Surface Skin Layer Research Articles

Investigation of surface thermal characteristics induced by the acceleration of a submerged vehicle

Surface thermal characteristics are significant targets for non-acoustic detection technologies of underwater vehicles. This study aims to investigate the thermal characteristics induced by underwater vehicles during acceleration. The acceleration process of the self-propelled vehicle was obtained by simulation. Experimental and simulation studies were conducted using the temperature stratification measured in an outdoor pool as the background, while also considering the presence of a cool surface skin layer of the water. A comparative analysis between experimental and simulation results shows that the position and morphology of the surface thermal characteristics are consistent, and the area error of the thermal characteristics is within 15%. The findings reveal that, during the acceleration process of the underwater vehicle, the wake can still be divided into two stages despite the increasing speed. In the initial stage, the wake is relatively weak, making it difficult to form noticeable thermal characteristics on the water surface. Additionally, the study shows that at shallower depths, the acceleration state of the vehicle can be directly inferred from the thermal characteristics on the water surface, allowing for rough localization of the acceleration position. In contrast, at greater depths, direct determination becomes more challenging.

Effect of a low‐mineralized thermal spring water on skin barrier mechanical properties using atomic force microscopy

AbstractThe mineral content of thermal spring water (TSW) applied to the skin surface can directly influence the skin barrier. Indeed, our previous study showed that Avène TSW (ATSW), a low mineral content thermal spring water, protects the stratum corneum from dehydration compared to a mineral‐rich TSW (MR‐TSW) and maintains skin surface ultrastructure. While many TSWs have been recognized to have beneficial effects on skin, little is known about their localized and specific effects on skin barrier biomechanics at the nanometric scale. The aim of this study was to compare the effects of ATSW with a reference, MR‐TSW, on the biomechanical barrier properties of the skin under homeostasis conditions using atomic force microscopy (AFM). AFM was used to obtain a precise nanomechanical mapping of the skin surface after three applications of both TSW. This provides specific information on the skin topographical profile and elasticity. The topographic profile of skin samples showed a specific compaction of the skin layers after application of MR‐TSW, characterized by an increase of the total number of external skin layers, compared to non‐treated samples. By contrast, ATSW did not modify the skin topographic profile. High‐resolution force/volume acquisitions to capture the elastic modulus showed that it was directly correlated with skin rigidity. The elastic modulus strongly and significantly increased after MR‐TSW application compared to non‐treated skin. By contrast, applications of ATSW did not increase elastic modulus. These data demonstrate that applications of MR‐TSW significantly modified skin barrier properties by increasing skin surface layer compaction and skin rigidity. By contrast, ATSW did not modify the topographical profile of skin explants nor induce mechanical stress at the level of the stratum corneum, indicating it does not disrupt the biophysical properties linked to skin surface integrity.

Beyond Traditional Sunscreens: A Review of Liposomal-Based Systems for Photoprotection.

Sunscreen products are essential for shielding the skin from ultraviolet (UV) radiation, a leading cause of skin cancer. While existing products serve this purpose, there is a growing need to enhance their efficacy while minimizing potential systemic absorption of UV filters and associated toxicological risks. Liposomal-based formulations have emerged as a promising approach to address these challenges and develop advanced photoprotective products. These vesicular systems offer versatility in carrying both hydrophilic and lipophilic UV filters, enabling the creation of broad-spectrum sunscreens. Moreover, their composition based on phospholipids, resembling that of the stratum corneum, facilitates adherence to the skin's surface layers, thereby improving photoprotective efficacy. The research discussed in this review underscores the significant advantages of liposomes in photoprotection, including their ability to limit the systemic absorption of UV filters, enhance formulation stability, and augment photoprotective effects. However, despite these benefits, there remains a notable gap between the potential of liposomal systems and their utilization in sunscreen development. Consequently, this review emphasizes the importance of leveraging liposomes and related vesicular systems as innovative tools for crafting novel and more efficient photoprotective formulations.

Tough polycyclooctene nanoporous membranes from etchable block copolymers.

