Skin Quality Research Articles

1142 Using Lipofilling to Improve Skin Quality Following Severe Radiation Necrosis to Enable Successful Joint Replacement – a Case Report and Literature Review

Abstract Case A 74-year-old female patient presented with severe osteoarthritis and pathological fracture of the left knee, following treatment with radiotherapy of osteosarcoma over a decade ago. Surgical management of the fracture was initially not possible, due to radiation-induced fibrosis of the skin. She was referred to the plastic surgery department where she underwent a total of three sessions of fat grafting over nine months. The rigotomy approach was applied to the large area of irradiated skin. As a result, her skin quality improved such that a successful total knee replacement was possible. The outcome of this was better mobility and improved quality of life. Conclusions Skin quality after radiotherapy can limit surgical options, even decades after treatment. Fat grafting, also known as lipofilling, is a commonly utilised reconstructive and cosmetic adjunct. However, recent reports of its effect on skin quality are gaining popularity. We present a case of successful use of fat transfer to improve irradiated skin quality prior to successful joint replacement; this is a novel use case which we believe to be the first published.

Skin quality sensor to evaluate vibration and friction generated when sliding over skins.

The mechanical condition and tactile evaluation of skin are essential for the development of skin care products. Most of the existing commercial instruments and studies aim to evaluate the skin surface by pressing it for hardness or by using imaging sensors, but there have been few instrumental measurements employing rubbing motion. Here, we have developed a sensor specialized for tactile sensation and the contact phenomenon during skin rubbing. The developed sensor has three features: It can measure body parts including cheeks and arms, automate the rubbing motion of the probe and measure vibration and friction simultaneously. It is hand-held, with metal probes that rub the skin surface while rotating under a motor drive; it has an accelerometer and a force sensor beneath the probe measuring vibration and friction forces. To evaluate the validity of the sensor's measurements, artificial skin models were measured using the developed sensor and commercially available sensors and the results were compared. The relationship between the sensor output, surface roughness measurement and sensory evaluation was also investigated. Additionally, we evaluated the inter-rater reliability when measuring actual skin. The measurements of five artificial skin models with different surface shapes showed a high correlation (r = 0.99) between the vibration intensity values evaluated by the developed sensor and those measured by a tri-axial acceleration sensor attached to a fingernail. The correlation coefficient between the vibration intensity values and surface roughness was r = 0.91, and the correlation with the sensory evaluation score of roughness was r = 0.99. The friction coefficients measured by the developed sensor and the force plate had r = 0.93, based on measurements of five artificial skin models with different friction conditions. The inter-rater correlation coefficients between the three participants of the developed sensor were as high as 0.92 and 0.94 for the vibration and friction measurements respectively. The vibration intensities and friction coefficients from the sensor were highly correlated with those of the conventional sensor. The inter-rater reliability was also high. The developed sensor can be useful for tactile evaluation in skin-care product development.

Combined treatment in aesthetic medicine using LPG endermologie for facial rejuvenation: a case series

Background: The request of aesthetic treatment is growing year on year and more and more treatments are available on the market. Over the last few years, more and more studies showing the importance of using a combination approach for optimum results. Objective: This case series aims to evaluate the efficacy of combining non-surgical aesthetic procedure with LPG Endermologie for Facial Rejuvenation. Patients and Methods: A total of twenty patients from 30 to 75 years old were treated using LPG Endermologie and a specific aesthetic procedure. Results: At D0, clinical skin quality scoring showed that LPG Endermologie significantly reduced downtime, enhanced outcome and longer lasting effect. The Global Aesthetic Improvement Scale (GAIS) by the evaluator at D0 reported much improved. Conclusions: Our findings show that combining LPG Endermologie treatment with a non-surgical aesthetic procedure injection can significantly improve the skin’s overall appearance and decrease the downtime compare to the non-surgical procedure alone. The results suggest that the combinatory strategy is effective, safe, and associated with a high level of patient satisfaction.

A clinical evaluation of the efficacy and tolerability of a novel topical antioxidant formulation featuring vitamin C, astaxanthin, and fermented turmeric.

