Small Disk Research Articles

Synchronous Vibration Parameter Recognition of Constant-Speed Blades Based on Blade Tip Clearance Measurement

A new method for the synchronous vibration parameter identification of constant-speed rotating blades based on blade tip clearance (BTC) measurement and blade tip timing (BTT) is introduced. A BTC sensor is used to measure the BTC when the blade tip passes through each sensor. The BTT method is used to determine whether the blade tip arrives in advance or lags. The geometric model between the BTC and the blade tip vibration displacement (BTVD) is established, and the BTVD of the blade tip passing through each sensor is obtained. Then, the nonlinear least squares method is used to determine the synchronous vibration parameters of the constant-speed rotating blade. The results show that with an increase in amplitude, the higher the accuracy of the vibration parameter identification proposed in this paper; with a decrease in the random error of the BTC measurement, the higher the accuracy of the vibration parameter identification proposed in this paper; with a decrease in the random error in the measurement of the blade disk dimensions, the higher the accuracy of the vibration parameter identification proposed in this paper. In addition, the smaller the ratio of the blade length to the blade disk radius, the higher the accuracy of the vibration parameter identification method introduced in this paper. Because the structure of the gas turbine compressor and turbine blade disk has a small blade disk ratio, the method proposed in this paper is suitable for the simultaneous vibration parameter identification of gas turbine compressor blades and turbine blades.

Artificial intelligence in glaucoma detection using color fundus photographs.

To explore the potential of artificial intelligence (AI) for glaucoma detection using deep learning algorithm and evaluate its accuracy for image classification of glaucomatous optic neuropathy (GON) from color fundus photographs. A total of 1375 color fundus photographs, 735 normal optic nerve head and 640 GON, were uploaded on the AI software for training, validation, and testing using deep learning model, which is based on Residual Network (Res Net) 50V2. For initial training and validation, 400 fundus images (200 normal and 200 GON) were uploaded and for the final training and testing 975 (535 normal and 440 GON) were uploaded later. Accuracy, sensitivity, and specificity were used to evaluate the image classification performance of the algorithm. Also, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio were calculated. The model used in the study showed an image classification accuracy of 81.3%, sensitivity of 83%, and specificity of 80% for the detection of GON. The false-negative grading was 17% and false-positive grading was 20% for the image classification of GON. Coexistence of glaucoma in patients with high myopia, early glaucoma in a small disc, and software misclassification of GON were the reasons for false-negative results. Physiological large cupping in a large disc, myopic or titled disc, and software misclassification of normal optic disc were the reasons for false-positive results. The model employed in this study achieved a good accuracy, and hence has a good potential in detection of GON using color fundus photographs.

10269-ET-10 ARRAYS FOR DELIVERING TUMOR TREATING FIELDS (TTFIELDS) TO THE MOUSE HEAD

Abstract INTRODUCTION Tumor Treating Fields (TTFields) therapy is an approved treatment for glioblastoma (GBM), the most common malignant brain tumor. TTFields therapy is delivered continuously by two pairs of arrays placed orthogonally on the skin surrounding the tumor region. Investigational in vivo work in the field of GBM currently utilizes mouse models. To expand the possibility for TTFields-GBM in vivo studies, TTFields arrays for the mouse head are needed. The small dimensions and specific geometries of the mouse head make the development of such arrays challenging. METHODS We tested a variety of layouts for the arrays to identify one that will be suited to the geometries of the mouse head, and that will minimally restrict head movement. Efficient treatment delivery requires good adherence to the skin; hence, we investigated different skin attachment adhesive tapes. To validate the ability of the selected arrays to deliver therapeutic field intensity to the desired region, we performed direct fields measurements and simulations. RESULTS We employed 2 strategies to overcome the small size and confining geometries of the mouse head: (1) only two of the four arrays were situated on the head – opposing arrays were placed on the mouse torso; (2) the arrays on the head were each divided into two small disks instead of just one large disk. We identified an adhesive tape for securing the arrays to the skin that was thin and transparent, facilitating correct positioning of the arrays on the mouse head. The tape also offered good tackiness, and allowed for easy removal without leaving residual adhesive on the skin, facilitating repeated array placement. The arrays met the requirements for efficient treatment: field intensity ≥ 1 V/cm RMS, current ≥ 50 mA, usage ≥ 75%. CONCLUSIONS We were able to develop flexible mouse head arrays, that adheres strongly to the skin, enabling efficient electric field delivery with minimal animal discomfort. These arrays provide means to expand TTFields-GBM treatment research, and will contribute to advance this field.

