Slight Correlation Research Articles

Cytokine Profiles of Chronic Urticaria Patients and The Effect of Omalizumab Treatment.

Cytokines are key mediators in immunological and inflammatory conditions, including chronic spontaneous urticaria (CSU). To investigate Th1, Th2, and Th17 cytokine profiles in CSU and to evaluate the possible effect of omalizumab treatment. Patients who were followed up for CSU, as well as healthy volunteers, were included in the study. To assess urticaria activity, the 7-day-Urticaria Activity Score (UAS-7), the Urticaria Control Test (UCT), and the Chronic Urticaria Quality of Life Questionnaire (CU-QoL) were filled. Serum levels of IL-6, IL-17, IL-31, eotaxin, RANTES, TNF-α, and TSLP were analyzed by ELISA and compared in CSU and control groups. The patients were analyzed in two groups as the omalizumab group and the non-omalizumab group based on their treatment status. Total IgE, ESR, CRP, RANTES, and TNF-a were significantly different in the overall comparison of the three groups: CSU-receiving omalizumab, CSU-not receiving omalizumab, and control groups (P <0.01, 0.015, <0.01, <0.01 and <0.01 respectively). Total IgE, CRP, RANTES, and TNF-α values were similar in those who received and did not receive omalizumab, yet these biomarkers were significantly higher in both groups than in the control group (P < 0.05). Statistical significance in ESR was observed only between the CSU-receiving omalizumab group and the control group (P = 0.01). Within the CSU patients, there was a slight but significant correlation between UCT and TNF-α (P = 0.008, r = 0.32) and IL-17 (P = 0.06, r = 0.33) levels. The investigated cytokine profile in CSU patients may differ from healthy controls, particularly with the higher levels of RANTES and TNF-α, and omalizumab treatment does not seem to affect that profile in CSU patients.

Smartphone obsession linked behavioural changes among Indian adolescents.

The best technological gifts of the 21st century are mobile phones, which are especially well-liked to adolescents. Infinite resources with numerous uses and applications are available on modern mobile devices. Adolescents have behavioral changes as a result of its excessive use. Therefore, it is of interest to explore the connection between smartphone obsession and potential behavioral changes. A School based, co relational study was conducted among 100 adolescents at selected schools at Tamil Nadu. Samples were selected by simple random sampling technique. Data were collected to assess the mobile addiction by using Smartphone Addiction Scale - Short Version (SVSAC) and Pediatric symptom checklist - 17was used to evaluate the behavioral changes. Collected data were analyzed by using descriptive and inferential statistics. The Study shows that 52 adolescents had a high smartphone Obsession, in that 37 had negative behavioral changes due to overuse of the smart phone and also had slight positive correlation between smartphone obsession and behavioral changes. A significant relationship was seen between smart phone obsession with behavioral changes (p<0.001) among adolescents. The study concluded that smart phone obsession and behavioral changes having strong connection in adolescents was significantly associated with their behaviors.

Sequential riparian vegetation alteration in Japanese river landscapes

Bare gravel bed channels have been a common landscape feature of the middle reaches of rivers throughout Japan. They are disappearing these days because of vegetation colonization. Vegetation coverage of the riparian zones in the midstream reaches of rivers distributed throughout Japan was investigated using aerial photo images taken in 1946, 1975, and 2010. It was then compared with hydrological and water quality records, locations of dams and weirs, residential conditions of the surrounding areas, sediment yields, and forest coverage of the upstream mountainous areas. Riparian vegetation coverage has substantially increased in the last 70 years, from nearly 0 to 30-40%. Herbaceous vegetation coverage is higher than tree coverage. The total vegetation coverage did not correlate with water quality parameters. However, vegetation coverage had a significant negative correlation with the upstream basin's sediment yield and a slight negative correlation with the maximum flood peak flow rate. It was positively correlated with the terrestrial area fraction between levees. Riparian vegetation coverage was high within the 2 km downstream of dams or weirs, intercepting sediment flows. These results indicated that the gravelly sediment supplied from the upstream and deposited in the midstream at flood time has been the major contributor to keeping the vegetation coverage low rather than flushing by flood water. Reforestation since World War II has reduced the coarse sediment supply into the midstream river channels. This reforestation, together with gravel mining and intercepting sediment flow by dams and weirs, has caused the recent increase in vegetation coverage of the riparian zones. Human intervention can affect the vegetation conditions in riparian zones by decreasing sediment supply to river channels.

