Skin Potential Research Articles

The Role of Stem Cell on Wound Healing After Revascularization-Healing Following Revascularization-Unlocking Skin Potential.

Wound healing is a complex and dynamic process involving a series of cellular and molecular events. Revascularization, the restoration of blood flow to ischemic or damaged tissue, is a key step in wound healing. Adequate vascularization has been recognized as a necessary factor for successful tissue regeneration. In the later stage of revascularization and tissue remodeling in wound healing, stem cells regulate other repair cells and matrix formation by influencing the maturation of blood vessels. The reductive oxidation (REDOX) state may be a key mechanism through stem/progenitor cells to influence endothelial cells to mature blood vessels and improve the quality of healing. Mitochondria may play an important role in this process.

Optimizing Energy Efficiency in High-Rise Residential Buildings in Abu Dhabi’s Hot Climate: Exploring the Potential of Double Skin Façades

This study investigates energy efficiency in high-rise residential buildings in Abu Dhabi, where the increased use of glass building façades has led to increased air-conditioning costs due to heat gain. The research focuses on evaluating the type of glass and the appropriate cavity between glass façades to minimize energy consumption while incorporating sustainability and innovative design principles. To achieve these objectives, this study employs a Double Skin Façade (DSF), a high-performance façade that adapts to the external climate conditions to fulfill internal cooling load requirements and meet occupants’ needs. Data were collected through an online survey distributed among residents of a selected residential tower, and a combination of qualitative and quantitative approaches was utilized to analyze the gathered information. The selected case study was analyzed using Energy Plus simulation software using the existing data and available details. The analysis aimed to identify the optimal DSF design that significantly enhances energy efficiency. The findings of this study emphasize the substantial impact of the optimum DSF design on energy efficiency in high-rise residential buildings. Through modeling existing data and comparing them with new model results for each variable, this study demonstrates that a DSF with a 35 cm cavity, comprising a double-glazed single skin layer in the interior and a Low-E double-glazed single skin layer as an outer layer, can reduce overall air-conditioning energy consumption by over 25%. These outcomes provide valuable insights into implementing DSF as a solution to address the unique energy challenges presented by high-rise residential buildings in hot climates.

Equilibrium and fixed-bed kinetics study on hazelnut skin polyphenols extraction using choline chloride –lactic acid-based NADES and water as solvents

This paper focuses on the potential of Hazelnut Skin, a waste product from the food industry, as a source of polyphenols in line with circular economy principles. Two environmentally friendly solvents, water and Natural Deep Eutectic Solvent (NADES), were utilized for the extraction process. First of all, the extraction potential of both solvents was evaluated and an amount of 172.2 mg/g and 470.2 mg/g of free polyphenols per unit mass of solid were obtained using Water and NADES respectively. The solid–liquid equilibrium was also deeply investigated observing that two main phenomena are involved during the process: solubilisation and adsorption. An innovative model based on the combination of Langmuir isotherm and the introduction of a partitioning coefficient to describe a progressive approach to the solubility limit was then proposed to characterize the thermodynamics of the system. While NADES showed promising results compared to water in terms of amount of polyphenols extracted, there are several challenges that need to be addressed before implementing NADES in large-scale extraction processes. Hence, in this study continuous tests were conducted to observe the behavior of both solvents in a fixed-bed column that emulates a section of an industrial belt extractor. The experimental data collected were fitted by means of the Broken Intact Cells (BIC) Model. It was found out that the internal mass transfer resistance is the controlling one and the correspondent mass transfer coefficient estimated was 1.3·10-3 min−1 for Water and 6.67·10-4 min−1 for NADES. The results obtained from this study can be considered valuable resources for improving the existing methods of extracting polyphenols from waste matrices using water and for developing innovative approaches that utilize NADES as a solvent.

In vitro assessment of inflammatory skin potential of poly(methyl methacrylate) at non-cytotoxic concentrations.