Ultraviolet light, visible light, infrared light, and pollution are a few examples of environmental factors that exacerbate the formation of reactive oxygen species (ROS) that cause damage to skin cells' DNA, proteins, and lipids. By supplementing the skin with antioxidants, we can help neutralize ROS formed by these extrinsic factors before they can damage the skin. This prospective open-label study explores the safety and efficacy of this novel topical formulation of antioxidants (vitamin C, astaxanthin, fermented turmeric, and vitamin E) designed to fight free radical damage and improve overall skin quality, as well as the appearance of fine lines, wrinkles, radiance, and hyperpigmentation of the skin. This single-center clinical study evaluated the efficacy of twice-daily application of the test article (Asta C™ Vitamin C Age Defense Serum, Dr. Whitney Bowe Beauty) in 32 subjects for 12 weeks. Healthy female subjects aged 35-60 with mild to moderate fine lines, wrinkles, and hyperpigmentation/uneven skin tone were enrolled in this study. Fitzpatrick skin types I-VI, all skin types (dry, normal, combination, oily), and subjects with sensitive skin were included. All subjects demonstrated improvement in overall skin quality (face, neck, and chest) by the end of the 12-week study period. One hundred percent of subjects demonstrated improvement in the appearance of fine lines at Week 12. Overall, the current clinical study demonstrates that Asta C™ is safe, well-tolerated, and effective in improving overall skin quality, as well as the appearance of fine lines, wrinkles, radiance, and hyperpigmentation of the skin.

The objective and subjective impact of a daily self-massage on visible signs of stress on the skin and emotional well-being.

Currently, levels of stress, worry and sadness are increasing worldwide. Considered a part of healthcare, massage is associated with morphological, biological and psychological benefits. Little is known about using daily facial self-massage to improve skin quality and well-being. To evaluate the impact of a daily self-massage on the visible signs of stress on facial skin and well-being in women. This open, prospective, clinical study was conducted in Paris, France. The visible signs of facial ageing were assessed with an objective 10-point scale and a subjective skin and well-being assessment with an online self-questionnaire. Each day for 2 weeks, participants performed a prescribed, 3-min self-massage routine at-home using a lubricant made of botanical oils. The prescribed massage included 14 gestures including stretching, flicking, deep typing, friction and smoothing on the face. Overall, 50 women, with Fitzpatrick skin type II or III, aged between 40 and 60 years were enrolled. Several statistically significant improvements on skin ageing signs were observed ptosis (p < 0.005, Student's t-test, -4.9%), fine lines (p < 0.0001 Student's t-test, -23.8%), plumpness (p < 0.005, Student's t-test, +4.4%) and radiance (p < 0.0001 Student's t-test, +16.7%). Subjective benefits were also declared. Most participants (>85%) agreed that their skin looks smoother, more bouncy and fine lines were reduced. Also, 100% of women declare that the massage boosts their feeling of well-being. This study showed that facial self-massage provided significant, visible clinical, and self-observed skin benefits, and feelings of well-being.

A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study

BackgroundNCTF®135HA is a bio-revitalizing solution containing hyaluronic acid designed to compensate for skin dehydration, fatigue, and fine wrinkles associated with endogenous and environmental aging.MethodsWe conducted a randomized, active-controlled study to evaluate the efficacy and tolerability of NCTF®135HA injections on the face (crow’s feet), neck, and décolleté regions. Subjects were randomly assigned (3:1) to receive three NCTF®135HA treatment sessions plus twice-daily anti-aging moisturizer cream or cream alone (control). The primary outcome was the reduction in superficial wrinkles between baseline and Day (D)75 in the three areas, assessed by profilometric measures, clinical scoring, subjective changes, and tolerability.Results146 subjects were randomized to NCTF®135HA (n = 107) or control (n = 38). At D75 and D120, NCTF®135HA significantly reduced wrinkles in all three areas and improved facial radiance scores compared with the control. Skin hydration significantly increased 7 d after the last NCTF®135HA injection. Self-esteem scales showed statistically significant improvements at D75 and D120 in subjects treated with NCTF®135HA versus baseline. Most adverse events were mild, resolved within 48 h, and were related to the injection procedure.ConclusionNCTF®135HA is an effective and well-tolerated treatment to reduce the skin signs of aging. The results are significantly superior to a routine anti-aging cream alone.(Funded by Laboratories FILLMED; ID-RCB number: 2018-A03167-48; clinicaltrials.gov number: NCT05609617)

Guided Superficial Enhanced Fluid Fat Injection (SEFFI) Procedures for Facial Rejuvenation: An Italian Multicenter Retrospective Case Report.

