To investigate the influence of psychoticism (P) and neuroticism (N) on emotional responding, a re-analysis was carried out on subjective and physiological data collected while Ss ( n = 50) repeatedly imagined anxious (intrusive) or depressive, and pleasant thoughts or images. High N was associated with a greater negative mood state subsequent to imagining the distressing cognitive stimuli, though there was no relation with physiological reactivity. However, high P scorers did evidence less overall cardiac reactivity and, to a lesser extent, fewer skin resistance responses than low P Ss. The results are discussed in light of the moderating influence that stimulus and response characteristics as well as gender differences can have on the interaction between personality traits and emotional responding.