Porous materials with pore dimensions of the nanometer length scale are useful as nanoporous membranes. ABA triblock copolymers are convenient precursors to such nanoporous materials if the end blocks are easily degradable (e.g., polylactide or PLA), leaving nanoporous polymeric membranes (NPMs) if in thin film form. The membrane properties are dependent on midblock monomer structure, triblock copolymer composition, overall molar mass, and polymer processing conditions. Polycyclooctene (PCOE) NPMs were prepared using this method, with tunable pore sizes on the order of tens of nanometers. Solvent casting was shown to eliminate film defects and allowed achievement of superior mechanical properties over melt processing techniques, and PCOE NPMs were found to be very tough, a major advance over previously reported NPMs. Oxygen plasma etching was used to remove the surface skin layer to obtain membranes with higher surface porosity, membrane hydrophilicity, and flux of both air and water. This is a straightforward method to reliably produce highly tough NPMs with high levels of porosity and hydrophilic surface properties.

Ocean Warm Skin Signals Observed by Saildrone at High Latitudes

AbstractThe existence of a cool sea surface skin layer in the global ocean during both day and night is generally recognized. However, a warm skin should be present if the total surface net heat flux () were to be from the atmosphere into ocean. Saildrone, an advanced uncrewed surface vehicle, has been shown to be able to provide sufficiently accurate sea skin temperature (SSTskin) and subsurface temperature (SSTdepth) data at high latitudes. Using those SST data along with meteorological parameters from a Saildrone deployed in the Arctic in the summer of 2019, some warm skin layers were identified due to the gain resulting from the combined effect of positive air‐sea temperature difference, humid surface air and cloudy skies. Furthermore, most warm skins here were found during and shortly after rainfall events. It is essential to incorporate the ability to simulate warm skin layers in the present cool skin models.

Effect of Dissolution Time on the Development of All-Cellulose Composites Using the NaOH/Urea Solvent System

Innovative and sustainable all-cellulose composites (ACCs) can be obtained by partial dissolution of cellulosic fibers and regeneration of the dissolved fraction. Among cellulose solvents, sodium hydroxide/urea solutions are recognized as promising low-environmental impact systems. In this work, filter paper (FP) was dissolved with a 7 wt% NaOH/12 wt% urea aqueous solution, kept at −18 °C for different time intervals, regenerated with distilled water and finally dried under different conditions. The developed films were characterized in terms of morphology, porosity, optical properties, crystalline structure, hydration and mechanical properties. The porosity of the composites decreased with dissolution time due to the progressive filling of voids as the cellulosic fibers’ surface skin layer was dissolved and regenerated. Samples treated for 4 h showed the minimum values of porosity and opacity, high hydration and a substantial change from cellulose I to cellulose II. Hot pressing during drying led to relevant improvements in ACCs stiffness and strength values.

A 3D-printed transepidermal microprojection array for human skin microbiome sampling

Skin microbiome sampling is currently performed with tools such as swabs and tape strips to collect microbes from the skin surface. However, these conventional approaches may be unable to detect microbes deeper in the epidermis or in epidermal invaginations. We describe a sampling tool with a depth component, a transepidermal microprojection array (MPA), which captures microbial biomass from both the epidermal surface and deeper skin layers. We leveraged the rapid customizability of 3D printing to enable systematic optimization of MPA for human skin sampling. Evaluation of sampling efficacy on human scalp revealed the optimized MPA was comparable in sensitivity to swab and superior to tape strip, especially for nonstandard skin surfaces. We observed differences in species diversity, with the MPA detecting clinically relevant fungi more often than other approaches. This work delivers a tool in the complex field of skin microbiome sampling to potentially address gaps in our understanding of its role in health and disease.

Radon Solubility and Diffusion in the Skin Surface Layer.

In specific situations such as bathing in a radon spa, where the radon activity concentration in thermal water is far higher than that in air, it has been revealed that radon uptake via skin can occur and should be considered for more precise dose evaluation. The primary aim of the present study was to numerically demonstrate the distribution as well as the degree of diffusion of radon in the skin, with a focus on its surface layer (i.e., stratum corneum). We developed a biokinetic model that included diffusion theory at the stratum corneum, and measured radon solubility in that tissue layer as a crucial parameter. The implementation of the model suggested that the diffusion coefficient in the stratum corneum was as low as general radon-proof sheets. After a 20-min immersion in water, the simulated depth profile of radon in the skin showed that the radon activity concentration at the top surface skin layer was approximately 103 times higher than that at the viable skin layer. The information on the position of radon as a radiation source would contribute to special dose evaluation where specific target cell layers are assumed for the skin.

