Slow Beat Research Articles

A slower beat: Aglianico grape pomace extract as a novel modulator of cardiac rhythmicity

A slower beat: Aglianico grape pomace extract as a novel modulator of cardiac rhythmicity

Slow pathway ablation in pediatric patients: long-term outcomes in a high-volume center according to baseline electrophysiologic characteristics

Abstract Background Slow pathway ablation (SPA) in pediatric patients with documented paroxysmal supraventricular tachycardia (PSVT) has been proven safe and effective. Arrhythmia induction is often difficult in the pediatric population. Accordingly, empirical SPA is frequently adopted in this population. Real-world data about long-term outcomes of slow pathway ablation (SPA) in relation to tachycardia inducibility and electrophysiologic characteristics in pediatric patients with PSVT in a high-volume center are lacking. Purpose To compare long-term clinical outcomes of SPA in pediatric patients with and without intraprocedural documentation of DAVP and AV nodal reentrant tachycardia induction. Methods In this retrospective sigle-center study, all SPA procedures performed on pediatric patients (under 18 years) at our Institution since 2016 were considered. All patients had documented PSVT with short RP interval, no evidet ventricular pre-excitatio on surface ECG and normal echocardiography. Baseline EPS was performed to exclude the presence of concealed accessory pathway and isoproterenol infusion was used to exclude focal atrial tachycardias. According to intraprocedural EP characteristics, three group of patients were identified: Group 1 with AVNRT induction; Group 2 with dual atrioventricular nodal physiology (DAVP) and no tachycardia induction; Group 3 without DAVP. According to previous documentation of a short RP PSVT and after discussion with patients’ families, SPA was performed in all patients. The endpoint of the ablation was to eliminate slow pathway conduction and AV node re-entrant beat. Follow up visits were scheduled three and twelve months after ablation for all patients. Results 1734 patients underwent SPA since 2016 at our Institution. 1092 patients (73.4%) showed AVNRT induction during EPS (Group 1). 433 patients (14.2%) showed DAVP without tachycardia induction (Group 2). 209 patients (12.4%) didn’t show DAVP at EPS (Group 3). Age and gender were similar among the three groups. SPA was performed with acute procedural success in all patients. After 36-month median follow-up, freedom from palpitations was 98.5% in Group 1, 97.1% in Group 2 and 92.3% in Group 3. A survival analysis showed the best outcomes in group 1 and no significant difference in recurrence rate among the groups 2 and 3 (Figure 1). No permanent heart blocks, neither other major complication was observed. Conclusions When performed by experienced operators and in high-volume centers, SPA is a safe and effective procedure in pediatric patients with documented short RP PSVT. Success rate is highest with AVNRT induction and good without AVNRT induction, regardless of AV node dual conduction at baseline EPS. Such high success rate depends on careful exclusion of others arrhythmia mechanisms (i.e., focal atrial tachycardias, AV re-entrant tachycardias) that, although infrequent in children, are the main determinants of arrhythmia recurrences.

Timbral effects on consonance disentangle psychoacoustic mechanisms and suggest perceptual origins for musical scales

The phenomenon of musical consonance is an essential feature in diverse musical styles. The traditional belief, supported by centuries of Western music theory and psychological studies, is that consonance derives from simple (harmonic) frequency ratios between tones and is insensitive to timbre. Here we show through five large-scale behavioral studies, comprising 235,440 human judgments from US and South Korean populations, that harmonic consonance preferences can be reshaped by timbral manipulations, even as far as to induce preferences for inharmonic intervals. We show how such effects may suggest perceptual origins for diverse scale systems ranging from the gamelan’s slendro scale to the tuning of Western mean-tone and equal-tempered scales. Through computational modeling we show that these timbral manipulations dissociate competing psychoacoustic mechanisms underlying consonance, and we derive an updated computational model combining liking of harmonicity, disliking of fast beats (roughness), and liking of slow beats. Altogether, this work showcases how large-scale behavioral experiments can inform classical questions in auditory perception.

Music influences performance without increasing perceived exertion during high-intensity rowing intervals: a cross-over design study.