Poly(methyl methacrylate) (PMMA) is considered an attractive substrate material for fabricating wearable skin sensors such as fitness bands and microfluidic devices. Despite its widespread use, inflammatory and allergic responses have been attributed to the use of this material. Therefore, the main objective of this study was to obtain a comprehensive understanding of potential biological effects triggered by PMMA at non-cytotoxic concentrations using in vitro models of NIH3T3 fibroblasts and reconstructed human epidermis (RhE). It was hypothesized that concentrations that do not reduce cell viability are sufficient to activate pathways of inflammatory processes in the skin. The study included cytotoxicity, cell metabolism, cytokine quantification, histopathological, and gene expression analyses. The NIH3T3 cell line was used as a testbed for screening cell toxicity levels associated with the concentration of PMMA with different molecular weights (MWs) (i.e., MW ~5,000 and ~15,000 g/mol). The lower MW of PMMA had a half-maximal inhibitory concentration (IC50 ) value of 5.7 mg/cm2 , indicating greater detrimental effects than the higher MW (IC50 = 14.0 mg/cm2 ). Non-cytotoxic concentrations of 3.0 mg/cm2 for MW ~15,000 g/mol and 0.9 mg/cm2 for MW ~5,000 g/mol) induced negative metabolic changes in NIH3T3 cells. Cell viability was severely reduced to 7% after the exposure to degradation by-products generated after thermal and photodegradation degradation of PMMA. PMMA at non-cytotoxic concentrations still induced overexpression of pro-inflammatory cytokines, chemokines, and growth factors (IL1B, CXCL10, CCL5, IL1R1, IL7, IL17A, VEGFA, FGF2, IFNG, IL15) on the RhE model. The inflammatory response was also supported by histopathological and gene expression analyses of PMMA-treated RhE, indicating tissue damage and gene overexpression. Results suggested that non-cytotoxic concentrations of PMMA (3.0 to 5.6 mg/cm2 for MW ~15,000 g/mol and 0.9 to 2.1 mg/cm2 for MW ~5,000 g/mol) were sufficient to negatively alter NIH3T3 cells metabolism and activate inflammatory events in the RhE skin.

Super anti-freezing, fast-responsive nanocomposite organohydrogels with excellent mechanical properties as multifunctional sensors for human motion monitoring

Conventional hydrogel sensors are always restricted in real applications due to weakness in mechanical properties, freezing and dehydration ability, as well as limited sensing functionality. Herein, a multifunctional nanocomposite organohydrogel is constructed by polyvinyl alcohol, tannic acid green reduction of graphene oxide with ethylene glycol-water (EG/H2O) binary solvent through a common freezing-thawing process to overcome the above challenges. The organohydrogel shows favorable stretchability (369%), tensile toughness (up to 1850.48 KJ/m3) and strength (tensile/compressive strength of 603 kPa/2181.63 kPa). Meanwhile, it exhibits a super anti-freezing (−133.7 °C) and moisturizing performance. As multifunctional sensors (strain/pressure/temperature sensors), it shows stable and sensitive detection in a large temperature range, and fast response (66 ms/5 ms as a strain/pressure sensor respectively). This high-performance multifunctional organohydrogel shows promising potential in flexible electronic devices, electronic skin and soft robots.

Assessment of the feed additive consisting of Lactiplantibacillus plantarum (formerly Lactobacillus plantarum) NCIMB 30084 for all animal species for the renewal of its authorisation (Chr. Hansen A/S).

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on assessment of the application for renewal of authorisation Lactiplantibacillus plantarum (previously Lactobacillus) NCIMB 30084 as a technological feed additive, silage additive for all animal species. The applicant has provided evidence that the additive currently on the market complies with the existing conditions of authorisation. There is no new evidence that would lead the FEEDAP Panel to reconsider its previous conclusions. Thus, the Panel concludes that the additive remains safe for all animal species, consumers and the environment under the authorised conditions of use. Regarding user safety, the additive should be considered as a respiratory sensitiser. No conclusions can be drawn on the skin sensitisation, and skin and eye irritancy potential of the additive. There is no need for assessing the efficacy of the additive in the context of the renewal of the authorisation.

Skin properties of itching without symptoms and associated factors among older adults in long-term care facilities.