Microstructure manipulation in PVDF/SMA/MWCNTs ultrafiltration membranes: Effects of hydrogen bonding and crystallization during the membrane formation

• The hydrogen bonding and nucleation of MWCNTs affected the membrane microstructures. • The hydrogen bonding strength followed the tendency like MWCNT-COOH > MWCNT-NH > MWCNT-OH. • MWCNT-OH induced the transformation of unstable β-phase to stable α-phase in PVDF. • MWCNT-COOH modified membranes had high permeation, rejection and antifouling ability. Amphiphilic copolymers and functionalized nanoparticles have been severally used to modify polymeric membranes to enhance their antifouling properties. However, their synergistic effects on the membrane microstructure and performance have been rarely reported. Herein, sodium styrene-maleic anhydride copolymer (SMANa) and functionalized multi-walled carbon nanotubes with carboxyl groups (MWCNT-COOH), amino groups (MWCNT-NH) and hydroxyl groups (MWCNT-OH) were utilized to blend with poly (vinylidene fluoride) (PVDF) to fabricate the composite membrane by phase inversion. The hydrogen bonding between functional groups and SMANa, and the nucleation of MWCNTs were systematically investigated during the membrane formation. The hydrogen bonding strength followed the tendency of MWCNT-COOH > MWCNT-NH > MWCNT-OH. For MWCNT-NH, weak hydrogen bonding resulted in its aggregation in the dope solution and some large pores on the membrane surface. The α-nucleation of MWCNT-OH mainly dominated the membrane microstructure instead of hydrogen bonding, leading to a dense surface skin layer. In contrast, uniform and suitable pore structures were constructed on the MWCNT-COOH modified membrane thanks to the strong hydrogen bonding. Correspondingly, the resultant membrane simultaneously exhibited a better permeate flux (1266.50 L/m 2 ·h·bar) and rejections to BSA (98.60%), Congo red (62.85%) and methyl blue (29.19%), and the highest flux recovery ratio (88.5%), indicating excellent antifouling properties.

Mesoporous TiO2 Microparticles with Tailored Surfaces, Pores, Walls, and Particle Dimensions Using Persistent Micelle Templates.

Mesoporous microparticles are an attractive platform to deploy high-surface-area nanomaterials in a convenient particulate form that is broadly compatible with diverse device manufacturing methods. The applications for mesoporous microparticles are numerous, spanning the gamut from drug delivery to catalysis and energy storage. For most applications, the performance of the resulting materials depends upon the architectural dimensions including the mesopore size, wall thickness, and microparticle size, yet a synthetic method to control all these parameters has remained elusive. Furthermore, some mesoporous microparticle reports noted a surface skin layer which has not been tuned before despite the important effect of such a skin layer upon transport/encapsulation. In the present study, material precursors and block polymer micelles are combined to yield mesoporous materials in a microparticle format due to phase separation from a homopolymer matrix. The skin layer thickness was kinetically controlled where a layer integration via diffusion (LID) model explains its production and dissipation. Furthermore, the independent tuning of pore size and wall thickness for mesoporous microparticles is shown for the first time using persistent micelle templates (PMT). Last, the kinetic effects of numerous processing parameters upon the microparticle size are shown.

Deep-skin multiphoton microscopy of lymphatic vessels excited at the 1700-nm window in vivo.

Visualization of lymphatic vessels is key to the understanding of their structure, function, and dynamics. Multiphoton microscopy (MPM) is a potential technology for imaging lymphatic vessels, but tissue scattering prevents its deep penetration in skin. Here we demonstrate deep-skin MPM of the lymphatic vessels in mouse hindlimb in vivo, excited at the 1700 nm window. Our results show that with contrast provided by indocyanine green (ICG), 2-photon fluorescence (2PF) imaging enables noninvasive imaging of lymphatic vessels 300 μm below the skin surface, visualizing both its structure and contraction dynamics. Simultaneously acquired second-harmonic generation (SHG) and third-harmonic generation (THG) images visualize the local environment in which the lymphatic vessels reside. After removing the surface skin layer, 2PF and THG imaging visualize finer structures of the lymphatic vessels: most notably, the label-free THG imaging visualizes lymphatic valves and their open-and-close dynamics in real time. MPM excited at the 1700-nm window thus provides a promising technology for the study of lymphatic vessels.