On the Study of Starlike Functions Associated with the Generalized Sine Hyperbolic Function

Geometric function theory, a subfield of complex analysis that examines the geometrical characteristics of analytic functions, has seen a sharp increase in research in recent years. In particular, by employing subordination notions, the contributions of different subclasses of analytic functions associated with innovative image domains are of significant interest and are extensively investigated. Since ℜ(1+sinh(z))≯0, it implies that the class Ssinh* introduced in reference third by Kumar et al. is not a subclass of starlike functions. Now, we have introduced a parameter λ with the restriction 0≤λ≤ln(1+2), and by doing that, ℜ(1+sinh(λz))>0. The present research intends to provide a novel subclass of starlike functions in the open unit disk U, denoted as Ssinhλ*, and investigate its geometric nature. For this newly defined subclass, we obtain sharp upper bounds of the coefficients an for n=2,3,4,5. Then, we prove a lemma, in which the largest disk contained in the image domain of q0(z)=1+sinh(λz) and the smallest disk containing q0(U) are investigated. This lemma has a central role in proving our radius problems. We discuss radius problems of various known classes, including S*(β) and K(β) of starlike functions of order β and convex functions of order β. Investigating Ssinhλ* radii for several geometrically known classes and some classes of functions defined as ratios of functions are also part of the present research. The methodology used for finding Ssinhλ* radii of different subclasses is the calculation of that value of the radius r<1 for which the image domain of any function belonging to a specified class is contained in the largest disk of this lemma. A new representation of functions in this class, but for a more restricted range of λ, is also obtained.

MODL-13. DEVELOPMENT OF TUMOR TREATING FIELDS (TTFIELDS) ARRAYS FOR TREATMENT OF HEAD TUMORS IN MICE MODELS

Abstract INTRODUCTION Glioblastoma (GBM) is the most common malignant brain tumor. Tumor Treating Fields (TTFields) therapy is an approved treatment for GBM, delivered continuously by two array pairs placed on the skin surrounding the tumor region. Currently, most GBM animal models are based on mice. Since arrays for TTFields application to the mouse head are lacking, GBM-TTFields in vivo studies are limited. The small dimensions and specific geometries of the mouse head make the development of such arrays challenging. METHODS We tested different array layouts to identify one that will optimally accommodate the geometries of the mouse head while minimally restricting head movement. Additionally, we investigated adhesive tapes for array attachment to the skin, to allow good adherence and hence provide efficient treatment delivery. To validate that the selected array layout delivers therapeutic field intensity to the desired region, we performed simulations and fields measurements. RESULTS To overcome the issue of small head size we developed a layout in which the arrays on the head were divided into two smaller disks, with the opposing arrays situated on the mouse torso. We also identified a thin and transparent adhesive tape that facilitated the correct positioning of the arrays on the mouse head, offered good tackiness, and allowed for easy removal without leaving residual adhesive on the skin. The arrays met the minimum treatment requirements: field intensity ≥ 1 V/cm RMS, current ≥ 50 mA, usage ≥ 75%. CONCLUSIONS Our newly developed mouse head arrays are a flexible construct, that adheres strongly to the skin to enable efficient electric field delivery. By facilitating TTFields delivery to the heads of mice, we will expand the scope of GBM treatment research and will contribute to further advance this field.

Non-Arteritic Anterior Ischemic Optic Neuropathy (NA-AION): A Comprehensive Overview.

Non-arteritic anterior ischemic optic neuropathy (NA-AION) represents one of the most important causes of blindness or severely impaired vision in middle-aged and elderly people. Unilateral optic disc edema and abrupt, painless vision loss are its defining features. It is commonly assumed that NA-AION is caused by an ischemic infarction of the optic nerve head, and, although the exact pathogenesis is still unknown, several risk factors and comorbidities associated with its development have been found. NA-AION occurs generally in patients older than 50 years who have small optic discs and vasculopathy risk factors. Even though numerous treatment options have been proposed, no available effective medical or surgical therapy or prophylactic measure for NA-AION currently exists. The purpose of present-day therapeutic strategies is therefore to identify and possibly control any underlying modifiable risk factors, aiming to prevent the development of new NA-AION episodes in the affected and fellow eye. A thorough assessment of NAION, including its history, epidemiology, etiology, pathophysiology, risk factors, associated comorbidities, clinical findings, diagnostic tests, treatment choices, prognosis, and future research, is the goal of this work.

