Slavic Population Research Articles

Rs11927381 Polymorphism and Type 2 Diabetes Mellitus: Contribution of Smoking to the Realization of Susceptibility to the Disease.

In the study that included 579 patients with type 2 diabetes mellitus and 542 healthy individuals from Slavonic population, an association was found between IGF2BP2 gene rs11927381 polymorphism and increased risk of developing the disease. However, this association was observed for smoking patients and was not detected for non-smokers. Bioinformatics analysis showed that the spectrum of transcription factors binding with high-risk C allele differ from the spectrum of transcription factors specifically binding with the reference T allele; these factors are involved in the regulation of the biosynthesis of ketone bodies and cellular response to glucocorticoid hormones. The results suggest that smoking plays a trigger role in the relationship of the polymorphic variant rs11927381 of the IGF2BP2 gene with the development of type 2 diabetes mellitus.

Patterns and Mechanisms of Lexical Changes in the Languages of Symbiotic Communities: Kinship Terminology in Karashevo (Banat, Romania)

This article deals with the ethnolinguistic situation in one of the most archaic areas of language and cultural contact between South Slavic and Eastern Romance populations — the Karashevo microregion in Banat, Romania. For the first time, the lexical-semantic group of kinship terms in the Krashovani dialects from the Slavic-speaking village of Carașova and the Romanian-speaking village of Iabalcea is being analysed in a comparative perspective as two separate linguistic codes which “serve” the same local culture. The main goal of the research was to investigate patterns of borrowing mechanisms which could link lexical (sub)systems of spiritual cultureunder the conditions of intimate language contact in symbiotic communities. It will be shown that, in such situations, the equivalent translation becomes relevant as a specific strategy of linguistic code interrelationships. Even though kinship terminology in closely contacting dialectshas the potential to help linguists trace back the socio-historical conditions and outcomes of language contact (such as marriage patterns), linguistic methods have their limitations in the case of poorly documented vernaculars. These limitations could be overcome by compiling more data on “isocontacting” communities and, possibly, by analysing this data using quantitative tools.

REFLECTION OF ETHNOCULTURAL INTERACTION IN THE MICROTOPONYMICS OF THE MIDDLE VOLGA REGION

The microtoponymy of the Middle Volga region is of particular interest to the author because of the polyethnic and multilingual environment. It is a region of cohabitation of Slavic, Turkic and Finno-Ugric population groups. The facts of ethnocultural interaction are revealed in substrate microtoponyms, which often have Turkic origins.There are also Finno-Volga substratum elements.Many of them were reinterpreted in Russian language.

A magyar keresztény terminológia bizánci rítusú szláv elemei

The 10th­century Byzantine conversion of Hungarians was carried out through Slavic media-tion, as there were many Slavic­Hungarian bilinguals among the Hungarians settled in the midst of Slavic population, and Slavic­Greek bilingual missionaries were easy to find in the Balkan provinces of the Byzantine Empire (e.g. in Macedonia). Most of the early Slavic borrowings to Hungarian came from the Slavic substrate of the Carpathian Basin (Pannonian Slavic), and this is also true of Christian terminology. Due to the high degree of similarity between 10th­century Slavic dialects, it is difficult to separate terms locally borrowed from Pannonian Slavs from those introduced by the Byzantine missionaries speaking Slavic in Hungary. However, there are some words and expres-sions of Balkans origin (hálát ad ‘give thanks’, karácsony ‘Christmas’, pitvar ‘porch’, formerly ‘limbo, edge of Hell’, etc.) that could hardly have been found in Pannonian Slavic; these were most probably brought by the Byzantine missionaries and spread among the Hungarians.

Ethnoconfessional features and national-cultural life of the Ruthenian population of the Habsburg monarchy in the perception of M. M. Levchenko in 1849

The article is devoted to the publication published in 1855 by Mikhail Mikhailovich Levchenko (1830–1891 or 1892) “Memories of the campaign in Hungary in 1849. (Notes of an infantryman)”. A member of the Hungarian campaign, infantry officer M. M. Levchenko (a little Russian patriot, later a well-known lexicographer and ethnographer) personally got acquainted with the life of various peoples of the Austrian Empire. The officer paid considerable attention to the East Slavic population of Hungary and Galicia — Ruthenians. Unlike other participants of the Hungarian campaign, whose diaries and memoirs were published, Levchenko was initially keenly interested in Slavs, so he clearly characterized the Ruthenians as “tribesmen of our Little Russians”. At the same time, despite certain knowledge in the field of Slavic studies, Levchenko’s text also contains obvious inaccuracies, which are analyzed in this article. Levchenko was greatly impressed by the nascent national and cultural life of Ruthenians, especially Galicians, and the development of literature and education. Apparently, Levchenko’s stay in 1849 in the lands of the Habsburg monarchy with an East Slavic population had a noticeable impact on all his further activities. Thus, it is noteworthy that Levchenko popularized in Russia the ethnonym Rusyn as a national name for all Little Russians and Ruthenians.