Crumple-textured polyamide membranes via MXene nanosheet-regulated interfacial polymerization for enhanced nanofiltration performance

Nanofiltration (NF) membranes based on polyamide (PA) chemistry have been broadly utilized in saline water desalination and advanced treatment of drinking water. The creation of a nanomaterial interlayer between the support and PA film is known as a promising strategy to improve the filtration performance of traditional PA NF membranes. However, an ultrahigh selective PA NF film featuring ultrathin and crumple-like morphology is still in great challenge. Herein, a highly efficient NF membrane with both enhanced water permeance and salt rejections was prepared via a brush-painting MXene-assisted interfacial polymerization (MA-IP) process. An ultrathin and crumple-textured PA film with ~15 nm thickness was constructed on the MXene-painted polyethersulfone support. The effects of MXene painting cycles on the performance of the support and subsequent PA layer were systematically characterized. The presence of the MXene layer increased the hydrophilicity and PIP adsorption of the pristine support, leading to an accelerated IP reaction rate. The resultant NF membranes exhibited rougher surface, greater hydrophilicity, higher electronegativity and denser skin layer. Excellent water permeability of 27.8 ± 2.1 L m−2 h−1 bar−1 together with satisfactory α(NaCl/Na2SO4) of ~480 was obtained for the MXene-interlayered NF membrane, overcoming the trade-off effects between water permeance and salt selectivity. The MA-IP strategy of this work is expected to provide a new approach for fabricating low-pressure NF membranes for brackish water desalination.

Confined batch foaming of semi‐crystalline rubbery elastomers with carbon dioxide using a mold

AbstractConfined foaming of poly(ethylene‐co‐vinyl acetate‐co‐carbon monoxide) using carbon dioxide as a physical blowing agent in a mold with either permeable or impermeable boundaries has been explored as a strategy to control final foam dimensions and morphology. The results are discussed in terms of comparisons to free‐foaming experiments conducted at the same pressure and temperature conditions following the same pressurization and depressurization paths. Foaming experiments were carried out at 30 and 40°C and 100, 200, and 300 bar followed by rapid depressurization of the foaming cell. Confined foaming led to smaller pores with more uniform distributions across the polymer cross‐section. However, bulk foam densities of the foams generated under confinement were higher than those generated under the free‐foaming mode. Surface characteristics and skin layer formation were altered by expansion against both the permeable and impermeable boundaries. Confined foaming promotes uniform pore distribution and overall dimensional uniformity and may impart surface texture but the trade‐off is in the degree to which the bulk foam density can be lowered.

An X-Band Dielectric Rod Antenna for Subdermal Tumor Heating to Assist Electroporation-Mediated DNA Delivery

An end-fire dielectric rod antenna is proposed as a heating device for integration with an array of electroporation electrodes in order to enable efficient delivery of DNA into the cells that comprise subcutaneous tumors. A 5-7 °C temperature elevation of tumors that are located near the fat-muscle boundary and 3-7 mm below the skin surface can be achieved in a short period of time without damaging surrounding tissues. This capability is demonstrated through a combination of a directional antenna applicator operating at 8 GHz, and utilization of forced air cooling of the outer surface (skin layer). The directionality of the antenna is improved by cladding its high permittivity core with 3D printed, low permittivity dielectric material. Experimental data using a pork skin-fat-muscle tissue show that the desired temperature elevation at the tumor location is obtained after 2.5 W RF illumination for 3 minutes, which is in good agreement with electro-thermal simulations. With the addition of realistic human body model parameters to the same simulation setup, the results indicate that tumors can be uniformly heated with 3 minutes of illumination at 2.5 W input power while keeping the surrounding healthy tissues at a safe temperature.

Влияние облучения низкоэнергетическими ионами гелия на спектральный коэффициент отражения монокристаллических молибденовых зеркал

The results of a comparative study of the effect of irradiation with helium ions on the optical properties of single-crystal molybdenum mirrors with crystallographic orientations <110> and <111> are presented. The irradiation regime corresponds to the conditions in plasma cleaning systems of the entrance mirrors from contamination in optical diagnostics of ITER while helium is using as a working gas. As a result of such irradiation, a change in specular reflection and diffuse scattering of the mirror occurs, which is practically independent of the initial structure of the surface layer of the mirror and the duration of the irradiation process. Authors explain the observed changes in the optical characteristics of the mirror by the formation of nanosized bubbles in the surface skin layer. Rayleigh scattering of incident radiation on these bubles decreases the intensity of specular reflection and increases diffuse scattering. A model of the formation and growth of nanosized bubbles and their effect on optical properties is proposed. The obtained results should be taken into account when analyzing experimental data in optical diagnostics of ITER after removing contaminants using helium, when choosing a working gas for mirror cleaning, and also for the formation of a nanoporous structure in a thin surface layer of metals.