Predictors of Glaucomatous Progression in Individuals with Small and Large Optic Discs

To identify factors associated with glaucomatous progression in individuals with small and large optic discs. Retrospective review. 4,505 individuals with glaucoma at UCLA; 233 (59.7%) with small discs, 157 (40.3%) with large discs. Small and large disc sizes were defined by optical coherence tomography (OCT) or Heidelberg Retinal Tomography (HRT) disc area ≤5% (≤ 1.3 mm2) and ≥95% (≥ 2.9 mm2), respectively. Medical records were reviewed for demographics, systemic comorbidities, glaucoma type, ocular comorbidities, and ocular surgery. Logistic regression was used to identify predictors of visual field (VF) progression in individuals with small and large discs, and predictors of large versus small discs. VF deterioration with mean deviation (MD), pointwise linear regression (PLR), and glaucoma rate index (GRI); large versus small disc. In individuals with small discs, Asian versus Non-Hispanic White ethnicity was associated with increased progression (adjusted odds ratio [aOR] = 4.05, 95% confidence interval [CI] = 1.12,14.59 for GRI). Higher intraocular pressure (IOP) range and peak were associated with increased progression in individuals with both small discs (aOR = 1.12, CI = 1.00, 1.27 and aOR = 1.05, CI = 1.00-1.10 per 1 mmHg for range and peak with GRI) and large discs (aOR = 1.35, CI = 1.12,1.66 and aOR = 1.11, CI = 1.03,1.20 per 1 mmHg for range and peak with GRI). Multivariable predictors of having large versus small discs included vasospastic phenotype (aOR = 2.58, CI = 1.35,5.19) and Black (aOR = 20.46, CI = 8.33,61.84), Hispanic/Latino (aOR = 9.65, CI = 4.14,25.39), Asian (aOR = 4.87, CI = 2.96,8.1), and Other (aOR = 2.79, CI = 1.69,4.63) versus Non-Hispanic White ethnicity. Increased odds of glaucomatous progression were associated with Asian versus Non-Hispanic White ethnicity in glaucoma patients with small optic discs, as well as with increased IOP range and peak in those with small and large discs. Individuals with a vasospastic phenotype and those from racial and ethnic minority backgrounds had increased odds of having large versus small optic discs. Further characterization of discernible phenotypes would improve disease prognostication and help individualize glaucoma treatment.

How to make giant planets via pebble accretion

Planet formation is directly linked to the birthing environment that protoplanetary disks provide. The disk properties determine whether a giant planet will form and how it evolves. The number of exoplanet and disk observations is consistently rising, however, it is not yet possible to directly link these two populations. Therefore, a deep theoretical understanding of how planets form is crucial. Giant planets are not the most common exoplanets, but their presence in a disk can have significant consequences for the evolution of the disk itself and the planetary system undergoing formation. Their presence also offers more chances of spotting observational features in the disk structure. We performed numerical simulations of planet formation via pebble and gas accretion, while including migration, in a viscously evolving protoplanetary disk, with dust growing, drifting, and evaporating at the ice lines. In our investigation of the most favorable conditions for giant planet formation, we find that these are high disk masses, early formation, and a large enough disk to host a long-lasting pebble flux, so that efficient core growth can take place before the pebble flux decays over time. Specifically, core growth needs to start before 0.9 Myr to form a giant, with an initial disk mass of 0.04 M⊙ (or higher) and the disk radius needs to be larger than 50 AU. However, small disks with the same mass allow more efficient gas accretion onto already formed planetary cores, leading to more massive gas giants. Given the right conditions, high viscosity (α = 10−3) leads to more massive cores (compared to α = 10−4) and it also enhances gas accretion. At the same time, it causes faster type II migration rates, so the giants have a decreasing final position for increasing viscosity. Intermediate dust fragmentation velocities, between 4 and 7 m s−1, provide the necessary pebble sizes and radial drift velocities for maximized pebble accretion with optimal pebble flux. The starting location of a planetary embryo defines whether a giant planet will form, with the highest fraction of giants originating between 5 and 25 AU. Finally, a dust-to-gas ratio of 0.03 can compensate for lower disk masses with fDG ≤ 0.015, but early formation is still important in order to form giant planets. We conclude that there is no specific initial parameter that leads to giant planet formation; rather, it is the outcome of a combination of complementary factors. This also implies that the diversity of the exoplanet systems is the product of the intrinsic diversity of the protoplanetary disks and it is crucial to take advantage of the increasing number and quality of observations to constrain the disk population properties and ultimately devise planet formation theories.

