Comparative research on studying the influence of phytobioadditives from natural plant raw materials and with synthetic adaptogen Aurol in complex with arabinogalactan on quail productive indices were carried out. Daily inclusion of bio-additives in the diets of quails, from 5 days to 107 days of age, had a different effect on the safety and their productive performance. The control group received the basic diet, the 1st experimental group – the basic diet with drinking aqueous solution of aurol with arabinogalactan; in the 2nd experimental group 0.1% of bio-additive No. 1 consisting of roseroot powder with arabinogalactan was added to 99.9% of the basic diet; in the 3rd experimental group – 98.4% of the basic diet + 1.6% of bio-additive No. 2 consisting of roseroot powder, pine nut shell and pine needles with arabinogalactan in the first period of growing; in the second period – 98.3% of the basic diet + 1.7% of bio-additive No. 2a. Biochemical composition of blood, muscle tissue of quail carcasses, quail eggs was studied. In the period of quails growing, inclusion of complex bio-additives of plant origin with arabinogalactan No. 1 and No. 2 in the main composition of the diet of experimental groups increased their live weight by 7.6 and 11.1%; average daily gain by 8.6 and 12.4%; slaughter yield of gutted carcass by 0.9 and 1.5%; increased safety by 5.7 and 1.4% compared to the control group. At the beginning of egg production, the best results were with natural complex bio-additives. The laying hens of the 2nd and 3rd experimental groups started egg laying 2 days earlier, they had the highest egg laying intensity (66,98 and 61,67%). In comparison with the control group, a higher average weight of one egg was observed in the 2nd experimental group – by 5.7%, the intensity of oviposition was higher – by 15.0%, egg mass – by 38.9.