The Interaction of Slavic Traditions in the Eastern Carpathians (On the Material of Demonological Vocabulary)

Slavic–non-Slavic contacts in the Carpathian region have long attracted the attention of researchers. Less attention has been paid to the interaction between different Slavic traditions. The difficulties of studying closely related traditions are obvious. At the same time, understanding of the convergent processes between them, the direction of cultural borrowing, etc., can provide additional information on the history of the studied peoples and the development of their languages. The analysis of demonyms allows us to draw preliminary conclusions about the processes of interference and cultural exchange over a wide area of the borderlands of Poland and Slovakia in the Eastern Carpathians, where in the 14th century the East Slavic population (Rusyns, Lemkos) developed. A detailed analysis of some demonyms, taking into account their form and semantics, distribution areas, and etymology, showed that, for example, the term boginka ‘forest woman abducting children’ should be distinguished from bohiňa ‘healer, sorceress’, and that there is another etymological possibility for the word boginka; that it spread in the region from the Polish-speaking areas. A common Slavic term with the root *jęg- (baba Yaga, ježibaba, etc.) demonstrates formal and semantic differences in the East, West, and South Slavic language groups. The Carpathian Rusyns eventually adopted the West Slavic look and meaning of the word (hindžibaba ‘witch, wild woman’). From Polish demonology, a character called mamuna came to the Slovaks and Rusyns. Surprisingly, the Rusyns were practically unaffected by the West Slavic image of the mora / mara; the latter remained generally within the framework of East Slavic reflections and root vowels. Other terms were also analysed. In general, it can be stated that despite the common Carpathian layer, the national Slavic demonologies in the Eastern Carpathians are distinctly different; they do not mix much and do not easily borrow names and images from each other.

Dynamics of ecosystems and land use in the Dnieper left-bank forest-steppe for the last two thousand years: Kurilovka 2 case study

The paper presents the first results of comprehensive studies of the multi-layer settlement Kurilovka 2 (Kursk region, Russia). It is located on a remnant of a low terrace above the floodplain of the Sudzha River (tributary of the Psel River – tributary of the Dnieper). The site contains archaeological materials of two main periods: proto- and early Slavonic (2nd – 8th centuries) and the Modern Period (end of the 17th – 20th century). The mail attention is paid to the results of archaeological, pedological, palynological, phytolith, anthracological study of the soil profile/archaeological pit 10/2016, located within the boundaries of the habitation zone. The data obtained allow us to reconstruct the history of the site development and dynamics of the site-encasing ecosystems over the past two thousand years. The area was initially forested and cleared for shifting agriculture, probably by the proto- and early Slavonic population. At the end of the 1st millennium AD the settlement was abandoned. The site was reforested and cleared again in the Modern Period. Now the arable land is not farmed, the site is covered with the herbaceous vegetation.

The Nomadic Component of the Middle Dnieper (Right Bank Ukraine) Population of Ancient Rus Time According to Anthropological Data

The relationship between the nomadic and Slavic population of the Middle Dnieper during Kievan Rus period was considered by historians, archaeologists and linguists. The issue connected with the influence of nomads on the anthropological composition of the population formation in the region was considered poorly by anthropologists. Anthropologists associated separate skulls with people from nomadic groups, the Caucasoid features of which were weakened (flattening of the facial skeleton). The number of such skulls at Christian burial grounds of the Middle Dnieper is insignificant. However, among the nomad populations of Eastern Europe there were groups with pronounced Caucasoid features. These are primarily groups genetically related to the Caucasus. In this work, craniological materials from 12 Ancient Rus series were considered in a wide range of groups that represent the nomadic peoples of Eastern Europe. The analysis included nomadic groups of steppe regions of Ukraine, the Caucasus, the Don region and the Volga region (V—XIII c.). Statistical processing of materials was carried out using the Systat software package. For the Ancient Rus period, the biological presence of people who were genetically associated with the Alanian (Iranian-speaking) groups is recorded in this region. They dominate at two burial grounds out of 12. The Alans were a group with Caucasoid features. They were one of the components of the Saltovo-Mayakш culture population. Еру Alans are represented at the medieval burial grounds of the North Caucasus. Their physical presence is recorded at a number of Lower Dnieper burial grounds. The Alans (Jassy) could also be a part of the Chorni Klobuky Union. Perhaps they were more ready to accept Christian ideas and that is why they were better integrated into the Slavic environment. All Turkic series turned out to be morphologically and statistically far removed from the Slavic groups of the Middle Dnieper (Right Bank Ukraine). This is especially true for Polovtsians and Pechenegs. For these groups of nomads, brachycrania (or a tendency towards it), large face sizes, and weakened profiling of the facial skeleton were typical.