A new high elevation species of Oreophryne Boettger (Anura: Microhylidae) from Sulawesi, Indonesia.

We examined the morphology of 50 specimens of Sulawesian Oreophryne and recognize a distinct, undescribed species. Based on morphological data and supported with phylogenetic analysis of the 16S rRNA gene, it is herein described and named as Oreophryne riyantoi sp. nov. The new species is diagnosed by having a combination of rounded snout in dorsal and lateral view, indistinct tympanum, narrow interorbital distance, small hands, small terminal discs on fingers and toes, toes without webbing, short legs, and dorsal surfaces of head, body and limbs irregularly tuberculated in life. It was found in leaf litter on the forest floor in extremely wet primary montane forest on Mount Mekongga at an altitude of 2528 m asl. The forest-dwelling habit of this terrestrial frog is unusual because other terrestrial Oreophryne occuring at high-altitude live in open grassy or fern dominated meadows. Four endemic species of Oreophryne are now known from Sulawesi. However, herpetological research activities, including high elevation surveys and additional taxonomic work, are necessary to achieve a comprehensive understanding of Oreophryne diversity and phylogeography in Sulawesi.

Disclinations in vibration-induced size segregation

Vibration segregates large disks embedded in a medium of small disks and transits structurally the arrays of disks from the loosely disordered packing to the densely ordered packing. Our experiments on a monodisperse or bidisperse medium of small disks reveal that several types of topological defects, emerging during this disordered-to-ordered transition, are an isolated 5-fold disclination, an isolated 7-fold disclination, a 5-7 pair, a quadrupole of two 5-7 pairs, a grain boundary of alternating 5- and 7-fold disclinations and a closed loop of a grain boundary. The dominant types are an isolated 5-fold disclination and a 5-7 pair. Vibration eliminates more effectively 5-7 pairs than isolated 5-fold disclinations. After sufficient vibration the resulting orientational order is quasi-long-range only in two cases, i) in a monodisperse medium and ii) in a dilute bidisperse medium vibrated at small acceleration, while translational order is always short-range. The arrangement of disks in such two cases is thus hexatic-like.

HOW BRAND ENGAGEMENT, BRAND EXPERIENCE ON BRAND LOYALTY THROUGH BRAND TRUST AND BRAND COMMITMENT: SPOTIFY ONLINE MUSIC EVIDENCE

In ancient times, humans listened to music using music records in the form of discs that were quite large. Then it developed into smaller discs, then added cassettes and radio. In this modern era, music preservation is received through online applications, and one application that provides these services is Spotify. But this success does not cover the importance of service factors to compete with other brands competitively. Therefore, this study uses quantitative methods to examine the factors influencing consumer loyalty as seen from the community's involvement, experience, Trust, and commitment to the Spotify brand. The Sampling technique uses a non-probability sampling approach. Data was collected using a purposive sampling technique, taking 351 respondents with had experience using the Spotify application. The measurement model for the inner model in this study was analyzed using AMOS 26. In the internal model, testing was discovered by using this study's R2, discriminant, and fitness models. The outer model research includes validity and reliability tests done with SPSS 26 application

Comparison of Heat Transfer Through Various Fixed Prosthetic Materials During Grinding.