Since itching without rash frequently among older adults' population, study about skin properties of itching without rash is important to develop prevention methods. Therefore, this study explored the skin properties related to itching without rash and the factors associated with them. A correlation, predictive designs study was conducted at Indonesian Long-term Care (LTC) facilities. Skin properties including skin barrier function and skin inflammation were examined by photographs (macroscopic and microscopic), stratum corneum (SC) hydration, skin Potential of Hydrogen (pH), and skin blotting. Itching experience and skincare behavior were obtained by questionnaire. The itching-related skin properties and associated factors were analyzed. A total of 405 residents participated in this study, with mean age was 74 years. The prevalence of itching on the whole body was 69.1%, and 50.3% of those manifesting itching on the left forearm involved itching without macroscopic abnormalities (itching without rash). SC hydration, skin pH, albumin and nerve growth factor β (NGFβ) were associated with itching without rash (p = 0.007, 0.012, < 0.001, and < 0.001, respectively). Additionally, factors associated with skin properties were age, sex, sun exposure experience, skincare, and hygiene care in the linear regression analysis. Measurement of skin biomarkers using skin blotting was a possible objective measurement of itching skin properties without rash regardless of the environmental condition.

Waterproof Flexible Pressure Sensors Based on Electrostatic Self-Assembled MXene/NH2-CNTs for Motion Monitoring and Electronic Skin.

Flexible wearable sensors to monitor human movement and for electronic skins must exhibit high sensitivity, a wide detection range, and waterproof characteristics. This work reports a flexible, highly sensitive, and waterproof sponge pressure sensor (SMCM). The sensor is made by assembling SiO2 (S), MXene (M), and NH2-CNTs (C) on the backbone of melamine sponge (M). The SMCM sensor exhibits excellent sensitivity (10.8 kPa-1), an ultra-short response/recovery time (40 ms/60 ms), a wide detection range (30 kPa), and an extremely low detection limit (4.6 Pa). Benefiting from layer-by-layer self-assembly, the sensor still exhibits excellent stability after 5000 cycles. In addition, the SMCM sensor also has excellent waterproof performance (a water contact angle of 142°), enabling it to operate unaffectedly under wet conditions. The SMCM sensor can accurately detect small body movements such as pulse and swallowing while also accurately detecting finger and elbow movements. In addition, the sensor can be designed as an array to construct an electronic skin for detecting the magnitude and distribution of external pressure. This work holds great application potential in next-generation electronic skin, fitness detection, and flexible pressure sensors.

Assessment of the feed additive consisting of Pediococcus pentosaceusNCIMB 30168 for all animal species for the renewal of its authorisation (Volac International Ltd).

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the assessment of the application for renewal of Pediococcus pentosaceus NCIMB 30168 as a technological additive for use in forage for all animal species. The applicant has provided evidence that the additive currently on the market complies with the existing conditions of authorisation. There is no new evidence that would lead the FEEDAP Panel to reconsider its previous conclusions. Thus, the Panel concludes that the additive remains safe for all animal species, consumers and the environment under the authorised conditions of use. Regarding user safety, the additive should be considered as a respiratory sensitiser. No conclusions can be drawn on the skin sensitisation, and skin and eye irritancy potential of the additive. There is no need for assessing the efficacy of the additive in the context of the renewal of the authorisation.

Skin and eye irritancy assessment of six lactic acid bacteria strains

Here we investigate the suitability of in vitro models to assess the skin and eye irritation potential of six microbial strains. Acute skin irritation was tested according to the unmodified and modified OECD test guideline (OECD TG) 439, while acute eye irritation was examined using the OECD TG 491 and 492. The OECD TG 439 guideline, modified to introduce 8–10 μg/mL of streptomycin during the recovery phase and use of test items containing 100% microbial product instead of finished formulae, was found to be suitable for skin irritation evaluation. On the other hand, the OECD TG 491 procedure was the most appropriate for evaluating eye irritation. None of the six microbial strains, namely, Lactiplantibacillus plantarum (IMI 507026, IMI 507027, IMI 507028), Lacticaseibacillus rhamnosus (IMI 507023), and Pediococcus pentosaceus (IMI 507024, IMI 507025), tested in this study caused skin or eye irritation under the study condition.

