Small Amounts Research Articles

Hybrid Polystyrene-Plasmonic Systems as High Binding Density Biosensing Platforms.

Sensitive, accurate, and early detection of biomarkers is essential for prompt response to medical decisions for saving lives. Some infectious diseases are deadly even in small quantities and require early detection for patients and public health. The scarcity of these biomarkers necessitates signal amplification before diagnosis. Recently, we demonstrated single-molecule-level detection of tuberculosis biomarker, lipoarabinomannan, from patient urine using silver plasmonic gratings with thin plasma-activated alumina. While powerful, biomarker binding density was limited by the surface density of plasma-activated carbonyl groups, that degraded quickly, resulting in immediate use requirement after plasma activation. Therefore, development of stable high density binding surfaces such as high binding polystyrene is essential to improving shelf-life, reducing binding protocol complexity, and expanding to a wider range of applications. However, any layers topping the plasmonic grating must be ultra-thin (<10 nm) for the plasmonic enhancement of adjacent signals. Furthermore, fabricating thin polystyrene layers over alumina is nontrivial because of poor adhesion between polystyrene and alumina. Herein, we present the development of a stable, ultra-thin polystyrene layer on the gratings, which demonstrated 63.8 times brighter fluorescence compared to commercial polystyrene wellplates. Spike protein was examined for COVID-19 demonstrating the single-molecule counting capability of the hybrid polystyrene-plasmonic gratings.

Fabrication of Ru-doped CuMnBP micro cluster electrocatalyst with high efficiency and stability for electrochemical water splitting application at the industrial-level current density

Electrochemical water splitting has been considered as a key pathway to generate environmentally friendly green hydrogen energy and it is essential to design highly efficient electrocatalysts at affordable cost to facilitate the redox reactions of hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). In this work, a novel micro-clustered Ru/CuMnBP electrocatalyst is introduced, prepared via hydrothermal deposition and soaking-assisted Ru doping approaches on Ni foam substrate. Ru/CuMnBP micro-clusters exhibit relatively low HER/OER turnover overpotentials of 11 mV and 85 mV at 10 mA/cm2 in 1 M KOH. It also demonstrates a low 2-E turnover cell voltage of 1.53 V at 10 mA/cm2 for the overall water-splitting, which is comparable with the benchmark electrodes of Pt/C||RuO2. At a super high-current density of 2000 mA/cm2, the dual functional Ru/CuMnBP demonstrates an exceptionally low 2-E cell voltage of 3.13 V and also exhibits superior stability for over 10 h in 1 M KOH. Excellent electrochemical performances originate from the large electrochemical active surface area with the micro cluster morphology, high intrinsic activity of CuMnBP micro-clusters optimized through component ratio adjustment and the beneficial Ru doping effect, which enhances active site density, conductivity and stability. The usage of Ru in small quantities via the simple soaking doping approach significantly improves electrochemical reaction rates for both HER and OER, making Ru/CuMnBP micro-clusters promising candidates for advanced electrocatalytic applications.

Distribution and propagation of stress and strain in cube honeycombs as trabecular bone substitutes: Finite element model analysis

For designing trabecular (Tb) bone substitutes suffering from osteoporosis, finite element model (FEM) simulations were conducted on honeycombs (HCs) of 8 × 8 × 1 (2D) and 8 × 8 × 8 (3D) assemblies of cube cellular units consisting of 0.9 mm long Nylon® 66 (PA, Young's modulus E: 2.83 GPa) and polyethylene (PE, E: 1.1 GPa) right square prisms. Osteoporotic damage to the Tb bone was simulated by removing the inner vertical struts (pillars; the number of removed pillars: Δn ≤ 300) and by thinning the strut (thickness, d: 0.4–0.1 mm), while the six facade lattices were kept flawless. Uniform and uniaxial compressive loads on the HCs induced elastic deformation of the struts. The pillars held almost all the load, while the horizontal struts (beams) shared little. E for PA 3D HCs of all d smoothly decreased with Δn. PA 3D HCs of 0.2 mm struts deserved to be the substitutes for Tb bone, while PE 3D HCs of 0.05 mm struts were only for the Tb bone of the poorest bone quality. For the PA 3D HCs, the maximum von Mises stress (σM) first rapidly increased with Δn and showed a break at Δñ50, then gradually approached the yield stress of PA (50 MPa). Moreover, small portions of the stress were transferred from the façade pillars to the adjacent inner beams, especially those near the lost-pillar sites, denoted as X defects. The floor beams of thinner struts associated with the X-defects were lifted, and similar lifting effects in smaller amounts were propagated to the other floors. The 3DHCs of the thicker struts showed no such flexural deformations. The concept of force percolation through the remaining struts was proposed to interpret those mechanical behaviors of the HCs.