Determinants of regional fertility in Russia: a dynamic panel data analysis

ABSTRACTThe aim of this paper is to empirically examine the regional determinants of the fertility rate in Russia using panel data for the period of 2005–2015. The estimation results of a system GMM dynamic model revealed that economic growth, employment opportunity, favourable local business conditions, educational opportunity, quality of social infrastructure, and housing supply serve to increase the fertility rate in Russian regions, while the presence of a Slavic population, migration inflow, poverty and ecological risks tend to suppress it. Furthermore, we found that combinations of factors that strongly affect the reproductive behaviour of Russian women vary greatly among age groups and regions. To mitigate the declining trend of fertility in Russia, it is necessary to implement policies that take generational differences and regional heterogeneity into serious consideration.

Briga za narod u dijaspori do latentnog sukoba sa domicilnim narodom – aktualizacija prošlosti na sadašnjost u Bosni i Hercegovini

The beginning of the 19th and the 20th century marked the period of nations’ constitution in southeastern Europe and greater care for nations’ oases living out of their parent nations. Sometimes that care turned into intended or unintended hegemony over other nations. This phenomenon is actual even today in various nations, especially in the Balkans, so it is interesting how "the care of the people out of their home country" (nowadays people would say "diaspora"), implemented various "actions" that were sometimes politically conducted from the Austro-Hungarian centres of power to the territory of Bosnia and Herzegovina, Croatia and Slavonia, especially in the case of the Hungarian government's pro-government project "Julian Action".So-called Julian Action was not unique at that time, neither it was the only, nor the first or special, but it can be somewhat comparable to the same work methodology in the same regions, for example, with the similar German project Schulvereine, the Italian action by Dante Alighieri, and even to not so significant Slavic action of the Cyril and Methodius societies, as well as to some other less-known "actions" that operated abroad, i.e. mainly outside the home countries, on the territory of Austria-Hungary. The opposite views were mostly manifested in the interpretation of justification, e. g. of Julian Action (which got the prosaic name). For instance, the Hungarian side (similar to German, Italian ... through their associations), justified the action of the association "Julian" by the care of its own people outside the borders of the home state (in order to preserve identity, culture and language). On the contrary, the Croatian (and also Bosnian-Herzegovinian,…) side in the activity of the "Julian" organization recognized a sort of political alienation and Hungarization (or Germanization, Italianization, ...) of the majority of domicile population. The Hungarian Julian campaign was conducted on the basis of: A) Statute of the Julian Society, (voted in 1903), and B) Hungarian, Bosnian-Herzegovinian and Croatian-Slavonic-Dalmatian laws. For example, the Hungarian Julian Schools in Bosnia and Herzegovina, Croatia and Slavonia could be founded, organized and act not only on the basis of the applicable Hungarian laws, but also on the basis of the school laws of Bosnia and Herzegovina, Croatia, Slavonia and Dalmatia, which allowed and even encouraged the organization of public and private schools, rural and wilderness schools (e. g. through Hungarian Julian schools), factory schools (e. g. Hungarian state railway schools), confessional schools (e. g. Hungarian reformatory schools), which opened a wide area of the Hungarian Julian Action operation from 1904 in Croatia and Slavonia, and from the 1908 occupation in Bosnia and Herzegovina. A vast majority of pupils were of non-German nationality, and they were enrolled there because of better conditions, employment opportunities in enterprises, state and public services, as well as because of future education. Hungarian schools and Hungarian railways, as well as Hungarian churches and societies in Croatia and Slavonia, existed in the second half of the 19th century. They had the purpose of implementing the so-called Hungarian State Thought (Magyar Állami eszme), which had been politically instrumentalized. Since 1904 until the end of the First World War they put the so-called Julian action into their systems and programmes. Almost identical relationship had existed in Bosnia and Herzegovina since 1908. There were constant conflicts between the state of Hungary and Julian campaign with the majority of Slavic population outside of Hungary, for example, in Bosnia and Herzegovina. When the Julian campaign was politically instrumentalized because of “taking care of its people in diaspora", and in some parts crossed the boundaries of "preserving" them, it began with "unintentional" assimilation through schools, railways and cultural societies. So it necessarily had to come into conflict with other nations. From the Hungarian point of view, the so-called "Bosnian Action" and "Slavonic Action" of the Hungarian Government were directed towards the care of Hungarians in the so-called "affiliated" and annexed province, as well as to strengthening and expansion of Hungarian influence in the countries where the majority of population were Muslims-Bosnians, Serbs and Croats. The same action ranged from the accusation of "Hungarianization” to the theory of the Hungarians threatened by assimilation; however, the action did not achieve a long-term goal and did not prove permanent because, after the end of the First World War, a small group of Hungarians in the newly established countries did not have any legal guarantees, and new authorities did not ensure its survival.

