Slow Growth Research Articles

Gastrointestinal manifestations in Williams syndrome: A prospective analysis of an adult and pediatric cohort.

Williams syndrome (WS) is a multi-system condition caused by the deletion of 25-27 coding genes on human chromosome 7. Irritability, gastrointestinal (GI) reflux and slow growth are commonly reported in infants with WS, but less data exist regarding GI concerns in older children and adults with the condition. This study evaluates 62 individuals with WS (31 children aged 3-17, and 31 adults aged 18-62) as well as 36 pediatric and adult controls to assess current and historical rates of common GI symptoms. Data were evaluated using a regression model including age, sex, self-reported race, and diagnosis. Symptoms including food intolerance, reflux, dysphagia, choking/gagging, vomiting, constipation, bloating, diarrhea, hematochezia, rectal prolapse, abdominal pain, and weight loss are more common in those with WS relative to controls. In addition, people with WS utilize more GI medications, specialty care, procedures, and supplemental feeds. Among those with WS, symptoms were present at similar rates in children and adults, except for diverticular disease, which was not noted until adulthood. GI symptoms are frequent in people with WS and serve as a significant source of morbidity.

Occurrence and Environmental Risk Assessment of Contaminants of Emerging Concern in Brazilian Surface Waters.

We investigated the occurrence and the environmental risk of eight contaminants of emerging concern (CECs; acetaminophen, naproxen, diclofenac, methylparaben, 17β-estradiol, sulfathiazole, sulfadimethoxine, and sulfamethazine) in three Brazilian water bodies, namely, the Monjolinho River Basin (São Paulo State), the Mogi Guaçu River (São Paulo State), and the Itapecuru River (Maranhão State) in three sampling campaigns. The CECs were only quantified in surface water samples collected at the Monjolinho River Basin. Acetaminophen, naproxen, and methylparaben were detected in the range of <200 to 575.9 ng L-1, <200 to 224.7 ng L-1, and <200 to 303.6 ng L-1, respectively. The detection frequencies of the three measured compounds were between 33% and 67%. The highest concentrations of CECs were associated with intense urbanization and untreated sewage discharge. Furthermore, CEC concentrations were significantly correlated with total organic carbon, electrical conductivity, and dissolved oxygen levels, suggesting that domestic pollution from urban areas is an important source in the distribution of CECs in the Monjolinho River Basin. The environmental risk assessment indicated a high risk for acetaminophen (risk quotient [RQ] values between 2.1 and 5.8), a medium risk for naproxen (RQs between 0.6 and 0.7), and a low risk for methylparaben (RQs < 0.1) to the freshwater biota of the Monjolinho River Basin. Our findings show potential threats of CECs in Brazilian water bodies, especially in vulnerable areas, and reinforce the need for improvements in environmental regulations to include monitoring and control of these compounds in aquatic systems. Environ Toxicol Chem 2024;00:1-12. © 2024 SETAC.

Investigating of Spatial Urban Growth Pattern and Associated Landscape Dynamics in Congolese Mining Cities Bordering Zambia from 1990 to 2023

This study investigates the spatial urban growth patterns of cities along the Democratic Republic of the Congo (DRC) and Zambia border, a region of significant economic importance characterized by cross-border trade. This activity has led to rapid but unplanned urban growth. The objective is to quantify the spatial expansion of Congolese cities (Kipushi, Kasumbalesa, Mokambo, and Sakania) bordering Zambia and to evaluate associated landscape changes. The methodology of this study includes the supervised classification of Landsat images with a spatial resolution of 30 m for the years 1990, 2000, 2010, and 2023. This classification was validated using field data. Subsequently, landscape metrics such as class area, patch number, Shannon diversity index, disturbance index, urban expansion intensity index, largest patch index, and mean Euclidean distance were calculated for each city and each date. The results reveal substantial landscape transformations in the border cities between 1990 and 2023. These changes are primarily driven by rapid urban expansion, particularly pronounced in Kasumbalesa. Between 1990 and 2023, forest cover declined from 70% to less than 15% in Kipushi, from 80% to 10% in Kasumbalesa, from 90% to 30% in Mokambo, and from 80% to 15% in Sakania. This forest cover loss is accompanied by an increase in landscape element diversity, as indicated by the Shannon diversity index, except in Kipushi, suggesting a transition towards more heterogeneous landscapes. In these border cities, landscape dynamics are also characterized by the expansion of agriculture and savannas, highlighted by an increase in the disturbance index. Analysis of spatial pattern changes shows that built-up areas, agriculture, and savannas exhibit trends of patch creation or aggregation, whereas forests are undergoing processes of dissection and patch attrition. Congolese cities bordering Zambia are undergoing substantial spatial changes propelled by intricate interactions between economic, demographic, and infrastructural factors. Our results underscore the need for sustainable development strategies to address urban sprawl through smart growth policies and mixed-use developments, mitigate deforestation via stricter land use regulations and reforestation projects, and enhance cross-border cooperation through joint environmental management and collaborative research initiatives.

