Small Conduits Research Articles

The Limoeiro Deposit: Ni-Cu-PGE Sulfide Mineralization Hosted Within an Ultramafic Tubular Magma Conduit in the Borborema Province, Northeastern Brazil

The Limoeiro deposit, located in a high-grade mobile belt of the Brasiliano orogenic cycle (650–500 Ma), represents one of the few magmatic Ni-Cu(-PGE) sulfide discoveries in recent years. The deposit is hosted by an ultramafic chonolith consisting in a partly deformed and metamorphosed tube-like body affected by brittle faults within high-grade gneiss and schist. The absolute age of the ultramafic intrusion that hosts the Limoeiro deposit is not yet known, but regional geologic constraints suggest that both intrusion and host rocks belong to a terrane older than the orogenic cycle. Peak metamorphic parageneses of the ultramafic intrusion and country rocks indicate granulite facies of metamorphism, interpreted as the result of the Neoproterozoic Brasiliano orogenic cycle. The Limoeiro deposit is the first significant discovery of Ni-Cu sulfide in the Borborema province, opening a new window for exploration in this large orogenic belt. Despite the high-grade metamorphism and the tectonic deformation, the primary magmatic structure of the intrusion hosting the Limoeiro deposit is remarkably well preserved. This intrusion forms a tube-like conduit (chonolith) with cross sections a few hundreds of meters in diameter and with a considerable length of more than 4 km. The conduit consists of two distinct sequences of ultramafic rocks, denominated Upper and Lower sequences, each one consisting of a core of harzburgite enveloped by orthopyroxenite, with an irregular and discontinuous outer shell of amphibolite. These ultramafic sequences, characterized by similar composition and structure, have distinctively different S contents resulting from the presence of disseminated Ni-Cu sulfide mineralization only in the Upper sequence. The magmatic system of the Limoeiro deposit is interpreted to result from the input of two major pulses of magma with similar composition, but sulfide saturation and segregation is restricted to the second magma pulse (Upper sequence). Nickel-Cu(-PGE) sulfide mineralization is broadly concordant with the Upper sequence and different orebodies resulted from tectonic slicing of the originally continuous tube-like structure. The bulk of the mineralization in all orebodies consists of thick (up to 150 m) and elongated (up to 1 km) masses of rock containing disseminated sulfides broadly concordant with the chonolithic structure. Thin layers of massive ore occur in the lower portions of some of the orebodies, and represent about 3 vol % of the Limoeiro deposit. The intrusion hosting the Limoeiro deposit is probably the best preserved chonolith that has been overprinted by granulite facies metamorphism within an orogenic terrane. This study indicates that reconstruction of small magma conduits, an important tool for exploration for Ni-Cu sulfide deposits, may be successfully achieved within high-grade orogenic terranes.

The comparison of hydrodynamic characteristics of karst aquifers: application on two karst formations in Zagros (Asmari and Ilam-Sarvak), southwest Iran

In order to study the function, hydrodynamic behavior, and hydraulic properties of the karst aquifers in Izeh, southwest Iran, time series analysis was applied to the precipitation, spring discharge, and piezometric head data of two representative karst systems of Zagros (Ilam-Sarvak and Asmari Formations). Time series analysis was applied to two karst aquifers, those of Asmari and Ilam-Sarvak Formations. The daily precipitations of anticlines were estimated based on the precipitation–elevation function which was applied on digital elevation model (DEM) of the area. The mean estimated daily precipitations were considered in bivariate time series analysis as input data of each karst system. The total length of time series was about 2.7 years, extending from May 2007 to December 2009. During the research, several one-parameter probe data loggers were installed, which daily measure the water surfaces in karst aquifers. Time series analysis was applied for describing Izeh karst aquifers with a focus on both univariate (autocorrelation and spectral analysis) and bivariate (cross-correlation, gain function, and coherency function) methods. The results show that Asmari karst aquifer in Kamarderaz Anticline has a large storage capacity. Because of lacking a well-organized karst network, in the Asmari karst aquifer, baseflow dominates with low contribution of quick-flow. In the Ilam-Sarvak karst aquifer (Shavish and Tanush Anticlines), the karstification occurred in fractures and small diameter conduits, which caused to quick-flow between dense limestone. The Ilam-Sarvak karst aquifer could be regarded as a transition between two extreme types of karst, e.g., highly karstified system and in the opposite, extremely diffused one. The analysis of well hydrograph in Ilam-Sarvak karst aquifer shows that the karst aquifer has a low storage capacity. Unlike Asmari karst aquifer, the fractures and small diameter conduits in Ilam-Sarvak karst aquifer are more enhanced, producing a better developed karst network. Contrary to the typical karst systems, however, diffuse flow and conduit flow coexist in the Asmari Formation.

