The spacing of PVDs is an essential factor affecting the consolidation effect of vacuum preloading. For exploring the influence of spacing of PVDs on the impact of sludge drainage consolidation, FeCl3, a commonly used inorganic coagulant, was used to pretreat the sludge. In the experiment a vacuum filtration test was carried out to determine the optimal addition amount of FeCl3, and then the landfill sludge was pretreated according to the FeCl3 optimal addition amount. And two different spacing of PVDs were used to carry out a vacuum preloading contrast test. Then, the drainage and settlement were recorded, and water content and vane shear strength (VSS) were measured after the experiment. Finally, Mercury intrusion porosimetry (MIP) was carried out to explore the pore characteristics of the sludge further. The main conclusions are as follows: After conditioning by FeCl3, the sludge’s flocculent structure was destroyed, the intracellular water was released, and the effect of drainage capacity was significantly improved. After the spacing of PVDs is halved, the average volume reduction ratio and shear strength increases, and the effect of advanced dewatering and volume reduction of sludge improved significantly, leading to a better consolidation effect. In the progress of vacuum drainage consolidation, halving the spacing of PVDs results in large pores transformation into small pores, and the range of drainage consolidation is greatly expanded.