The Effect of Crime on Foreign Investment and Economic Development in Sub-Saharan Africa: A Panel Data Analysis

This study investigates the effect of crime on economic development in 22 sub-Saharan African countries between 2000 and 2020, using data from global sources. The study utilized a panel vector autoregression (VAR) approach to analyze the dynamic correlations between variables. This was achieved through the examination of impulse response functions and error variance decomposition. The study established a definitive cause-and-effect connection between the crime rate and growth indicators. The panel vector autoregression (VAR) technique resolves the issue of endogeneity by permitting endogenous interaction among the variables in the system. The findings indicate that the crime rate has a significant effect on economic growth in sub-Saharan countries, though with very low magnitude. The economic prosperity of most sub-Saharan African countries may be attributed to the abundant availability of natural resources in the region. The causality test findings indicate a diverse causal connection between the crime rate and growth indicators. While there is no direct causal relationship between economic growth and the crime rate, there is a one-way causality between economic growth and foreign investment. This means that economic growth can enhance foreign investment, suggesting that in sub-Saharan countries, economic growth plays a crucial role in improving foreign investment. However, as indicated by the findings, there exists a bidirectional causal relationship between foreign investment and crime rates. In summary, it is clear that the crime rate in sub-Saharan African nations has a significant impact. In the future, countries with higher crime rates are likely to see slow economic growth and less foreign investment.

Unicystic ameloblastoma: Clinico-radiological and histopathological correlation with management

Unicystic ameloblastoma is a distinct entity of ameloblastoma characterized by slow growth and relatively locally aggressive behavior. This retrospective study aimed to assess the efficacy of different treatment modalities for unicystic Ameloblastoma, focusing on clinic-radiological and histopathological features. Data from patients diagnosed with unicystic ameloblastoma were retrospectively analyzed. Patients were categorized into luminal and intraluminal (Group A), and mural (Group B) variants based on the Ackermann classification, which has a significant influence on their biological behavior, treatment approaches, and prognosis. Patients in Group A underwent enucleation with chemical cauterization and peripheral ostectomy and Iodoform packing, whereas those in Group B were treated with resection and reconstruction. Postoperatively, the patients were subjected to radiographic assessments via digital orthopantomogram (OPG) at regular intervals. Because of the rarity of unicystic ameloblastoma, 17 patients were included in the study (Group A: 9 patients; Group B: 8 patients), utilizing a mean follow-up of 4.9 years (range: 1.4 - 11.8 years).The primary outcome measure was the absence of recurrence, which indicated treatment success. No patient in either group presented with recurrence during the follow-up period. This study provides evidence supporting the successful treatment of luminal and intraluminal variants of unicystic ameloblastoma in young individuals using a conservative approach. However, the more aggressive mural variant demonstrated favorable outcomes with radical treatment. These findings emphasize the importance of Ackermann classification in guiding treatment decisions for unicystic ameloblastoma and contribute valuable insights into optimizing therapeutic strategies based on clinicoradiologic and histopathological findings.

Incidental discovery of unilateral hydronephrosis unveiling psoas major desmoid-type fibromatosis in a 24-year-old male: A case report with a 5-year follow-up.