CFAP300: Mutations in Slavic Patients with Primary Ciliary Dyskinesia and a Role in Ciliary Dynein Arms Trafficking.

Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous hereditary disease from a class of ciliopathies. In spite of the recent progress, the genetic basis of PCD in one-third of patients remains unknown. In search for new genes and/or mutations, whole-exome sequencing was performed in 120 unrelated Polish patients with PCD, in whom no genetic cause of PCD was earlier identified. Among a number of pathogenic variants in PCD genes, mutations in CFAP300 (alias C11orf70) were detected. Extended screening in the whole Polish PCD cohort revealed the relatively high frequency (3.6%) of otherwise rare c.[198_200 del_insCC] variant, indicating that it should be included in population-specific genetic tests for PCD in Slavic populations. Immunofluorescence analysis of the respiratory epithelial cells from patients with CFAP300 mutations revealed the absence or aberrant localization of outer and inner dynein arm markers, consistent with transmission electron microscope images indicating the lack of both dynein arms. Interestingly, the disparate localization of DNAH5 and DNALI1 proteins in patients with CFAP300 mutations suggested differential mechanisms for the trafficking of preassembled outer and inner dynein arms to the axoneme. The profile of CFAP300 expression during ciliogenesis in suspension culture was consistent with its role in cilia assembly. Gene silencing experiments, performed in a model organism, Schmidtea mediterranea (flatworm), pointed to the conserved role of CFAP300 in ciliary function.

Взаимодействие музыкальных культур в контексте современных проблем образования

Статья посвящена актуальной проблеме взаимодействия музыкальных культур в многонациональных регионах юга России. Автор рассматривает особенности традиционной музыки Ростовской области, Ставрополья, Астрахани, Кубани, Карачаево-Черкеcии, Адыгеи и подчёркивает, что её органичное вхождение в академическое искусство происходило в специализированных учебных заведениях музыкальных училищах и музыкальных педагогических институтах. Привлекавшиеся для работы в них педагоги, переплавляя в единое художественное целое местный фольклор и традиции академической музыки, создавали благоприятные условия для формирования нового поколения музыкантов, в произведениях которых находит свое подлинное воплощение диалог культур. Этот опыт, приходит к выводу автор, может быть взят на вооружение современной системой музыкального образования, в связи с чем изучение вопроса не должно прекращаться.The article is devoted to the urgent problem of the interaction of musical cultures in the multinational regions of Southern Russia. In the context of the growing globalization, the search for ideas that can become the basis for intercultural dialogue is becoming relevant. In these conditions, music can be considered as the clearest example of a powerful resource for creating and strengthening the space of interethnic interaction. Russian musical heritage is enormous in its characteristics, distinguished by the wealth of national schools. This heritage is a unique laboratory in which distinctive cultures constantly experience mutual influence thus enriching each other. The author notes that Russian composers constantly turned to Oriental themes not only reflecting the corresponding musical specifics, but also creating a new image of the East in the eyes of their compatriots, acting as artists carrying Russian culture. Currently, this tradition continues, which is shown by an example of the musical culture of the South of Russia, whose development reflects the constant interaction of academic music and folklore. The culture of dialogue, which made the integration of traditional music and academic art possible, originated in specialized educational institutions. The first of these institutions was the Music and Pedagogical Institute (later Rostov State Rakhmaninov Conservatoire), which trained composers whose works expressed all musical forms and genres. The joint work of teachers and students in the early 1970s positively reflected in the work of the Ensemble of Don Cossacks. The founding of Astrakhan State Conservatory (1969) became an important link in the formation of the space for cultural interaction between the peoples of the region (Kalmyks, Volga Germans, Kazakhs, Volga Tatars, etc.). Of great importance for the work of local composers were folklore works recorded on tape during ethnographic expeditions and then decrypted in the form of musical notation. Of considerable importance was the activity of graduates of Astrakhan Conservatory in the neighboring Kalmykia. According to composers and musicologists, the traditional music of the Kalmyk people is notable for its significant originality. One example of cultural interaction in the musical sphere is the Kalmyk dance melody Chichirdyk, which appeared in one of the villages populated by Kalmyks and Ukrainians. In Stavropol Krai, the opening of Stavropol School of Music in 1903 had a positive impact on the local traditional song and dance culture. The musical tradition of this region began to form during the period of active development of the region by the East Slavic population since the end of the 18th century. Krasnodar Krai is the center that has been attracting many ethnic groups, each of which brought its own unique shade to the local musical palette. The carriers of ethnic cultures that actively influenced the formation of the musical picture of the region were the Adyghe, Black Sea Cossacks, Armenians, Greeks, Assyrians and many other peoples. Currently, the Krasnodar Branch of the Union of Composers of Russia includes professionals who are fluent in various genres of music and embody the ideas of dialogue of cultures in the form of musical works.