This study assessed how exposure to slow (SBM) versus fast beat music (FBM) during high-intensity rowing intervals affects performance, heart rate (HR), lactate levels, relative perceived exertion (RPE), and recovery. The A/B crossover design involved 21 participants performing 5 × 500 m rowing intervals under two conditions: FBM and SBM. Primary endpoint was the difference in total rowing time. Secondary endpoints included average HR, average RPE as well as rowing interval times, RPE, and HR per interval. For exploratory purpose, HR and lactate drop during the initial 5 min post completion was analyzed. Listening to FBM resulted in significantly shorter total rowing times (p = 0.009, rB = 0.59), especially during the 1st interval. The 1st interval was also significantly faster than intervals 2-5 (p < 0.001), with the greatest performance drop between the 1st and 2nd interval during FBM. Average HR was significantly lower when listening to SBM (p = 0.03, rB = 0.48), while average RPE showed no significant difference (p = 0.47, rB = 0.02). Lactate values after interval 5 were significantly lower in SBM (p = 0.05, rB = 0.41), but no significant difference was found for lactate drop (p = 0.21, rB = 0.21). However, participants exhibited a higher HR drop rate with SBM (p = 0.05, rB = 0.42). FBM improved performance without increasing RPE, while SBM proved superior for recovery. Systematic customization of music based on intended training stimuli holds broad potential for the competitive sports, fitness, and health sector.

Gyroscopically coupled in-plane and transverse vibrations of an annular free-clamped microplate

In this work, we construct and study a model of coupled plane-transverse oscillations of a circular thin plate with a concentric hole under the action of Coriolis and centrifugal inertia forces caused by the rotation of the system along an axis located in the plane of the plate. Equations of vibrations in partial derivatives are obtained using the variational principle of Hamilton - Ostrogradsky. Assuming the smallness of the angular velocity of rotation with respect to the frequency of the working skew-symmetric flexural form of the plate oscillations, an approximate analytical solution is found for both the radial and circumferential, and transverse components of the displacement field in the free oscillation mode. Using the Galerkin projection method, the problem was reduced to a system of two second-order linear differential equations for modal coordinates of mutually orthogonal basic skew-symmetric modes of the plate vibrations. It is found that the regime of initially excited harmonic oscillations in the presence of rotation is transformed into the regime of amplitude-modulated beats. Analytical expressions are found both for the frequency of the slow beat envelope and for the relative depth of their amplitude modulation. The fundamental possibility of determining the modulus of the projection of the angular velocity vector onto the plane of the plate from the measured value of the envelope frequency is shown. The problem of choosing the optimal geometric shape of the resonator from the point of view of maximizing the sensitivity of the system to changes in the value of the angular velocity of rotation is studied. The question of determining the direction of the projection of the angular velocity vector onto the plane of the plate from the measured depth of the amplitude modulation of the beat regime is considered.

Abstract 15885: A Masquerading Early Beat Induces Ventricular Fibrillation

Clinical Case: A 51 year old male with a history of hypertension, G6PD deficiency, thrombotic thrombocytopenic purpura, prior stroke, and morbid obesity presented with resuscitated out of hospital VF arrest. Electrolytes and ECG were normal. During his admission, the patient had two VF events that were induced by what appeared to be a short coupled right bundle branch block (RBBB) morphology PVC. He was brought to the electrophysiology lab for PVC ablation and ICD implantation. Baseline rhythm was sinus with what appeared to be both RBBB morphology PVCs and junctional extrasystoles. With both extrasystoles, the His potential preceded the QRS by 50 ms, and atrial activation in the His catheter and coronary sinus catheter was also earlier than the QRS. Activation mapping of the right bundle showed later activation than the His potential. This was all consistent with junctional premature complexes (JPC) with frequent RBBB aberrancy rather than fascicular PVCs. Slow pathway modification was performed to attempt to ablate the JPCs. After multiple ablations along the tricuspid annulus and back to the coronary sinus os that triggered slow junctional beats, the patient’s JPC burden was significantly reduced. An ICD was also implanted. The patient was discharged on flecainide. At 4 month follow up he had not had recurrence. Discussion: Early coupled PVCs are a well-known cause of ventricular fibrillation, but JPCs inducing VF have not been described previously. Placement of a coronary sinus and His catheter helped identify early that this was not simply a fascicular PVC. This case demonstrates the importance of keeping a broad differential diagnosis when starting any EP study. Ablating the slow pathway area can be effective to treat JPCs while preserving native AV conduction as demonstrated in this case.

