Small Intestinal Metastasis Research Articles

Small intestinal metastasis from primary breast cancer: a case report and review of literature

Small intestinal metastasis from primary breast cancer remains a rare clinical occurrence. Despite extensive research into its clinicopathological features and treatment options, the specific pathogenesis and optimal management strategies remain incompletely understood. This case report presents a patient with breast cancer that metastasized to the small intestine. The primary breast tumor was diagnosed as classic invasive lobular carcinoma. Subsequent surgical intervention successfully addressed the intestinal obstruction and confirmed the metastatic origin of the small intestinal tumor. Interestingly, the metastatic lesions exhibited features suggestive of pleomorphic lobular carcinoma. A PET-CT scan was performed to evaluate the distant metastasis status of this patient. Notably, hormonal receptor status shifted from positive to negative, while HER2 expression changed from negative to low between the primary tumor and metastatic lesions. The presence of an undiagnosed pleomorphic component in the primary tumor might explain the disease’s progressive nature. In this case, systemic treatment with trastuzumab deruxtecan yielded favorable therapeutic outcomes. Overall, our findings suggest that re-evaluation of receptor status in breast cancer metastases is crucial for tailoring treatment strategies. Furthermore, a combination of palliative resection of small intestinal metastases and targeted therapy for HER2-low breast cancer may potentially improve survival.

Clinicopathological analysis of small intestinal metastasis from extra-abdominal/extra-pelvic malignancy.

The metastatic tumors in the small intestine secondary to extra-abdominal/extra-pelvic malignancy are extremely rare. However, the small intestine metastases are extremely prone to misdiagnosis and missed diagnosis due to the lack of specific clinical manifestations and examination methods, thus delaying its treatment. Therefore, in order to improve clinical diagnosis and treatment capabilities, it is necessary to summarize its clinical pathological characteristics and prognosis. To summarize the clinicopathological characteristics of patients with small intestinal metastases from extra-abdominal/extra-pelvic malignancy, and to improve the clinical capability of diagnosis and treatment for rare metastatic tumors in the small intestine. The clinical data of patients with small intestinal metastases from extra-abdominal/extra-pelvic malignancy were retrieved and summarized, who admitted to and treated in the Air Force Medical Center, Chinese People's Liberation Army. Then descriptive statistics were performed on the general conditions, primary tumors, secondary tumors in the small intestine, diagnosis and treatment processes, and prognosis. Totally 11 patients (9 males and 2 females) were enrolled in this study, including 8 cases (72.3%) of primary lung cancer, 1 case (9.1%) of malignant lymphoma of the thyroid, 1 case (9.1%) of cutaneous malignant melanoma, and 1 case (9.1%) of testicular cancer. The median age at the diagnosis of primary tumors was 57.9 years old, the median age at the diagnosis of metastatic tumors in the small intestine was 58.81 years old, and the average duration from initial diagnosis of primary tumors to definite diagnosis of small intestinal metastases was 9 months (0-36 months). Moreover, small intestinal metastases was identified at the diagnosis of primary tumors in 4 cases. The small intestinal metastases were distributed in the jejunum and ileum, with such clinical manifestations as hematochezia (5, 45.4%) and abdominal pain, vomiting and other obstruction (4, 36.4%). In addition, 2 patients had no obvious symptoms at the diagnosis of small intestinal metastases, and 5 patients underwent radical resection of small intestinal malignancies and recovered well after surgery. A total of 3 patients did not receive subsequent treatment due to advanced conditions. Small intestinal metastases of extra-abdominal/extra-pelvic malignancy is rare with high malignancy and great difficulty in diagnosis and treatment. Clinically, patients with extra-abdominal/extra-pelvic malignancy should be alert to the occurrence of this disease, and their prognosis may be improved through active surgery combined with standard targeted therapy.

Carcinoma esophagus with small bowel metastasis: a case report with review of literature.

Small intestinal metastasis is extremely rare and only 13 cases have been reported till date and almost all such patients have presented with intestinal obstruction. The 5-year overall survival for metastatic esophageal cancer is as low as 5% while the patients with small intestinal metastasis have a median survival of only 3months (range 1-12months) despite undergoing radical resection of the small bowel. We present a case of a male in his 50's who presented with difficulty in swallowing for 4months. On evaluation, he was found to have squamous cell carcinoma in the mid thoracic esophagus. He underwent radical chemo-radiation up to 60Gy in 25 fractions over 5weeks. One week after completion of treatment he presented with ileal obstruction and omental nodules and surgical resection and evaluation of the respective ileal segment and omental biopsy revealed a metastatic squamous cell carcinoma. The patient expired 3months post-surgery. Carcinoma esophagus with small bowel metastasis has a very grave prognosis that patients rarely survive beyond 1year despite undergoing resection. Hence it is imperative to consider a small bowel metastasis when such patients present with clinical features of intestinal obstruction for early diagnosis and aggressive management.

