parallel orientation of ionization chambers in the beam for nominal field sizes ranging from 0.5 cm2 × 0.5 cm2 to 10 cm2 × 10 cm2. The present study is the second part of an extensive research conducted by our group.MethodsOutput correction factors kQclin,Qreffclin,fref were experimentally determined on two linacs, Elekta Versa HD and Varian TrueBeam for 6 and 10 MV beams with and without flattening filter for nine square fields ranging from 0.5 cm2 × 0.5 cm2 to 10 cm2 × 10 cm2, for seven mini and micro ionization chambers, IBA CC04, IBA Razor, PTW 31016 3D PinPoint, PTW 31021 3D Semiflex, PTW 31022 3D PinPoint, PTW 31023 PinPoint, and SI Exradin A16. An Exradin W1 plastic scintillator and EBT3 radiochromic films were used as the reference detectors.ResultsFor all ionization chambers, values of output correction factors kQclin,Qreffclin,fref were lower for parallel orientation compared to those obtained in the perpendicular orientation. Five ionization chambers from our study set, IBA Razor, PTW 31016 3D PinPoint, PTW 31022 3D PinPoint, PTW 31023 PinPoint, and SI Exradin A16, fulfill the requirement recommended in the TRS‐483 Code of Practice, that is, 0.95<kQclin,Qreffclin,fref<1.05, down to the field size 0.8 cm2 × 0.8 cm2, when they are positioned in parallel orientation; two of the ionization chambers, IBA Razor and PTW 31023 PinPoint, satisfy this condition down to the field size of 0.5 cm2 × 0.5 cm2.ConclusionsThe present paper provides experimental results of detector‐specific output correction factors for seven small volume ionization chambers. Output correction factors were determined in 6 and 10 MV photon beams with and without flattening filter down to the square field size of 0.5 cm2 × 0.5 cm2 for two orientations of ionization chambers — perpendicular and parallel. Our main finding is that output correction factors are smaller if they are determined in a parallel orientation compared to those obtained in a perpendicular orientation for all ionization chambers regardless of the photon beam energy, filtration, or linear accelerator being used. Based on our findings, we recommend using ionization chambers in parallel orientation, to minimize corrections in the experimental determination of field output factors. Latter holds even for field sizes below 1.0 cm2 × 1.0 cm2, whenever necessary corrections remain within 5%, which was the case for several ionization chambers from our set.TRS‐483 recommended perpendicular orientation of ionization chambers for the determination of field output factors. The present study presents results for both perpendicular and parallel orientation of ionization chambers. When validated by other researchers, the present results for parallel orientation can be considered as a complementary dataset to those given in TRS‐483.

Impact of magnetic fields on dose measurement with small ion chambers illustrated in high-resolution response maps.

PurposeDosimetry of ionizing radiation in the presence of strong magnetic fields is gaining increased relevance in light of advances for MRI‐guided radiation therapy. While the impact of strong magnetic fields on the overall response of ionization chambers has been simulated and measured before, this work investigates the local impact of the magnetic field on dose response in an ion chamber. High‐resolution 1D and 2D response maps have been created for two small clinical thimble ionization chambers, the PinPoint chambers 31006 and 31014 (Physikalisch Technische Werkstaetten Freiburg, Germany).MethodsWorking on the Imaging and Medical Beam Line of the Australian Synchrotron an intense kilovoltage radiation beam with very low divergence, collimated to 0.1 mm was used to scan the chambers by moving them on a 2D motion platform. Measured current and beam position were correlated to create the response maps. Small neodymium magnets were used to create a field of about 0.25 T. Chamber axis, magnetic field, and beam direction were perpendicular to each other. Measurements were performed with both orientations of the magnetic field as well as without it. Chamber biases of 5 and 250 V in both polarities were used.ResultsThe local distribution of the response of small thimble‐type ionization chambers was found to be impacted by a magnetic field. Depending on the orientation of the magnetic field, the chamber response near the stem was either enhanced or reduced with the response near the tip behaving the opposite way. Local changes were in the order of up to 40% compared to measurements without the magnetic field present. Bending of the central electrode was observed for the chamber with the steel electrode. The size of the volume of reduced collection near the guard electrode was impacted by the magnetic field.As the here investigated beam and field parameters differ from those of clinical systems, quantitatively different results would be expected for the latter. However, the gyroradii encountered here were similar to those of a 6–7 MV MRI linac with a 1.5 T magnet.ConclusionsMagnetic fields impact the performance of ionization chambers also on a local level. For practical measurements this might mean a change in the effective point of measurement, in addition to any global corrections. Further knowledge about the local response will help in selecting or constructing optimized chambers for use in magnetic fields.