The aging process starts in the center of the face, in the periocular region and around the mouth, with a combination of volume loss, tissue descent, deepened wrinkles, and the loss of skin structure and quality. Recently, several studies have demonstrated the efficacy of therapies based on autologous adipose tissue grafting, which leverages the properties of stromal vascular fraction (SVF) and adipose-derived mesenchymal stem cells (ADSCs) to accelerate the regenerative processes of the skin. This study aims to verify the ability of guided superficial enhanced fluid fat injection (SEFFI) in the facial area to correct volume loss and skin aging, proving that this standardized procedure has a very low rate of complications. We retrospectively collected data from 2365 procedures performed in Italian centers between 2019 and 2021. Guided SEFFI was performed alone or combined with cosmetic treatments, including the use of hyaluronic acid filler, suspension threads, synthetic calcium hydroxylapatite, botulin toxin, and microneedling. guided SEFFI was used alone in more than 60% of the patients and in all facial areas. In about one-tenth of the patients, guided SEFFI was combined with a botulin toxin treatment or hyaluronic acid filling. Other procedures were used more rarely. Ecchymosis in the donor or injection sites was the most frequent adverse event but was only observed in 14.2% and 38.6% of the patients, respectively. The guided SEFFI technique is standardized and minimally invasive, leading to very few complications. It constitutes a promising antiaging medical treatment that combines effectiveness, safety, and simplicity.

Evaluation of short-term face rejuvenation effects of non-ablative bipolar radiofrequency treatment performed by Med-RF© device.

Skin laxity and wrinkling are common signs of the aging process. This physiological condition of the skin is often accompanied by psychological and social concerns, especially for females, entailing considerable expenses for cosmetics and pharmaceuticals to cease or slow down its advancement. The objective of this study was to evaluate the short-term impact of a new non-ablative radiofrequency device available in the skin face cosmetic field. A randomized study was run on 62 healthy subjects with normal-age related-grade skin laxity, subdivided into two groups. Group 1 received one treatment with Modula RF device (Wavemed, San Cesareo RM, Italy) over the whole face surface. Group 2 received three monthly treatments. Clinical improvements of the exposed areas were detected by measuring skin parameters, such as total water content, elasticity, and sebum levels at baseline and 1 h after the treatment. Data showed significant effects of Med-RF treatment on skin hydration (p < 0.001), skin elasticity (p < 0.0001), and sebum (p = 0.0009). Moreover, a negative linear correlation was obtained between women's age and hydration. In conclusion, the results of this study suggest that radiofrequency significantly improves the subjective and objective judgment of patients and doctors, supported by the positive results obtained on the skin quality parameters evaluated. These results confirm that Med-RF technology represents an important tool to achieve face rejuvenation in the field of non-invasive procedures.

Subjective and Objective Measurements of the Facial Effects of Microdoses of Botulinum Toxin.

Studies have suggested that botulinum toxin A may improve skin quality, and application protocols using hyper-diluted doses of botulinum toxin (microdosing) have been studied as a way to achieve therapeutic goals without fully paralyzing the targeted muscles. To evaluate the effects of a combined protocol utilizing both the standard dosing and the microdosing of AbobotulinumtoxinA for the improvement of skin quality, measured by objective and subjective measurements. Thirty patients were treated with botulinum toxin using both the standard technique and the microdosing technique. Objective (Sebumeter®, Mexameter® and digital dermoscopy pictures) and subjective (Global Aesthetic Improvement Scale and a clinical scale for evaluating the quality of facial skin) measurements of the effects in the treated areas were taken to assess the efficacy of the treatment. Digital dermoscopy showed a marked reduction of erythema and telangiectasias. Erythema and telangiectasias improved both on objective and subjective measurements. Skin oleosity, static rhytids, papules and pustules and enlarged pores improved on subjective measurements. Patient satisfaction was high (93%) despite the high rate of adverse events (56%). The combined application of standard doses and microdoses of AbobotulinumtoxinA is effective in improving the overall quality of facial skin. The effects on erythema and telangiectasias suggest that it is an effective treatment option for patients with erythematotelangiectatic rosacea. When applying microdoses of botulinum toxin in the lower and mid-face, the doses and pattern of injection should be customized for each patient to reduce the occurrence of adverse events.

