Infestation Research Articles

The Relationship Between Student’s Personal Hygiene Behavior and Scabies Prevalence in Islamic Boarding School

Sarcoptes scabiei, a variant of the hominid mite, is the cause of scabies, a skin infestation. In Indonesia, scabies accounted for three of the top 12 skin infestations. Scabies infections are particularly common in islamic boarding schools largely due to poor personal hygiene, which increases the risk of the students being infected. This study aimed to determine the relationship between personal hygiene and the prevalence of scabies. A total of 184 samples that met the inclusion and exclusion criteria were obtained for this study using a cross-sectional method and purposive sampling. Fisher’s exact test and Chi-square analysis were performed on the data. The results showed that the prevalence of scabies is 28.8%. The findings indicate a significant relationship between the prevalence of scabies and showering behavior (p=0.002), hand and nail hygiene (p=0.006), and bedding hygiene (p=0.013). However, no correlation was found between the prevalence of scabies and clothing hygiene (p=0.931). When considering overall showering habits, hand and nail hygiene, and bedding hygiene, there was a significant correlation between student hygiene and scabies prevalence (p=0.030). Islamic boarding schools could address this issue by promoting clean and healthy living habits, imposing sanctions for violations, and cooperating with health facilities to carry out periodic treatment for students suffering from scabies.

Burden and determinants of scabies in a pastoralist community: a case–control study from Southwest Ethiopia

BackgroundScabies is a skin infestation caused by the human itch mite, affecting people globally across all demographics. However, it is more prevalent among children, individuals with poor hygiene, those in...

Knowledge, Attitude, and Prevention Practice Towards Scabies Among Haramaya University Health and Medical Science Students, Harar, Ethiopia 2022

Background: Scabies is a skin disease caused by infestation and sensitization to Sarcoptes scabies mites and is an endemic in tropical and subtropical areas. It is a common skin infestation, endemic in developing countries, usually affecting families and large groups of people living together. Objective: The study was aimed to assess Knowledge, attitude, and prevention practice towards scabies among Haramaya university health and medical science students, Harar, Ethiopia, 2022. Methods: Institutional -based Cross-sectional study was conducted from April 25- May 21, 2022 among 417 randomly selected students. Self-administered questioner was used to collect data. The collected data was entered into SPSS version 22 for analysis. Descriptive and analytic data was used to present the finding. Result: Approximately 62.85% of the students demonstrated a high understanding of scabies, encompassing its transmission, symptoms, and prevention methods. Conversely, 6.1% exhibited poor knowledge. A finding of attitudes towards scabies among students only 36.7% demonstrating good attitude towards the condition. The data provided underscores a significant variation in scabies prevention practices among students with 65.8% exhibiting good practices. Conclusion: The study highlights the importance of continuous education and awareness programs to enhance knowledge and attitudes, which in turn can lead to better practices. It also underscores the need for targeted interventions to address the gaps identified in both knowledge levels and attitudes to foster a more proactive approach to scabies prevention and management. The findings serve as a valuable benchmark for the university and health authorities to develop tailored strategies that can improve health outcomes related to scabies within the community.

Knowledge, Attitude, and Prevention Practice towards Scabies among Haramaya University Health and Medical Science Students, Harar, Ethiopia 2022

Background: Scabies is a skin disease caused by infestation and sensitization to Sarcoptes scabies mites and is an endemic in tropical and subtropical areas. It is a common skin infestation, endemic in developing countries, usually affecting families and large groups of people living together. Objective: The study was aimed to assess Knowledge, attitude, and prevention practice towards scabies among Haramaya university health and medical science students, Harar, Ethiopia, 2022. Methods: Institutional -based Cross-sectional study was conducted from April 25- May 21, 2022 among 417 randomly selected students. Self-administered questioner was used to collect data. The collected data was entered into SPSS version 22 for analysis. Descriptive and analytic data was used to present the finding. Result: Approximately 62.85% of the students demonstrated a high understanding of scabies, encompassing its transmission, symptoms, and prevention methods. Conversely, 6.1% exhibited poor knowledge. A finding of attitudes towards scabies among students only 36.7% demonstrating good attitude towards the condition. The data provided underscores a significant variation in scabies prevention practices among students with 65.8% exhibiting good practices. Conclusion: The study highlights the importance of continuous education and awareness programs to enhance knowledge and attitudes, which in turn can lead to better practices. It also underscores the need for targeted interventions to address the gaps identified in both knowledge levels and attitudes to foster a more proactive approach to scabies prevention and management. The findings serve as a valuable benchmark for the university and health authorities to develop tailored strategies that can improve health outcomes related to scabies within the community.