Desmoid-type fibromatosis (DTF), also known as aggressive fibromatosis, is a rare neoplasm originating from the fascial or musculoaponeurotic tissues. While benign and characterized by slow growth, it exhibits local aggressiveness and lacks specific clinical characteristics. However, in a considerable percentage of patients, it could be asymptomatic and discovered by accident during routine clinical examinations. Only a few cases of DTF arising from the psoas major muscle have been reported in the medical literature. A 24-year-old male, asymptomatic and without significant personal or family medical history, was diagnosed with grade 2 hydronephrosis by abdominal ultrasonography during a routine physical examination. This diagnosis was made 15 days after undergoing uncomplicated open-heart surgery to repair an atrial septal defect. Intravenous pyelogram revealed hydronephrosis with dilation of the pelvicalyceal system. Ureteroscopy ruled out any intrinsic lesions of the ureter. Contrast-enhanced computed tomography identified a 3.5 × 2 × 5.2 cm mass in the retroperitoneum, closely associated with the psoas muscle and enveloping the ureter adjacent to the iliac artery. Postoperative pathological analysis confirmed a definitive diagnosis of sporadic DTF. The patient underwent exploratory abdominal surgery, during which the tumor was resected without any intraoperative complications. After close monitoring over a 5-year follow-up period, which included periodic physical examinations, magnetic resonance imaging, and ultrasonography, no local recurrence was detected. Achieving an accurate preoperative diagnosis presents a challenge in cases involving retroperitoneal tumors originating from the psoas major muscle and encasing the ureter. However, the insertion of a double J stent is deemed a crucial step in the surgical process, facilitating the dissection and isolation of the ureter from the tumor while preserving kidney function.

Is England’s Office for Students likely to falsely identify courses as below threshold on the B3 progression metric?

ABSTRACT Rising inflation and slow growth globally have led to governments focussing on value for money, and in the sphere of higher education policy that is often translated into graduate outcomes. In England, the Office for Students (OfS) has created the progression metric which for full-time, first degree and UK domiciled students requires courses to have 60% of graduates with positive outcomes 15 months after graduation. This paper utilises simulations to evaluate the likelihood that the OfS’s approach will fail to identify courses below the threshold (false positives) and incorrectly identify courses at or above the threshold (false negatives). The simulation adapts the levels of positive outcomes within the population (20-90%), sample size (40–1000), percentage sampled (30-90%) and crucially confidence intervals applied (90%, 95% and 99%) to identify courses below threshold. The three main findings are: the choice of 90% CI minimises the likelihood of false positives compared to 95% or 99% CIs; second, larger samples are essential to reduce likelihood of false positives; and third, preferring the 95% confidence interval instead of 99% for taking regulatory action will result in more courses incorrectly identified as below threshold. Governments that choose a statistical approach to regulate educational standards, like the application of confidence intervals to identify provision below quality standards, should utilise simulations to check the likelihood of false positives and false negatives since failure to do so could lead to both: (a) courses below standard not being identified and (b) regulatory action taken incorrectly against provision at or above standards.

Trichoderma gamsii, a new pathogen causing disease on cultivated mushroom Cordyceps militaris in China

The fungal disease of Cordyceps militaris has become the primary disease during the cultivation of C. militaris. However, some of the causal organism remains unclear. During our investigation in 2020–2022, three fungal strains were isolated from both the mycelium and fruiting bodies of C. militaris in mushroom farms located in Changchun. The observed disease incidence was approximately 20%. White villous mycelium on the surface of hyphae or fruiting bodies of C. militaris, is one of the main features of the disease, which can cause slow growth of mycelium, delayed primordia differentiation, and growth failure. Finally, the white cotton flocculent mycelium covered the surface of the medium, and the C. militaris stopped differentiating and failed to produce the primordium, ultimately leading to the stunted growth and lodging of the fruiting body. The objective of this study was to identify the pathogen based on Koch's Postulates, thereby confirming its pathogenicity and characterizing it through morphological and molecular features. The phylogenetic analyses showed that they belong to the Trichoderma gamsii. This study presented the first evidence of T. gamsii caused fungal disease in C. militaris, providing a theoretical basis for the prevention and control measures.