REVIEW OF MODERN PUBLICATIONS ON THE ETHNIC COMPOSITION OF THE COSSACK ARMIES

A review of modern publications devoted to the study of the ethnic composition of the Don, Kuban, Tersky, Orenburg, Ural, Siberian, Far Eastern Cossack troops is presented. The ethnic and confessional core of the Cossacks was the Orthodox East Slavic population, but it also included representatives of the Turkic-Mongolian and Caucasian peoples who profess Islam and Buddhism. The article provides information provided by Russian, Ukrainian and Kazakh scientists about the main ethnic groups that made up the population of Cossack troops by the end of the 19th century, when in terms of their legal status the Cossacks represented a military service class. The specificity of structuring their identity, characteristic of non-Slavic Cossacks of different troops, the organizational basis of this identity is shown. A description is also given of the interaction of ethno-linguistic and confessional factors in the formation of various identities within the Cossack troops. An analysis of research in this problem area showed that scientific research is more focused on studying the ethnic composition of troops at the stage of their formation and development. The authors of the scientific review conclude that, first of all, researchers need to pay attention to establishing the reasons for the entry of representatives of various ethnic groups into the ranks of the Cossacks, collectivity or individuality in accepting the Cossack status. Secondly, to analyze whether the groups of foreign ethnic Cossacks were the structural units of the local social organization of the Eastern Slavs, or did not depend on it. Thirdly, to what extent the organization of society of different groups of Cossacks was unified or had differences. This is especially important in conditions of absolute quantitative and organizational predominance of the East Slavic Cossacks at the indicated time. Fourth, how did acculturation in the Cossack troops take place and what social institutions and groups implemented this process.

Genetic and clinical characterization of congenital fibrinogen disorders in Polish patients: Identification of three novel fibrinogen gamma chain mutations

IntroductionCongenital fibrinogen disorders are poorly explored in Slavic populations. The aim of this study was to characterize the genetic background and clinical manifestations of fibrinogen disorders in the Polish case series. Materials and methodsIn 27 unrelated patients (mean [SD] age, 30.4 [19.2] years, 30% men) with fibrinogen concentration (von Clauss method) < 1.8 g/L, exons and intron-exon junctions of the fibrinogen alpha chain (FGA), fibrinogen beta chain (FGB), and fibrinogen gamma chain (FGG) genes were analyzed using polymerase chain reaction (PCR) amplification followed by sequencing. ResultsAt enrollment, 15 (55.6%) and 2 (7.4%) of patients experienced bleeding and thrombotic events, respectively, and the remainder were asymptomatic. The following congenital fibrinogen disorders were identified: 1A. afibrinogenemia, n = 1; 2A. severe hypofibrinogenemia, n = 2; 2B. moderate hypofibrinogenemia, n = 4; 2C. mild hypofibrinogenemia, n = 6; 3A. dysfibrinogenemia, n = 12; 3B. thrombotic related-dysfibrinogenemia, n = 1; 4C. mild hypodysfibrinogenemia, n = 1.Eight dysfibrinogenemic patients (62%) were carriers of hotspot mutations. Fifteen patients were heterozygous and one (afibrinogenemia) homozygous for known causative mutations. Three new heterozygous mutations were detected, all affecting splicing in FGG: fibrinogen Poznan II, a 177 bp deletion eliminating parts of intron 6 and exon 7 in a dysfibrinogenemic woman with recurrent bleeding; fibrinogen Zakopane, (intron 2 acceptor splice site) and fibrinogen Belchatow (intron 1 donor splice site), found in hypofibrinogenemic patients.During follow-up (median 60, interquartile range 10–60 months), bleeding episodes, mainly menorrhagia and easy bruising were reported in 15 (55.6%) patients. One thromboembolic event was observed. ConclusionThis study of the largest cohort of Slavic patients with congenital fibrinogen disorders has enabled the identification of 3 new FGG mutations and shows a high prevalence of bleeding manifestations with recurrences.