Anatomical regulation of ice nucleation and cavitation helps trees to survive freezing and drought stress

Water in the xylem, the water transport system of plants, is vulnerable to freezing and cavitation, i.e. to phase change from liquid to ice or gaseous phase. The former is a threat in cold and the latter in dry environmental conditions. Here we show that a small xylem conduit diameter, which has previously been shown to be associated with lower cavitation pressure thus making a plant more drought resistant, is also associated with a decrease in the temperature required for ice nucleation in the xylem. Thus the susceptibility of freezing and cavitation are linked together in the xylem of plants. We explain this linkage by the regulation of the sizes of the nuclei catalysing freezing and drought cavitation. Our results offer better understanding of the similarities of adaption of plants to cold and drought stress, and offer new insights into the ability of plants to adapt to the changing environment.

Granulocyte Colony-Stimulating Factor Minimizes Negative Remodeling of Decellularized Small Diameter Vascular Graft Conduits but Not Medial Degeneration

Poor endothelialization and intimal hyperplasia are major causes of small diameter vascular conduit (SDVC) failure. The present study was aimed to investigate the influence of granulocyte colony-stimulating factor (G-CSF) on inhibiting adverse remodeling of decellularized SDVCs. Sprague-Dawley rats implanted with allograft infra renal abdominal aortic conduits were divided into 2 groups according to whether they were treated with G-CSF (+G-CSF group; n=6) or without (Decell group; n=6). The conduits were harvested at 8 weeks after surgery and examined for intimal hyperplasia, collagen deposition, and -actin-staining cells. The medial layer was also examined for signs of cellular repopulation and changes in the elastic fiber morphology. Intergroup comparison of the intimal composition showed relatively sparse collagen content and predominance of -actin-staining cells in the +G-CSF group. The medial layer in the 2 groups showed similar degrees of elastic fiber degeneration and wall thinning relative to the normal aortic wall. However, the enhanced staining for von Willebrand factor and CD31, along with transmission electron microscopy findings of superior cellular and ultrastructural preservation, suggested that the remodeling and endothelialization in the +G-CSF conduits were superior to those in the Decell conduits. This study suggests that G-CSF exerts a positive influence on inhibiting adverse vascular remodeling of decellularized vascular conduit implants. However, whether G-CSF administration may also effectuate an improved ability to preserve the medial structural integrity is unclear.

Hydrogeologic and topographic controls on evolution of karst features in Illinois’ sinkhole plain

In the sinkhole plain of southwestern Illinois, the size and morphology of cover-collapse sinkholes can be used as an indicator of the size of the associated underlying crevice/conduit system. Sinkholes that lead to relatively small crevices and small conduit systems (sinkhole volumes >103 m3, but <105 m3) typically are found in areas with relatively high water tables and, based on storage capacity of conduits and secondary porosity of adjacent bedrock, are incapable of accepting large, rapidly inflowing volumes of surface-water runoff without backflooding. Once flooded, sinkholes become low-energy environments and sites of deposition of fine sediments; consequently, their growth potential (via erosion by runoff within and at the margins of the sinkhole) is limited. Conversely, in those areas where sinkholes lead to relatively large, branchwork-type cave systems, water tables are typically deeper and the storage capacities of the cave system and adjacent bedrock can be one or more orders of magnitude greater. Because these large cave systems can accept greater volumes of rapidly inflowing runoff without backflooding, the sinkholes associated with large cave systems typically become sites of extensive erosion. The aerial extent of a sinkhole draining to large cave systems may continue to increase and incorporate other sinkholes within its drainage area, thereby creating large, compound sinkholes up to 30 ha in area. These sinkholes can have direct or indirect connections to cave passages and have volumes that can be as small as 104 m3 and as large as 106 m3. Beneath the glacial till and loess cover, and in the vicinity of the largest cover-collapse sinkholes, irregularities in bedrock topography appear to have had an effect on the location of the initiation of large caves in the sinkhole plain. The coincidence of bedrock depressions and swales in close proximity to the initiation point of the large caves suggests that focused recharge to fractures leading to bedding-plane partings in bedrock played a major role in the initiation and evolution of the large branchwork-type caves of Illinois’ sinkhole plain.