The Improvement in High-Temperature Oxidation Resistance of Ni0.25Co0.25Cr0.22Mo0.14Re0.14 High Entropy Alloy via Industrial Chemical Vapor Aluminizing Process

The effects of the protective coating (NiAl coating) on the high temperature isothermal oxidation resistance of Ni0.25Co0.25Cr0.22Mo0.14Re0.14 high entropy alloy (HEA) was discussed in this work. A nickel aluminide (NiAl) coating was obtained on the Ni0.25Co0.25Cr0.22Mo0.14Re0.14 HEA via the industrial chemical vapor aluminizing (CVA) process. Isothermal oxidation tests were applied to NiAl-coated and uncoated samples in ambient laboratory air for durations of up to 200 hours at 1050°C to investigate the effects of the NiAl coating on high-temperature isothermal oxidation resistance of Ni0.25Co0.25Cr0.22Mo0.14Re0.14 HEA. The results revealed that a protective and slowly growing α-Al2O3 oxide layer formed on the surface of the NiAl-coated HEA samples and remained stable even after 200 hours of isothermal oxidation. For uncoated HEA samples, not only Cr2O3 but also non-protective spinel oxides (CoCr2O4 and NiCr2O4) were detected on the surface. Weight gain was observed in the NiAl-coated HEA samples due to the formation of a protective and slowly growing α-Al2O3 oxide layer on the NiAl coating. In contrast, the uncoated HEA samples experienced weight loss even after 6 hours of isothermal oxidation, as Cr2O3 lost its stability at 1050°C and non-protective spinel oxides formed. Therefore, it has been determined that the NiAl coating significantly enhance the isothermal oxidation resistance of the Ni0.25Co0.25Cr0.22Mo0.14Re0.14 HEA. The α-Al2O3 oxide layer has prevented severe oxidation of NiAl-coated samples due to its stability at 1050°C over 200 hours and its slow growth rate.

Existence and stability of weak solutions of the Vlasov–Poisson system in localised Yudovich spaces

We consider the Vlasov–Poisson system both in the repulsive (electrostatic potential) and in the attractive (gravitational potential) cases. Our first main theorem yields the analog for the Vlasov–Poisson system of Yudovich’s celebrated well-posedness theorem for the Euler equations: we prove the uniqueness and the quantitative stability of Lagrangian solutions f=f(t,x,v) whose associated spatial density ρf=ρf(t,x) is potentially unbounded but belongs to suitable uniformly-localised Yudovich spaces. This requirement imposes a condition of slow growth on the function p↦‖ρf(t,⋅)‖Lp uniformly in time. Previous works by Loeper, Miot and Holding–Miot have addressed the cases of bounded spatial density, i.e. ‖ρf(t,⋅)‖Lp≲1 , and spatial density such that ‖ρf(t,⋅)‖Lp∼p1/α for α∈[1,+∞) . Our approach is Lagrangian and relies on an explicit estimate of the modulus of continuity of the electric field and on a second-order Osgood lemma. It also allows for iterated-logarithmic perturbations of the linear growth condition. In our second main theorem, we complement the aforementioned result by constructing solutions whose spatial density sharply satisfies such iterated-logarithmic growth. Our approach relies on real-variable techniques and extends the strategy developed for the Euler equations by the first and fourth-named authors. It also allows for the treatment of more general equations that share the same structure as the Vlasov–Poisson system. Notably, the uniqueness result and the stability estimates hold for both the classical and the relativistic Vlasov–Poisson systems.

Characteristics of Invasive Cribriform Carcinoma

Invasive cribriform carcinoma (ICC) is a type of malignant tumor with slow growth and good prognosis. The study was a single center retrospective study. The percentage of ICC among patients diagnosed with breast cancer was 0.3% (8/2454 patients). All patients tested positive for estrogen or progesterone receptors and 12.5% (1/8) patients tested positive for human epidermal growth factor receptor type2 (HER2). The present study suggests that the clinicopathological features of ICC are low-grade hormone receptor-positive luminal type with a good prognosis. However, some patients were HER2-positive and require careful follow-up.