Phantom development and implementation for Gamma Knife® dosimetry

Stereotactic radiosurgery is a procedure that primarily treats intracranial lesions to destroy tumour cells that are inaccessible surgically. Gamma Knife® is a stereotactic radiosurgery unit that can treat brain lesions using 60Co beams, non-invasively. Fields from Gamma Knife® helmets are considered small, therefore, in order to ensure accurate dosimetry, detectors for dose measurements have to be carefully chosen. The IAEA TRS 483 code of practice is a standardized guide for dosimetric procedures and indication of detectors for reference dosimetry of small fields used in radiotherapy beams. The objective of this work was to assess the implementation of the TRS 483 recommendations for Gamma Knife® dosimetry, using two micro-ionization chambers, Exradin A16 and PTW Pinpoint 3D 31016. An acrylic phantom with the same dimensions as those provided by Elekta, Gamma Knife’s manufacturer, was built as an alternative. The phantom was characterized for its implementation for Gamma Knife® dosimetry and to be used as part of an audit kit by a Secondary Standard Dosimetry Laboratory (SSDL) in Brazil. Alanine pellets were used as reference detector. Dosimetry results for the acrylic phantom were compared with the ones obtained in phantoms specified by Elekta, which are made of Acrylonitrile Butadiene Styrene (ABS) and Solid Water materials. TRS 483 recommended correction factors were used to calculate the absorbed dose to the water taking into consideration the phantom material. Absorbed dose measurements performed using the designed acrylic phantom showed results comparable to the ones obtained with commercially available phantoms. The new phantom is suitable for Gamma Knife reference and relative dosimetry. The results of this work aim to contribute to the implementation of the TRS 483, mainly in the area of Gamma Knife dosimetry and the use of small volume ionization chambers.

Methodology paper: a novel phantom setup for commissioning of scanned ion beam delivery and TPS

BackgroundCommissioning of treatment planning systems (TPS) and beam delivery for scanned light ion beams is an important quality assurance task. This requires measurement of large sets of high quality dosimetric data in anthropomorphic phantoms to benchmark the TPS and dose delivery under realistic conditions.MethodA novel measurement setup is described, which allows for an efficient collection of a large set of accurate dose data in complex phantom geometries. This setup allows dose measurements based on a set of 24 small volume ionization chambers calibrated in dose to water and mounted in a holder, which can be freely positioned in a water phantom with various phantoms mounted in front of the water tank. The phantoms can be scanned in a CT and a CT-based treatment planning can be performed for a direct benchmark of the dose calculation algorithm in various situations.ResultsThe system has been used for acceptance testing in scanned light ion beam therapy at Heidelberg Ion Beam Therapy Center for scanned proton and carbon ion beams. It demonstrated to be useful to collect large amounts of high quality data for comparison with the TPS calculation using various phantom geometries.ConclusionThe setup is an efficient tool for commissioning and verification of treatment planning systems. It is especially suited for dynamic beam delivery, as many data points can be obtained during a single plan delivery, but can be adapted also for other dynamic therapies, like rotational IMRT.

An evaluation of computed tomography dose index measurements using a pencil ionisation chamber and small detectors

The aim of this study was to compare the values of the computed tomography dose index 100 (CTDI100) obtained using two small detectors (i.e. a small ionisation chamber and a small solid state detector) with those obtained from a 100 mm pencil ionisation chamber for various input CT parameters: beam width, kVp, mAs, pitch, and head-body phantom variation. The measurement of CTDI100 using the 100 mm pencil chamber was carried out in a single rotation of axial mode, while the measurement using small detectors was carried out in helical mode. The differences of CTDI100 values obtained with two small detectors were about 7% for all variations. The differences of CTDI100 values obtained with small detectors and a 100 mm pencil ionisation chamber for beam widths of more than 4 mm were within 40%. However, for the narrowest beam widths (4 mm), the difference between them was very large (about 150%).