Assessment of bisphenol accumulation from disposable devices used sequentially in IVF routine procedures

Research question: To investigate the release of bisphenols (BPs) from disposable devices (DDs) used in ART procedures and to determine whether they accumulate when several DDs are used sequentially under routine conditions.Design: A comprehensive assessment of 19 individual DDs (31 measurements) and 9 combinations of DDs replicating the main steps in an ART procedure was undertaken. The extraction of BPs followed routine use conditions (temperature and duration). The concentration of 10 BPs was determined using on-line solid phase extraction/liquid chromatography/mass spectrometry methodology.Results: Bisphenol S (BPS) was quantified consistently from 100 mm culture dishes (32 ± 20 pg) and from high security sperm straws (3 ± 1 pg). Also, BPS and Bisphenol A (BPA) were quantified consistently from spermicide-free condoms (95 ± 78 and 83 ± 49 pg, respectively). No other BPs were detected in individually tested DD.When DDs were used together, BPA and BPS were both detected consistently in the association of 13 DDs mimickin;g the sperm collection in condom and its preparation (46 ± 16 and 43 ± 32 pg, respectively). BPS was quantified consistently in the association of 14 DDs mimicking the sperm collection, its preparation and freezing (10 ± 4 pg), and in the association of 17 DDs mimicking the oocyte pick-up (37 ± 22 pg).Conclusions: BPA and BPS are released in small quantities from some DDs used in routine conditions during ART procedures, but do not clearly accumulate when these consumables are used together.

Semisupervised Change Detection Based on Bihierarchical Feature Aggregation and Extraction Network.

With the rapid development of remote sensing (RS) technology, high-resolution RS image change detection (CD) has been widely used in many applications. Pixel-based CD techniques are maneuverable and widely used, but vulnerable to noise interference. Object-based CD techniques can effectively utilize the abundant spectrum, texture, shape, and spatial information but easy-to-ignore details of RS images. How to combine the advantages of pixel-based methods and object-based methods remains a challenging problem. Besides, although supervised methods have the capability to learn from data, the true labels representing changed information of RS images are often hard to obtain. To address these issues, this article proposes a novel semisupervised CD framework for high-resolution RS images, which employs small amounts of true labeled data and a lot of unlabeled data to train the CD network. A bihierarchical feature aggregation and extraction network (BFAEN) is designed to achieve the pixelwise together with objectwise feature concatenation feature representation for the comprehensive utilization of the two-level features. In order to alleviate the coarseness and insufficiency of labeled samples, a confident learning algorithm is used to eliminate noisy labels and a novel loss function is designed for training the model using true- and pseudo-labels in a semisupervised fashion. Experimental results on real datasets demonstrate the effectiveness and superiority of the proposed method.

Safety and behavior of implantable electronic devices during cremation

BackgroundThe current standard of practice for cremating patients with cardiac implantable electronic devices (CIEDs) is surgical explantation before cremation to mitigate the risk of device explosion. This surgery may conflict with patient or family beliefs, whereas cremation of CIEDs may create occupational hazards. ObjectiveThis study sought to establish an ex vivo model for screening CIED behavior during cremation. MethodsSeven CIEDs underwent testing including projectile/sound testing, impact testing, and gas analysis. In the projectile test, devices were heated until thermal failure (explosion) and filmed with a high-speed camera and microphone. For impact testing, brick structures were built to assess damage after explosion. Gas chromatography–mass spectrometry identified released gases. Findings were compared with occupational health standards, where available. ResultsThe implantable loop recorder and leadless pacemaker produced minimal kinetic energy and impact risk with thermal failure. The remaining devices demonstrated explosive disintegration at thermal temperatures <500°C. The pacemakers and implantable cardiac defibrillators produced sound levels >120 dB and resulted in damage to brick structures. Small quantities of benzene and hydrogen fluoride were produced but at quantities within acceptable occupational exposure limits in a cremation chamber. ConclusionAll tested CIEDs experienced explosion at temperatures below crematorium standards. The smallest devices produced minimal risk of damage or injury, suggesting that they may safely remain in situ during cremation, whereas the larger devices produced more kinetic energy, testing chamber damage, and louder explosions, suggesting potential risk with cremation. Cadaveric testing in full-sized cremation chambers is required to determine real-world risk.