A system for assessing the functional state of blood flow in the skin surface layers by the speckle structure of multiply scattered optical radiation

Assessment of the parameters of skin microcirculation is an urgent and important task of modern medicine in the development of methods for diagnosing diseases of the nervous system. The system for assessing the functional state of blood flow in the skin surface layers in the wavelength range from 400 to 850 nm has been improved based on the use of an extended mathematical model of the propagation of optical radiation in human skin by taking into account additional parameters: optical anisotropy of the skin, diameter and shape of erythrocytes in the dermis layer, blood pressure in the brachial artery in the range from 90/60 to 195/130 mm·Hg, plasma protein concentration in the blood (α1, α2, β1, β2, γ-globulins and fibrinogen, g/l), rheological properties of blood flow with a diameter of blood vessels from 4.5 to 500 microns in the skin surface layers, skin temperature from +35 to +41 °C. The developed system makes it possible to determine the severity of microhemodynamic shifts in relation to metabolic disorders, improve diagnosis and evaluate the treatment efficacy of a number of neurological disorders; it also made it possible to reduce the patient examination time and increase the accuracy of measuring the blood flow microcirculation parameters by 10 % (linear and volumetric blood flow velocities) to detect blood flow disturbances in the surface layers of the skin in the normal and abnormal condition of the nervous system.

Optimization of laser technology for removing tatuage pigment

Purpose: To study the effectiveness of tattoo pigment removal with laser light depending on the wavelength and depth of penetration into tissues in order to optimize a technique of laser selective photocavitation. Material and methods. 127 male white mongrel rats, aged 8 weeks, were intradermally injected with pigment particles into their backs looking like 2 rows of spots 0.5 cm in diameter. In 6 weeks, 367 skin samples with tattoo pigment were taken. Each sample was a patch of epidermis with pigment crystals surrounded by connective tissue capsules not less than 2.5 mm of thickness. Before the experiment, the epidermal stratum corneum – 10–15 mkm in depth and about 1 mm in diameter- was removed with spray-coagulation (apparatus EHVCH-50-MEDSI). The rest of skin flap surface remained intact. Thus, each skin sample had two areas on the surface – one with removed stratum corneum (experimental) and the other one intact (control). To register changes in the luminous flux, the authors placed an emitter (IPL xenon lamp 7.65.130), tissue sample and photomultiplier (PMT-62) on one and the same axis. To cut off light waves, the authors used a set of light filters – 315, 364, 400, 440, 490, 540, 590, 670, 750, 870, 980 nm. Results. Destruction of skin surface layers was not statistically significant under wavelengths up to 450 nm and after 1000 nm. The epidermal stratum corneum prevents laser light penetration with wavelengths 450–694 nm by 27%, in average, and with wavelengths 700–1000 nm by 33%, in average. Conclusion. Epidermal stratum corneum destruction statistically significantly increases light density in deep tissue layers and increases the depth of penetration of laser light into biological tissues.

Photo-triggered large mass transport driven only by a photoresponsive surface skin layer

Since the discovery 25 years ago, many investigations have reported light-induced macroscopic mass migration of azobenzene-containing polymer films. Various mechanisms have been proposed to account for these motions. This study explores light-inert side chain liquid crystalline polymer (SCLCP) films with a photoresponsive polymer only at the free surface and reports the key effects of the topmost surface to generate surface relief gratings (SRGs) for SCLCP films. The top-coating with an azobenzene-containing SCLCP is achieved by the Langmuir–Schaefer (LS) method or surface segregation. A negligible amount of the photoresponsive skin layer can induce large SRGs upon patterned UV light irradiation. Conversely, the motion of the SRG-forming azobenzene SCLCP is impeded by the existence of a LS monolayer of the octadecyl side chain polymer on the top. These results are well understood by considering the Marangoni flow driven by the surface tension instability. This approach should pave the way toward in-situ inscription of the surface topography for light-inert materials and eliminate the strong light absorption of azobenzene, which is a drawback in optical device applications.

Numerical modeling of body heat dissipation through static and dynamic clothing air gaps

The clothing air gap between the skin surface and clothing layer plays an important role in the body heat dissipation. In this study, we built a numerical model to investigate the heat transfer phenomenon through the clothing air gap in a single layer loose-fitting garment with large air gaps. Firstly, we investigated the thermal performance of the static air gaps with closed ends and open ends, respectively, against their thickness and height at different environmental temperatures. Then, the dynamic air gaps with oscillating clothing layers were studied to examine the influence of the so called pumping effect (viz. the oscillation of clothing layer) on the heat transfer through the air gaps. The results showed that closing the ends of the static air gap (i.e. simulation of closing the openings of clothing) can double the thermal resistance when the air gap thickness is sufficiently large. On the other hand, the pumping effect, which may be caused by body motion or external forces, can halve the thermal resistance of the air gap with open ends in some conditions. This study is of great importance for the design of functional clothing for human body thermal management.