To measure and compare the mean temperature values due to heat generated during the grinding of different prosthetic materials with diamond burs using a high-speed instrument with and without water cooling. In total, 120 disk-shaped specimens (10 × 2 mm), each with a smaller disk in the center (3 × 2 mm), were fabricated from yttrium-stabilized zirconia, monolithic zirconia, glass-ceramic, indirect composite, polyetheretherketone (PEEK), and cast metal (Ni-Cr alloy). The specimens were divided into six groups (n = 20) according to material type. The specimens in each group were ground continuously with a high-speed handpiece and diamond burs with (n = 10) and without (n = 10) water cooling until the smaller disks were removed. Two different methods (thermocouple and thermal camera) were used to measure the temperature during the grinding process. Results were analyzed using two-way ANOVA and paired-samples t test (P < .05). PEEK had the lowest mean temperature and metal had the highest values, both with and without water cooling, according to data measured with a thermocouple. Zirconia and monolithic zirconia samples without water cooling had the highest mean temperature when measured with a thermal camera. Both with and without water cooling, composite samples had the lowest mean temperatures for thermal camera measurements. Water cooling is strongly recommended when grinding all prosthetic materials. The heat transferred to the supporting teeth may depend on the thermal conductivity of the material used.

Thermodynamic and structural properties of lipid-photosensitizer conjugates mixed with phospholipids: Impact on the formation and stability of nano-assemblies

The photosensitizer Phenalenone (PN) was grafted with one or two lipid (C18) chains to form pure nano-assemblies or mixed lipid vesicles suitable for photodynamic therapy. Mixtures of PN-C18 conjugates with stearoyl-oleoyl phosphatidylcholine (SOPC) form vesicles that disintegrate into bilayer sheets as the concentration of PN-C18 conjugates increases. We hypothesized that PN-C18 conjugates control the thermodynamic and structural properties of the mixtures and induce the disintegration of vesicles due to PN π-π-interactions.Monolayers were analyzed by surface pressure and grazing incidence X-ray diffraction (GIXD) measurements, and vesicles by differential scanning calorimetry and cryo-TEM. The results showed that PN-triazole-C18 (1A) and PN-NH-C18 (1B) segregate from the phospholipid domains. PN-(C18)2 (conjugate 2) develops favorable interactions with SOPC and distearoyl-phosphatidylcholine (DSPC). GIXD demonstrates the contribution of SOPC to the structuring of conjugate 2 and the role of the major component in controlling the structural properties of DSPC-conjugate 2 mixtures. Above 10 mol% conjugate 2 in SOPC vesicles, the coexistence of domains with different molecule packing leads to conjugate segregation, vesicle deformation, and the formation of small bilayer discs stabilized by the inter-bilayer π-π stacking of PN molecules.

Lopsidedness as a tracer of early galactic assembly history

ABSTRACT Large-scale asymmetries (i.e. lopsidedness) are a common feature in the stellar density distribution of nearby disc galaxies both in low- and high-density environments. In this work, we characterize the present-day lopsidedness in a sample of 1435 disc-like galaxies selected from the TNG50 simulation. We find that the percentage of lopsided galaxies (10 per cent–30 per cent) is in good agreement with observations if we use similar radial ranges to the observations. However, the percentage (58 per cent) significantly increases if we extend our measurement to larger radii. We find a mild or lack of correlation between lopsidedness amplitude and environment at z = 0 and a strong correlation between lopsidedness and galaxy morphology regardless of the environment. Present-day galaxies with more extended discs, flatter inner galactic regions, and lower central stellar mass density (i.e. late-type disc galaxies) are typically more lopsided than galaxies with smaller discs, rounder inner galactic regions, and higher central stellar mass density (i.e. early-type disc galaxies). Interestingly, we find that lopsided galaxies have, on average, a very distinct star formation history within the last $10\, \mathrm{Gyr}$, with respect to their symmetric counterparts. Symmetric galaxies have typically assembled at early times (∼8–$6\, \mathrm{Gyr}$ ago) with relatively short and intense bursts of central star formation, while lopsided galaxies have assembled on longer time-scales and with milder initial bursts of star formation, continuing building up their mass until z = 0. Overall, these results indicate that lopsidedness in present-day disc galaxies is connected to the specific evolutionary histories of the galaxies that shaped their distinct internal properties.

Preclinical to clinical translation for intervertebral disc repair: Effects of species-specific scale, metabolism, and matrix synthesis rates on cell-based regeneration.