MP-453081-9 CARDIAC SYMPATHOEXCITATION MONITORING DURING PULMONARY VEIN ISOLATION BY PSYCHOGENIC SWEATING: POSSIBILITY OF REPRESENTING CARDIAC SYMPATHETIC NEUROMODULATION

Vagal responses during pulmonary vein isolation (PVI) have been reported, suggesting cardiac neuromodulation in atrial fibrillation (AF) patients. The cardiac sympathetic nervous system also innervates the left atrium (LA) and its nerve fibers are reported to be greatly distributed around the PV antrum. However, the sympathetic nervous system’s response during PVI is unclear and the precise method to evaluate the cardiac sympathetic reflex is still not established. Psychogenic sweating (skin potential response; SPR) occurs during sympathetic excitation and may be useful to represent cardiac sympathoexcitation during PVI. We investigated whether the SPR could represent a cardiac sympathetic response during a balloon-based PVI and considered its clinical implications in persistent AF patients. Eighty persistent AF patients (Hot-balloon;45pt, Cryoballoon;35pt) were enrolled and the SPR was monitored during balloon-based ablation of each PV. The SPR was measured by the difference in two skin potentials recorded from skin electrodes (Figure top row). The reduction in the activation recovery interval (ARI), suggesting sympathetic excitation, was examined from the ventricle unipolar electrogram of the great cardiac vein recorded from an electrode catheter placed inside the coronal sinus (Figure bottom row). An ROC analysis was used to determine a valid reduction in the SPR, with a reduction cut-off value of 3.5mV in the heart rate (HR) increase due to sympathoexcitation (sensitivity 73%, specificity 97%). SPRs occurred in 41% of the PVs (LSPV=41%, RSPV=38%, LIPV=28%, RIPV=20%). The SPR was related to a significant increase in the blood pressure and HR, and a reduction in the ARI (p<0.01, Table). A total of 18 patients (20%) had AF recurrences within the 1-year follow-up. The number of SPRs within the 4PVs was 1.08PV in non-recurrence patients and 1.83PV in AF recurrent patients (p=0.07). The patients that had early recurrences but recovered sinus rhythm (SR) within 3 months, had more frequent SPRs than the other recurrent patients (2.80 vs. 0.63PV, p<0.01). The SPR was strongly related to cardiac sympathoexcitation during PVI. The SPR was suggested to represent the cardiac sympathetic reflex during PV antrum ablation, which may lead to an investigation of the cardiac sympathetic neuromodulation during PVI. Frequent SPRs were related to SR recovery after early AF recurrences and a cardiac sympathetic response may have an important role in the outcome of the PVI.

Preparation and Antibiosis Investigation of Kaolinite Nanotubes and Silver Nanowires Co-Doped Electrospinning-Silk Fibroin/Gelatin Porous Fiber Films

Skin wounds are one of the most common injuries for the human body; they can lead to an infection and cause tissue necrosis and even life-threatening injuries. Therefore, it is an urgent task to develop skin scaffold materials to meet the various needs of restoring skin’s structural integrity. In this research, kaolinite nanotubes and silver nanowires co-doped silk fibroin and gelatin composite porous fiber films were fabricated by an electrospinning method. The composition, micrograph, chemical states of elements included, biocompatibility, and antimicrobial properties of the samples produced were analyzed. After co-doping kaolinite nanotubes and silver nanowires, the fiber diameter of the porous fiber films became uniform, and the beads in the film were reduced significantly. The silk fibroin/gelatin/kaolinite nanotubes/silver nanowire (SF/GEL/KA-N/AgNWs) film shows antibacterial activity against S. aureus and E. coli, and the antibacterial rings were 7.42 mm and 5.76 mm, respectively. All the films were free of cytotoxicity and provided good biocompatibility, which is a great clinical application potential in skin.

Review of Studies on Emotion Recognition and Judgment Based on Physiological Signals

People’s emotions play an important part in our daily life and can not only reflect psychological and physical states, but also play a vital role in people’s communication, cognition and decision-making. Variations in people’s emotions induced by external conditions are accompanied by variations in physiological signals that can be measured and identified. People’s psychological signals are mainly measured with electroencephalograms (EEGs), electrodermal activity (EDA), electrocardiograms (ECGs), electromyography (EMG), pulse waves, etc. EEG signals are a comprehensive embodiment of the operation of numerous neurons in the cerebral cortex and can immediately express brain activity. EDA measures the electrical features of skin through skin conductance response, skin potential, skin conductance level or skin potential response. ECG technology uses an electrocardiograph to record changes in electrical activity in each cardiac cycle of the heart from the body surface. EMG is a technique that uses electronic instruments to evaluate and record the electrical activity of muscles, which is usually referred to as myoelectric activity. EEG, EDA, ECG and EMG have been widely used to recognize and judge people’s emotions in various situations. Different physiological signals have their own characteristics and are suitable for different occasions. Therefore, a review of the research work and application of emotion recognition and judgment based on the four physiological signals mentioned above is offered. The content covers the technologies adopted, the objects of application and the effects achieved. Finally, the application scenarios for different physiological signals are compared, and issues for attention are explored to provide reference and a basis for further investigation.