Off‐label use of percutaneous pulmonary valved stents in the right ventricular outflow tract: Time to rewrite the label?

Percutaneous pulmonary valve implantation is now considered feasible and safe. "Native" right ventricular outflow tract (RVOT), small diameter conduits (<16 mm) and relatively large RVOT with a dynamic outflow aneurysm are currently considered off-label uses. Extending indications creates concerns of safety, ethics, reimbursement, and liability. To report the safety and feasibility of off-label application of percutaneous pulmonary valve implantation. Retrospective analysis of prospectively collected data. Off-label indications: conduit-free RVOT or patients with an existing but undersized conduit. Twenty-one Melody® valves and two Sapien® valves were successfully implanted in 23 patients (16.9 years; range 6.1-80.5 years). In 22 patients, prestenting was performed 4.8 months (range 0-69.2) before valve implantation (15 covered and 13 bare stents). Stent endothelial ingrowth was allowed for at least 2 months prior to implantation of the percutaneous valve if stent stability or sealing by the covering was presumed to be insufficient. Group 1 patients (n = 8) had a "conduit-free" RVOT after transannular/infundibular patch and after prestenting underwent percutaneous pulmonary valve implantation (PPVI), with a final RVOT diameter of 21.5 mm (range 16-26 mm). Group 2 patients consisted of two elderly patients with pulmonary valve stenosis and severe RVOT calcifications. Group 3 (n = 13) had an existing conduit (nominal 15.9 ± 3.2 mm; range 10-20 mm). The conduit was augmented from 14.7 ± 3.5 to 20 ± 1.6 mm with PPVI. The RVOT preparation and valve implantations were uneventful. PPVI is safe and feasible in selected patients with an off-label indication. Creating an adequate "landing zone" by prestenting makes the procedure safe and predictable. Updating the indications for PPVI should be considered.

Aortic Conduit Valve Model With Controlled Moderate Aortic Regurgitation in Rats

The objective of this study was to describe a small animal aortic conduit model that could analyze long-term conduit valve (CV) function by echocardiography. Recipient Wistar rats (200-250g, n=20) underwent aortic leaflet injury of their native aortic valve under echocardiographic control. After 2 weeks, U-shaped decellularized CVs obtained from other rats were implanted onto the abdominal aorta. Implanted CVs were analyzed via pulsed-wave echocardiography at day 0, 4 and 12 weeks. CV stenosis was assessed as systolic flow velocity (post-pre CV)/flow velocity in the ascending aorta. CV regurgitation was assessed as the ratio of the amount of reversed diastolic flow to forward systolic flow in post-pre CV. The endpoint was set at 12 weeks. Three rats died immediately after aortic valve injury and all surviving rats received CV implantation (n=17, 85%). The survival rate after conduit implantation was 100% at 4 weeks and 88% (15/17) at 12 weeks. Regarding the CV function at 0, 4 and 12 weeks, the average observed value of CV stenosis was 3.8±7.9%, 3.1±4.1% and 14±10% (P<0.01), respectively. The average value of CV regurgitation was 0%, 12±27% and 52±43%, respectively (P<0.001). By using this model, the degeneration of implanted CV could be assessed not only qualitatively, but also quantitatively.

