Remote sensing-based tectonic geomorphology is widely applied to study neotectonic processes. This technique is relatively cheap and easy to apply, and it allows investigating large areas for tectonic activity. Existing literature comprises a variety of indices and techniques, seemingly able to work in almost all tectonic settings. In this paper we study a particularly challenging region in W Slovenia and NE Italy, characterised by slow deformation rates, high precipitation, dense vegetation, and intense modification of the landscape and drainage system due to karst processes. We apply a suite of well-established geomorphic indices including terrain ruggedness, surface roughness, hypsometric integral and analyses of drainage parameters, as well as several less commonly applied analyses, such as the assessment of doline density and doline geometry. The aim was to test the capabilities of the applied techniques at various spatial scales and to extract information about the active tectonics. We begin with broad, regional analyses to detect the morphological imprint of active faults in the landscape. Then, we perform detailed studies of selected sites and single faults. Finally, we analyse a polje located on the trace of an active fault in the highest detail. We then compare the different techniques and different digital elevation models regarding their usefulness for detecting tectonic influences on the karstic landscape. The results show that most of the well-established methods we tested are not suitable to detect even the largest, clearly active faults in the area. The resolution of the used DEMs also has a notable impact on the analyses. We conclude that it is almost impossible to identify active faults solely based on the used techniques. This is mainly due to the low deformation rates and to the intense karstification of the study area that leads to a disconnected surface drainage system. Additional problems arise from the strike-slip mechanism of active faulting. Lithological contrasts and inactive dip-slip faults can lead to false-positive signals of tectonic activity. However, some of our results also show a tectonic signal, indicating neotectonic strike-slip deformation with a notable dip-slip component. Remote sensing studies have demonstrated to be powerful tools for tectonic geomorphology studies, but low tectonic rate karstic landscape conditions as in W Slovenia/NE Italy push even the most trusted methods to their limits and highlight the importance of validation and ground-checks of the results.