Metabolic engineering of fast growing cyanobacteria for phototrophic production of 2,3-butanediol

Metabolic engineering of cyanobacteria holds great potential for sustainable photosynthetic production of platform chemicals from CO2. However, product titers have been significantly low due to the slow growth rates of available model strains and lack of adequate synthetic biology tools. Here, we engineered three newly isolated fast growing Synechococcus elongatus strains PCC 11801, PCC 11802, and IITB6 for production of the platform chemical 2,3-butanediol. Importantly, we used native cyanobacterial promoters to enable inducer-free gene expression and 2,3-butanediol production. Different combinations of these native promoters were employed to optimize expression of the three-gene 2,3-butanediol synthesis pathway. Among the strains tested in this study, the highest 2,3-butanediol titer of 1.62 g L−1 (130 mg L−1 Day−1) was obtained in IITB6 (PcpcB300:alsS::PpsbAIII:alsD::PrbcL:adh), with the highest reported photosynthetic productivity in cyanobacteria cultivated on minimal media. The findings from our study highlight the potential of using fast growing S. elongatus isolates with native cyanobacterial promoters for metabolic engineering applications.

Unraveling the interactions of Esteya vermicola, pinewood nematode, and pine hosts: Insights into population dynamics and molecular responses

Esteya vermicola has shown promise as an efficient biological control agent against pine wilt disease, a devastating disease in pine forests caused by the pinewood nematode (PWN, Bursaphelenchus xylophilus). However, the in vivo interactions among E. vermicola, PWN, and pine hosts are less understood, both at the population and molecular levels. In this study, we performed a series of bioassays to investigate E. vermicola colonization patterns in pine xylem and its population responses to PWN invasion in healthy and PWN-induced wilting trees. Our results demonstrated that although E. vermicola exhibits slow growth, its conidia germinate and grew along the pine tracheid, even producing lunate conidia capable of initiating PWN infections within the xylem. Interestingly, while fungal hyphae became undetectable in pine sapling xylem after inoculation, the E. vermicola population increased immediately in response to PWN invasion. Furthermore, we observed a “leap-frog” dispersal pattern of fungal colonization in PWN-induced wilting pines, facilitated by the migration of fungal-infected nematodes. Moreover, we explored the molecular mechanisms underlying fungal tolerance to pine defense systems using transcriptomic analysis. Comparative transcriptomics revealed that carbohydrate metabolism and abiotic stress-induced oxidoreductive activities are involved in the fungal tolerance to the pine defense compound β-pinene. This study enhances our understanding of how E. vermicola colonizes and persists within pine xylem, its molecular responses to plant defense compounds, and its population dynamics upon PWN invasion, validating its efficacy as a biocontrol agent against pine wilt disease.

CRP improves the survival and competitive fitness of Salmonella Typhimurium under starvation by controlling the cellular maintenance rate.

Catabolite repression is a mechanism of selectively utilizing preferred nutrient sources by redirecting the metabolic pathways. Therefore, it prevents non-essential energy expenditure by repressing the genes and proteins involved in the metabolism of other less favored nutrient sources. Catabolite repressor protein (CRP) is a chief mediator of catabolite repression in microorganisms. In this context, we investigated the role of CRP in starvation tolerance, at both cell physiology and molecular level, by comparing the growth, survival, competitive fitness, maintenance rate, and gene and protein expression of wild type (WT) and ∆crp of Salmonella Typhimurium, under nutrient-rich and minimal medium condition. The ∆crp shows slow growth upon the arrival of nutrient-limiting conditions, poor survival under prolong-starvation, and inability to compete with its counterpart WT strain in nutrient-rich [Luria broth (LB)] and glucose-supplemented M9 minimal medium. Surprisingly, we observed that the survival and competitive fitness of ∆crp are influenced by the composition of the growth medium. Consequently, compared to the glucose-supplemented M9 medium, ∆crp shows faster death and a higher maintenance rate in the LB medium. The comparative gene and protein expression studies of WT and ∆crp in LB medium show that ∆crp has partial or complete loss of repression from CRP-controlled genes, resulting in a high abundance of hundreds of proteins in ∆crp compared to WT. Subsequently, the addition of metabolizable sugar or fresh nutrients to the competing culture showed extended survival of ∆crp. Therefore, our results suggest that CRP-mediated gene repression improves starvation tolerance and competitive fitness of Salmonella Typhimurium by adapting its cellular maintenance rate to environmental conditions.IMPORTANCESalmonella Typhimurium is a master at adapting to chronic starvation conditions. However, the molecular mechanisms to adapt to such conditions are still unknown. In this context, we have evaluated the role of catabolite repressor protein (CRP), a dual transcriptional regulator, in providing survival and competitive fitness under starvation conditions. Also, it showed an association between CRP and nutrient composition. We observed that Δcrp growing on alternate carbon sources has lower survival and competitive fitness than Δcrp growing on glucose as a carbon source. We observed that this is due to the loss of repression from the glucose and CRP-controlled genes, resulting in elevated cellular metabolism (a high maintenance rate) of the Δcrp during growth in a medium having a carbon source other than glucose (e.g., Luria broth medium).