Speleogenesis of the “Buco dei Vinchi” inactive swallow hole (Monte Croara karst sub-area, Bologna, Italy), an outstanding example of antigravitative erosion (or “paragenesis”) in selenitic gypsum. An outline of the “post-antigravitative erosion”

Inactive swallow hole Buco dei Vinchi developed along a plane dividing selenitic gypsum stratum and an underlying shale interlayer, mostly by antigravitative erosion and by post-antigravitative erosion. It formed through six speleogenetic phases starting from a phreatic phase followed by several antigravitative erosion (= paragenetic) and post-antigravitative erosion phases and vadose phase. During first antigravitative erosion phase, the phreatic protoconduits evolved into small antigravitative conduits with typical cross-section in shape of an inversed U or a bulb. At the end of this phase the small antigravitative conduits converged and merged together in successive stages to form ever-bigger conduits, until – at a certain point – most of them flowed into a single, much wider antigravitative conduit, which later evolved into a composite conduit. Wwe demonstrate that the subhorizontal flat ceilings are not a characteristic feature of the antigravitative passages tout court – as claimed by most authors –, but instead they evolved in caves during periods when the piezometric surface was tangent to the vault of the cave (post-antigravitative erosion phenomenon). Thus these flat ceilings are traces of ‘paleo-piezometric surfaces’; moreover these flat ceilings, being sub-horizontal originally, can provide important information on possible tectonic movements or breakdowns occurred after their formation. The possible ages of the karstic phenomena in the selenitic gypsum near Bologna are discussed. This paper points out that the Buco dei Vinchi and the Cava a Filo swallow holes, presently located in “topographic highs”, were very probably in “topographic lows” at the time of their hydrologic activity, and that this is evidence of a relief inversion started at least 127,000 years ago. Therefore the beginning of the first karstic phenomena in the Bologna karst area is much older than this date. It is explained why the absolute altimetrical lowering of the Monte Croara karst sub-area (with respect to the present sea level) should be of about – 0.39 mm/year.

Bare metal stenting for obstructed small diameter homograft conduits in the right ventricular outflow tract

Our aim was to assess acute hemodynamic changes with stent insertion, outcomes, and factors associated with increased longevity of stented small diameter homograft conduits. Right ventricle-to-pulmonary artery (RV-PA) homograft conduits are commonly used to palliate RV outflow tract obstruction. Bare metal stenting (BMS) and transcatheter pulmonary valve implantation have been shown to relieve obstructed larger diameter conduits and may delay surgical conduit reintervention. Less is known about BMS of small conduits. From 1992 to 2009, BMS was performed to relieve obstruction in 106 homograft conduits that were ≤12 mm at implant. The peak RV-PA gradient fell from 54.3 ± 17.4 mm Hg at baseline to 46.1 ± 15.2 mm Hg after balloon dilation alone and to 25.1 ± 11.4 mm Hg with stenting (all P < 0.001). Higher pre-BMS gradient and RV pressure were the only factors associated with higher post-BMS RV-PA gradient (≥30 mm Hg; both P < 0.001). There were no procedural deaths, two patients required surgical removal of embolized stents. At a median follow-up of 1.6 years, 83 conduits were replaced; freedom from conduit reoperation after BMS was 66% ± 5% at 1 year and 28% ± 5% at 3 years. Factors associated with shorter freedom from reoperation included implanted conduit diameter <10 mm (P = 0.009), higher post-stent RV-PA gradient (P = 0.026), and higher post-stent RV pressure (P < 0.01); only post-stent RV pressure remained significant on multivariable analysis (P < 0.001). BMS was acutely effective for the treatment of obstructed small diameter homograft conduits, with low morbidity. Prolongation of small diameter homograft conduit longevity with BMS may be useful in the lifetime management of conduit dysfunction in this patient population.

Effects of gravity on the stability of the steady propagation of a liquid plug in a small conduit

In this work we numerically study the stability of the steady state displacement of a liquid plug in a capillary tube when gravity, inertia and surface forces are important. The methodology employed is based on the analysis of steady state solutions and has been presented in previous publications. Gravity is assumed to act only along the axis of the tube.