MANUFACTURING AND TESTING HIGH VOLTAGE FILTER CAPACITORS

This paper presents the manufacturing and testing methods of 30kV and 33nF high voltage filter capacitors. One of the biggest advantages of small companies is that they are able to produce a high diversity of capacitors in small quantities. One of the prices of this flexibility is a higher level of manual manufacturing process in production. But this higher level of manual manufacturing does not mean lower quality in the final product. For high quality products in the high voltage industry, it is necessary to do routine tests in all of the products. For high voltage capacitors the following three tests must be done to ensure quality: voltage strength test, partial discharge test, capacitance and dissipation factor test. The capacitance and dissipation factor test have to be done at different voltage levels. The voltage strength test has to be done at least 20% higher than the rated voltage. This kind of test gives us information not only about the quality of the product itself, but about distribution of the capacitance for example, or about the strength of the production process, and about the quality management system of the company.

Starch phosphorylation—A needle in a haystack

Phosphoesterification is the only naturally occurring covalent starch modification identified to date, and it has a major impact on overall starch metabolism. The incorporation of phosphate groups mediated by dikinases [α-glucan, water dikinase (GWD), EC 2.7.9.4; phosphoglucan, water dikinase (PWD), EC 2.7.9.5] massively alters the starch granule properties; however, previous studies did not determine whether the starch-related dikinases bind the phosphate to the glucosyl units within the amylopectin molecules in a specific pattern or randomly. In order to answer this challenging question, a number of approaches were initially pursued until a protocol could be established that enabled a massive step forward in the in vitro analysis of phosphorylated glucan chains obtained from starch. For this purpose, phosphorylation by GWD was investigated, including the final state of phosphorylation i.e., the state of substrate saturation when GWD lacks further free hydroxyl groups at OH-C6 for the catalysis of monophosphate esters. Since the separated phosphorylated glucan chains were required for the analysis, isoamylase digestion was performed to cleave the α-1,6-glycosidic bonds and to allow for the removal of the huge number of existing neutral chains by means of anion exchange chromatography. Via Matrix-Assisted Laser Desorption/Ionization–Time of Flight (MALDI-TOF) MS and MALDI-MS/MS, the phosphorylated α-glucan chains were analysed, and the position of the phosphate group within the chain in relation to the reducing end was determined. Here, we demonstrate a protocol that enables the analysis of phosphorylated oligosaccharides, even in small quantities.

Efficient phosphorus recovery from waste activated sludge: Pretreatment with natural deep eutectic solvent and recovery as vivianite

Recycling phosphorus from waste activated sludge (WAS) is an effective method to address the nonrenewable nature of phosphorus and mitigate environmental pollution. To overcome the challenge of low phosphorus recovery from WAS due to insufficient disintegration, a method using a citric acid-based natural deep eutectic solvent (CA-NADES) assisted with low-temperature pretreatment was proposed to efficiently release and recover phosphorus. The results of 31P nuclear magnetic resonance (NMR) confirmed that low-temperature pretreatment promoted the conversion of organic phosphorus (OP) to inorganic phosphorus (IP) and enhanced the effect of CA-NADES. Changes in the three-dimensional excitation-emission matrix (3D-EEM) and flow cytometry (FCM) indicated that the method of CA-NADES with low-temperature thermal simultaneously release IP and OP by disintegrating sludge flocs, dissolving extracellular polymeric substances (EPS) structure, and cracking cells. When 5 % (v/v) of CA-NADES was added and thermally treated at 60 °C for 30 min, 43 % of total phosphorus (TP) was released from the sludge. The concentrations of proteins and polysaccharides reached 826 and 331 mg/L, respectively, which were 6.30 and 14.43 times higher than those of raw sludge. The dewatering and settling of the sludge were also improved. Metals were either enriched in the solid phase or released into the liquid phase in small quantities (most efficiencies of less than 10 %) for subsequent clean recovery. The released phosphorus was successfully recovered as vivianite with a rate of 90 %. This study develops an efficient, green, and sustainable method for phosphorus recovery from sludge using NADES and provides new insights into the high-value conversion of sludge.