805 FAILURE OF RYTHMIQ, AN ALGORITHM FAVOURING INTRINSIC CONDUCTION: WHEN IS TOO MUCH OF A GOOD THING?

Abstract An 80-year-old woman received a dual chamber pacemaker (Boston Scientific Accolade MRI DR) for pre-syncopal episodes associated with transient type 1 and 2:1 II degree atrioventricular block, recorded in 24-hour Holter monitoring. Due to residual AV conduction, pacemaker was set with RYTHMIQ algorithm, in order to reduce inappropriate ventricular pacing. A month later, the patient began to complain of severe asthenia and bradycardia (46-48 bpm). Telemetry-supported pacemaker control revealed III degree AV block with junctional escape rhythm, unmasking failing to switch of RYTHMIQ algorithm. Why did it happen? The RythmIQ algorithm has been designed to promote intrinsic conduction in Boston Scientific devices. With RythmIQ the device provides AAI(R)[i] at the lower rate limit and/or sensor indicated rate. It provides backup VVI pacing at a rate 15 bpm slower than the programmed lower rate limit, with backup VVI pacing rate limited to no slower than 30 bpm and no faster than 60 bpm. If 3 slow ventricular beats are detected in a window of 11 beats, the device automatically switches to DDD(R) mode. A slow beat is defined as a ventricular paced or ventricular sensed event that is at least 150 ms slower than the AAI(R) pacing rate. Slow ventricular beats are any of the following: - V paced event- V sensed event &amp;gt; AAI lower rate limit + 150 ms- V sensed event &amp;gt; AAI(R) sensor indicated rate + 150 ms In our case LRL was set at 50 bpm (1200 ms). During III degree AV block, patient's ventricular rate was always about 46-48 bpm, due to stable junctional escape rhythm. Thus no ventricular sensed event occurred with a V-V cycle greater than AAI lower rate limit + 150 ms, namely 1350 ms (around 44 bpm). Moreover the device didn't provide backup VVI pacing at a rate 15 bpm slower, namely 35 bpm. This two conditions impaired Rhythm IQ switching from AAI with VVI backup to DDD. The device was set manually in DDD with restoring of AV synchrony and adequate ventricular rate followed by complete resolution of symptoms. Rhythm-IQ algorithm doesn't check for AV synchrony, providing switch from AAI with VVI backup to DDD just in case of sudden and marked bradycardia. Loss of AV synchrony doesn't represent a switching criteria and moreover it is not recognized by the device. This condition could be dangerous failing to correct AV conduction disturbances in pacemaker recipient, especially if LRL was set ≤ 50 bpm. For this reason, adequate knowledge of the algorithm would indicate greater caution in using RythmIQ in certain categories of patients, such as the one in the case just described.

Mutual information resonances in delay-coupled limit cycle and quasi-cycle brain rhythms.

We elucidate how coupling delays and noise impact phase and mutual information relationships between two stochastic brain rhythms. This impact depends on the dynamical regime of each PING-based rhythm, as well as on network heterogeneity and coupling asymmetry. The number of peaks at positive and negative time lags in the delayed mutual information between the two bi-directionally communicating rhythms defines our measure of flexibility of information sharing and reflects the number of ways in which the two networks can alternately lead one another. We identify two distinct mechanisms for the appearance of qualitatively similar flexible information sharing. The flexibility in the quasi-cycle regime arises from the coupling delay-induced bimodality of the phase difference distribution, and the related bimodal mutual information. It persists in the presence of asymmetric coupling and heterogeneity but is limited to two routes of information sharing. The second mechanism in noisy limit cycle regime is not induced by the delay. However, delay-coupling and heterogeneity enable communication routes at multiple time lags. Noise disrupts the shared compromise frequency, allowing the expression of individual network frequencies which leads to a slow beating pattern. Simulations of an envelope-phase description for delay-coupled quasi-cycles yield qualitatively similar properties as for the full system. Near the bifurcation from in-phase to out-of-phase behaviour, a single preferred phase difference can coexist with two information sharing routes; further, the phase laggard can be the mutual information leader, or vice versa. Overall, the coupling delay endows a two-rhythm system with an array of lead-lag relationships and mutual information resonances that exist in spite of the noise and across the Hopf bifurcation. These beg to be mapped out experimentally with the help of our predictions.