A significant hurdle for potential cell-based therapies is the subsequent survival and regenerative capacity of implanted cells. While many exciting developments have demonstrated promise preclinically, cell-based therapies for intervertebral disc (IVD) degeneration fail to translate equivalent clinical efficacy. This work aims to ascertain the clinical relevance of both a small and large animal model by experimentally investigating and comparing these animal models to human from the perspective of anatomical scale and their cellular metabolic and regenerative potential. First, this work experimentally investigated species-specific geometrical scale, native cell density, nutrient metabolism, and matrix synthesis rates for rat, goat, and human disc cells in a 3D microspheroid configuration. Second, these parameters were employed in silico to elucidate species-specific nutrient microenvironments and predict differences in temporal regeneration between animal models. This work presents in silico models which correlate favorably to preclinical literature in terms of the capabilities of animal regeneration and predict that compromised nutrition is not a significant challenge in small animal discs. On the contrary, it highlights a very fine clinical balance between an adequate cell dose for sufficient repair, through de novo matrix deposition, without exacerbating the human microenvironmental niche. Overall, this work aims to provide a path towards understanding the effect of cell injection number on the nutrient microenvironment and the "time to regeneration" between preclinical animal models and the large human IVD. While these findings help to explain failed translation of promising preclinical data and the limited results emerging from clinical trials at present, they also enable the research field and clinicians to manage expectations on cell-based regeneration. Ultimately, this work provides a platform to inform the design of clinical trials, and as computing power and software capabilities increase in the future, it is conceivable that generation of patient-specific models could be used for patient assessment, as well as pre- and intraoperative planning.

Zellweger Spectrum Disorder: Ophthalmic Findings from a New Natural History Study Cohort and Scoping Literature Review

Individuals with Zellweger spectrum disorder (ZSD) manifest a spectrum of clinical phenotypes but almost all have retinal degeneration leading to blindness. The onset, extent, and progression of retinal findings have not been well described. It is crucial to understand the natural history of vision loss in ZSD to define reliable endpoints for future interventional trials. Herein, we describe ophthalmic findings in the largest number of ZSD patients to date. Retrospective review of longitudinal data from medical charts and review of cross-sectional data from the literature. Sixty-six patients with ZSD in the retrospective cohort and 119 patients reported in the literature, divided into 4 disease phenotypes based on genotype or clinical severity. We reviewed ophthalmology records collected from the retrospective cohort (Clinicaltrials.gov NCT01668186) and performed a scoping review of the literature for ophthalmic findings in patients with ZSD. We extracted available ophthalmic data and analyzed by age and disease severity. Visual acuity (VA), posterior and anterior segment descriptions, nystagmus, refraction, electroretinography findings, visual evoked potentials, and OCT results and images. Visual acuity was worse at younger ages in those with severe disease compared with older patients with intermediate to mild disease for all 78 participants analyzed, with a median VA of 0.93 logarithm of the minimum angle of resolution (Snellen 20/320). Longitudinal VA data revealed slow loss over time and legal blindness onset at an average age of 7.8 years. Funduscopy showed retinal pigmentation, macular abnormalities, small or pale optic discs, and attenuated vessels with higher prevalence in milder severity groups and did not change with age. Electroretinography waveforms were diminished in 91% of patients, 46% of which were extinguished and did not change with age. OCT in milder patients revealed schitic changes in 18 of 23 individuals (age range 1.8 to 30 years), with evolution or stable macular edema. In ZSD, VA slowly deteriorates and is associated with disease severity, serial electroretinography is not useful for documenting vision loss progression, and intraretinal schitic changes may be common. Multiple systematic measures are required to assess retinal dystrophy accurately in ZSD, including functional vision measures. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

The Inner 2 pc of Sagittarius A*: Simulations of the Circumnuclear Disk and Multiphase Gas Accretion in the Galactic Center

The inner few parsecs of the Milky Way’s Galactic center contain the central accreting supermassive black hole, over a million stars, and multiple large gaseous structures. In the past, the structures at these length scales have generally been modeled independently of each other. It is consequently not well understood how these complex features interact with each other, nor how gas flows between the outer few parsecs and the inner subarcsecond region (1″ ≈ 0.04 pc). In this work, we present hydrodynamic simulations of the inner few parsecs of the Galactic center that, for the first time, combine a realistic treatment of stellar winds and the circumnuclear disk (CND) as they interact with the gravitational potential of the nuclear star cluster and Sagittarius A*. We observe interactions of the stellar winds with the inner edge of the CND, which leads to the growth of instabilities, induced accretion of cool gas from the inner edge of the disk, and the eventual formation of a small accretion disk of ∼104–105 K within r ∼ 0.1 pc. The formation of an inner disk qualitatively agrees with observations. This disk grows in radial extent and mass with time on ≳10 kyr timescales, with a growth rate of . We discuss additional physical mechanisms not yet included in this work that can improve our model.