Penggunaan Kulit Pisang pada Proses Pemurnian Minyak Esensial Kulit Buah Jeruk Pontianak

This study aims to investigate the effect of using banana peels in the process of refining Pontianak orange peel essential oil and to assess the effect of soaking time on banana skin yield, clarity value, and quality of Pontianak orange peel essential oil. Completely randomized design (CRD) method with four different treatments, namely soaking time of banana peels for 1 day, 2 days, 3 days, and 4 days, was used in this study with three repetitions. The results showed that the longer the banana peel soaked in orange peel essential oil, the turbidity level of the oil decreased significantly. The highest turbidity was recorded at 37 NTU, while the lowest turbidity reached 17 NTU. The organoleptic test results for clarity, color, and aroma showed significant differences between the samples, which can be seen from the calculated F value which is greater than the table F value at a significance level of 5% and 1%.

Histological indicators of sheep skin of different directions of productivity

The purpose of the research was to study the histological indicators of sheep skin of different directions of productivity and to identify the effectiveness of using sheep of foreign breeds on the breeding stock of domestic fine-wooled sheep of the meat-wool direction of productivity. An analysis of histological indicators of sheep skin in diff erent areas of productivity, including the histostructure of the skin of sheep breeds of foreign selection such as Poll Dorset, Charolais and Ile de France, sheep breeds of domestic selection Stavropol, Manych merino and Dzhalginsky merino has been presented in the article. The study of the mechanism of growth and development of wool fi bers is one of the main tasks of increasing the quantity and improving the quality of wool. In studying the morphology of the skin, it is important to establish the breed and age features of the structure of the root, glandular systems, collagen structures that ensure the quality of sheep skin and wool fi bers. Thus, in sheep of Poll Dorset breed the total skin thickness was 10,3 and 3,6 % higher than in Charolais and Ile-de-France animals, respectively. At the same time, the thickness of the epidermis was almost 1,0 % of the total thickness of the skin, while the pilar layer averaged 61,8 %, the reticular layer 37,23 %, which is consistent with the breed parameters. The biggest density of follicles was observed in sheep of Ile-de-France and Charolais breeds. The superiority over animals of Poll Dorset breed was 17,5 and 10,0 %, respectively. By the ratio of secondary follicles/primary follicles animals of Poll Dorset and Ile-de-France breeds had superiority over Charolais breed by an average of 12,4 and 11,2 %. Sheep of domestic selection had an advantage in skin thickness in animals of Manych merino breed. They surpassed their herdmates of Stavropol breed by 5,2 % and Dzhalginsky merino breed by 11,2 %. In terms of the total density of follicles, animals of Stavropol breed had a slight advantage. The animals of Manych merino breed were 3,2 % inferior to them and Dzhalginsky merino by 1,4 %. There was no diff erence between the breeds by the ratio of secondary follicles/primary follicles.

Quality of Fermented Coffee Skin Waste with Several Types of Probiotics and Fermentation Time

&#x0D; &#x0D; &#x0D; &#x0D; Coffee skin waste, which is abundant in Bali's coffee-producing regions, has not been utilized and has become a public health hazard. Therefore, it is necessary to make an effort to utilize it as a beneficial raw material for animal feed, while simultaneously enhancing its quality through fermentation. Using various types of probiotics, the research conducted seeks to improve the quality of the fermentation of coffee skin waste. The study employed a completely randomized design with four kinds of probiotics: EM-4 (P1), Bio Bali Tani (P2), MOL from coffee husk (P3), and Aspergillus niger (P4), with each treatment being administered three times. In weeks 1, 2, and 3, the grade of the fermented product was evaluated in the laboratory. The results demonstrated that fermentation of coffee skin residue improved the quality of coffee skin by reducing the crude fiber content from 27.17–29.46% to 19.18–19.44% and increasing the crude protein content from 9.53–10.23% to 11.56–17.67%. The optimal fermentation period was 2 weeks, with a protein concentration of 14.67%, which was significantly different (P 0.05) from 1 week and 3 weeks. It was statistically significant (P 0.05) that LMO probiotics were 16.67% higher than EM-4 probiotics, Bio-Bali Tani, and Aspergillus niger probiotics. It can be concluded that the fermentation of coffee skin waste as animal feed can enhance the crude protein (CP) content, with local microorganisms (LMO) and a fermentation time of two weeks being optimal.&#x0D; &#x0D; &#x0D; &#x0D; &#x0D; &#x0D;

An Interim 6-Month Analysis of the Dermatologic Effects and Midface Volume Correction With XTR CL Filler in a Prospective, Single-Center Study.