AYURVEDIC PERSPECTIVES ON MANAGING PAMA KUSHTHA (SCABIES) IN CHILDREN: A COMPREHENSIVE REVIEW

Skin diseases are considered a serious health problem in children because they cause discomfort and considerable morbidity. Dermatological disorders account for nearly one-third of all paediatric outpatient appointments. Scabies is a frequent skin infestation caused by tiny mites known as "Sarcoptes scabiei." It is very contagious and typically spreads through skin-to-skin contact with someone who is already afflicted. Almost all skin problems in Ayurveda are explained by the wide term "Kushtha." Pama can be correlated with scabies, which is one type of Kshudra Kushtha as described in the classics. Because it is highly contagious, it spreads swiftly in crowded environments. The scabies rash can lead to cellulitis, folliculitis, boils, and impetigo. It was discovered that "Pama" Vyadhi It has been found that "Pama" vyadhi is one of the most prevalent diseases seen at lower socioeconomic levels and occurs in unsanitary individuals. This paper explored Pama disease diagnosis and therapy using in Ayurveda.

Scabies Emergence! A Critical Health Crisis Demands Immediate Action

Scabies, caused by Sarcoptes scabiei ectoparasites, is a skin infestation marked by itching and erythematous lesions. Recognized as a global public health issue, especially in crowded settings, it was added to the Neglected Tropical diseases list by the World Health Organization in 2017. The International Alliance for the Control of Scabies (IACS) provides diagnostic criteria, emphasizing definitive, clinical, and suspicious cases. Microscopic examination is key for a definitive diagnosis, while clinical and suspected cases rely on characteristic lesions and patient history.

Efficacy of an Artificial Intelligence App (Aysa) in Dermatological Diagnosis: Cross-Sectional Analysis.

Dermatology is an ideal specialty for artificial intelligence (AI)-driven image recognition to improve diagnostic accuracy and patient care. Lack of dermatologists in many parts of the world and the high frequency of cutaneous disorders and malignancies highlight the increasing need for AI-aided diagnosis. Although AI-based applications for the identification of dermatological conditions are widely available, research assessing their reliability and accuracy is lacking. The aim of this study was to analyze the efficacy of the Aysa AI app as a preliminary diagnostic tool for various dermatological conditions in a semiurban town in India. This observational cross-sectional study included patients over the age of 2 years who visited the dermatology clinic. Images of lesions from individuals with various skin disorders were uploaded to the app after obtaining informed consent. The app was used to make a patient profile, identify lesion morphology, plot the location on a human model, and answer questions regarding duration and symptoms. The app presented eight differential diagnoses, which were compared with the clinical diagnosis. The model's performance was evaluated using sensitivity, specificity, accuracy, positive predictive value, negative predictive value, and F1-score. Comparison of categorical variables was performed with the χ2 test and statistical significance was considered at P<.05. A total of 700 patients were part of the study. A wide variety of skin conditions were grouped into 12 categories. The AI model had a mean top-1 sensitivity of 71% (95% CI 61.5%-74.3%), top-3 sensitivity of 86.1% (95% CI 83.4%-88.6%), and all-8 sensitivity of 95.1% (95% CI 93.3%-96.6%). The top-1 sensitivities for diagnosis of skin infestations, disorders of keratinization, other inflammatory conditions, and bacterial infections were 85.7%, 85.7%, 82.7%, and 81.8%, respectively. In the case of photodermatoses and malignant tumors, the top-1 sensitivities were 33.3% and 10%, respectively. Each category had a strong correlation between the clinical diagnosis and the probable diagnoses (P<.001). The Aysa app showed promising results in identifying most dermatoses.

Dermatology Quality of Life and Depression, Anxiety, and Stress Scale-42 in Scabies Patients.