Dietary Intake of Polyphenols and All-Cause Mortality: A Systematic Review with Meta-Analysis.

Polyphenols are secondary metabolites found in plants, foods, and drinks, occurring in small quantities and showcasing antioxidant and anti-inflammatory qualities. The primary polyphenols consist of flavonoids, phenolic acids, stilbenes, and lignans. However, there is currently no comprehensive quantitative analysis of epidemiological data on overall death rates. This systematic review with meta-analysis aims to identify the exposure-response relationship between dietary polyphenol intake and all-cause mortality. The literature was reviewed from its earliest study to May 2024, utilizing six distinct electronic databases. No specific criteria were used to choose participants based on the recruiting environment, their general health condition, country, or ethnicity. The inclusion criteria for studies were as follows: a longitudinal design, exposure to dietary polyphenols, all-cause mortality as the outcome, and hazard risk (HR) as the impact measure. The Newcastle-Ottawa Scale was used to evaluate the methodological rigor of the study. The hazard risks (HRs) and 95% confidence intervals (CIs) were estimated by pooling data using common effects models. A protocol has been registered on PROSPERO with the identification number CRD42024545524. The meta-analysis comprised seven cohort studies that involved 178,657 adult people aged 18 years and older. These studies examined the relationship between total dietary polyphenol consumption and the risk of all-cause death. The recruitment settings exclusively used community-based approaches, with a preference for Europe (71%) in terms of geographic distribution. The study's quality was assessed to be moderate to high. The meta-analysis showed consistent evidence that increased dietary exposure to polyphenols reduces the risk of all-cause mortality by 7% (HR 0.93, 95% CI 0.91-0.95, I2: 48%). Pooled data from the available evidence consistently show that individuals exposed to an antioxidant diet rich in polyphenol sources may be at lower risk of all-cause mortality.

SYNTHESIS AND CHARACTERIZATION OF MAGNETITE NANOMATERIALS IN TIANYAR IRON SAND USING CO-PRECIPITATION METHOD

In the current era of scientific and technological progress, nanomaterials have emerged as a deeply fascinating and significant field of research. This paper presents a case study on the synthesis and characterization of Fe₃O₄ nanomaterials derived from the iron sand of the Tianyar, utilizing the co-precipitation method with modifications made to the pH values during synthesis. The research encompasses three primary stages: extraction of iron sand, synthesis of Fe3O4 nanomaterials, and subsequent characterization of these nanomaterials. The iron sand extraction phase involved passing it through a permanent magnet ten times to remove impurities. Subsequent synthesis produced a dark black magnetite nanomaterial powder displaying magnetic properties, rendering it responsive to magnet attraction. Analysis of these nanomaterials using X-ray diffraction (XRD) unveiled discernible peaks in the diffraction pattern, suggesting that the magnetite nanomaterials possess a cubic crystal structure. The size of the Fe3O4 nanomaterials decreases as the pH of precipitation increases, with respective sizes of approximately 18.00 nm for pH 9, 14.69 nm for pH 10, and around 13.68 nm for pH 11, as determined using Scherrer’s formula. The lattice parameters observed for samples synthesized at pH 9, 10, and 11 are sequentially measured as a = 8.59 Å, 8.81 Å, and 8.80 Å. Analysis using SEM-EDS revealed that the sample morphology appears rough, with evidence of particle agglomeration leading to uneven particle distribution. There are additional trace elements present, including C, Al, S, Ti, and Cl, albeit in smaller quantities. Nevertheless, the primary elements crucial for forming Fe3O4 nanomaterials, namely Fe and O, exhibit the highest percentages in composition analysis.