Hyaluronic acid-based filler injections with parenteral anesthetics have become the standard in treating midface volume deficits. There are currently limited data on the effects of these types of fillers on skin density, thickness, and firmness. This study aimed to assess the efficacy of XTR CL filler in improving skin quality and tissue volume in women with midface volume loss. In this prospective, noncomparative, single-center study, 50 women aged between 40 and 60 years with midface volume loss were recruited. The primary endpoint was the improvement in investigator-assessed Global Aesthetic Improvement Scores (GAIS) 1 month after treatment. Secondary endpoints include objective measurements of skin density, thickness, and quality measurements, facial and/or cheek volume augmentation, subjective GAIS, and device evaluation from after the first injection until 6 months, and the documentation of injection site reactions and adverse events. XTR CL use led to significant improvement in midface volume deficits, and skin quality and skin thickness. Injector and subject satisfaction with the treatment were documented and only mild-to-moderate adverse reactions were reported. XTR CL was shown to be effective in improving volume loss and skin quality at 6 months.

Progressive hemifacial atrophy or Parry Romberg syndrome case report and literature review

Parry-Romberg syndrome is a condition characterized mainly by left-sided hemifacial atrophy that affects skin, subcutaneous tissue, muscle, and bone. The pathophysiology is not established and several theories have been proposed, among which lymphocytic neurovasculitis manifested as a chronic vascular lesion measured by incomplete endothelial regeneration stands out. The actual treatment consists of autologous fat transfer, making voluminous grafts to restore symmetry and improve the quality of the skin. An overcorrection is recommended to compensate for the reabsorption estimated of up to 80%. The treatment consists of repeated applications until correction is achieved, there is currently no consensus regarding the preparation of the graft. The objective of this work is to propose an alternative to conventional treatment by enriching fatty tissue with platelet-rich plasma, which favors the formation of extracellular matrix, collagen fibers, and angiogenesis in an accelerated manner. We conclude that the use of platelet-rich plasma significantly improves skin quality and fat graft integration.

Reverse skin aging signs by red light photobiomodulation.

Photobiomodulation is a process by which the absorption of red light energy produces a series of physiological effects at the cellular level such as the enhancement of mitochondrial Adenosine Triphosphate (ATP) production, cell signaling and growth factor synthesis, and the reduction of oxidative stress. Light emitting diodes (LEDs) photobiomodulation is an increasingly popular therapy for treating skin problems, especially for reversing the signs of skin aging. The objective of this study is to demonstrate the effectiveness of a photobiomodulation treatment using red LEDs on the facial skin at a rate of two sessions per week for 3 months. The LED mask used is the Skin Light Dior x Lucibel mask diffusing a cold red light with a wavelength of 630±10nm and a power of 15.6 J/cm2 for a duration of 12 min. In order to demonstrate the effectiveness of the mask in reversing the signs of skin aging, a clinical study was conducted on 20 healthy Caucasian women: the antiwrinkle effect by measuring the depth of the crow's feet wrinkle, the relaxation of the oval of the face by clinical scoring, the firmness and elasticity of the skin by cutometric measurement, the density of the dermis by ultrasound analysis, the smoothness of the skin by measuring the roughness at the cheek, the homogeneity of the complexion by chromametric measurement, the diameter of the pores by macrophotographs and finally the sebo-regulating effect by measurement of the rate of sebum and quantification of the number of pores containing porphyrin in the subjects presenting a mixed to oily skin. The satisfaction of the volunteers was also evaluated at the end of the study via a self-questionnaire. The efficacy results measured after 1, 2, and 3 months of use are progressive and confirm the interest of LED photobiomodulation to reverse the visible signs of skin aging. All the volunteers observed an overall improvement in skin quality. All the results observed confirm the interest of using photobiomodulation to reverse the visible signs of aging. These results last for up to 1 month after stopping the use of the mask, which is a sign of lasting structural and functional rejuvenation of the skin.

