AbstractThis study examines entropy generation in the peristaltic flow of Johnson–Segalman fluid through a curved channel, considering the effects of Hall and ion slip due to an externally applied magnetic field and activation energy. The fluid dynamics are modeled using a highly nonlinear mathematical framework, which is non‐dimensionalized and simplified with a lubrication approach. Numerical solutions are obtained using the shooting technique to analyze fluid flow properties. The results, presented graphically, provide a comprehensive understanding of the interactions between the non‐Newtonian characteristics of the Johnson–Segalman fluid, entropy generation, and activation energy effects. The study finds that increasing the Hall parameter enhances entropy generation. Higher activation energy increases the rate of chemical reactions and by‐products, raising system randomness. Additionally, reducing the channel curvature or increasing the curvature parameter elevates the system's entropy. These insights are valuable for biomedical and industrial applications.