The spectrum of mutations predisposing to familial breast cancer in Poland.

To optimize genetic testing, it is necessary to establish the spectrum of breast cancer-predisposing mutations in particular ethnic groups. We studied 1,018 women with a strong family history for breast cancer (families with hereditary breast cancer; HBC) from genetically homogenous population of Poland, which is populated by ethnic Slavs, for mutations in 14 cancer susceptibility genes. Additionally, we compared the frequency of candidate pathogenic variants in breast cancer cases and controls. Germline mutations were detected in 512 of 1,018 probands with breast cancer (50.3%), including BRCA1/2 mutations detected in 420 families and non-BRCA mutations seen in 92 families. Thirteen BRCA1/2 founder mutations represented 84% of all BRCA1/2-positive cases. Seven founder mutations of CHEK2, PALB2, NBN and RECQL represented 73% of all non-BRCA-positive cases. Odds ratios for hereditary breast cancer were 87.6 for BRCA1, 15.4 for PALB2, 7.2 for CHEK2, 2.8 for NBN and 15.8 for RECQL. Odds ratios for XRCC2, BLM and BARD1 were below 1.3. In summary, we found that 20 founder mutations in six genes (BRCA1/2, CHEK2, PALB2, NBN and RECQL) are responsible for 82% of Polish hereditary breast cancer families. A simple test for these 20 mutations will facilitate genetic testing for breast cancer susceptibility in Poland. It may also facilitate genetic testing for breast cancer susceptibility in other Slavic populations and women of Slavic descent worldwide.

Localised enamel hypoplasia of human primary canines (LHPC) in the Necropolis of Great Moravia in Znojmo-Hradiště (the so called Stronghold of Znojmo, 9th - 10th century CE, Czech Republic) and analysis of chemical elements on surface enamel and hypoplastic defect via EDX method.

The present study aimed to evaluate the frequency and time of the development of enamel hypoplasia of the primary canine of the Slavic population from the 9th to the first half of the 10th century CE in the South Moravian burial ground of Znojmo-Hradiště, to establish the association with incidence of dental caries, and to analyse the chemical element content of the enamel. The frequency and time of the development of enamel hypoplasia of the primary canine were established macroscopically. The chemical element content of the enamel was analysed via the EDX method. The incidence of LHPC is very high in this analysed collection in comparison with other Slavic populations. 45.59% individuals (n = 31) displayed at least one hypoplastic defect on their canines. Most individuals were 2-5 years old and more than a quarter of them had multiple hypoplasia. The most frequent shape of enamel defect is irregular. The difference between the defects originating in the perinatal period and those originating in the postnatal or prenatal period is statistically significant. Individuals with LHPC (localised hypoplasia of primary canines) have a higher presence of dental caries in primary teeth than individuals without LHPC, but without statistical significance. Individuals with LHPC have other hypoplasia on the primary teeth more often than individuals without LHPC. The EDX analysis shows the average value of the Ca/P ratio in Spectrum 1 to be highest in teeth with unsolid enamel (LHPC), decreasing to Spectrum 2 and subsequently to Spectrum 3. The concentration of phosphor is increasing from Spectrum 1 to Spectrum 3. Magnesium was most commonly present in Spectrum 1, and less often in Spectrum 2 and Spectrum 3 in mean concentration 0.27 and 0.39 at.%. Values of Mg content rise to on average 0.63 at.% on the base of hypoplastic defects. In agreement with the findings of Robinson et al. (1981), this might mean a lower density of enamel in the place of a hypoplastic defect. However, this cannot be argued clearly, because the difference in concentration could have been caused by diagenetic processes over the time that the samples lay deposited in soil. Sodium is found in our collection of teeth about as often in all three spectra in an almost identical mean concentration (0.51, 0.46 and 0.56 at.%, respectively).