Achievement and maintenance of therapeutic response to brodalumab in patients with moderate‐to‐severe plaque psoriasis: An Italian, observational, retrospective and prospective study (BRIGHT study)

AbstractBackgroundBrodalumab, a fully human anti‐interleukin (IL)‐17 monoclonal antibody that blocks IL‐17RA, is approved in Europe for the treatment of adult patients with moderate‐to‐severe plaque psoriasis who are candidates for systemic treatment.ObjectivesThis study evaluated the achievement and maintenance of therapeutic response for 1 year in psoriasis patients treated with brodalumab in the Italian clinical practice.MethodsReal‐world, multicenter, observational, retrospective and prospective study. The retrospective phase ranged from enrolment visit to initiation of brodalumab (12 ± 4 weeks before). The prospective phase ranged from enrolment to a routine follow‐up visit set after 52 ± 4 weeks.ResultsOne hundred eighty‐four patients were eligible and 164 completed the observation period (median 11.9 months; Q1–Q3: 11.4–12.3). At enrolment, the mean duration of disease was 13.9 years (standard deviation; 13.3), 94% of patients (N = 172) had ≥1 clinical manifestation of psoriasis, mainly erythema and itching, and 95.6% had received ≥1 antipsoriatic treatment before brodalumab. Patients who reached an absolute Psoriasis Area and Severity Index (PASI) score ≤3 at week 12 and maintained it ≤3 through week 52 were 97 (64.7%). At week 12, 72.7% of patients achieved PASI 75, 54.5% PASI 90 and 42.0% PASI 100. At Week 52, 92.9% of patients achieved PASI 75, 84.4% PASI 90 and 61.7% PASI 100. A static Physician's Global Assessment (sPGA) score = 0 was obtained by 55.0% of patients after 12 weeks of brodalumab and by 77.0% after 52 weeks. A Dermatology Life Quality Index ≤1 was reported by 71.9% of patients after 12 weeks and by 89.9% after 52 weeks of treatment. No significant outcome differences were shown among patient subgroups defined by previous antipsoriatic treatments (none, systemic other than biologics or biologic) at either brodalumab initiation or any of the subsequent study visits.ConclusionsIn this real‐world setting, brodalumab was rapidly effective on skin lesions and quality of life both in biologic‐naïve and biologic‐experienced moderate‐to‐severe psoriasis patients, with a favourable safety profile.

Assessing the effectiveness of turmeric and tamarind leaves extract cream as anti-aging in vivo

Turmeric and tamarind leaves extract creams have potential as anti-aging agents, but their use has never been studied in vivo. Therefore the purpose of this study was to determine the effectiveness of turmeric and tamarind leaves extract cream in maintaining skin quality in vivo. This research was carried out by applying turmeric and tamarind leaf extract cream to 24 volunteers (having received approval from the ethical commission). Variables observed included sebum content, pore size, pigment content, moisture or moisture content, elasticity and collagenase content. The results showed that turmeric and tamarind leaves extract cream can increase sebum content up to 31.1%, reduce pore size to 0.017 mm, increase pigment content up to 13.2%, moisture up to 54.2%, elasticity up to 21.4% and collagenase content up to 37.3%.

Panthenol Citrate Biomaterials Accelerate Wound Healing and Restore Tissue Integrity.

Impaired wound healing is a common complication for diabetic patients and effective diabetic wound management remains a clinical challenge. Furthermore, a significant problem that contributes to patient morbidity is the suboptimal quality of healed skin, which often leads to reoccurring chronic skin wounds. Herein, a novel compound and biomaterial building block, panthenol citrate (PC), is developed. It has interesting fluorescence and absorbance properties, and it is shown that PC can be used in soluble form as a wash solution and as a hydrogel dressing to address impaired wound healing in diabetes. PC exhibits antioxidant, antibacterial, anti-inflammatory, and pro-angiogenic properties, and promotes keratinocyte and dermal fibroblast migration and proliferation. When applied in a splinted excisional wound diabetic rodent model, PC improves re-epithelialization, granulation tissue formation, and neovascularization. It also reduces inflammation and oxidative stress in the wound environment. Most importantly, it improves the regenerated tissue quality with enhanced mechanical strength and electrical properties. Therefore, PC could potentially improve wound care management for diabetic patients and play a beneficial role in other tissue regeneration applications.

