CKD patients must undergo regular therapy, one of them is hemodialysis. Side effects of hemodialysis therapy that are often encountered are pain and sleep quality disorders. PMR is one of the non-pharmacological therapies that can be applied to CKD patients who experience nausea and pain and impaired sleep quality. The design of this study was quasy-experimental time series design with a pre-test and post-test design with control group design. Sampling with simple random sampling technique consisted of 50 respondents in the intervention group and 50 respondents in the control group with bivariate analysis using chi square. PMR is given every day for 4 weeks. Research instruments use BPI and PSQI. The results of the study there were differences in the level of pain and sleep quality between the control group and the intervention group with a value of p <0.05. Non-pharmacological therapy for PMR can be applied to hemodialysis patients who experience pain and impaired sleep quality, so that quality of life increases