Association between serum 25-hydroxyvitamin D and prostate-specific antigen: a retrospective study in men without prostate pathology.

Recently, vitamin D status has been associated with prostate cancer risk. However, some studies argue that there is no association of vitamin D with prostate cancer risk and serum prostate-specific antigen (PSA) concentrations. No clear conclusions can be drawn from the studies found in the literature. Our aim was to assess the relationship between PSA and 25-hydroxyvitamin D [25(OH)D]. We selected 415 individuals without prostate pathologies and subgroups were generated according to age and 25(OH)D. Statistical analyses were performed using Shapiro-Wilk test, Student's t and ANOVA tests, and Pearson's correlation. Besides, the minimum sample size needed to obtain statistically significant results between groups according to 25(OH)D concentration was calculated and a Student's t-test for paired samples was performed to study individuals with two PSA measurements over time, where 25(OH)D concentration increased or decreased more than 25 %. We observed a slight correlation between age and PSA concentration (r=0.379, p<0.001). However, we found no significant differences when we compared PSA concentrations between groups according to 25(OH)D concentrations (p=0.891): 1.25±1.32 μg/L (group with 25(OH)D<50 nmol/L) and 1.17±0.90 (group with 25(OH)D≥50 nmol/L). Pearson's correlation coefficient was close to 0. The minimum samples size to obtain statistically significant results was 815,346 men, and we observed no differences in PSA concentrations in individuals with two measurements. Our findings show no association in men without prostate pathologies, based on 25(OH)D levels.

Pan-cancer genetic analysis of disulfidptosis-related gene set

BackgroundA recent study has identified a novel programmed cell death pathway, termed disulfidptosis, which is based on disulfide proteins. This discovery provides new insight into the mechanisms of cell death and may have implications for therapeutic strategies targeting cell death pathways. This study aimed to evaluate the pan-cancer genomics and clinical association of disulfidptosis and disulfidptosis-related cell death genes, including SLC7A11, INF2, CD2AP, PDLIM1, ACTN4, MYH9, MYH10, IQGAP1, FLNA, FLNB, TLN1, MYL6, ACTB, DSTN, and CAPZB. MethodsUsing multi-omics profiling data, this study provides a comprehensive and systematic characterization of disulfidptosis genes across more than 9000 samples of over 30 types of cancer. ResultsFLNA and FLNB were the two most frequently mutated disulfidptosis cell death genes in cancer. UCEC and SKCM were the two cancer types that have the highest mutation rates while the mutation of ACTN4 was associated with worse survival of CESC and ESCA. Breast cancer was potentially affected by disulfidptosis because its subtypes are different in disulfidptosis gene expression. Similarly, KIRC might also be associated with disulfidptosis. Additionally, the association of disulfidptosis-related cell death genes with survival was analyzed, with MESO and LGG as the top cancer types with survival associated with disulfidptosis cell death genes. The correlation between CNV and survival across multiple cancer types found that UCEC, KIRP, LGG, and KIRC were the top cancer types where the CNV level was associated with survival. There was a negative correlation between expression and methylation for most of the genes and there was only a slight correlation between methylation levels and survival of cancer in LGG. About half of the disulfidptosis-related cell death proteins were associated with the activation of EMT. Disulfidptosis genes were correlated to immune cell infiltration levels in cancers. Multiple compounds were identified as potential drugs that might be affected by disulfidptosis-related cell death for future study. ConclusionDisulfidptosis cell death genes are potentially involved in many cancer types and can be developed as candidates for cancer diagnosis, prognosis, and therapeutic biomarkers.