Stretchable self-adhesive and self-powered smart bandage for motion perception and motion intention recognition

The research on flexible and stretchable self-powered sensors perceiving human body motion and physiological signals has become a hot spot in recent years. Aided with machine learning, more features of the human motion and physiological signals can be intelligently interpreted. Here, we first propose a triboelectric nanogenerator (BMS-TENG) based on highly conductive multi-walled carbon nanotubes, flexible and stretchable silica gel, and a self-adhesive elastic bandage, which is highly stretchable and self-adhesive for easy fixation on the skin. The maximum stretchability of the sensor is 502%. BMS-TENG sensor can collect a variety of human motion and physiological signals, such as bending fingers and elbows, lifting legs, breathing, and swallowing. With the support of machine learning, we propose a smart bandage system capable of acquiring motion signals and recognizing intentions. By collecting signals from the forearm near the elbow instead of the fingers, the smart bandage can recognize various gestures and muscle action features. Applications of intention-manipulating diverse gestures from the robotic hand and individual identification work well. The system has great potential in human motion monitoring, electronic skin, human-computer interaction, gesture recognition, biomedicine, and other fields.

Safety and efficacy of a feed additive consisting of vitamin B2 (riboflavin) produced by Bacillus subtilisCGMCC 13326 for all animal species (Kempex Holland B.V.).

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) of EFSA was asked to deliver a scientific opinion on the safety and efficacy of vitamin B2 (riboflavin) produced by Bacillus subtilis CGMCC 13326 as a nutritional feed additive for all animal species. The additive is produced by a genetically modified production strain. Although the production strain harbours some genes coding for resistance to antimicrobials, viable cells and DNA of the production strain were not detected in the final product. Therefore, the use of B. subtilis CGMCC 13326 to produce vitamin B2 does not raise safety concerns. The use of riboflavin 80% produced by B. subtilis CGMCC 13326 in animal nutrition does not represent a safety concern for the target species, consumers and for the environment. In the absence of data, the FEEDAP Panel cannot conclude on the potential skin and eye irritation or potential toxicity by inhalation of the additive under assessment. Riboflavin is a known photosensitiser which may elicit skin and eye photoallergic reactions. The additive under assessment is effective in covering the animals' requirements of vitamin B2 when administered via feed.

Assessment of eight feed additives consisting of Lactiplantibacillus plantarumCNCM I-3235, L. plantarumCNCM I-3736/DSM 11672, Pediococcus acidilacticiCNCMI-3237, P. acidilacticiCNCM I-4622/DSM 11673, Pediococcus pentosaceusNCIMB 12455, Acidipropionibacterium acidipropioniciCNCM I-4661, Lentilactobacillus buchneriNCIMB 40788/CNCM I-4323 and L. buchneriNCIMB 40788/CNCM I-4323 plus Lentilactobacillus hilgardiiCNCM I-4785 for all animal species for the renewal of their authorisation (Danstar Ferment AG).

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the assessment of the application for renewal of eight technological additives, including two Lactiplantibacillus plantarum (formerly Lactobacillus plantarum) [CNCM I-3235 and CNCM I-3736/ DSM 11672], two Pediococcus acidilactici [CNCM I-3237 and CNCM I-4622/DSM 11673], one Pediococcus pentosaceus [NCIMB 12455], one Acidipropionibacterium acidipropionici (formerly Propionibacterium acidipropionici) [CNCM I-4661], one Lentilactobacillus buchneri (formerly Lactobacillus buchneri) [NCIMB 40788/ CNCM I-4323], and the additive composed by the two active agents L. buchneri NCIMB 40788/ CNCM I-4323 and Lentilactobacillus hilgardii (formerly Lactobacillus hilgardii) CNCM I-4785, as silage additives for use in forage for all animal species. The applicant has provided evidence that the additives currently on the market comply with the existing conditions of authorisation. There is no new evidence that would lead the FEEDAP Panel to reconsider its previous conclusions. Thus, the Panel concluded that the additives remain safe for all animal species, consumers and the environment under the authorised conditions of use. Regarding user safety, the additives should be considered as respiratory sensitisers. In the absence of data, no conclusions could be drawn on the skin sensitisation, and skin and eye irritancy potential of the additives, with the exception for Pediococcus acidilactici CNCM I-4622/DSM 11673 (for which the Panel concluded that is non-irritant to skin and eyes). There is no need for assessing the efficacy of the additives in the context of the renewal of the authorisation.