The Effect of Individual Hydrocarbons in the Composition of Diesel Fuel on the Effectiveness of Depressant Additives

The use of depressant additives is the most effective and cost-effective way to improve the low-temperature properties of diesel fuels, like the cloud point, cold filter plugging point and pour point. However, the effectiveness of depressant additives depends on the composition of the diesel fuel and the content of certain groups of hydrocarbons in it. In this work, the effect of adding individual hydrocarbons of various groups and structures on the effectiveness of depressant additives is studied. This study is carried out on model aromatic (toluene, tetralin) and n-paraffin hydrocarbons (cetane, heptadecane, heneicosane, docosane) in various concentrations. It is shown that the most negative effect on the depressant additives’ effectiveness is due to the content of the most polar aromatic hydrocarbons and light n-paraffins in the composition of diesel fuel, and the most positive effect is exerted by the content of heavy n-paraffins in small quantities. It is proposed to involve small concentrations (1–3% vol.) of heavy n-paraffin hydrocarbons (heneicosane, docosane) to increase the effectiveness of the depressant additive. It has been established that for the more effective action of the depressant, it is necessary to take into account the content and structure of individual hydrocarbons in the diesel fuel’s composition.

Dyeing of Mixed Cotton and Polyester Fabrics with New Dyes—Complexes of Collagen with Transition Metal Ions

Uniform, stable, one-step dyeing of textile fabrics made from a mixture of natural and synthetic fibers using traditional methods remains problematic to this day. As an alternative to traditional methods, a one-step method for dyeing mixed cotton and polyester fabrics with a new natural dye—a complex of collagen and [Formula: see text] and [Formula: see text] ions—was proposed for the first time. Dyeing of pre-prepared cotton, polyester, and cotton–polyester fabrics is carried out by dipping in an aqueous dye solution, squeezing, drying, and heat setting. The influence of the mass ratio of dye components, fixation temperature, and pH of the solution on the degree of dye fixation was determined. A degree of sorption of dyes (14–25%) from the solution onto the surface of fabrics was established, which after heat fixation decreases slightly (1–3%). During washing processes, the copper complex is almost completely washed out from polyester and blended fabrics and remains in small quantities (2.4–3.8%) on the surface of cotton fabrics. After water washing, the degree of fixation of the collagen–chrome complex in fabrics is as follows: in cotton—8–10%, in polyester—10–12%, and in cotton–polyester—8–9%. The color coordinates of cotton and cotton–polyester fabrics hardly change before and after washing, but for polyester fabric, the changes are significant. The mechanism of interaction of the complex dye with the fibers was studied using the Fourier transform infrared method, and the morphology and distribution of the dye on the surface of the samples using the SEM-EDS method. The dye binds to cellulose through ionic and coordination bonds, and to polyester through joint melting. Therefore, unlike pure polyester fabric, cotton and cotton–polyester fabrics demonstrated high color fastness to washing and light fastness. The use of production waste, the exclusion of synthetic dyes and harmful chemicals, and single-stage dyeing of the material reduce the environmental burden.

Coagulation of Wastewater Containing Polyethylene Terephthalate (PET) Microplastics by Using Ferric Chloride, Aluminum Sulfate and Aluminum Chlorohydrate: A Comparative Study

This study investigated the efficacy of different coagulants, namely ferric chloride and aluminum sulfate at a concentration of 1.95 g/L, and aluminum chlorohydrate at a concentration of 2.1 g/L, in removing microplastics from plastic recycling facility wastewater under different pH conditions. The results showed that the presence of microplastics in wastewater was 76% in the form of fragments, followed by films and fibers in smaller amounts. The size of these microplastics varies, with a dominant size range of 251-500 μm. At pH 6, ferric chloride and aluminum sulfate were able to remove 75% and 90% of the microplastic abundance, respectively, by adding a dose of 1.95 g/L. However, the highest removal efficiency was obtained by adding a dose of 2.1 g/L Aluminium chlorohydrate at pH 8. These findings underscore the importance of selecting suitable coagulants and optimizing treatment operational conditions based on the type and size distribution of microplastics present in the wastewater system.

