This study examined negative emotion vulnerability and its relationship to borderline personality disorder (BPD), depression, and anxiety symptoms. Emotion vulnerability has been described as a biological risk factor for BPD consisting of three components: heightened baseline emotional arousal, intense emotional reactivity to negative stimuli, and a slow return to baseline (Linehan 1993). However, few studies have fully examined negative emotion vulnerability as a three-factor construct. In addition, because there is reason to believe that BPD shares a common vulnerability factor with comorbid disorders, such as depression and anxiety, we also examined if heightened negative emotion vulnerability was related to those symptoms as well. A sample of 307 participants completed two mood induction tasks to assess all components of emotion vulnerability. Self-report questionnaires were also completed. Results confirmed a three-factor model of negative emotion vulnerability, with two factors, heightened baseline arousal and slow return to baseline emotion, uniquely predicting all symptoms. This study provides evidence for a trandiagnostic conceptualization of negative emotion vulnerability as descrbed by Linehan (1993).