The Effect of Different Genres of Music on Blood Pressure among Different Age Groups

Many people listen to music during their day to day activities. Music is a combination of frequency, beat, density, tone, rhythm, repetition, loudness and lyrics. When we listen to fast beat music we get excited and slow beat music makes us to relax.There are different genres of music like rock, hip hop, pop ,classical, country, fazzy and these types of music has effect on blood pressure.The aim of the study is to know whether different types of music has effect on blood pressure or not. For this a cross sectional survey was conducted. This survey consisted of a self structured questionnaire. The sample size used for the study is 101. This standard questionnaire has been prepared and uploaded in google forms and circulated among the population, all the data were collected and the data has been analysed by using chi square analysis using the software IBM SPSS. The aim of the study is to evaluate the effect of different genres of music on blood pressure among the different age groups.

The optimization of a closed loop medical device for cardiac arrythmias control and monitoring

The cardiovascular diseases take around 17,9 million of lives world widely each year [1]. The first examination in the cariology department and the famous medical device is the Electrocardiograph (ECG), the ECG gives an idea about the heart physiology because it is an electrical signal that represents the electrical activity of the heart system, and via that signal the cardiologist can observe too many parameters, such as the heart rate, the mechanical contraction of the heart muscles etc. In fact, the heart rate or the heart beating area is included in a medical specialty called rhythmology. That field of study deals mainly with the heart rate troubles or arrythmias. Actually, there are several arrythmias but in this paper we will mention only about bradycardia and tachycardia that correspond respectively to the slow heart beats and fast heart beats. In our paper we suggest the enhancement of an implantable closed loop system to monitor and control the heart beating. We will design and simulate our system using LabVIEW

Report on Steroid- Responsive Encephalopathy in a Case of Hashimoto’s Thyroiditis

Introduction: Thyroiditis caused by Hashimoto's common, Thyroid gland enlargement that is painless and diffuse that affects mostly women in their forties and fifties. While most patients are euthyroid, hypothyroidism may grow. In addition, several patients have thyroid antigen-specific cell-mediated immunity, which can be demonstrated using a variety of strategies. The annual number of cases per 10,000 people prevalence of at least 2% among women. Thyroiditis causes the thyroid gland to become extinct capacity to keep iodine in a safe place, generate together with secrete circulating iodoproteins in the blood, and produce inefficient hormone. As a result, the thyroid gland is overstimulated, and the patient has a high rate of Iodine in the thyroid turnover.&#x0D; Clinical Finding: enlargement of thyroid gland. Difficulty in swallowingand breathing, unexplained weight gain,constipation, slow heart beat, fatigue, swelling in extremities, dryness.&#x0D; Medical History: In 2010 she was suffering from same problems. Hashimoto thyroiditis cured for medical intervention in Nagpur medical college, after that treatment of Hashimoto thyroiditis she took the treatment in A.V.B. R. Hospitalfor management of Hashimoto thyroiditis. Now she is admitted in peadiatrics ward for further management of Hashimoto thyroiditis.&#x0D; The Diagnosis and Therapeutic Intervention: After physical examination and investigation, this case was diagnosed as Hashimoto thyroiditis. Thyroid hormone replacement therapy was used to treat the condition. This normally entails taking levothyroxine.&#x0D; Leoxyl Check: After six to eight weeks of treatment, the TSH level should be normal with dose 12.5-25 mcg. Absorption of levothyroxin may be affected by some drugs, supplements, and diets taken 4 hours. Triiodothyronine 5 to 10 mcg received in twice in day.&#x0D; Nursing Perspectives: Assessement of anterior or posterior location of the thyroid IV Fluid was provided. Check blood pressure and vital signs per hourly. Monitor the Pulse oximetry, ABG, and respiratory rate, and pattern are all factors to consider.&#x0D; Conclusion: Comprehensive systemic review of autoimmune disease, our best estimate of incidence rates for hypothyroidism in female and male treatment and management improves the outcomes of Hashimoto thyroiditis.