Application de la courbe diagnostique aux essais de pompage en milieu karstique

Diagnostic plots applied to pumping tests in karst systems. Pumping tests conducted on wells intersecting karst heterogeneities such as the conduit network are difficult to interpret. Nevertheless, this case can be solved by assimilating the horizontal karst conduit to a finite-conductivity vertical fracture. In this case, several flow patterns corresponding to the respective contributions of karst subsystems (fractured matrix, small conduits, and main karst drainage network) can be identified on the diagnostic plot of the drawdown derivative. This is illustrated on two examples from Mediterranean karst systems in southern France. A pumping test on a well intersecting the main karst drainage network of the Cent-Fonts karst system shows (i) a preliminary contribution of the karst conduit storage capacity followed by (ii) linear flows into the fractured matrix. A pumping test on a well intersecting a small karst conduit of the Corbières karst system shows the existence of(i) bi-linear flow within both the karst conduit and the fractured matrix at early times, followed by (ii) radial flows within the fractured matrix and (Hi) finally the contribution of a major karst cavity. The use of diagnostic plots allows identifying the various flow regimes during pumping tests, corresponding to the response of the individual karst aquifer subsystems. This is helpful for improving the understanding of the structure of the karst aquifer and flow exchanges between subsystems.

A small intestine trans-epithelial conduit system assists in lamina propria DC sampling (90.2)

Abstract The mechanisms by which lamina propria DCs sample antigens from the gut remains a crucial topic in mucosal immunology. DCs acquire antigen by several distinct processes including M cell transcytosis, specialized transport involving the neonatal Fc receptor, paracellular leak and by DC trans-epithelial dendrite extension. The continuous sampling of luminal contents by gut resident DCs could both contribute to rapid pathogen recognition and provide normal flora and food antigens for tolerance induction. We used two-photon microscopy, to examine DC sampling behavior in vivo and discovered a previously unreported small-intestine-trans-epithelial-conduit (SiTEC) system. We found that SiTECs could carry macromolecules across the epithelium to the lamina propria where they were taken up by resident DCs. SiTECs have a functional molecular weight cut-off of approximately 70kD based on dextran permeability and can pass small proteins as well. The SiTEC system presents a simple mechanism to deliver luminal antigens to lamina propria DCs for the maintenance of tolerance in the steady-state.

Factors Influencing Pleural Effusion after Fontan Operation: an Analysis with 95 Patients

To investigate the association between preoperative, operative, and postoperative factors and persistent pleural effusion after the extracardiac Fontan procedure. Ninety-five consecutive patients diagnosed with univentricular heart underwent extracardiac connection using Gore-Tax conduits at the Department of Children's Heart Centre, Justus-Liebig-University Giessen in Germany from June 1996 to July 2007. The outcome measures were duration and volume of chest tube drainage after surgical intervention. The investigated factors included age and weight at the time of operation, anatomical diagnosis, preoperative oxygen saturation, mean pulmonary artery pressure, ventricular end-diastolic pressure, fenestration, cardiopulmonary bypass time, conduit size, postoperative pulmonary artery pressure, administration of angiotensin-converting enzyme inhibitors, and postoperative infection. Associations between these factors and persistent pleural effusion after the extracardiac Fontan procedure were analyzed. Every patient suffered postoperative effusion. The median duration of postoperative chest tube drainage was 9 days (range, 3-69 days), and the median volume was 12 mL kg(-1) x d(-1) (range, 2.0-37.5 mL x kg(-1) d x (-1)). Thirty-seven (38.9%) patients had pleural drainage for more than 15 days, and the volume in 35 (36.8%) patients exceeded 25 mL x kg(-1) x d(-1). Nineteen (20%) patients required placement of additional chest tubes for re-accumulation of pleural effusion after removal of previous chest tubes. Fifteen (17.8%) patients were hospitalized again due to pleural effusion after discharge. The median length of hospital stay after the operation was 14 days (range, 4-78 days). Multivariate analysis results showed that non-fenestration, low preoperative oxygen saturation, and postoperative infections were independent risk factors for prolonged duration of pleural drainage (P < 0.05). Long cardiopulmonary bypass time, non-fenestration, small conduit size, and low preoperative oxygen saturation were independent risk factors for excessive volume of pleural drainage (P < 0.05). For reduing postoperative duration and volume of pleural drainage following Fontan procedure, it seems to be important to improve the preoperative oxygen saturation, use large size of conduit, shorten cardiopulmonary bypass time, and make fenestration during the operation, as well as avoid postoperative infections.