Case Report: Genetic profiling of small intestine metastasis from poorly differentiated non-small cell lung cancer: report of 2 cases and literature review of the past 5 years

BackgroundPoorly differentiated non-small cell lung cancer (NSCLC) is characteristic of high rate of distant metastasis and late stages at diagnosis. Small intestine metastasis is a rare but severe complication of lung cancer with a high rate of mortality. However, there is currently a lack of genetic profile studies on the small intestine metastasis of lung cancer.Case presentationsWe present 2 cases of male patients in their 60s with primary NSCLC of low differentiation, initially with no distant metastasis detected. Biopsy samples were obtained from the primary pulmonary lesions, and both patients received systematic radiotherapy (RT) and chemotherapy. However, both cases presented with abdominal pain and distension, and immunohistochemistry of small intestine biopsy samples obtained by endoscopy confirmed lung cancer metastasis. Next generation sequencing was used to explore the genetic profiles from the biopsy samples of both the primary pulmonary lesions and small intestine metastases. The correlated genes responsible for the small intestine metastasis from poorly differentiated NSCLC in these 2 patients included TP53, LRP1B, and FGFR2. The reports of small intestine metastasis from poorly differentiated NSCLC with the past 5 years were systematically reviewed and summarized subsequently.ConclusionsPoorly differentiated NSCLC with small intestine metastases, while rare, substantially impacts the prognosis and poses major challenges for diagnosis and treatment. Through comparisons of genetic profiles between patients and in the same patient before and after metastasis, we identified the mutations in genes such as TP53, LRP1B, and FGFR2, which were correlated with the occurrence and progression of poorly differentiated NSCLC, as well as its small intestinal metastasis. This discovery has the potential to guide clinicians in developing personalized treatment plans through the manipulation of targeted and radiation therapies.

Laparoscopic resection of a metastatic myxoid liposarcoma in the mesentery of the small intestine: a case report

BackgroundMyxoid liposarcoma (MLS), with its risk factors, tends to spread to the lungs and extraperitoneally, with intraperitoneal metastases occurring rarely. We present an unusual case of a myxoid liposarcoma that metastasized to the abdominal organs.Case presentationA 60-year-old female patient was referred to our hospital for the evaluation of a right upper limb tumor that had been growing for 7 years. The patient refused surgery, and during follow-up, tumor hemorrhage resulted in hemorrhagic shock. The patient’s right upper limb was immediately amputated. MLS was diagnosed histopathologically. Subsequently, the patient underwent adjuvant chemotherapy. Computed tomography (CT) revealed a right buttock mass, a pelvic mass, and left cardiophrenic angle lymph nodes 3 years after the initial surgery. Contrast-enhanced abdominal CT revealed a relatively low-density, lobulated pelvic tumor. Contrast-enhanced pelvic magnetic resonance imaging (MRI) revealed a low-intensity, lobulated mass on T1-weighted images and a high-intensity mass on T2-weighted images. The pelvic mass showed no significant fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET)-CT. On clinical examination, gynecological malignancies were ruled out as the origin of the pelvic lesions. After resection of the right buttock mass, pelvic mass, and left cardiophrenic angle lymph nodes, the patient underwent laparoscopic surgery for a preoperative diagnosis of small intestinal mesenteric metastasis of MLS. A tumor was found in the mesentery of the small intestine and removed with a margin of 5 cm on both the proximal and distal sides. The specimen measured 10 × 8 × 5 cm and contained a multifocal mass. The tumor was found in the mesentery of the small intestine, with no mucosal or submucosal invasion. The patient was diagnosed with MLS with small mesenteric intestinal metastases. On postoperative day 8, the patient was discharged after an uneventful postoperative course. Twelve months after the surgery, there was no evidence of local or distant recurrence.ConclusionsSmall intestinal mesenteric metastases of MLSs are rare. Moreover, there are few reports on laparoscopic resection. In this case, the laparoscopic approach was useful in detecting the tumor location and determining the range of resection.

