AbstractBackgroundThe effect of aging on susceptibility to interference on Stroop‐like tasks is not clearly understood. Some previous studies have suggested slowed reaction time explains age‐related diminution on Stroop performance, while more recent meta‐analyses suggest that disproportionate interference effects are seen with aging, regardless of slower reaction times. In addition, other variables such as education and IQ have been suggested to mediate Stroop‐like effects in older participants.MethodIn the current study, we assessed the relationship between age and Stroop effects in 348 participants, aged 40‐89, with a wide range of educational achievement. The Stroop tasks were administered as part of a novel computerized neuropsychological battery that utilizes advanced automatic speech recognition and transcription software, the California Cognitive Assessment Battery (CCAB). We are currently utilizing the CCAB to track changes in cognition associated with aging, including evolution of mild cognitive impairment (MCI) and dementia, in an ongoing longitudinal study.ResultMultiple regression analysis showed that age independently predicted both Stroop interference (incongruent minus neutral response times) and facilitation effects (neutral minus congruent response times). However, other variables including gender and vocabulary also independently predicted Stroop facilitation, while gender also independently predicted Stroop interference.ConclusionIn summary, while aging has a significant impact on interference and facilitation effects on Stroop‐like tasks, additional variables such as gender and vocabulary (a proxy for IQ) also play a role in performance on these measures of selective attention.