Transient Bradyarrhythmia

Amiodarone is a class III anti-arrhythmic drug which is commonly used in various cardiac arrhythmias. Hypothyroidism is one important complication linked with this drug. Herein, we recount a case of amiodarone-induced hypothyroidism, which presented as atrial fibrillation (AF) with slow ventricular response. A middle-aged gentleman was brought to the casualty in unconscious state. He was a known case of hypertension and on amiodarone treatment for AF for the past 2 years. On presentation, the patient had a slow pulse rate and his electrocardiogram was suggestive of AF with very slow ventricular beat. This was managed medically and a temporary cardiac pacemaker was instituted thereafter. In search of the cause for bradycardia, his thyroid function test depicted hypothyroidism with 2-fold raised thyroid-stimulating hormone and decreased levels of free tetraiodothyronine hormone, but the patient had no other features suggestive of hypothyroidism. Therefore, the patient was started on oral thyroxine hormone, which led to considerable pulse rate improvement.

Keamanan Kunci Ruang Dosen Elektro UMSIDA Menggunakan Ketukan Berbasis Arduino

The development of modern technology now are much more advanced and it can make doing a job much easier such as security problems for door locks that are applied to the electrical lecturer room UMSIDA. This tool is designed to run a solenoid lock by using a knock code applied to the door locking system by using microcontroller and piezo electric sensor which will be seen with a security system with knock method. The purpose of this study was to determine the constraints of the door safety device using an electric piezo sensor based on the Atmega328 microcontroller and the system can correctly recognize the beat pattern received and process it. This tool system works when there is an input in the form of a password code through the beats detected by electric piezo if the password code is applied correctly then the microcontroller provides input on relay to activate the solenoid and stepper motor, so the door would open. The result of this research shows that it can identify the correct number of beats a maximum of 15 beats, if it is more than 15 times the beat is wrong. From the result of the trial, fast or not a knock is declared true if the beat time ratio is slow by 4 times knock and the door opens. If the knock pattern is different from what has been determined, then the knock is declared wrong and the door can not open. The test results indicated that it can be concluded that from the test or trial carried out by the object provides true overall results even though the results do not provide 100% results. The results of the analysis of the trial carried out by each objects for 15 times, which affects fast or slow beats, number of beats, the ratio of time between knock

Effect of Background Music for Attentive Concentration in Working

Purpose: Recently, many young people have preferred to work in café than traditional library because the café is equipped with coffee, music, and cozy seats. When working in the café, whether listeners’ attentive concentration could be affected by a kind of the background music needs to be investigated as the purpose of the present study. We also aimed to confirm the attentive concentration of listeners might be caused by their music inclination.Methods: A total of ninety young adults was randomly assigned as five kinds of background music [e.g., rhythm and blues (R&amp;B)/ballad, dance/rock, classic/jazz, fast beats, slow beats] and no music after responding to simple questions to ask their preference of music genre. While listening to the music, the subjects took an attentive concentration test, namely Frankfurter aufmerksamkeits-inventar (FAIR). The obtained data were analyzed by three subcategories of the FAIR test which consists of performance, quality, and continuity.Results: For the music genre, classic/jazz showed significantly higher continuity scores than R&amp;B/ballad, fast beats, and no music, which means that classic/jazz music of the café could help the workers maintain the attention. In the subgroup who listened to preferred music genre, their performance scores (i.e., selective attention) was significantly higher than that of the participants who being exposed to non-preferred music.Conclusion: Current results supports that music genre and individual music inclination may partially affect listener’s ability of the attentive concentration when background music was presented in the café, although a further study to find certain possible causal factors with objective methods should be followed.