Enlightenment for clinicians from the case of digestive tract metastases from primary lung cancer: a case report

Background: About 50% of patients with initially diagnosed lung cancer have developed distant metastasis. The probability of occurrence of digestive tract metastases found by autopsy is rarely. This report presents a rare clinical case of small intestinal metastasis from primary squamous cell carcinoma of the lung. Case presentation: An 82-year-old male with aggravated cough and more acute shortness of breath than usual was diagnosed with primary squamous cell carcinoma of the lung Stage IV,because of the advanced age, underlying diseases, and poor cardiopulmonary function,the family refused the chemoradiotherapy. One month later, the patient gradually developed right lower quadrant pain. An upright abdominal X-ray suggested small intestinal obstruction and partial resection and anastomosis of the small intestine were performed. Postoperative pathology revealed poorly differentiated squamous-cell carcinoma of the small intestine. The patient died of sudden cardio-respiratory arrest one month later. Conclusions:We conclude that the real incidence of digestive tract metastases from lung cancer may be higher than the reported because of the symptoms of those patients are not obvious. Clinicians should select the appropriate examination methods (such as positron emission tomography) and pay attention to the assessment of abdominal hollow organs

A Rapidly Growing Small-Intestinal Metastasis from Lung Cancer.

Small-intestinal metastasis from lung cancer, although relatively rare, often causes intestinal obstruction, gastrointestinal perforation, and gastrointestinal bleeding, making it an oncological emergency. Many patients have undergone emergency surgery for treatment of rapid progression of an intestinal metastatic lesion; however, information on changes in such metastases is lacking. We analyzed data from 4 patients with small-intestinal metastases from lung cancer who were treated during a 10-year period (January 2011 to December 2020) and for whom data on change in tumor diameter were available. The average rate of growth in tumor volume was 1.48-fold (range, 1.31- to 1.78-fold) during a median observation period of 22 (4-39) days, a rapid increase. Histopathological analysis showed that, in patients with a high degree of primary tumor atypia, rapid tumor growth may be caused by intratumoral hemorrhage, which was the reason for the rapid increase in tumor volume.

Pathochistological and immunohistochemical study in small intestine metastasis as first clinical expression of invasive lobular breast carcinoma: Prognosis and complex treatment

The gastrointestinal metastases (GIM) of breast carcinoma (BC) are a rare clinical finding, even more rarely diagnosed as initial symptoms at unknown BC. We present a 50-year-old woman with metastases in the terminal ileum combined with multiple bone metastases from an unknown invasive carcinoma of left mammary gland. Gastrointestinal metastases are rarely observed in invasive lobular breast carcinoma. Differential diagnosis between intestinal metastases from primary BC and primary intestinal neoplasm is extremely difficult. Determination of tumor pathohistogenesis require careful pathohistological and immunohistochemical analysis. Complex treatment follows the primary neoplasm principles. The prognosis in such clinical cases is unfavorable, but after timely complex oncological treatment, including emergency operation, chemotherapy, hormone and target therapy, 36 monthly survival is achieved. Keywords: gastrointestinal metastases; invasive lobular breast carcinoma; pathohistological analysis; immunohistochemical analysis; complex treatment.

Lethal multiple colon necrosis and perforation due to fulminant amoebic colitis: a surgical case report and literature review

BackgroundAmoebiasis caused by the protozoan species Entamoeba histolytica rarely develops into fulminant amoebic colitis (FAC), but when it does, it shows an aggressive clinical course including colonic perforation, necrotizing colitis, and high mortality. Surgical treatment for FAC patients should be carried out urgently. However, even after surgery, the mortality rate can be 40–50%. Although FAC is one of the most unfavorable surgical diseases with a poor prognosis, there are a few reports on the perioperative diagnosis and management of FAC based on autopsy findings. We herein report the surgical case of a 64-year-old man who developed multiple colon necrosis and perforation due to FAC. A detailed autopsy revealed FAC as the cause of death. Additionally, we reviewed the existing literature on FAC patients who underwent surgery and followed their perioperative diagnosis and management.Case presentationA 64-year-old man presented with anorexia, diarrhea, and altered consciousness on arrival to our hospital. Computed tomography revealed a large mass in the upper right lobe of his lung, and the patient was admitted for close investigation. Bloody diarrhea, lower abdominal pain, and hypotension were observed soon after admission. Urgent abdominal contrast-enhanced computed tomography scan revealed extensive intestinal ischemia, intestinal pneumatosis, and free intra-abdominal gas. The preoperative diagnosis was bowel necrosis and perforation with intussusception of the small intestinal tumor. Emergency subtotal colectomy and enterectomy were performed soon after the contrast-enhanced computed tomography. He was taken to an intensive care unit after surgery. However, he could not recover from sepsis and died with disseminated intravascular coagulation and multiple organ failure on the 10th-day post-surgery. A histopathological examination of the resected colon showed transmural necrosis and massive amoebae invasion. He was diagnosed with FAC. An autopsy revealed that he had developed pulmonary large cell carcinoma with small intestinal metastasis. The death was caused by intestinal ischemia, necrosis and the perforation of the residual bowel caused by amoebae invasion.ConclusionsSince FAC is a lethal disease with a high mortality rate and antibiotic therapies except metronidazole are ineffective, preoperative serological testing and perioperative metronidazole therapy in FAC patients can dramatically improve their survival rates.

