Skin Manifestations In Patients Research Articles

Serum Lactate Dehydrogenase Is a Novel Marker for the Evaluation of Disease Severity in the Early Stage of Toxic Epidermal Necrolysis

Objective: To evaluate serum lactate dehydrogenase (LDH) and its correlation with skin manifestations in patients with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Methods: Serum LDH levels were measured in 33 patients (17 SJS and 16 TEN), from initial hospital admission to remission stage. Results: The mean LDH level was 920.82 ± 655.50 U/l in TEN and 595.35 ± 182.03 U/l in SJS (normal range: 218–472). We arbitrarily divided these patients into 2 groups, the first were admitted within 3 days of onset (early stage) and the second after 4 days of onset (late stage). The ratio of early- to late-stage patients was 7:9 in TEN and 7:10 in SJS. The mean LDH level for 7 TEN patients in the early stage was 1,319.14 ± 843.10 U/l, which was significantly higher than that of the SJS group (686.71 ± 171.81 U/l; p = 0.024). In the late-stage patients, the mean levels of TEN and SJS patients were 611.0 ± 160.33 and 531.4 ± 167.89 U/l, respectively; these differences between TEN and SJS were not significant. Conclusion: Serum LDH levels can be used as a marker of disease severity in the early stage of TEN.

A case of Behçet’s disease associated with necrotizing small vessel vasculitis

Cutaneous manifestations are an important feature of Behçet's disease (BD) and are classified as a major diagnostic criterion by the International Study Group (ISG). Necrotizing vasculitis as a skin manifestation in patients with BD has been reported rarely. In this report, we describe a patient who fulfills ISG criteria for the diagnosis of BD with necrotizing small vessel vasculitis developed necrosis on distal part of the fifth finger of right foot and the heel.

Manifestations cutanées des leucémies

Skin manifestations in patient with malignant hematology diseases are very diverse. Knowledge of these manifestations is important in clinical practice. On one hand, it permits the diagnosis of an unknown malignant hematology diseases, and on the other hand, certain skin lesions can alter the prognosis or therapeutic approach in known disease. These skin manifestations can be split into four categories : specific skin lesions, “satellite” or paraneoplastic lesions, skin infections, and skin lesions induced by chemotherapy. The clinical, and histological aspects of these manifestations are very rich indeed. The specific skin manifestations are often easily diagnosed, but can be mistaken for cases of myelodysplastic syndromes. The satellite manifestations are characterized by neutrophilic dermatoses and vasculitis.The skin infections may be misleading as a result of the neutropenia. Skin biopsy should be repeat for histological, bacteriological, virological, and mycological examinations in patient with malignant hematology diseases.

Aspectos dermatológicos da toxoplasmose

São efetuadas considerações sôbre manifestações cutâneas encontráveis em pacientes com toxoplasmose adquirida. Fundamentalmente, foram verificadas as seguintes alterações: a) erupção máculo-papular petequial; b) alteração mãculo-papular; c) erupção vesiculosa: d) erupção escarlatiniforme; e) eritema nodoso; f) erupção de caráter misto. O assunto mereceu comentários sobretudo som a finalidade de ser apresentada uma sistematização inicial, tendo ficado salientado que a toxoplasmose oferece aos dermatologistas, sem dúvida, motivos justificadores de cabais interesse e atenção.

Erythema gyratum repens; skin manifestations in patient with carcinoma of breast.

THE DERMATOLOGIST of the twentieth century has been trained to consider the possibility of internal diseases in all cases of atypical, bizarre, or recalcitrant dermatoses. As skin lesions are frequently the first signs of various types of malignant lymphoma, he is often in a position to suspect these fatal diseases before a clinical or laboratory diagnosis is possible. The association of acanthosis nigricans and visceral cancer is well known, as are metastases to the skin from internal cancers. Other skin eruptions have been observed in the presence of cancer and sarcoma, but they are rather rare. In some instances they may have been coincidental; in others a causal relationship is almost certain. In most cases the patients came first to the dermatologist, who later referred them to the surgeon or roentgenologist. REVIEW OF LITERATURE In 1925 Rothman1wrote a comprehensive review on the subject of cutaneous manifestations in patients