Scabies is a pruritic skin infestation with a globally increasing prevalence. Sleep problems and impaired social and personal interactions, mainly due to itching, have been reported. We aimed to determine the influence of scabies on quality of life and psychosocial health using Dermatology Life Quality Index (DLQI) and Depression Anxiety and Stress Scale-42 (DASS-42) and analyze whether there is a correlation between the two scales and any sociodemographic and clinical characteristic. Scabies patients (>16 years) who presented to our outpatient clinics were enrolled. Age, sex, occupation, marital status, and education level and clinical features were recorded. DLQI and DASS-42 were used. Possible influence of demographic and clinical characteristics on total scores were analyzed. The Spearman coefficient analysis was performed to determine whether there is a correlation between these scores. Of 92 patients (mean age:37.76±15.355, Female/Male: 1.09/1), 63% were married and 35.9% were high-school graduates; 27.2% and 23.9% were housewives and officers, respectively. Disease was generalized in 57.6% and duration of disease was mostly <4 weeks. Mean DLQI and DASS-42 scores were 13.16±7.638 and 42.10±30.644, respectively. Symptoms/feelings were affected predominantly. DLQI was affected 'severely' in 41.3% of patients. Impairment of DLQI is a significant predictive parameter for higher DASS levels. Scabies is not only associated with impairment in DLQI but may also lead to psychosocial problems. All scabies patients should be evaluated and consulted-if needed-for possible problems of psychosocial status, including depression, anxiety, and stress, as well as clinical symptoms and secondary complications.

Personal Hygiene as Scabies Factors Incidence in the Institute Rehabilitation Center of the Vagrants, Scrounger and Mental Disabilities in South Sumatra Region

Introduction: Scabies, caused by the mite Sarcoptes scabiei, is a highly contagious skin infestation. Poor personal hygiene often contributes to its prevalence. This study aims to identify specific aspects of personal hygiene that influence the incidence of scabies among residents of the Institute Rehabilitation Center of The Vagrants, Scroungers, and Individuals with Mental Disabilities in the South Sumatra Region. Methods: This observational-analytic study employed a case-control design. Data collection involved clinical records, observations, and questionnaire-based interviews. A total of 160 occupants, comprising 80 cases and 80 controls, were selected through simple random sampling. Data analysis utilized chi-square test and multiple logistic regression tests. Results and Discussion: Chi-square analysis revealed significant associations (p-value = 0.000) between scabies incidence and bathing habits, cleanliness of mattresses and bed linen, cleanliness of clothing, and open defecation behavior. Multiple logistic regression indicated that open defecation behavior (OR = 56.336; 95% CI = 17.281 – 158.500) was the primary personal hygiene factor influencing scabies incidence. Thus, maintaining proper open defecation practices is crucial for residents' hygiene and health. Conclusion: Poor personal hygiene practices, including inadequate bathing habits, unclean bedding, dirty clothing, and open defecation behavior, contribute to the occurrence of scabies. Effective education and counseling by healthcare professionals are essential for promoting better hygiene practices among residents.

Traditional healers' perception on scabies causation and management in Ghana.

Scabies is an underdiagnosed skin infestation caused by the Sarcoptes scabiei mite. The infection causes severe itching and a skin rash but can be effectively treated using topical or systemic drugs. Scabies outbreaks are commonly reported in resource-poor countries, including Ghana. Traditional healers play an important role in primary care in rural areas. The role of these traditional healers in the management of scabies has so far not been explored. The aim of this study was therefore to investigate the perceptions of traditional healers regarding the causation and management of scabies. A phenomenological qualitative approach was employed. Traditional healers in the Asante Akim North and Central districts in Ghana were approached with an interview request. Using a semi-structured interview protocol, 15 traditional healers were interviewed. The results were coded and analysed, after which seven themes were extrapolated. Scabies infections were frequently reported by traditional healers. Itching and skin rash were unanimously regarded as the major symptoms of scabies. The majority acknowledged the infectious nature of scabies, but no participant reported the causative organism. A dichotomous disease classification was noted, consisting of 'natural' and 'spiritual' variants each with a unique disease profile and management requirements, as reported by the traditional healers. All but two traditional healers reported to treat scabies using almost exclusively herbs and spiritual rituals. The majority of traditional healers were open to collaboration with allopathic healthcare providers. Collaboration could broaden the primary care network in rural areas, but mistrust and lack of transparency form potential barriers to collaboration. We, therefore, emphasise the need for additional efforts to investigate strategies for future collaboration.

Dermatologic Care for Refugees: Effective Management of Scabies and Pediculosis.