A Case of Primary Lung Cancer Detected by Perforated Peritonitis Associated with a Small Intestinal Metastasis

A Case of Primary Lung Cancer Detected by Perforated Peritonitis Associated with a Small Intestinal Metastasis

S2853 Metastatic Lung Adenocarcinoma Presents as Small Bowel Perforation

INTRODUCTION: Lung adenocarcinomas are often diagnosed at the advanced stage of disease and gastrointestinal metastases from pulmonary neoplasms are rare with the incidence of 0.2-0.5%. Early diagnosis of small intestinal metastasis is difficult due to the low incidence of symptoms and scarcity of imaging modalities to evaluate small intestinal lumen. Here, we present a case of visceral perforation of the ileum from lung adenocarcinoma metastasis. CASE DESCRIPTION/METHODS: A 61 years old Caucasian male with a history of lung adenocarcinoma and metastatic lymphadenopathy presented with severe acute abdominal pain. A recent PET scan revealed interval improvement of the lung mass with decreasing nodal sizes after chemotherapy with docetaxel and ramucirumab. Vital signs were unremarkable and physical examination revealed a distended abdomen with significant abdominal tenderness, involuntary guarding, and Blumberg sign. Laboratory results noted marked leukocytosis of 30,000 per microliter with 16% band neutrophils. Computerized tomography (CT) of the abdomen and pelvis revealed extraluminal gas and ruptured viscus (Figure 1). Exploratory laparotomy revealed mid ileal perforation and a totally constricted lumen. The patient underwent resection of 30 cm of the mid-ileum with end-to-end anastomosis. Histology (Figure 2) and immunochemistry (Figure 3) findings were similar to the carcinoma in the previous nodal biopsy. The patient was referred to outpatient oncology follow-up with chemotherapy and a short-term follow up in 6 months was uneventful. DISCUSSION: Perforations occurs more commonly in Jejunum (53%) than ileum (28%). Histological type associated with gastrointestinal metastasis is still unclear. Small bowel perforation can occur even with a favorable prognosis as evidenced by our patient’s staging PET/CT scan showing improved tumor burden. Once metastasis occurred to small bowel, they trend to perforate due to tumor necrosis rather than obstruction. Intestinal tumor metastases are uncommon but should be considered in the diagnosis of a patient with an acute abdomen with a history of pulmonary neoplasm. The surgical approach is mandatory even as a palliative measure. Preoperatively establishing, or suspecting, a diagnosis of metastases to the small bowel can help inform surgical planning and ultimately enhance outcomes.Figure 1.: Coronal Imaging of computed tomography (CT) of the abdomen pelvis with contrast revealed extraluminal gas and ruptured viscus (white circle).Figure 2.: Small bowel resection showing poorly differentiated adenocarcinoma (hematoxylin-eosin, original magnification 40X).Figure 3.: Small bowel resection poorly differentiated adenocarcinoma showing positive TTF-1 nuclear expression by immunohistochemistry most consistent with metastatic poorly differentiated adenocarcinoma of lung primary (original magnification 200X).