Validation and comparison of four DNA extraction methods for genetically modified organisms analysis: From DNA quality control to quantification of genetically modified content in real‐life samples matrices

AbstractBackgroundThe analysis of genetically modified organisms (GMOs) in food and feed is broadly based on the detection of target DNA sequences using PCR‐based methods. The first step of a typical workflow in a GMO testing laboratory is DNA extraction and purification. Several DNA extraction methods have been described for this purpose so far. Whatever the method adopted, the yield and the quality of the extracted DNA are essential factors for the success of GMO analysis.ResultsThe DNA extraction yield was variable between the different methods, while quality and efficiency appeared comparable. Each method allowed a different yield and a slight correlation between inhibition and the food/feed matrix extracted was observed. Particularly for challenging matrices, the method used for DNA extraction has a remarkable influence on both the quality and quantity of the recovered DNA. Small variations in value % GM content were observed in complex, heterogeneous matrices but not in CRMs and homogeneous matrices.ConclusionsIn this study, the purpose is not to establish the best method of extraction but to examine several parameters that play an important role in GMO detection and verify a possible effect on the quantified GMO percentage. In particular, it was found that the yield and quality of extracted DNA depends on the type of sample, notably the degree of processing, composition, particle size, and the protocol used, especially in relation to sample intake. The slightly different GM content observed in heterogeneous matrices could raise doubt in the case of samples close to the legal threshold.

The complex relationship between carbon literacy and pro-environmental actions among engineering students

Lifestyle choices and consumption play a large role in contributing to per capita greenhouse gas emissions. Certain activities, like fossil fuel ground transportation, long-haul flights, diets with animal products and residential heating and cooling contribute significantly to per capita emissions. There is uncertainty around whether literacy about these actions encourages individuals to act pro-environmentally to reduce personal carbon footprints or to prioritize the most effective actions. This study investigated the relationship between carbon literacy and pro-environmental actions performed to reduce greenhouse gas emissions among undergraduate engineering students at the University of Toronto. The pro-environmental actions by the participants produced an average carbon footprint of 4.8 tCO2 (within the subset of actions included in the survey) which was lower than the average for residents each of Toronto, Ontario, and Canada overall but still higher than the global target of ∼2.8 tCO2e. The carbon literacy by participants was best for high impact actions like ground transportation and dietary choices but less so for air travel and there was mixed awareness for the moderate and low impact actions. For high impact actions and many moderate and low impact actions, participants who thought the action was high impact (even if incorrect) had lower carbon footprints related to the associated activity than those who thought the action was moderate or low impact. The overall relationship between pro-environmental action and carbon literacy was weak. It showed that for high impact actions, there is a slight negative correlation between carbon literacy and personal carbon footprint whereas for moderate and low impact actions, there is a positive correlation.

Evaluating the Primary Macronutrients and their Correlations with pH, Electrical conductivity, Organic Carbon and Soil Nutrient index in the Arid and Semi-Arid Climatic Zones of Anantapur District, Andhra Pradesh, India

