IntroductionThere are numerous dependable techniques of wound closure, employing a wide range of materials. The proposed hypothesis for this single blind prospective randomized comparative study is tissue adhesive has better clinical outcome in terms of time taken, inflammatory changes, complications, esthetic outcome and cost efficacy for surgical wound closure of standardized submandibular incisions with sutures and staples. MethodsPatients from either gender in the age group of 15–40 years, undergoing closure of submandibular incision were randomly allocated to three group i.e tissue adhesive, suture and staples groups respectively. Following surgical intervention patients were then followed up for a period of 4 months. Wounds were evaluated by two independent investigators on 7th, 14th, 30th, 60th, 90th and 120th post-operative day. The parameters measured were time consumption for closure during surgery, quality of wound healing and cosmesis during follow up. Results42 patients, 14 in each group were treated in the present study. A statistically significant time efficiency was noted in the staple group (64.5 ± 21.4 s, p < 0.001) as compared to the others. However in terms of cosmesis, suture group outstands the other with a statistical significance of P1 = 0.009, P2 = 0.029. No significant difference was observed among the groups in terms of inflammatory changes and complications. ConclusionThe hypothesis was thus rejected as tissue adhesive has no significant clinical outcome in submandibular incision. The result of the present study demonstrate that skin closure by suture may increase the duration of surgery but wound cosmesis was better and face being an esthetic area, cosmetic outcome is paramount.