(Meth)acrylate‐based photoelastomers as tailored biomaterials for artificial vascular grafts

AbstractCardiovascular disease is one of the leading causes of morbidity and mortality in the western hemisphere. Currently available synthetic vascular conduits, like Dacron or ePTFE show excellent long‐term results for large‐caliber arterial reconstruction (aorta, iliac vessels) but when used for small diameter (&lt;4 mm) vessel reconstruction, patency rates are extremely poor. We therefore aim at developing suitable blood vessel substitutes out of biocompatible photopolymer formulations, which can be printed by rapid prototyping. Rapid prototyping offers the possibility to create cellular structures within the grafts that favor the ingrowth of tissue. To meet the high requirements for artificial biomaterials, it is necessary to develop new resin formulations. Beside the biocompatibility, the mechanical properties—a low elastic modulus (500 kPa) at a relatively high tensile strength (1.0 MPa) and a high strain at break (130%)—play a central role. Resin systems containing cyanoethyl acrylate have shown to be highly reactive, have good mechanical properties and sufficient in vitro biocompatibility. Elastic modulus and tensile strength which should be similar to natural blood vessels were adjusted by the ratio of acrylate‐based crosslinkers and—in case of hydrogels —the percentage of water. Finally, we were able to print small diameter conduits by microstereolithography. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 2664–2676, 2009

Mid-term follow-up of the status of Gore-Tex graft after extracardiac conduit Fontan procedure☆

Extracardiac conduit Fontan procedure (ECFP) using Gore-Tex graft has been performed with increasing frequency for the patients with functional single ventricle. However, lack of growth potential and longevity of the conduit are consistent concerns and main points of criticism of the ECFP. In this study, we investigated the mid-term status of the Gore-Tex graft used in the ECFP by comparing the internal diameter of the graft with the inferior vena cava (IVC) diameter at 1 month and 5.2 years after the ECFP. Of 79 patients who underwent ECFP using Gore-Tex graft between November 1997 and December 2007, 33 patients who had completed cardiac catheterization at 1 month (21-73 days) and 5.2 years (3.3-9.6 years) after the ECFP were included in this study. We measured the internal diameter of the Gore-Tex graft and IVC at both catheterizations retrospectively. The size of the Gore-Tex graft used in the ECFP was 16 mm in 17 patients, 18 mm in 9 patients, and 20mm in 7 patients. Laminar flow through the conduits was maintained without any stenosis or kinking of the graft in these 33 patients. No intervention or reoperation related to the extracardiac conduit has been required. There were no significant differences in mean cross-sectional area (CSA) of the conduits at 1 month versus 5.2 years after the ECFP for each conduit size, and no significant changes in the conduit-to-IVC CSA ratio (0.98+/-0.40 vs 0.82+/-0.21 for 16 mm, 1.09+/-0.30 vs 0.92+/-0.33 for 18 mm, and 1.16+/-0.55 vs 0.94+/-0.44 for 20mm conduit). The conduit CSA and conduit-to-IVC CSA ratio remained unchanged in small caliber grafts down to 16 mm at 5.2 years after the ECFP. However, further investigation is necessary to evaluate the fate of the Gore-Tex graft and late hemodynamics in the patients with small conduits after they achieve full somatic growth.