In the year 2022, the study was carried at Agricultural Research Station, Anantapur aimed to assess macronutrient levels and their correlation with soil physico chemical properties in the arid and semi-arid regions of Anantapur district, Andhra Pradesh. A total 42 samples were collected from farmers field under different land use. The soil analysis revealed a pH range of 6.53 to 8.94, with a mean pH of 7.89 and a majority of samples exhibiting alkaline properties. Soil electrical conductivity (EC) varied from 0.05 to 0.83 dS/m, with a mean EC of 0.22 dS/m, and most samples falling within the non-saline and very low salinity categories. Organic carbon content ranged from 0.07% to 1.15% with a mean of 0.38%, and a significant proportion of samples displayed low organic carbon levels. Available nitrogen content ranged from 50.4 to 264.6 kg/ha (mean: 139.44 kg/ha), mostly below the critical threshold. Phosphorus availability was medium (range: 16.1 to 44 kg/ha, mean: 29.97 kg/ha), while available potassium content varied widely (range: 15.68 to 311 kg/ha, mean: 129.65 kg/ha), with a substantial proportion of samples indicating low levels. The nutrient index categorized nitrogen and potassium as low in fertility and phosphorus as medium, reflecting values of 0.71, 1.37, and 1.09 (L, M, L) respectively. Correlations showed EC negatively related to pH (-0.056), while organic carbon positively correlated with EC (0.288*), and nitrogen displayed positive correlations with both organic carbon (0.283*) and pH (0.257). Phosphorus exhibited a positive correlation with organic carbon (0.224), and potassium displayed robust positive correlations with EC (0.592**) and moderate positive correlations with organic carbon (0.392**), nitrogen (0.311*), and a slight negative correlation with pH (-0.253). This result helps to understand nutrient status in the arid and semi-arid areas of Anantapur and recommended to incorporate compost, crop residues and green manure crops and use cover crops as live mulching helps to increase organic carbon, nitrogen and potassium and it also decrease nitrogen losses through volatilization.

A Method for Evaluation of Streetscapes: Relationship between Visual Entropy and Interesting Streetscape

The present research studies the complexity of urban facades, which is related to the visual diversity and correlation of the components of urban facades. It studies how the complexity of urban facades affects their desirability amongst citizens and what their preferences are when it comes to facade complexity. In addition, it addresses the complexity of urban facades in both quantitative and qualitative forms and investigates the relationship between quantitative and qualitative data and the desirability of using the correlation analysis method in urban facades.&#x0D; To obtain quantitative data, a survey was conducted on Nowshahr citizens, and the data was analyzed through MATLAB software. The data obtained is the image entropy, which indicates the number of image irregularities. The results indicated that the Nowshahr citizens prefer the second complexity level, then the first complexity level, followed by the third complexity level, and finally the fourth complexity level, respectively.&#x0D; There is a slight correlation in the results of the quantitative-qualitative data comparison. Therefore, using entropy as a measure of complexity cannot be confirmed in this study, and further research is needed.

Portfolio Selection in the Field of Social Media

With the development of the Internet and the popularity of smart phones, social media has become the new mode of communication in the global world and covered many aspects of live of people such as working and education. The rise of the e-commerce economy has also increased the economic value of social media platforms. Therefore, this market is growing rapidly and has great investment value. This paper has created a portfolio of five stocks including Meta, Twitter, Tencent, Pinterest and Match Group in social media market to analyze the viability. Portfolio diversification plays an important role in reducing risk, and the capital asset pricing model (CAPM) explains the relationship between market and unsystematic (portfolio) risk. In Excel sheet, it builds two models to find the optimal weights of portfolio and Sharp ratio by using the Solver tool and the CAPM. The research shows that there is a certain correlation between each asset of the portfolio, and it is easily affected by the uncertainty of social media, which increases the risk of the portfolio. When investing a portfolio in real life, investors could select assets with slight correlation in different industries, which could reduce risk and uncertainty effectively.

Glucose metabolism in posterior cingulate cortex has supplementary value to predict the progression of cognitively unimpaired to dementia due to Alzheimer's disease: an exploratory study of 18F-FDG-PET.