Substructures in Compact Disks of the Taurus Star-forming Region

Observations of substructure in protoplanetary disks have largely been limited to the brightest and largest disks, excluding the abundant population of compact disks, which are likely sites of planet formation. Here, we reanalyze ∼0.″1, 1.33 mm Atacama Large Millimeter/submillimeter Array (ALMA) continuum observations of 12 compact protoplanetary disks in the Taurus star-forming region. By fitting visibilities directly, we identify substructures in six of the 12 compact disks. We then compare the substructures identified in the full Taurus sample of 24 disks in single-star systems and the ALMA DSHARP survey, differentiating between compact (R eff,90% < 50 au) and extended (R eff,90% ≥50 au) disk sources. We find that substructures are detected at nearly all radii in both small and large disks. Tentatively, we find fewer wide gaps in intermediate-sized disks with R eff,90% between 30 and 90 au. We perform a series of planet–disk interaction simulations to constrain the sensitivity of our visibility-fitting approach. Under the assumption of planet–disk interaction, we use the gap widths and common disk parameters to calculate potential planet masses within the Taurus sample. We find that the young planet occurrence rate peaks near Neptune masses, similar to the DSHARP sample. For 0.01 M J/M ⊙ ≲M p/M * ≲0.1 M J/M ⊙, the rate is 17.4% ± 8.3%; for 0.1 M J/M ⊙ ≲M p/M * ≲1 M J/M ⊙, it is 27.8% ± 8.3%. Both of them are consistent with microlensing surveys. For gas giants more massive than 5 M J, the occurrence rate is 4.2% ± 4.2%, consistent with direct imaging surveys.

Crossmodal association between visual and acoustic cues in a tortoise (Testudo hermanni).

Humans spontaneously match information coming from different senses, in what we call crossmodal associations. For instance, high-pitched sounds are preferentially associated with small objects, and low-pitched sounds with larger ones. Although previous studies reported crossmodal associations in mammalian species, evidence for other taxa is scarce, hindering an evolutionary understanding of this phenomenon. Here, we provide evidence of pitch-size correspondence in a reptile, the tortoise Testudo hermanni. Tortoises showed a spontaneous preference to associate a small disc (i.e. visual information about size) with a high-pitch sound (i.e. auditory information) and a larger disc to a low-pitched sound. These results suggest that crossmodal associations may be an evolutionary ancient phenomenon, potentially an organizing principle of the vertebrate brain.

Seed and seed coat morphology in monotypic and endemic genera of Korean angiosperms

The basic information of ovule and seed characteristics was investigated for five monotypic and endemic genera in the Korean peninsula as categorized by the Flora of Korea category. The carpels and seeds were sectioned with a rotary microtome. Mature seeds were coated with platinum using an ion sputter and observed using a scanning electron microscope. As a result, &lt;i&gt;Abeliophyllum&lt;/i&gt; was found to be anatropous and a unitegmic ovule, with a slightly colliculate seed surface and exotestal seed coat type. The ovule of &lt;i&gt;Coreanomecon&lt;/i&gt; was anatropous and bitegmic, having a distinct echinate seed surface, and exo-endotestal seed coat type with a prismatic crystal in the mesotesta. The ovule of &lt;i&gt;Hanabusaya&lt;/i&gt; was anatropous and a unitegmic, with a long reticulate seed surface sculpture, and distinct exotestal seed coat type. In addition, a wing developed at the opposite side of the raphe bundle. &lt;i&gt;Megaleranthis&lt;/i&gt; was an anatropous and bitegmic ovule, having a small pentagonal disk shape, a concave seed surface and exotestal seed coat type. Finally, &lt;i&gt;Pentactina&lt;/i&gt; was also anatropous and a unitegmic ovule, reticulate seed sculpture, and endotestal seed coat type. These data will be proving to be a source of good information for securing bio-sovereignty in the near future.