Slope failures frequently occur under storm rainfall, for which the constant shear drained (CSD) stress path is more pertinent to the soil element underneath the slope surface. Soil mass in man-made slopes or other compacted slopes is often at medium-dense or even dense state. Evaluating the stability of such slopes entails a comprehensive understanding of the behavior of dilative granular packings under the CSD stress path. Here we use a robust grain-scale model to simulate responses of dilative granular packings along the CSD, constant-volume (CDCV), and conventional drained (CD) stress paths. We show that the behavior under the CSD stress path complies with the critical state theory at both macro- and micro-scale. When the second-order work becomes nonpositive, a substantial plastic strain starts to develop under the CSD loading, while a significant drop of shear strength happens along the CDCV stress path for medium-dense packing and along the CD stress path for dense packings. In these conditions, the second-order work vanishes at an almost identical stress ratio which marks the onset of strength reduction or large deformation, and such stress ratio is well correlated with the initial state parameter of the granular packing. Furthermore, we show that the CSD stress path drives an intensified fabric anisotropy and there exists a quantitative correlation between anisotropy parameters and mobilized shear strength.