Amyloid-β (Aβ) and tau are important biomarkers to predict the progression of cognitively unimpaired (CU) to dementia due to Alzheimer's disease (AD), according to the diagnosis framework from the US National Institute on Aging and the Alzheimer's Association (NIA-AA). However, it is clinically difficult to predict those subjects who were already with Aβ positive (A +) or tau positive (T +). As a typical characteristic of neurodegeneration in the diagnosis framework, the hypometabolism of the posterior cingulate cortex (PCC) has significant clinical value in the early prediction and prevention of AD. In this paper, we proposed the glucose metabolism in the PCC as a biomarker supplement to Aβ and tau biomarkers. First, we calculated the standard uptake value ratio (SUVR) of PCC based on fluorodeoxyglucose positron emission computed tomography (FDG PET) imaging. Secondly, we performed Kaplan-Meier (KM) survival analyses to explore the predictive performance of PCC SUVR, and the hazard ratio (HR) was calculated. Finally, we performed Pearson correlation analyses to explore the physiological significance of PCC SUVR. As a result, the PCC SUVR showed a consistent downward trend along the AD continuum. KM analyses showed better predictive performance when we combined PCC SUVR with cerebro-spinal fluid (CSF) Aβ42 (from HR = 2.56 to 3.00 within 5years; from HR = 2.76 to 4.20 within 10years) and ptau-181 (from 2.83 to 3.91 within 5years; from HR = 2.32 to 4.17 within 10years). There was a slight correlation between Aβ42/Aβ40 and PCC SUVR (r = 0.14, p = 0.02). In addition, several cognition scales were also correlated to PCC SUVR (from r = -0.407 to 0.383, p < 0.05). Our results showed that glucose metabolism in PCC may be a potential biomarker supplement to the Aβ and tau biomarkers to predict the progression of CU to AD.

Varietal and environmental influences on organoleptic and cooking quality of water yam (Dioscorea alata) landraces.

Yam is a major staple food that provides both energy (starch) and bioactive compounds. However, there is a lack of knowledge on its cooking quality. We have determined the cooking quality of five varieties of water yam (among those most appreciated by consumers), when they were steamed or boiled. The yams were grown in two contrasting locations with regard to pedoclimatic conditions. Ratio of length to mean circumference of the tuber, difficulty to peel, cooking time, color attributes, hardness of steamed pulp, and dry matter (DM) and starch contents significantly varied among varieties. Cooking time and hardness of the cooked pulp, either steamed or boiled, were higher for tubers grown at the drier location, with vertisols, than at the rainy one, with a ferralitic soil. The raw pulp was richer in starch at the rainy location. We found no correlation between either textural properties or DM and the cooking time. A slight (r = 0.44) but significant correlation was recorded between the DM of the raw pulp and the hardness of the steamed product. We propose a comprehensive multicriteria approach for determination of yam cooking quality, textural properties, color attributes and chemical composition, along with varietal and environmental influences. This approach takes into consideration the complexity of food quality, allows a better understanding of its determinants and provides a basis for useful guidelines for breeders. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Application of multi-echo Dixon and MRS in quantifying hepatic fat content and staging liver fibrosis

This study associated the liver proton density fat fraction (PDFF), measured by multi-echo Dixon (ME-Dixon) and breath-hold single-voxel high-speed T2-corrected multi-echo 1H magnetic resonance spectroscopy (HISTO) at 1.5 T, with serum biomarkers and liver fibrosis stages. This prospective study enrolled 75 patients suspected of liver fibrosis and scheduled for liver biopsy and 23 healthy participants with normal liver function. The participant underwent ME-Dixon and HISTO scanning. The agreement of PDFF measured by ME-Dixon (PDFF-D) and HISTO (PDFF-H) were compared. Correlations between PDFF and serum fat biomarkers (total cholesterol, triglyceride, and high- and low-density lipoproteins) and the liver fibrosis stages were assessed. PDFF were compared among the liver fibrosis stages (F0–F4) based on clinical liver biopsies. The Bland–Altman plot showed agreement between PDFF-D and PDFF-H(LoA, − 4.44 to 6.75), which have high consistency (ICC 0.752, P < 0.001). The correlations with the blood serum markers were mild to moderate (PDFF-H: r = 0.261–0.410, P < 0.01; PDFF-D: r = 0.265–0.367, P < 0.01). PDFF-D, PDFF-H, and steatosis were distributed similarly among the liver fibrosis stages. PDFF-H showed a slight negative correlation with the liver fibrosis stages (r = − 0.220, P = 0.04). Both ME-Dixon and HISTO sequences measured liver fat content noninvasively. Liver fat content was not directly associated with liver fibrosis stages.