Vocabulary Learning Autonomy through Incorporation of English Songs: Indonesian EFL Students' Perspectives

English songs have been widely used by learners as a medium to learn vocabulary. This qualitative study explored Indonesian students' experiences in using English songs as a medium to learn vocabulary autonomously outside in-class learning. Data were collected through in-depth interview to four second-year English Department students who reported using English songs to help them acquire vocabulary autonomously. The results of the interview showed that the participants preferred slow beat tempo of songs to obtain clear understanding on the words used in the songs. They also reported that the decision to use English songs was driven by their needs to the exposures of authentic and contextual English lexicons, the representations of learners' feelings and emotions through songs, the sense of enjoyable atmosphere songs created, and vocabulary retention. While listening to English songs, cognitive and metacognitive strategies were also applied by the participants to help them acquire vocabulary more effectively. At last, the study was concluded by proposing teachers' roles to enhance learners' autonomy in vocabulary learning through English songs . Keywords: autonomy; autonomous learning; vocabulary learning; songs in L2 learning; learning strategies

Slow and fast beat sequences are represented differently through space.

The Spatial-Numerical Association of Response Codes (SNARC) suggests the existence of an association between number magnitude and response position, with faster left-hand responses to small numbers and faster right-hand responses to large numbers. Recent studies have revealed similar spatial association effects for non-numerical magnitudes, such as temporal durations and musical stimuli. In the present study we investigated whether a spatial association effect exists between music tempo, expressed in beats per minutes (bpm), and response position. In particular, we were interested in whether this effect is consistent through different bpm ranges. We asked participants to judge whether a target beat sequence was faster or slower than a reference sequence. Three groups of participants judged beat sequences from three different bpm ranges, a wide range (40, 80, 160, 200 bpm) and two narrow ranges ("slow" tempo, 40, 56, 88, 104 bpm; "fast" tempo 133, 150, 184, 201 bpm). Results showed a clear SNARC-like effect for music tempo only in the narrow "fast" tempo range, with faster left-hand responses to 133 and 150 bpm and faster right-hand responses to 184 and 201 bpm. Conversely, a similar association did not emerge in the wide nor in the narrow "slow" tempo ranges. This evidence suggests that music tempo is spatially represented as other continuous quantities, but its representation might be narrowed to a particular range of tempos. Moreover, music tempo and temporal duration might be represented across space with an opposite direction.

Good things come in threes: triplet flow in recent hip-hop music

AbstractMCs (rappers) such as Cardi B, Kendrick Lamar, Drake, Big Sean and Young Thug use triplet rhythms in their rapping, a practice that is known as triplet flow. This paper argues that the prevalence of triplet flow is one of the most aurally salient features of contemporary hip hop, and exemplifies the popularity and influence of the Atlanta-centred genre of trap music through its sparse, slow beats. Three types of triplet flow are defined – mixed, phrasal and total – and are used to explore how various songs and artists active in the late 1980s and early 1990s provided the stylistic blueprint for triplet flow's recent explosion in popularity. With the aid of a 50 song mini-corpus, the paper concludes with a general survey of stylistic characteristics common in many songs featuring triplet flow, and further analysis of two of these songs in order to illuminate the creative, rhetorical and virtuosic potential that underpins this ostensibly simple style of rapping.

The Effect of Tempo of Musical Treatment and Acute Exercise on Vascular Tension and Cardiovascular Performance: A Case Study on Trained Non-Athletes

The higher incidence of hypertension strongly and significantly associated with unhealthy lifestyle and lack of physical exercise. This study aimed to investigate the fundamental correlation between musical tempo and physiological response particularly on vascular tension and cardiorespiratory activity in the nonathletes. This pre-posttest randomized design study involving non-athletes with age ranged from 19-21 years old, resting cardiac 60-80 beat/minute, maximal oxygen consumption (VO2 max) 37- 49 ml/KgBW, average body mass index (BMI) and hemoglobin level (Hb), and without smoking history. The experimental data were collected from 60 participants that divided into four criteria. The placebo was treated with high exercise in the acute model while another group was exposed by moderate exercise with fast and slow musical tempo during treatment for 20 minutes. The monitoring of vascular tension and cardiovascular performance were done by using standardized clinical test. Importantly, the slow tempo of musical beat and acute moderate exercise model significantly decreased the vascular tension in cardiovascular activity without significant alteration in the lung activity. The pre-treatment with slow beat of musical tempo strongly correlated to vascular wall pressure. The systolic and diastolic pressure was significantly different among the group (P < 0.05). Moreover, the combination treatment in our study improved the primary effect of musical tempo and muscular stretch on heart rate and cardiovascular performance. Our preliminary study suggests that co-treatment of slow beat musical and acute moderate exercise can reduce the progression of hypertension in the trained non-athletes.