Heterogeneity in PD-L1 expression on infiltrating immune cells between the primary and metastatic breast cancers

Objective: To investigate the expression difference in PD-L1 on mesenchymal infiltrating immune cells between the primary and metastatic breast cancers, and to explore its relationship with clinicopathological parameters. Methods: All cases of primary breast cancer and their matched metastases diagnosed at the Fourth Hospital of Hebei Medical University between January 2010 and December 2018 were included. Immunohistochemistry (IHC) was used to detect the expression of PD-L1 (SP142) in interstitial infiltrating immune cells, and the expression of ER, PR, HER2 and Ki-67 in primary and matched metastases was detected. Statistical software SPSS 24.00 was used for statistical analysis. Kappa test was used for concordance/agreement analysis and McNemar test for difference analysis. Results: Among the 140 identified primary breast cancers, there were 52 cases with matched lymph node metastasis, 88 cases with distant metastasis, including 35 cases with liver metastasis, 21 cases with lung metastasis, 13 cases with chest wall metastasis, 11 cases with bone metastasis, 6 cases with brain metastasis, 1 case with small intestine metastasis, and 1 case with eyeball metastasis. The overall concordance rate of the PD-L1 expression on mesenchymal immune cells between primary breast cancer and paired metastatic breast cancer was 72.9% (κ=0.441). The concordance rate of PD-L1 expression between primary breast cancers and paired lymph node metastases, and that between primary breast cancers and distant metastases were 75.0% (κ=0.472) and 71.6% (κ=0.472), respectively. The inconcordance rate of interstitial immune cell PD-L1 expression between primary breast cancer and matched lung metastasis was 28.6%(6/21), and the difference was statistically significant (P=0.031). The expression of PD-L1 in mesenchymal immune cells of primary breast cancer was significantly correlated with tumor size, histological grade, vascular invasion, lymph node metastasis, and Ki-67 index (P<0.05). The PD-L1 expression was independently associated with lymph node metastasis (P<0.05), while the expression of PD-L1 in metastatic breast cancer interstitial immune cells was significantly related to the expression of ER (P<0.05). Conclusions: The expression of PD-L1 in the primary breast cancer is moderately concordant with that in paired metastases, but different from that in paired lung metastases. Therefore, the expression of PD-L1 in distant metastasis needs to be re-evaluated to optimize the treatment outcomes of PD-L1 based therapy.

Oligometastasis with Brain Metastasis and Small Intestine Metastasis after Breast Cancer Surgery

Oligometastasis with Brain Metastasis and Small Intestine Metastasis after Breast Cancer Surgery

A Case of Solitary Small Intestinal Metastasis from Renal Cell Carcinoma Diagnosed Preoperatively

A Case of Solitary Small Intestinal Metastasis from Renal Cell Carcinoma Diagnosed Preoperatively

Small Intestinal Metastasis with Perforation from Malignant Pleural Mesothelioma: A Case of Triple Cancers (Lung Cancer, Gastric Cancer and Malignant Pleural Mesothelioma)

Small Intestinal Metastasis with Perforation from Malignant Pleural Mesothelioma: A Case of Triple Cancers (Lung Cancer, Gastric Cancer and Malignant Pleural Mesothelioma)

Perforation of small intestinal metastasis of lung adenocarcinoma treated with pembrolizumab: a case report

BackgroundPembrolizumab is an immune checkpoint inhibitor and is an anti-human programmed cell death-1 (PD-1) monoclonal antibody. Pembrolizumab is used for non-small cell lung carcinoma with high programmed cell death ligand-1 (PD-L1) expression. It has been found that better overall survival can be obtained using pembrolizumab compared to the existing chemotherapy. We report a case of perforation of small intestinal metastasis after pembrolizumab treatment.Case presentationA 62-year-old man was treated by pembrolizumab for PD-L1 highly expressed lung adenocarcinoma, with multiple metastasis (small intestinal, lymph nodes, and bone). The treatment was stopped owing to drug-induced pneumonitis. One month after drug withdrawal, the patient visited the emergency department of our hospital with the complaint of severe stomachache. He had a rigid abdomen and generalized tenderness, and computed tomography scans showed free air within the abdomen. We diagnosed bowel perforation and performed emergency surgery. Surgical findings revealed multiple small intestine metastasis and mesenteric lymph node metastasis. Perforation was found in the metastatic site in the jejunum located around 40 cm anal to Treitz’s ligament. This perforated part was resected, and functional end-to-end anastomosis was performed using linear staplers. The post-operative course was uneventful. Pathological examination revealed lung adenocarcinoma metastasis at the perforation site, and the effectiveness of pembrolizumab was grade 1b (Japanese Classification of the Colorectal Carcinoma, seventh edition).ConclusionsThis is the first report of perforation of small intestinal metastasis of lung adenocarcinoma after pembrolizumab treatment. Because pembrolizumab causes some side effects, particularly autoimmune side effects, careful attention during treatment is warranted.