Does a compact city really reduce consumption-based carbon emissions? The case of South Korea

Evidence to prove that compact cities, the core of smart growth strategies, are the vision for carbon-neutral cities has been insufficiently explored because analyses have not distinguished between production- and consumption-based carbon emissions. Empirically analyzing the relationship with compact cities by estimating the final demand and investigating carbon emissions generated from the consumption of goods is essential. This study estimated consumption-based carbon emissions in South Korea using nighttime satellite imagery. Subsequently, using spatial analysis, K-means clustering analysis, and a regression model, we comprehensively confirmed whether a compact city to reduce consumption-based carbon emissions should be pursued. The results showed that (1) based on the clustering analysis, consumption-based carbon emissions were the lowest in clusters with the most desirable development form from a compact city perspective; and (2) the OLS regression analysis showed that the higher the complex land use (diversity), population density (density), congestion frequency intensity (transit access), green area ratio (environment), and agricultural area ratio (environment), the lower the consumption-based carbon emissions. However, the results confirmed that the greater the Vehicle Kilometers Traveled (street accessibility) and the poorer the accessibility of high-speed rail, the higher the consumption-based carbon emissions. Therefore, we recommend pursuing a compact city to reduce consumption-based carbon emissions.

Prenatal exposure to PM2.5 and childhood body mass index growth trajectories from birth to 6 years old

This study aimed to determine the relationships between prenatal PM2.5 exposure and childhood growth trajectories during the first 6 years of life. A total of 47,625 pairs of mothers and children were recruited from a prospective birth cohort conducted between 2011 and 2013 in Wuhan, China, and followed for 6 years. We used the group-based trajectory models to classify the population into three trajectory groups: slow growth (n = 13,671, 28.7%), normal growth (n = 29,736, 62.4%), and rapid growth (n = 4218, 8.9%). Multinomial logistic regression models were used to determine the associations of prenatal PM2.5 exposure and childhood growth trajectories. Compared to normal growth trajectory, increased PM2.5 exposure in trimester 1, trimester 2 and the entire pregnancy showed significant associations with an increased risk of the slow growth trajectory but reduced the risk for the rapid growth trajectory, significant association of prenatal PM2.5 exposure with rapid growth trajectory was only observed in the trimester 3. Stratified analyses displayed relatively stronger associations among those mothers with maternal age over 35 years, pre-pregnancy BMI ≥ 25 kg/m2, and previous delivery experience. Prenatal exposure to PM2.5, particularly during the midpoint period of pregnancy, was more likely to have a slow growth trajectory and a lower risk of rapid growth trajectory. Maternal age, pre-pregnancy BMI, and previous delivery experience might modify these associations.

Molecular Cloning, Characterization, and Function of Insulin-Related Peptide 1 (IRP1) in the Haliotis discus hanna.

Abalone is a popular mollusk in the marine aquaculture industry of China. However, existing challenges, like slow growth, individual miniaturization, and the absence of abundant abalone, have emerged as significant obstacles impeding its long-term progress in aquaculture. Studies have demonstrated that insulin-related peptide (IRP) is a crucial factor in the growth of marine organisms. However, limited studies have been conducted on IRP in abalone. This study indicated that the hdh-MIRP1 open reading frame (ORF) was composed of 456 base pairs, which encoded 151 amino acids. Based on the gene expression and immunofluorescence analyses, the cerebral ganglion of Haliotis discus hannai (H. discus hannai) was the primary site of hdh-MIRP1 mRNA expression. Moreover, hdh-MIRP1 expression was observed to be higher in the larger group than in the smaller group abalones. Only single nucleotide polymorphism (SNP) was related to their growth characteristics. However, approximately 82 proteins that may interact with hdh-MIRP1 were identified. The functional enrichment analysis of the 82 genes indicated that hdh-MIRP1 may be involved in the regulation of glucose metabolism and the process of growth. This study established a benchwork for further investigating the role of IRP in the growth of abalone.

