This thesis takes the typical fill subgrade of squashy slope foundation of Qinglong-Xingyi Expressway in Guizhou Province as an example. Through engineering geological analysis, it was found that the topography and geomorphology conditions, formation lithology conditions and highway construction conditions were the basic conditions of water damage to highway subgrade, and hydrometeorological conditions are the direct cause of water damage of highway. Coupling calculation analysis using SEEP/W and SLOPE/W revealed the mechanism of short-term continuous heavy rainfall. When the short-term continuous heavy rainfall reached a certain level, the soil at the geotechnical interface reached saturation. At this time, the surge of pore water pressure at the geotechnical interface led to the sudden drop of effective stress, leading to the sudden decline of side slope stability, which was the starting condition for the formation of landslide caused by the water damage to subgrade. The implementation of emergency restore and the effect evaluation indicated that comprehensive treatment measures of the anti-sliding support combined with integrated drainage should be adopted for the prevention and control of the water damage to the subgrade. Underground drainage measures could effectively drain groundwater, playing a role in reducing groundwater level and pore water pressure in slip soil.