Manufacture of small calibre quadruple lamina vascular bypass grafts using a novel automated extrusion-phase-inversion method and nanocomposite polymer

Long-term patency of expanded polytetrafluoroethylene (ePTFE) small calibre cardiovascular bypass prostheses (<6 mm) is poor because of thrombosis and intimal hyperplasia due to low compliance, stimulating the search for elastic alternatives. Wall porosity allows effective post-implantation graft healing, encouraging endothelialisation and a measured fibrovascular response. We have developed a novel poly (carbonate) urethane-based nanocomposite polymer incorporating polyhedral oligomeric silsesquioxane (POSS) nanocages (UCL-NANO™) which shows anti-thrombogenicity and biostability. We report an extrusion-phase-inversion technique for manufacturing uniform-walled porous conduits using UCL-NANO™. Image analysis-aided wall measurement showed that two uniform wall-thicknesses could be specified. Different coagulant conditions revealed the importance of low-temperature phase-inversion for graft integrity. Although minor reduction of pore-size variation resulted from the addition of ethanol or N, N-dimethylacetamide, high concentrations of ethanol as coagulant did not provide uniform porosity throughout the wall. Tensile testing showed the grafts to be elastic with strength being directly proportional to weight. The ultimate strengths achieved were above those expected from haemodynamic conditions, with anisotropy due to the manufacturing process. Elemental analysis by energy-dispersive X-ray analysis did not show a regional variation of POSS on the lumen or outer surface. In conclusion, the automated vertical extrusion–phase-inversion device can reproducibly fabricate uniform-walled small calibre conduits from UCL-NANO™. These elastic microporous grafts demonstrate favourable mechanical integrity for haemodynamic exposure and are currently undergoing in-vivo evaluation of durability and healing properties.

Insights into Li and Li isotope cycling and sub-arc metasomatism from veined mantle xenoliths, Kamchatka

Harzburgitic xenoliths cut by pyroxenite veins from Avachinsky volcano, Kamchatka, are derived from the sub-arc mantle and record element transfer from the slab to the arc. Olivine and orthopyroxene in the harzburgites have Li isotopic compositions (δ7Li = +2.8 to +5.6) comparable to estimates of the upper mantle (δ7Li ~ +4 ± 2). The pyroxenite veins, which represent modal metasomatism and may therefore provide information about the metasomatic agent, have mantle-normalized trace element characteristics that suggest overprinting of their mantle source by an aqueous, slab-derived fluid. These include relative enrichments of Pb over Ce, U over Th and Sr over Nd. Li is enriched relative to the HREE, and ortho- and clinopyroxene from the veins are in Li elemental and isotopic equilibrium with each other and the surrounding harzburgite. Vein samples (δ7Li = +3.0 to +5.0) do not record a significant slab-derived δ7Li signature. These observations can be reconciled if slab Li diffusively re-equilibrates in the mantle wedge. Modeling demonstrates that Li equilibration of small (1–2 cm width) veins or melt conduits is achieved at mantle wedge temperatures within 101–105 years. We conclude that strongly fractionated Li isotopic signatures cannot be sustained for long periods in the sub-arc mantle, at least at shallow (<70 km) depths.

Numerical model of the hydrothermal system beneath Unzen Volcano, Japan

Drilling of the volcanic conduit in the Unzen Scientific Drilling Project (USDP) was completed in 2004. Some conduit materials of the 1990–95 eruption were encountered at the bottom of Well USDP-4 (150 m below sea level), and a bottom temperature of about 200 °C was estimated using logging data, although before drilling a temperature of about 700 °C had been inferred. Accordingly, conduit cooling from the initial temperature (850 °C) to the estimated temperature (about 200 °C) was evaluated by numerical simulation. The drilling provides constraints for the numerical model. The drilling indicates that the N–S width of the conduit of the latest eruption is 20 to 30 m and that it occupies a zone of about 300 m, which includes conduits of past eruptions. The process of cooling in the conduit, from an initial temperature of 850 °C in 1995 (the end of the eruption) to 200 °C in 2004 (completion of the conduit drilling), was replicated in models with permeabilities of 1 and 10 mdarcys. This result demonstrates that a highly permeable volcanic body surrounding a small conduit is required to explain the estimated bottom temperature. Our study also aimed to use a numerical simulation to construct a comprehensive hydrothermal model beneath Unzen Volcano. There are four large geothermal systems in the Shimabara Peninsula (Obama hot springs, Unzen fumarolic field, Shimabara hot springs and the West Unzen High Temperature Body [WUHTB]). Three pressure sources (“Sources A”, “B” and “C” from shallow to the deep) were determined by geodetic data during the 1990–95 eruption. Source C is located at about 8 km deep at WUHTB, and is considered to be a magma body. We attempted to explain the existence of the four geothermal systems from the large-scale structures (the topography of the Shimabara Peninsula and Unzen Graben) and the various heat sources. We first set a heat source around Source C and changed its position and size. This numerical model produced the upflow zones at the Obama and Shimabara hot springs and WUHTB; however, the Unzen fumarolic field became a recharge area. This result indicates that another heat source is required to explain the Unzen fumarolic field and that two heat sources beneath WUHTB and the Unzen fumarolic field are involved in the formation of the four hydrothermal systems in the Shimabara Peninsula.