Efficacy and safety of intensified platinum-based neoadjuvant chemotherapy in locally advanced triple-negative breast cancer: Preliminary results of non-randomized phase II study.

e12116 Background: patients with locally-advanced triple negative breast cancer (TNBC) have dismal prognosis with current standard of care therapy. Pathologic complete response (pCR) is the most important prognostic factor for long-term survival of these patients. Methods: this was non-randomized prospective single-center phase II study. Key inclusion criteria were histologically verified locally advanced TNBC, non-eligibility for primary surgical treatment (ie, TNM stage Т2-4N 2-3M0) and no evidence of metastatic disease. Patients were treated with 8 cycles of neoadjuvant doxorubicine, paclitaxel and cisplatin chemotherapy (ATP; doxorubicine 40 mg/m2 day 1, paclitaxel 160 mg/m2 day 1 and cisplatin 50 mg/m2 day 1 every two weeks) with G-CSF support (filgrastim 5 mcg/kg day 2-6). After 8 cycles of chemotherapy patients were referred for surgical treatment; adjuvant radiation therapy was prescribed to all patients. Primary end point was pCR assessed in modified intention-to-treat population (ie, in patients who underwent surgical treatment). Key secondary endpoints were disease-free survival (DFS) and pCR rate according to BRCA status. Results: we enrolled 80 patients, 79 (98.7%) of them underwent surgical treatment and were included in the analysis. Median age was 46 years (25-68), 22 (27.1%) patients had BRCA1 mutations, 5382insC was the most common mutation (17 [77.2%] of patients); 1 (1.2%) patient had CHEK2 mutation. pCR was achieved in 51 (64.5%) patients. In with BRCA1-mutation carriers pCR rate was 61.9%, in patients with 5382insC – 81.2%. 2-year DFS was 77.3%; 2-year overall survival was 91.0% . Most common grade 3-4 adverse events were anemia (29.3%), neutropenia (17.8%), neuropathy (4.9%), stomatitis (3.7%) and thrombocytopenia (1.8%). Conclusions: the ATP regimen was effective in treatment of locally-advanced TNBC, especially in patients with founder 5382insC BRCA1 mutation for Slavic population and deserves further investigation.

THE ARTICLE DEDICATED TO THE RESEARCH OF THE MEDIEVAL MOUND NEAR THE VILLAGE TEPENYTSIA (to the Question of the Mounds with Stone Constructions at the Middle Dnieper Region)