There is a large burden of treatable dermatologic conditions in refugee populations. Parasitic infestations are particularly common when there are barriers to basic hygiene, crowded living or travel conditions, and lack of access to health care. Body lice are associated with anemia and can transmit a variety of diseases; chronic impetigo secondary to scabies is a leading cause of chronic kidney disease globally. Dermatologists have unique skills to identify skin infections, inflammatory diseases, and infestations. Appropriate dermatologic care has the potential to improve overall outcomes.

Delusional parasitosis: the importance of a multidisciplinary approach

IntroductionDelusional parasitosis, also known as delusional infestation or Ekbom’s syndrome, is a rare psychotic disorder characterized by the false belief that a parasitic skin infestation exists, despite the absence of any medical evidence to support this claim. These patients often see many physicians, so a multidisciplinary approach among clinicians is important. Many patients refuse any treatment due to their firm belief that they suffer from an infestation, not a psychiatric condition, so it is crucial to gain the trust of these patients.ObjectivesThe comprehensive review of this clinical case aims to investigate Ekbom syndrome, from a historical, clinical and therapeutic perspective.MethodsLiterature review based on delusional parasitosis.ResultsA 65-year-old woman comes to the psychiatry consultation referred by her primary care physician concerned about being infested by insects that she perceives through scales on her skin for the last three months. She recognizes important impact on her functionality. She is also convinced that her family is being infected too. As psychiatric history she recognizes alcohol abuse in the past (no current consumption) and an episode of persecutory characteristics with a neighbor, more than ten years ago. On psychopathological examination, she shows delusional ideation of parasitosis, with high behavioral repercussions, cenesthetic and cotariform hallucinations, as well as feelings of helplessness and anger. Treatment with Pimozide was started and the patient was referred to dermatology for evaluation, a plan she accepted. Her primary care physician and dermatology specialist were informed about the case and the treatment plan. In the recent reviews, the patient is calmer, however, despite the corroboration of dermatology and in the absence of organic lesions in cranial CT, she is still unsatisfied with the results, remaining firm in her conviction of infestation. It was decided to start treatment with atypical neuroleptics (Aripiprazole), with progressive recovery of her previous functionality.ConclusionsDespite the increase in the number of studies in recent years, there are still few studies on this type of delirium. The female:male ratio varies in the bibiliography (between 2:1 and 3:1). The onset is usually insidious, generally appearing as a patient who comes to his primary care physician convinced of having parasites in different skin locations. It is usual to observe scratching lesions or even wounds in search of the parasite. In the past, the most used and studied treatment was Pimozide. Currently the treatment of choice is atypical neuroleptics due to their lower side effects. The latest reviews on the prognosis of this disorder show data with percentages of complete recovery between 51% and 70%, and partial responses between 16.5% and 20%. Finally, for a good diagnosis and therapeutic management, it is important to achieve a multidisciplinary approach.Disclosure of InterestNone Declared

The Association Between Internet Search Patterns and Scabies Incidence Across the United States

Background&#x0D; Scabies, a contagious skin infestation caused by Sarcoptes scabiei, is a significant public health concern [1]. Traditional surveillance methods for scabies suffer from time lag and incomplete data, hindering early detection and response [5]. The widespread use of the internet and search engines, such as GoogleTM, offer new opportunities for alternative surveillance approaches. &#x0D; Objective&#x0D; This study aimed to explore the association between scabies search volumes on Google TrendsTM (GTs) and scabies incidence at the state level across the United States.&#x0D; Methods&#x0D; GTs data for each U.S. state and scabies incidence from 2011 to 2019 were analyzed for summary statistics and association.&#x0D; Results&#x0D; The mean Spearman correlation coefficient for the period of 2011-2019 indicated a strong positive correlation between GTs RSVs for “scabies” and the incidence of scabies in the United States. Using an unpaired t-test, this correlation was found to be statistically significant. &#x0D; Conclusions&#x0D; In resource-scarce environments where access to care is a common barrier, healthcare providers and departments can leverage this information to effectively target populations and employ resources for scabies prevention and treatment. Analyzing search engine term patterns can enhance our understanding of people's behavior when they suspect a scabies infestation.