Sensing Bioavailable Water Content of Granulated Matrices: A Combined Experimental and Computational Study.

This paper represents the synthesis, characterization and validation of a cobalt chloride functionalised nano-porous cellulose membrane, a unique sensor for non-contact measurement of water potential in various biomedical and environmentally important matrices. The developed nano sensor, along with associated electronic components, is assembled as a prototype device called "MEGH" (Measuring Essential Good Hydration) to measure essential hydration of matrices of both environmental and biomedical importance, including soil and human skin. The relative humidity above the soil surface in equilibrium with the soil moisture has been studied for both hydrophobic and hydrophilic soil types. Our studies confirm that the percentage of water available to plants is greater in hydrophobic soil rather than in hydrophilic soil, which has also been corroborated using simulation studies. Furthermore, the requirement of hydration in human skin has also been evaluated by measuring the water potential of both dry and moist skin.

Islam and Environment (A Study of Durian Skin Waste as an Adsorbent to Overcome Water Pollution)

Nowadays environmental pollution has become a serious problem. Textile dye waste is one of the biggest contributors to environmental pollution. Durian (Durio zibethinus) has been known as a popular fruit in Indonesia. However, only several part of the durian fruit is used, namely its flesh. Durian skin is generally only thrown away and becomes waste pollutes the environment. Durian skin waste can be used as activated carbon in overcoming textile dye waste pollution. This study aims to determine the potential of durian skin from Luwu Regency, South Sulawesi as an adsorbent for textile dye waste. The process of making activated carbon is carried out through two stages that is physically by heating at 600 oC and chemically with hydrochloric acid 1M as activator and stirring for 24 hours. The quality test of activated carbon includes tests for water content, ash content, volatile matter content and fixed carbon content. The results showed that the activated carbon of the durian skin had met the standards of SNI 06-3730-1995, namely water content 12.1%, ash content 0.2%, volatile matter content 27.3% and bound carbon content 72.5%.

Advances and Innovations of 3D Bioprinting Skin.

Three-dimensional (3D) bioprinted skin equivalents are highlighted as the new gold standard for alternative models to animal testing, as well as full-thickness wound healing. In this review, we focus on the advances and innovations of 3D bioprinting skin for skin regeneration, within the last five years. After a brief introduction to skin anatomy, 3D bioprinting methods and the remarkable features of recent studies are classified as advances in materials, structures, and functions. We will discuss several ways to improve the clinical potential of 3D bioprinted skin, with state-of-the-art printing technology and novel biomaterials. After the breakthrough in the bottleneck of the current studies, highly developed skin can be fabricated, comprising stratified epidermis, dermis, and hypodermis with blood vessels, nerves, muscles, and skin appendages. We hope that this review will be priming water for future research and clinical applications, that will guide us to break new ground for the next generation of skin regeneration.

Multifunctional flexible conductive filament for human motion detection and electrothermal

Highly sensitive wearable e-textiles play an important role in flexible sensors and next-generation personalized electronics with application potential in human physiological monitoring, environmental monitoring, and electronic skin. Here, a scalable and simple strategy for preparing liquid metal (LM)/carbon nanotubes (CNTs)@Ecoflex (LCEF) coaxial conductive filaments were fabricated by wet spinning. The electro-mechanical response behaviors of LCEF sensors were explored to evaluate their sensitivity and stability. The results demonstrated that the filament strain sensors could be used for monitoring both large and subtle human motions. Besides, the LCEF fabrics as a large-area flexible heater exhibited efficient electrothermal response, evidenced by achieving a temperature of over 112.1 °C upon applying a voltage of 12 V with 52.6 °C obtained on the fabrics within 42 s. This work may shed lights on scalable fabrication of flexible strain sensors and electrothermal devices which pave the way for the development of multifunctional wearable electronic devices.