Comparative Analysis of the Mineral Associations in the Sediments from Buor-Khaya Bay

According to the results of analysis of 99 samples of bottom sediments and submarine permafrost from wells 1D-14, 3D-14 and 1D-15 drilled in the Buor-Khaya Bay, differences in their mineral composition due to paleogeographic factors, namely Late Quaternary changes in climate and sea level, as well as regional hydrodynamics are shown. The basis of the light fraction of minerals was quartz and feldspar (mainly plagioclases), found in the form of grains of various dimensions and sorting degree, as well as fine grains. To a lesser extent, the presence of chlorites, kaolinite and serpentines is noted, illite and smectite are rare. 42 accessory minerals were identified in the heavy fraction (average yield 0.95%) concentrated in fine-grained sands. It mainly consists of pyroxenes, amphiboles, carbonatite, epidote, zoisite, magnetite, mica, garnet, limonite, sphene, leucoxene, ilmenite. Rutile, kyanite, sillimanite, zircon, tourmaline, apatite, and stavrolite were found in smaller quantities. In the studied strata, plant remnants and carbon-like particles (kerogen) are found, the contribution of which exceeds 5% by weight in a number of samples. The results of the study allowed to conclude that the basis of the petrofund of the studied deposits are most likely sedimentary rocks of the Kharaulakh ridge of the Verkhoyansk mountain system (sandstones, siltstones and mudstones). The presence of characteristic accessory minerals in the sediments marks the unloading of igneous and metamorphic rocks, but their contribution is subordinate. They probably also include rocks of the Verkhoyansk complex, common near the Tiksi.

Regulation of osteogenesis and angiogenesis by cobalt, manganese and strontium doped apatitic materials for functional bone tissue regeneration

Strontium, cobalt, and manganese ions are present in the composition of bone and useful for bone metabolism, even when combined with calcium phosphate in the composition of biomaterials. Herein we explored the possibility to include these ions in the composition of apatitic materials prepared through the cementitious reaction between ion-substituted calcium phosphate dibasic dihydrate, CaHPO4·2H2O (DCPD) and tetracalcium phosphate, Ca4(PO4)2O (TTCP). The results of the chemical, structural, morphological and mechanical characterization indicate that cobalt and manganese exhibit a greater delaying effect than strontium (about 15 at.%) on the cementitious reaction, even though they are present in smaller amounts within the materials (about 0.8 and 4.5 at.%, respectively). Furthermore, the presence of the foreign ions in the apatitic materials leads to a slight reduction of porosity and to enhancement of compressive strength. The results of biological tests show that the presence of strontium and manganese, as well as calcium, in the apatitic materials cultured in direct contact with human mesenchymal stem cells (hMSCs) stimulates their viability and activity. In contrast, the apatitic material containing cobalt exhibits a lower metabolic activity. All the materials have a positive effect on the expression of Vascular Endothelial Growth Factor (VEGF) and Von Willebrand Factor (vWF). Moreover, the apatitic material containing strontium induces the most significant reduction in the differentiation of preosteoclasts into osteoclasts, demonstrating not only osteogenic and angiogenic properties, but also ability to regulate bone resorption.

Fully Consolidated Deposits from Oxide Dispersion Strengthened and Silicon Steel Powders via Friction Surfacing

Abstract The objective of this work is to study the ability of friction surfacing to deposit metal alloys that are difficult to process with traditional methods. Creep and neutron irradiation resistant oxide dispersion strengthened (ODS) materials cannot be produced via conventional casting route due to insolubility of the oxidic and metallic alloy constituents, causing unintended inhomogeneous oxide dispersion and material behavior. Increasing silicon content of Iron-Silicon (Fe-Si) improves electromagnetic properties but embrittles the material significantly and the fusion based manufacturing methods unable to process this steel. The solid-state nature of the friction surfacing process offers a potential alternative processing route to enable wider usage of difficult to process alloy systems. Both ODS and Fe-Si materials are available in powder forms. While the existing literature in friction surfacing focuses on depositing composites by incorporating small quantities powders through holes in consumable rod, this is a first study that shows a large charge of powder can be converted to a homogeneous fully consolidated deposit in friction surfacing. A novel methodology is used that incorporates the high portion of powder feedstock into hollow consumable friction surfacing rods (up to 35% volume fraction). It was found that fully consolidated deposits can be produced with powder feedstocks using proposed methodology. A recrystallized, homogeneous, equiaxed microstructure was observed in Fe-Si 6.8 wt% and a new generation FeAlOY ODS alloy deposits processed with hollow stainless-steel friction surfacing rods. Both powder and rod material plasticize and deposit without bulk intermixing.