The effectiveness of evidence-based nursing for propranolol treatment of the Intractable infantile hemangiomas

Objective To investigate the effecs of evidence-based nursing of the treatment with propranolol forthe intractable infantile hemangiomahemangioma. Methods Dividing the children who were treated with propranolol into experimental groups and matched groups randomly according to the random number table each 42. The experimental group adopted evidence-based care, according to PICO tool description of the problem and combining the results of theresponsibility nurse′s regular follow-up and assessment to come up with evidence-based problems, seeking for high-level evidences, combining the existing conditions of careand having formulated corresponding care norms,contingency plans for adverse reactions,healthy education card,the operation videos and other measures and they are implemented.The control group adopted the routine care procedure.two groups of effects were determined by the Achauer level 4 classification after 12 months of treatment, and evaluating the condition of occur of blood pressure drop,slow heart beat,diarrhea, sleepdisorders, hypoglycemia and other adverse reactions in both groups during the process of treatment. Results there was statistical significance in the difference of two groups′Achauer 4 levels. The numbers of Ⅰ, Ⅱ, Ⅲ, and Ⅳ in the two groups were 3, 7, 20, 12, and 11, 15, 11, 5, respectively (t1=1 372, t2=2 132, P<0.05). The two groups had a statistically significant difference in blood pressure, heart rate, diarrhea, sleep disorder, and low blood sugar response. The numbers of two groups were 12, 2, 3, 6, 1 and 26, 15, 12, 21, 8 respectively (χ2=6.098-12.464, all P<0.05). Conclusions Evidence-based nursing enhances the treatment effectiveness of theintractable infantile hemangioma with propranolol effectively and has preventing the occur of adverse reactions during the process of treatment. Key words: Propranolol; Infants; Intractable; Hemangioma; Vidence-based nursing; Adverse reactions

The Attenuation of Physical-Physiological Stresses through Musical-High Intensity Exercise Co-Treatment in Non-Athlete Individual

Exercise is a very effective strategy to improve people’s health. However, the unwell managed exercise potentially causes distress and decreases the health. Therefore, this research aimed to know the correlation of exercise combined with music to control stress/tissue injury by using physical-physiological neurohormonal paradigm approach. This study used randomized control group pre-test and post-test design with the sample of 30 non-athlete individuals randomly selected with the age range of 19-23 years old, the body mass index (BMI) of 19-23, VO2 Max of 46-56 ml/kg/BB, and they do not smoke. The experiment group was divided into high-intensity exercise by listening to hard beat music, high intensity-exercise by listening to slow beat music, high-intensity exercise without listening to the music. The high intensity, in this research, means the intensity with 85% load of maximum working capacity with the multilevel load test using ergometer. The measurement of distress level was performed by taking the sample of 10 ccs of the blood of cube vein and the measurement of heart rate before and after doing an exercise. The distress level was determined using a biomaterial secretion indicator in the form of cortisol hormone, endorphin, cytokine interleukin-6 (IL-6), and the heart work. The method that was used to check the blood sample to know the cortisol, endorphin, and IL-6 content was ELISA (Enzyme-Linked Immunosorbent Assay), while the measurement of heart work was carried out using polar heart rate monitor. The research results showed that there was a significant difference in circulating level of endorphin and IL-6 (P < 0.05) after treatment by listening to slow beat music compared to the other experimental groups. Nevertheless, there was no significant difference in the circulating levels of cortisol (P > 0.05). In summary, giving co-treatment of high-intensity exercise with slow beat music could decrease the physical-physiological stress of non-athlete individual. It is suggested that the treatment could decrease the inflammatory within the skeletal muscle and improve the decrease in physiological stress by modulating the anti-physiological stress neurohormonal secretion.