Comparative computational fluid dynamic study of two distal Contegra conduit anastomoses

A computational fluid dynamic (CFD) study compared two configurations of distal anastomosis of 12 mm Contegra conduit: conventional 'circular' vs. oblique 'elliptical' anastomosis extended on the left PA, evaluating pressure and velocity profiles, and shear stress, from PA origin to the bifurcation. 'Elliptical' anastomosis provides larger (=54% difference) cross-sectional area than 'circular' anastomosis. Velocity contours showed important stagnation at PA bifurcation in 'circular' anastomosis and minimal in 'elliptical' configuration, where fluid flow occurred preferentially in left PA. Pressure contours showed peak pressure zone at bifurcation in 'circular' anastomosis, while 'elliptical' exhibited more uniform pressure distribution. Shear stress distribution was more homogeneous in 'elliptical' than in 'circular' anastomosis. At bifurcation and in right PA artery velocity and pressure were higher for 'circular' than 'elliptical' anastomosis, while in left PA velocity was much higher for 'elliptical' anastomosis. CFD study demonstrates more homogeneous pressure, velocity and shear stress distributions for 'elliptical' compared to 'circular' anastomosis at PA bifurcation, and preferential flow in left PA. CFD results suggest that clinical application of 'elliptical' anastomosis, with cross-sectional area larger than conventional 'circular' anastomosis, may reduce incidence and degree of distal stenosis, particularly for small size conduits.

Temporal variations in crustal assimilation of magma suites in the East Greenland flood basalt province: Tracking the evolution of magmatic plumbing systems

We review published radiogenic isotope data (> 350 samples in total) on various suites of magmatic rocks within the Palaeogene central East Greenland flood basalt province to evaluate the types of crustal assimilants and the extent of crustal assimilation involved in each suite. We use these observations to build a regional picture of how magmatic plumbing systems changed with time and location during the sequential development of the province as magmatism responded to the development of a volcanic rifted margin and eventual plate separation. The earliest phase of magmatic activity (c. 62–57 Ma) is characterised by highly contaminated magmas that show a temporal change in assimilant type from amphibolite to granulite. This transition has been linked to the effects of an increasing magma supply rate which allows the more refractory granulite lithologies to be melted. The voluminous break-up phase of magmatism (c. 56–54 Ma) saw a significant decrease in the extent of assimilation because of the decreasing availability of assimilant material in the mature feeder systems, and many samples have Sr–Nd–Pb isotope compositions that overlap with those of asthenospheric melts (as represented by recent Icelandic basalts and North Atlantic MORB). Detailed study has allowed us to recognise packets of lavas that ponded at different levels in the crust and assimilated material of different compositions. The later stages of break-up magmatism show more diverse and more contaminated compositions that indicate a shift from a few large robust feeder systems to numerous small new conduits as the rifting continued. The post-break-up magmatism (c. 54–13 Ma) is characterised by a return to more highly contaminated magmas, which reflects a change in the style of magmatism: the eruption of small-volume alkalic lava flows from newly established conduits through the thicker inland crust, and the intrusion of mafic and silicic alkalic magmas at shallow levels in the Archaean basement along the present coast.