Influence of Pd-Layer Thickness on Bonding Reliability of Pd-Coated Cu Wire.

In this paper, three Pd-coated Cu (PCC) wires with different Pd-layer thicknesses were used to make bonding samples, and the influence of Pd-layer thickness on the reliability of bonded points before and after a high-temperature storage test was studied. The results show that smaller bonding pressure and ultrasonic power lead to insufficient plastic deformation of the ball-bonded point, which also leads to small contact area with the pad and low bonding strength. Excessive bonding pressure and ultrasonic power will lead to 'scratch' on the surface of the pad and large-scale Ag spatter. The wedge-bonded point has a narrowed width when the bonding pressure and ultrasonic power are too small, and the tail edge will be cocked, resulting in false bonding and low strength. When the bonding pressure or ultrasonic power is too large, it will cause stress concentration, and the pad will appear as an 'internal injury', which will improve the failure probability; a high-temperature environment can make Cu-Ag intermetallic compounds (IMCs) grow and improve the bonding strength. With the extension of high-temperature storage time, the shear force of Pd100 gradually reaches the peak and then decreases, due to Kirkendall pores caused by excessive growth of IMCs, while the shear force of Pd120 continued to increase due to the slow growth rate of IMCs. In the high-temperature storage test, the thicker the Pd layer of the bonding wire, the higher the bonding strength; in the cold/hot cycle test, the sample with the largest Pd-layer thickness has the lowest failure rate. The thicker the Pd layer, the stronger its ability to resist changes in the external environment, and the higher its stability and reliability.

Spillover Effects of Urban Expansion on Land Green Use Efficiency: An Empirical Study Based on Multi-Source Remote Sensing Data in China

Land is an important carrier of resource elements, and improving land green use efficiency (LGUE) is the key to achieving “smart growth” in cities. This study takes 269 cities in China from 2008 to 2020 as the research object and integrates multisource remote sensing data, GIS spatial analysis, and spatial econometric models to explore the evolutionary characteristics of LGUE and the spatiotemporal effects of urban expansion on LGUE. The results show that (1) urban LGUE increases over time and has certain gradient distribution and spatial dependence characteristics; (2) urban expansion has a significant inverted U-shaped relationship with LGUE, indicating that maintaining reasonable urban expansion is the key to improving LGUE, but excessive urban expansion has a strong negative spatial effect on LGUE. In terms of spillover effect, for every 1% increase in the square term of urban expansion, the LGUE of the local city decreases by 0.0673%, but the neighboring city increases by 0.2283%; and (3) urban expansion has significant spatiotemporal heterogeneous effects on LGUE, and spatial development boundaries must be reasonably determined to achieve “smart growth”. Currently, some cities in China are expanding rapidly, and we hope to provide key support for promoting the “smart growth” of cities and improving LGUE.

Financial and digital financial literacy through social media use towards financial inclusion among batik small enterprises in Indonesia

Batik, an Indonesian textile art form, holds immense economic and cultural importance. Small and medium enterprises (SMEs) specialising in batik play a crucial role in Indonesia's economic growth and cultural preservation, contributing significantly to the gross domestic product (GDP) and preserving the nation's heritage. Nevertheless, these enterprises face several challenges, such as slow growth and limited access to credit. The batik industry also lags in financial literacy and the adoption of digital marketing strategies, hindering its development. This quantitative study aims to investigate the relationship between financial literacy, digital financial literacy, and financial inclusion in batik SMEs and also examined the moderating effect of online social networks. A survey was conducted involving 535 managers, owners, and financial officers of small batik enterprises. Subsequently, the SmartPLS statistical analysis method was employed for data analysis. The results demonstrate that financial literacy and digital financial literacy play a significant role in accessing financial inclusion for batik small enterprises. Moreover, the utilisation of social media was found to moderate these relationships, amplifying the impact of financial and digital literacy on financial inclusion. The findings contribute to the existing knowledge, provide insights for enhancing batik small enterprises, and propose a digital financial model to promote financial inclusion.