Use of a propofol infusion for anaesthetic maintenance in Guinea pigs (Cavia porcellus): a retrospective case series

ObjectiveTo retrospectively evaluate the feasibility of a propofol infusion for anaesthetic maintenance in guinea pigs. Study designRetrospective case series. AnimalsClient-owned guinea pigs undergoing general anaesthesia. MethodsAnaesthetic records of guinea pigs anaesthetized between March 2015 and March 2018 were reviewed. Animals administered a propofol infusion for > 20 minutes were identified and evaluated. Procedure performed, pre-anaesthetic medication, preoperative and intraoperative respiratory rate (fR) and heart rates (HRs), total amount of propofol administered, total anaesthesia and recovery times were extracted from the records and analysed using descriptive statistics and Pearson correlation tests. Data are reported as mean (range). ResultsRecords of 14 animals meeting the criteria were identified. Following drug combinations were administered for premedication: butorphanol 0.43 (0.3–0.5) mg kg–1, medetomidine 0.1 (0.05–0.2) mg kg–1 and midazolam 1 (0.5–2) mg kg–1 (n = 3); methadone 0.33 (0.25–0.5) mg kg–1, medetomidine 0.07 (0.01–0.1) mg kg–1 and midazolam 0.66 (0.5–1) mg kg–1 (n = 3); butorphanol 0.5 mg kg–1, medetomidine 0.05 mg kg–1 and ketamine 5 mg kg–1 (n = 2); buprenorphine 0.01 mg kg–1, medetomidine 0.07 (0.04–1) mg kg–1 and ketamine 4 (3–5) mg kg–1 (n = 3); butorphanol 0.5 mg kg–1, alfaxalone 1 mg kg–1 and midazolam 0.5 mg kg–1 (n = 1); and methadone 0.38 (0.25–0.5) mg kg–1, medetomidine 0.08 (0.06–1) mg kg–1 with midazolam 0.75 (0.5–1) mg kg–1 (n = 2).Preoperative and intraoperative HRs were 240 (160–300) and 170 (140–200) beats minute–1, respectively. Preoperative and intraoperative fR were 63 (50–86) and 37 (18–80) breaths minute–1, respectively. The propofol infusion rate was 0.45 (0.17–0.80) mg kg–1 minute–1. Total anaesthesia and recovery times were 60 (25–145) and 17 (8–60) minutes, respectively. A slight correlation was found between total propofol dose infused and recovery time (r = 0.58). Conclusion and clinical relevancePropofol infusions may be a useful alternative to inhalant anaesthetics.

Antibody response to pneumococcal conjugate vaccine 10 among Nigerian children under 5 years.

Invasive pneumococcal diseases have been a major contributor to childhood mortality, particularly in the developing world and pneumococcal vaccines were introduced to reduce the burden. The Pneumococcal Conjugate Vaccine 10 (PCV 10) was incorporated into the Nigerian National Programme on Immunization (NPI) in 2014 to reduce the incidence of childhood pneumococcal infections. This study was done to determine the immunogenicity of the vaccine in our clime. This cross-sectional study was carried out between September 2019 and January 2020 at the Children Outpatient Clinic of the Federal Medical Center, Owerri, Nigeria. Two hundred and forty five children between the ages of 20 weeks and 59 months, who had received three doses of Pneumococcal Conjugate Vaccine 10 (PCV 10) at 6, 10 and 14 weeks according to the NPI schedule, were recruited into the study. The anti-pneumococcal PCV 10 IgG concentration was determined using Human Anti-Pneumococcal CPS 10 IgG vaccine ELISA Kit ®. Simple proportions, means and median (as appropriate) were used to analyse the data. Kruskal Wallis test and Spearman's correlation were done to test association. Significance was set as p< 0.05. The mean anti-pneumococcal IgG concentration was 11.01±1.23 IU/ml and all the study participants formed protective levels of anti-pneumococcal IgG. There was a slight positive correlation between antibody response and age (r=0.13, p=0.04), and the antibody response was slightly more in males than females. All the children under the age of five years who had received PCV 10 at 6, 10 and 14 weeks of age, who participated in this study formed protective levels of antibodies to the vaccine. Antibody levels increased slightly with age. The PCV 10 currently used in the Nigerian programme is sufficiently antigenic and a downward trend in pneumococcal diseases should soon be noticeable.