In the summer of 2015, Zhytomyr expedition conducted archaeological research at the burial mounds at the tract of Long Niva near the village Tepenitsa Olevsky district of Zhytomyr region. As a result, the burial with a stone construction under the embankment was explored and studied. The stone cover was discovered right after the turf layer and completely covered the embankment as if it was an armor. The construction consisted of granite fragments and pieces of quartzite and sandstone. At the bottom of the embankment were stone boulders of large size that became smaller at the top of burial. At the level of the mainland around the embankment placed small ditch that had a form of two arcuate sections. Remains of a skeleton or gravel pit in the burial mound was not discovered (cenotaph). Two large fragments of the potter’s pot was found on the sand pit in the central part of the embankment at the level of the ancient horizon. The practical absence of inventory does not allow date the archaeological complex clearly. A fragment of the pot can be attributed to two chronological periods: the end of IX — the first half of the X century or the second half of the XIII — XIV centuries.&#x0D; The stone constructions in the burial mounds are not inherent for Old Russian time in Ukraine. Stone fixt only in slightly more than 1 % of all investigated burial mounds. The discovery of such rare complex forced the authors refer to the history of research of this type of monuments on the territory of Ukraine. In the Middle Dnieper area, burial mounds with stone structures are located in two regions: on the territory of Zhytomyr Polissya (Ubort river basin, Slovechansko-Ovruch ridge) and in Porossya.&#x0D; The burial groups in Zhytomyr region were explored by the excavations of Ya. V. Yarotsky (1902), O. A. Fotinsky (1904), M. B. Shchukin (1976), B. A. Zvizdetsky (1988, 1996—1999), the exploration of V. O. Misiats (1961, 1978), A. P. Tomashevsky and S. V. Pavlenko (1996, 2006, 2013). There are 18 gravediggers with stone burial mounds on this territory currently. 42 burial mounds were excavated (more than 300 known). At the 29 burial complexes were fixed stones fragments. These sights don’t occupy a separate compact area and located next to burial mounds consisting exclusively of mounds with simple earthen embankments. Only at the 7 necropolises majority burial mounds contains stones. On other monuments such burial mounds was few. Different methods of using stones have been recorded in investigated burial mounds. Often different variants of stone designs are fixed in one monument. Different kinds of stone were used for constructions: sandstone, granite, quartzite. In burial mounds with stone structures under the embankment are fixed various types of burial ceremony (cremation on the site, cremation on the side, inhumation on the horizon, inhumation in undermount pits, cenotaph). The ritual is accompanied by typical Slavic equipment. The earliest complexes are dated by the X century, the most recent are the second half of the XIII century.&#x0D; Stone barrows Porossya are known since the middle of the nineteenth century (about 500 individual complexes was fixet). They were discovered by V. B. Antonovych (70s of XIX century), T. M. Movchanivsky (1928), V. Ye. Kozlovskaya (30s of the XX century), R. S. Orlov and P. M. Pokas (1986, 1988). 9 burial mounds with stone constructs under the embankment are known on the territory of Porossya. 78 monuments have been investigated at 5 a monuments, 37 of them — with stone crepes (the structure was mostly fixed in the of circle form of boulders, which engird the embankment). The burial ceremony and accompanying equipment are typical for Slavic monuments.&#x0D; There are two main hypotheses about the origin of this type of monuments. According to the first, the stone structures in the mounds are a purely practical tradition of local people, which arose in the territories characterized by significant presence of the stone (O. A. Fotinsky, V. B. Antonovych, A. V. Petrauskas). According to the second hypotheses, use of a stone is a tradition of the Slavic alien population. Ya. V. Yarotsky considered that this is a memorial of the Dregovichi burial mounds of Zhytomyr Polissya, Western Balts (Yotvingians) — I. P. Rusanova, B. A. Zvizdetsky, A. P. Tomashevsky, mixed Baltic-Dregoviches population — V. V. Sedov and A. P. Motsia. The tradition of using stones in the burial mounds of Porosyya was explained by the borrowing of the elements of the burial ceremony of the nomads S. V. Shamray, I. P. Rusanovа and O. P. Motsia. Influenced by the coming population from the western and northern territories of Old Rus — L. I. Ivanchenko. Some researchers have ruled out both hypotheses.

The Slavcleft: A three-center study of the outcome of treatment of cleft lip and palate. Part 2: Dental arch relationships

PurposeOur aim was to evaluate the dental arch relationship in a preadolescent Slavic population with unilateral cleft lip and palate (UCLP) by using the Goslon Yardstick. Materials and methodsPatients treated in Warsaw, Poland (n = 32), Prague, Czech Republic (n = 33) and Bratislava, Slovakia (n = 30) were included in this retrospective study. Each cleft center used a unique surgical protocol. Three raters scored blindly the dental arch relationship on plaster models. Intra- and inter-rater agreement were assessed with kappa statistics, and differences between the groups were evaluated with one-way analysis of variance. Intra-rater agreement was very good (k > 0.825), while inter-rater agreement was either good or very good (kappa >0.703). ResultsWe found that patients treated in Warsaw showed a more favorable dental arch relationship (Goslon score = 2.58, SD = 0.77) than patients treated in Prague (Goslon score = 3.21, SD = 1.04). Patients treated in Bratislava showed an intermediate Goslon score (3.07; SD = 0.99). ConclusionThis study showed that the dental arch relationships in patients treated in Warsaw with a one-stage repair were more favorable than in patients treated in Prague and Bratislava with a two-stage protocol and comparable to the best results obtained in the Eurocleft and Americleft studies.

Facial asymmetry in slavic populations: Sex dimorphism in healthy young ukrainians

Introduction: Facial and body asymmetry to some extent is present in all individuals. Because fluctuating asymmetry is of a stochastic nature, it cannot be studied at the level of individuals, but only its groups can be considering during studying the populations. Material and Methods: We conducted a survey of 200 students of 8–11 grades, from 13 to 17 years old, residents of Ukraine. Asymmetry measurements were made in the program GIMP-2.8. Results: Population distribution of eight points of the face asymmetry among the population of Ukraine was studied. Sex dimorphism was found under all average indicators of absolute and relative asymmetry. Higher indicators of asymmetry were common to males and also typical for the lower part of the face. Discussion and Conclusion: Obtained data complement the existing study on facial asymmetry in human. Some of our results are consistent with the existing data from previous studies of the world population, while others point to the differences of Slavic population in a number of features related to the facial asymmetry.