Enhanced SWIR Light Detection in Organic Semiconductor Photodetectors through Up-Conversion of Mid-Gap Trap States.

Shortwave-infrared (SWIR) photodetectors are vital for many scientific and industrial applications including surveillance, quality control and inspection. In recent decades, photodetectors based on organic semiconductors have emerged, demonstrating potential to add real value to broadband and narrowband imaging and sensing scenarios, where factors such as thermal budget sensitivity, large area aperture necessity, cost considerations, and lightweight and conformal flexibility demands are prioritized. It is now recognized that the performance of organic photodetectors (OPDs), notably their specific detectivity, is ultimately limited by trap states, universally present in disordered semiconductors. This work adopts an approach of utilizing these mid-gap states to specifically create a SWIR photo-response. To this end, this work introduces a somewhat counter-intuitive approach of "trap-doping" in bulk heterojunction (BHJs) photodiodes, where small quantities of a guest organic molecule are intentionally incorporated into a semiconducting donor:acceptor host system. Following this approach, this work demonstrates a proof-of-concept for a visible-to-SWIR broadband OPD, approaching (and, to some extent, even exceeding) state-of-the-art performance across critical photodetector metrics. The trap-doping approach is, even though only a proof-of-concept currently, broadly applicable to various spectral windows. It represents a new modality for engineering photodetection using the unconventional strategy of turning a limitation into a feature.

An Anaerobic Culture Study to Assess the Prevalence of Porphyromonas gingivalis in Periodontal Disease Incidences Among Adults.

Introduction Periodontitis is a complex condition influenced by various factors involving interactions between the host and bacterial plaque. Porphyromonas gingivalis, an anaerobic gram-negative bacterium, is commonly linked with periodontal disease. Aim This study aimed to examine the occurrence of P. gingivalis in individuals diagnosed with chronic periodontitis (CP) compared to those who show no clinical indications of periodontal disease. Methodology Patients diagnosed with CP (including both severe and moderate cases) and individuals without any signs of periodontal disease were recruited for this study. Samples were collected from the gingival pockets using curettes and were subsequently subjected to anaerobic culturing. Results A group of 30 patients, divided into moderate and severe CP, along with 30 healthy individuals serving as controls, were examined. In individuals with CP, P. gingivalis was found in 23 (78%) of cases, while in healthy individuals, the prevalence was 10 (34%). The presence of P. gingivalis was notably higher in those with periodontal diseases compared to healthy subjects, with rates of 23 (78%) vs. 10 (34%), respectively. Conclusion P. gingivalis is frequently found in individuals with periodontal diseases as well as in those without such conditions, albeit in smaller quantities. Consequently, the existence of P. gingivalis raises the probability of developing periodontal disease and may be regarded as a notable potential contributor to its initiation.

Non-invasive analyze of boron and lithium in 18th century Chinese porcelain enamel and glaze: A PIXE/PIGE study

In enamelling technology, the natural (raw) materials used before the middle of the 19th century combine by nature different elements whose role in the process can be important even in small quantities. Some of these elements – particularly boron, lithium – are difficult to measure non-invasively and are therefore rarely analyzed. Boron and lithium, often used as additional flux in glazes, were quantified by PIXE and PIGE analysis with the extracted beam of the New AGLAE facility in 18th century porcelains samples, French soft-paste from the Manufacture royale de Sèvres and Chinese hard-paste from the reign of the Qing dynasty. The results were compared to previous conclusions made using SEM/EDS and pXRF in order to assert the presence of boron, previously suspected by Raman microspectroscopy, and to detect the presence of lithium, both provided by a particular flux (borax), mentioned in the historical French and Chinese enamel recipes.