(Invited) Post-CMOS Compatible Silicon MEMS Nano-Tactile Sensor for Touch Feeling Discrimination of Materials

Semiconductor silicon has realized various kinds of valuable electron devices. CMOS technology is the present standard silicon process to fabricate integrated circuits and systems. Therefore, the word “Post-CMOS” has been an important word which means that the technology makes it possible to fabricate various kinds of MEMS sensors/actuators/passives with highly sophisticated modern CMOS devices. Also, it emphasizes that MEMS devices fabricated by post-CMOS technology has “high compatibility” with “silicon FABs” that are most universal and distributed fabrication facilities in the world. High performance devices and fine microstructures can be fabricated by universal post-CMOS fabrication processes at present.Post-CMOS compatible process is a key technology to realize ultra-high-performance silicon MEMS tactile sensors in this study. We, humans have very sophisticated sense of touch on our fingertip skin, and we can recognize and distinguish various and delicate difference of touch feelings obtained by “sweep motion” of fingertip on various kinds of materials and objects. Our fingertip skin has the highest density of force and vibration (mechanical) receptors like Meissner’s corpuscles and Merkel disks under the surface skin layer where fine pitch patterns of fingerprint are formed on. It is known that human’s fingertip has a very high spatial resolution below 100µm or less, and can recognize existence of 13nm-pitch patterns as reported recently. The high performance of our fingertip sense of touch has never been realized by any tactile sensor device. In order to reproduce artificial sense of touch like the fingertip, very high performances on “spatial resolution” and “input sensitivities” are required to integrate all on a small tactile sensor. Therefore, CMOS-compatible fabrication technology is the most suitable process to fabricate such high-performance tactile sensors with integrated functions.Based on a silicon post-CMOS compatible process, we have realized high performance silicon MEMS tactile sensor called “Nano-tactile sensor”, which is comparable to the performance of fingertip sense of touch. In this tactile sensor device, all the mechanical structures are made from single crystalline silicon which is the active layer of SOI wafers. No elastomer/polymer structures are used in the mechanical sensing structure, and softness and elasticity necessary to tactile sensing are realized by silicon micro mechanical structures. All the fine mechanical movements and sensing circuits with strain-sensitive diffusion resistors (i.e. piezoresistors) are designed by 2D-CAD, and the characteristics can be controlled by layout pattern sizes. The contactor parts of the tactile sensor have curved shape which is similarly designed to the cross-section of a fingerprint, and its suspension springs are designed to have similar spring constant with human’s fingertip skin surface.In the latest version of our “Nano-tactile sensors”, six contactors with fingerprint-like shape are integrated at a pitch of 500µm to get distributed tactile images at a high spatial resolution. The pitch of 500µm corresponds to the average value of human’s fingerprint patterns. Each fingerprint-like contactor reproduces vertical motion (by micro roughness) and horizontal motion (by frictional force) of a fingerprint closely under sweeping motion of fingertip in touch feeling measurement. Spatial resolution of our tactile sensor reaches to sub-micron (200nm) in the finest version, and its force resolution of input reaches below 50µN range. These high performances are enough high to reproduce part of our fingertip sense of touch. The Nano-tactile sensors can get touch feeling waveforms of “hair surface condition”, “skin texture and the condition”, and touch feelings of various kinds of “papers” and “clothes” at a high spatial resolution like our fingertip skin. In the lecture, experimental results of very high-resolution tactile sensing are presented, and their importance and novelty are discussed.Machine learning based on deep neural network (DNN) has become very important for sensing data analysis. We think DNN is very important to understand/reproduce human sense of touch since a trained DNN behaves similarly with human’s senses based on our experiences. Since a lot of sample data are required for such applications, we have developed a measurement system called “Touch-Feeling Scanner”. A number of tactile sensing data can be measured by the touch-feeling scanner integrating a Nano-tactile sensor device. Obtained signals with the scanner were applied to train a DNN for discrimination of different kinds of clothes. 10 kinds of cloth samples have been successfully discriminated at a correct percentage over 95% as an example. Combination of high-resolution Nano-tactile sensors and state-of-the-art machine learning (DNN) is a strong approach to reproduce human fingertip sensation for various valuable applications. Figure 1