Small fatigue crack initiation and propagation behavior of Inconel 617 was studied by in-situ SEM observation, electron back-scattered diffraction (EBSD), digital image correlation (DIC), crystal plasticity finite element method (CPFEM) and extended finite element method (XFEM) in this paper. The experimental results indicated that different surface corrosion methods used to display surface microstructure will affect the small fatigue cracking mode of Inconel 617. The local micro-scale strain field of Inconel 617 near the notch and crack tip was quantitatively measured by a new grain scale DIC method. The CPFEM-XFEM simulation model of small fatigue crack initiation and propagation characteristics of Inconel 617 was established. A new framework for small fatigue crack path and lifetime prediction at the polycrystalline scale was constructed, which includes the influences of slip system and grain boundary on small fatigue crack initiation and growth rate.