Anatomical morphometry for Cricothyrotomy puncture and incision

PurposeEmergency surgical airway securing techniques include cricothyrotomy, puncture, and incision. While the instruments used for these methods vary in size, no index of laryngeal morphology exists to guide instrument selection. Therefore, we measured the morphology of the cricothyroid ligament in Japanese individuals and assessed its correlations with height.MethodsThis retrospective study used 61 anatomical practice specimens. The cricothyroid ligament of the laryngeal area was dissected, and a frontal image was recorded. Next, images of the midsagittal sections of the larynx and trachea were recorded. The width and height of the cricothyroid ligament were measured from the frontal images, and the depth of the larynx and the angle to the lower edge of the cricothyroid plate were measured from the mid-sagittal cross-sectional images. The height was estimated from the tibial lengths of the specimens and statistically analyzed for correlations. ResultsThe width and depth were significantly greater in males. Overall, there was a slight correlation between the results of each laryngeal measurement and estimated height for all items.ConclusionThe morphology of cricothyrotomy revealed that the width and depth of the laryngeal area varied according to sex. Moreover, the results also showed a correlation with the estimated height. Thus, it is important to predict the morphology of the laryngeal area and cricothyroid ligament by considering factors such as patient sex, weight, and height.

The Concentration of PCSK9-Lp(a) Complexes and the Level of Blood Monocytes in Males with Coronary Atherosclerosis.

In this study we analyzed the concentration of lipoprotein(a) (Lp(a)), PCSK9-Lp(a) complexes and the circulating monocyte subsets in coronary atherosclerosis. For this study, 257 patients with coronary atherosclerosis and 68 patients without stenotic atherosclerosis in the coronary, carotid and lower extremity arteries (control group) were enrolled. The monocyte subpopulations (classical CD14++CD16-, intermediate CD14++CD16+ and non-classical CD14+CD16++) were analyzed by direct immunofluorescence and flow cytometry. The Lp(a) and PCSK9-Lp(a) complexes in the serum were detected by ELISA. The concentration of Lp(a) was higher in the coronary atherosclerosis group compared with the controls (23.0 (9.1; 73.3) mg/dL versus 10.7 (4.7; 25.0) mg/dL, p < 0.05). No correlations between the level of Lp(a) and the concentration of the PCSK9-Lp(a) complexes, nor between the level of Lp(a) or PCSK9 and the total number of monocytes, were observed in either group. A slight positive correlation between the concentration of PCSK9-Lp(a) complexes and the absolute level of monocytes was obtained (r = 0.20, p = 0.002) in the patients with atherosclerosis due to the intermediate monocyte subsets (r = 0.33, p = 0.04). According to regression analysis, both the PCSK9-Lp(a) complexes concentration and BMI were related to the absolute number of blood monocytes in patients with atherosclerosis. Further studies are required to determine the pathogenetic contribution of PCSK9-Lp(a) complexes to the development of atherosclerosis.