Carcinoma of Pulmonary Squamous Cells with Small Intestine Metastasis in a Cat

Background: Primary lung tumors in cats are mainly classified into adenocarcinoma arising from peripheral pulmonary epithelium and, in a smaller number of cases, into adenosquamous or squamous carcinoma, bronchioloalveolar carcinoma, and carcinoid tumor. There are few reports in the international literature describing lung cancer metastasis to visceral organs in cats, especially with regard to squamous tumors. This report describes the clinical pathological, histological, and immunohistochemical findings of lung squamous cell carcinoma with metastasis to small intestine in a cat.Case:A female, Siamese, unneutered, adult cat presented with an unhealed ulcerative crusted lesion on the left ear, previously diagnosed as squamous cell carcinoma (SCC). Six months later, the cat returned presenting with increased volume in the left pelvic limb and claudication due to severe osteolysis in metatarsal and tarsal bones, as shown in radiographic examinations. The limb was amputated forty day later, but it did not undergo histological examination. The cat died fourteen days after amputation and underwent necropsy. Macroscopically, significant changes were observed in the small intestine, including serous segmental necrotizing and hemorrhagic lesion with luminal stenosis and corrugation of mucous surface, which was covered with a fibrinopurulent pseudomembrane. Palpation of lung parenchyma showed small firm nodules. There was an ulcerative crusted lesion on the left ear. Histopatological examination revealed infiltration of pleomorphic neoplastic epithelial cells disrupting the architecture of small intestine and lung, with pronounced anisocyitosis and anisokaryosis. The neoplastic cells had indistinct borders; their cytoplasm was eosinophilic and pleomorphic and varied from moderate to abundant in amount; and their nuclei were markedly pleomorphic and large, with up to two evident nucleoli and salt-and-paper chromatin. Additionally, numerous keratin pearls and remarkable squamous differentiation were observed. Immunohistochemistry (IHC) was performed with the streptavidin-biotin-peroxidase method using anti-pan-cytokeratin and antivimentin antibodies. Neoplastic cells exhibited strong and uniform cytoplasmatic immunoreactivity for pan-cyitokeratin. Vimentin expression was absent in neoplastic cells but present in the connective tissue associated with the neoplasm. Discussion: Although there are some studies on primary lung squamous cell carcinoma, to the authors’ knowledge, this is the second report describing the metastasis of this tumor to small intestine in a cat. The diagnosis of lung SCC in a cat with metastasis to small intestine was confirmed by histopathological assessment and IHC. Although the amputated limb had not undergone histopathological examination, osteolytic lesions in metatarsal and tarsal bones suggested metastasis from primary lung tumors. The lack of involvement of head lymph nodes shows that cutaneous SCC was not related to lung tumors, because metastasis of this carcinoma always involves regional lymph nodes. Paleness of oral and ocular mucosae suggested anemia or paraneoplastic syndrome, which could not be confirmed because the animal was debilitated at presentation and eventually died. IHC confirmed the epithelial origin of the tumor, as evidenced by the presence of epithelial cells and keratin pearls in the small intestine, thus proving the existence of metastasis.

Hematogenous small intestinal metastasis 8 months after removal of epithelial ovarian cancer: a case report

Ovarian cancers usually spread in four different ways: Trans peritoneal spread, direct invasion, lymphatic, and hematogenous. The primary way of metastasis of ovarian carcinoma is considered to be direct peritoneal dissemination in the abdominal cavity and serosa of bowel. Conversely, hematogenous dissemination is rare, and seldom leads to gastrointestinal metastasis. We report a case of a patient who was operated for an epithelial ovarian cancer and presented with small intestinal metastasis 8 months later. Vascular cancer emboli could be detected by microscopy. Immunohistochemistry tests proved the small intestinal metastasis originated from primary ovarian cancer.

A Small Intestinal Metastasis from Esophageal Carcinoma Complicated with Progression of Anemia due to Intestinal Hemorrhage that Required Emergency Surgery: A Case Report

A Small Intestinal Metastasis from Esophageal Carcinoma Complicated with Progression of Anemia due to Intestinal Hemorrhage that Required Emergency Surgery: A Case Report

A Case of Invagination due to Small Intestinal Metastasis from a Renal Cell Carcinoma

A Case of Invagination due to Small Intestinal Metastasis from a Renal Cell Carcinoma