Blade slotting technology is an effective measure to improve the flow structure on the suction surface of a blade and enhance the performance of turbomachinery. To investigate the impact of various slot sizes on the flow field of a single-stage transonic compressor rotor, seven kinds of slot schemes were designed and calculated by numerical simulations. The results show that the above slotting schemes significantly enhance the stability margin of the compressor. In particular, the slotting scheme H9W3 increases the surge margin by 60.9% and slightly reduces peak efficiency by 0.3%, with an almost identical maximum pressure ratio. Slotting promotes high-energy fluid to generate jets from the slot located at the exit of the suction side, effectively controlling blade surface flow separation and reducing channel blockage. Square slots are more effective than elongated slots for controlling separation when using differently shaped slots with equal areas. Increasing slot area gradually decreases outlet total pressure at a constant aspect ratio. A slight increase in the overall blade load causes a backward shift in the front portion load.