Wave loading can lead to transient liquefaction and instability in a porous seabed and can therefore cause marine structures to fail. The failure mechanism of seabed involving many complex factors and uncertainties has not been fully revealed. The properties of marine sediments, usually assessed as constant parameters in traditional deterministic analyses, actually vary spatially because of geomorphic processes and loading history. This study therefore presents a probabilistic analysis of wave-induced dynamic responses in a poroelastic sloping seabed by applying a random finite element method. Spatial variabilities of the cross-correlated permeability and shear modulus of marine soils are taken into account using random field theory. The response of poroelastic sloping seabed is analyzed based on Biot's theory and linear wave theory considering changes in wave height and length when propagated from relatively deep to shallower water. A LiveLink code is written to integrate the random field simulation and the finite element model for the probabilistic analysis of a spatially heterogeneous seabed. Monte Carlo simulations are carried out to obtain the statistics and associated uncertainties of the seabed response. Effects of cross-correlation of random fields and the slope angle on the response of a poroelastic sloping seabed were also investigated.