Abstract: Quintuple friction pendulum (QFPS) bearing is a new generation sliding isolation system having multiple spherical sliding surfaces. The friction isolation system with single sliding surface is designed for a specific level of ground shaking, which may prove ineffective in case of other hazard levels. The QFPS bearing on the other hand, exhibits adaptive behavior and imparts greater amount of flexibility to the designer for various levels of earthquake shaking. Here, the effectiveness of Quintuple Friction pendulum system is carried out to study the seismic demands of base-isolated building frames with stiffness irregularities and plan irregularities subjected to various earthquake ground motions i.e. Far field ground motion, near field ground motion with fling step and near field ground motion with forward directivity by comparing their estimates with the benchmark responses obtained by the Non-Linear Time History Analysis (NLTHA). SAP 2000 Software has been used for the same. The two soft storey buildings and two buildings with plan irregularity will be modelled and analyzed. The seismic demands namely, Inter story drift, peak storey acceleration, maximum base shear are considered for the study.The reduction in absolute acceleration is found more in case of PI as compared to SS for all the considered time histories. The reduction in Maximum Base-Shear is found more in case of Plan irregularity as compared to Stiffness Irregularity (Soft Story) in all the considered Time History. In isolated structure, the Inter-storey drift is found to be maximum in case of structure having soft storey as compared to plan irregularity 1 and 2. Keywords: Multi storied RC structures, Plan irregularities, Soft storey, Quintuple Friction Pendulum, Non linear Time History Method(NLTHM)