New insights into pore fractal dimension from mercury injection capillary pressure in tight sandstone

Mercury injection capillary pressure (MICP) has been widely used for pore fractal dimension determination and thus leads to a variety of calculation models with different results. Here, taking the tight sandstone gas reservoir of Shaximiao Formation in Jinhua-Zhongtaishan area, central Sichuan Basin as the object, the theory, method and application of pore fractal dimension determination from MICP are explored. Based on Yu-Xia model and Washburn equation, rigorous analytical expressions on fractal dimension, capillary pressure and mercury saturation are deduced. After pre-processing including validation, consistency correction and shape-preserving interpolation, the fractal turning point is located with the local maximum of the front-back moving variance ratio of mercury saturation, and then the global, macropore and micropore fractal dimensions are determined respectively by nonlinear fitting. As suggested by the data processing results of the 39 MICP samples, there is no significant direct correlation between pore fractal dimensions and petrophysical properties represented by permeability. However, the combination of fractal model related parameters, especially global fractal dimension and entry pressure, can identify effectively reservoir quality ranks. Meanwhile, for gas layers with relatively high permeability, larger global fractal dimensions may imply roughly more favorable pore structure and better reservoir quality, while the total quality of the relatively low-permeability gas layers is poor and nearly independent of the fractal dimensions. The representative MICP-based pore fractal models, He-Hua and Shen-Li, are critically reviewed. The theoretical simplification and calculative approximate of these two models lead to some degree of error in pore fractal dimension determination, despite their slight correlation in the fitting results with those of the present model. This study may improve the understanding of the pore fractal dimension determined from MICP and provide reference for pore structure evaluation, reservoir quality classification and capillary pressure modeling.

Determining the Effect of Social and Academic Support on STEM Confidence and Learning Environment Among Female Engineering Students in Pakistan

Gender inclusion and female participation in STEM courses have always been challenging in a patriarchal country like Pakistan. Women are often underrepresented in engineering fields, as engineering fields are usually considered manly. Female students confront many challenges, be it workplace or educational institutes. Some of the self-perceived and determined challenges are discussed in this study. As determined through this research study, factors affecting female participation are low STEM confidence, Gender disparity, Social and Academic Support, and Learning Environment. Empirical Evidence is collected using a questionnaire with 25 items based on the Likert scale. The dependent variables are STEM Confidence and Learning Environment, whereas the independent variables are Social and Academic Support. Participants included 170 female UG and PG engineering students from 4 universities in Pakistan. Data were collected through the Questionnaire, which included an online survey. Correlation method and statistical test MANOVA were applied, using SPSS 21 to determine the effect of social and academic support on STEM confidence of female students and to find a relationship between the variables. Results indicate a positive correlation between the variables STEM confidence and social and academic Support and Learning environment, whereas a slight correlation has been observed between social Support and LE. MANOVA results indicated a significant effect of Social and Academic Support on the STEM confidence of female students. Empirical Evidence shows that Social and academic support can affect the STEM of female engineering students, and the LE of females can also be affected by social and academic Support.

A New Approach to the Development of Hollow Fiber Membrane Modules for Water Treatment: Mixed Polymer Matrices.

In this study, mixed matrix hollow fiber polymeric membranes were prepared using polyethersulfone (PES) and polyvinylidene fluoride (PVDF) as polymers in their composition. N-methyl-2-pyrrolidone (NMP) was used as a solvent and demineralized water with an electrical conductivity below 3 μS·cm-1 was used as a non-solvent. A new approach to producing enhanced polymeric hollow fiber membranes based on the preparation of a simple blend PVDF/PES solution, and on the conformation of the composite membranes through the extrusion technique followed by the phase inversion process in a non-solvent bath, was applied. The investigation focused on the preparation of polymeric membranes with different polymer ratios and further assessment of the effects of these proportions on the membrane performance and in specific physical properties. The amount of PVDF ranged from 10 to 90% with 10% steps. The presence of PVDF, although it increased the membranes' plasticity, had a negative effect on the overall mechanical properties of the composite membranes. Scanning electron microscopy (SEM) results showed good dispersion of both polymers in the polymeric matrix. Furthermore, the membrane permeability showed a slight negative correlation with contact angle, suggesting that membrane hydrophilicity played an important role in membrane permeability. Finally, it was found that membranes with low ratios of PVDF/PES may have potential for water treatment applications, due to the combined advantageous properties of PES and PVDF.