Design and Experimental Research of Intelligent Inspection and Classification System for Yuba Skin Quality

At present, the surface quality of Yuba skin is determined by sensory methods. In order to realize the intelligent classification detection of Yuba skin quality, this study designed a system that automatically determines the quality of Yuba skin surfaces based on image processing and support vector machine (SVM) approaches. Specifically, the system uses image preprocessing to extract the grayscale eigenvalues, gray level co-occurrence matrix (GLCM) eigenvalues, and gray level run length matrix (GLRLM) eigenvalues of the sample image and uses them as input values for a quality grading system. Through model evaluation of three classification models, the SVM classification model was selected according to the evaluation results, and different kernel functions were used in the model for sample training. Based on Matlab, the quality grading software of Yuba skin was developed and designed. Intelligent detection and grading were realized through the radial basis kernel function support vector machine (RBF-SVM) grading model. The best penalty factor (c = 3.50) and kernel parameter value (g = 0.98) were obtained through cross-validation. The accuracy of the model was 95.31% and 94.16% for the training and test sets, respectively. The grading accuracy of the RBF-SVM grading system was 93.56%, and the error was less than 5% compared with the traditional sensory method of grading; thus, the quality classification method based on the SVM classification system for Yuba skin is feasible and can be used for quality detection.

Tildrakizumab improves high burden skin symptoms, impaired sleep and quality of life of moderate-to-severe plaque psoriasis patients in conditions close to clinical practice.

Tildrakizumab (TIL) is an interleukin (IL)-23p19 inhibitor for the treatment of moderate-to-severe plaque psoriasis with long-term efficacy and safety demonstrated in Phase III trials. Studies conducted in conditions closer to clinical practice are needed. The TRIBUTE study (open-label, Phase IV) assessed the efficacy and impact on health-related quality of life (HRQoL) of TIL 100 mg in adult moderate-to-severe psoriasis patients (naïve to IL-23/Th17 pathway inhibitors) in conditions similar to clinical practice. Key efficacy measure was Psoriasis Area Severity Index (PASI). HRQoL was evaluated using the Dermatology Life Quality Index (DLQI) and Skindex-16. Additional patient-reported outcomes included Pain-, Pruritus- and Scaling-Numerical Rating Scale (NRS), Medical Outcome Study (MOS)-Sleep, Work Productivity and Activity Impairment (WPAI), Patient Benefit Index (PBI) and Treatment Satisfaction Questionnaire for Medication (TSQM). One hundred and seventy-seven patients were enrolled (six patients did not complete the study). After 24 weeks, the proportion of patients achieving PASI scores ≤ 3, PASI 75, PASI 90 and DLQI 0/1 was 88.4%, 92.5%, 74.0% and 70.4%, respectively. Skindex-16 overall score improved (mean absolute change from baseline, MACB [95%CI]: -53.3 [-58.1, -48.5]). Significant benefits (MACB [95%CI]) were found on pruritus-, pain- and scaling-NRS scores (-5.7 [-6.1, -5.2], -3.5 [-4.1, -3.0] and -5.7 [-6.2, -5.2], respectively), MOS-Sleep (-10.4 [-13.3, -7.4] Sleep problems Index II) and WPAI (-36.4 [-42.6, -30.2] activity impairment, -28.2 [-34.7, -21.7] productivity loss, -27.0 [-32.9, -21.1] presenteeism and -6.8 [-12.1, -1.5] absenteeism). 82.7% of patients reported PBI ≥ 3 and the mean (SD) global TSQM score was high (80.5 [18.5]). Only one serious treatment-emergent adverse event was reported (not-related to TIL). TIL 100 mg treatment after 24 weeks in conditions close to real clinical practice showed a quick and high improvement in psoriasis signs and HRQoL. Patient reported improvements in sleep outcomes and work productivity, relevant benefits and high treatment satisfaction. The safety profile was favourable and consistent with Phase III trials.