Efficacy of combination therapy 5% permethrin cream and precipitated sulfur (ointment 2-4) compared with single therapy of 5% permethrin cream in children

Introduction: Scabies is a skin infestation with the main pruritus symptom caused by Sarcoptes scabiei. The common complaints are discomfort due to itching and a picture of lesions on the skin in the form of papules, pustules, or vesicles. The study aims to analyze the comparative efficacy of using a combination therapy of 5% permethrin cream and precipitated sulfur (ointment 2-4) compared with single therapy of 5% permethrin cream in pediatric scabies patients at the Outpatient Clinic Dr. Soetomo General Academic Hospital in the 2019-2020 period. Methods: This study is an analytical study using a cross-sectional retrospective method, which aims to compare the effectiveness of using a combination of 5% permethrin cream and precipitated sulfur(ointment 2-4) compared to 5% permethrin cream as a single therapy. Study data were processed using SPSS, followed by univariate and bivariate analyses using statistical methods and comparative tests. Results: This study found 88 new scabies patients, with the number of patients who received permethrin single therapy as many as 43 patients (51.1%), while those who received combination therapy were 45 patients (48.9%). Scabies treatment using combination therapy has better effectiveness than single therapy 5% permethrin cream when seen from the absence of new complaints and improvement of skin lesions after receiving treatment. Analysis of therapy results for the emergence of new complaints with a p-value of 0.010 showed significant results. Analysis of the results of therapy seen in skin lesions improved on single therapy with a p-value of 0.014, indicating significant results. Conclusion: Significant results were found in the group that received combination therapy treatment seen from the improvement of skin lesions and no new lesions were found, while there were no significant comparison results when seen from complaints of itching

Morgellons disease: a narrative review.

Morgellons disease is characterized by the persistent delusion of skin infestation, ultimately inflicting wounds and impairing quality of life. There is insufficient and conflicting research pertaining to this condition, imposing challenges on clinicians in understanding, diagnosing, and treating it. In this review, we summarize the available literature on Morgellons disease including its historical evolution, epidemiology, proposed pathophysiology, underlying structural and functional brain pathologies, typical and atypical clinical presentations, diagnosis, and treatment. A comprehensive review of the literature was conducted on PubMed, Embase, and Scopus using specified keywords. Selected articles were screened by two independent reviewers based on set inclusion and exclusion criteria. Conflicts were resolved by a third reviewer as needed. No limit to the date of selected articles was set due to the scarce literature available on the subject. Morgellons disease is an underdiagnosed entity, owing mostly to the lack of an established pathophysiology and treatment guidelines. While many authors classify it as a type of delusional infestation (DI), others correlate MD with an underlying spirochetal infection, namely Lyme disease. Neuroimaging studies have revealed abnormalities in the "fronto-striato-thalamo-parietal network", a finding common to patients with DI, in addition to alterations in structures related to the "Itch Processing Pathway". Patients tend to extract fibers from their skin lesions and place them in a match box hence the term "match box sign". The diagnosis is that of exclusion, requiring extensive work up to rule out secondary causes and differential diagnoses. Treatment is largely based on the use of antipsychotics, with or without cognitive behavioral therapy. Despite being a diagnosis of exclusion, clinicians must be aware of this entity and have a profound understanding of the pathogenesis underlying it. Upon clinical suspicion, secondary Morgellons should always be ruled out through a thorough history taking, physical examination, and laboratory exams. Despite the challenges brought by the heterogeneous presentation of the condition and the paucity of research revolving around it, the great impact that Morgellons disease has on patients' quality of life forms a pressing need for its adequate detection, diagnosis, and treatment.

Salmon louse labial gland enzymes: implications for host settlement and immune modulation.

Salmon louse (Lepeophtheirus salmonis) is a skin- and blood-feeding ectoparasite, infesting salmonids. While feeding, labial gland proteins from the salmon louse may be deposited on the Atlantic salmon (Salmo salar) skin. Previously characterized labial gland proteins are involved in anti-coagulation and may contribute to inhibiting Atlantic salmon from mounting a sufficient immune response against the ectoparasite. As labial gland proteins seem to be important in the host-parasite interaction, we have, therefore, identified and characterized ten enzymes localized to the labial gland. They are a large group of astacins named L. salmonis labial gland astacin 1-8 (LsLGA 1-8), one serine protease named L. salmonis labial gland serine protease 1 (LsLGSP1), and one apyrase named L. salmonis labial gland apyrase 1 (LsLGAp1). Protein domain predictions showed that LsLGA proteins all have N-terminal ShK domains, which may bind to potassium channels targeting the astacins to its substrate. LsLGA1 and -4 are, in addition, expressed in another gland type, whose secrete also meets the host-parasite interface. This suggests that LsLGA proteins may have an anti-microbial function and may prevent secondary infections in the wounds. LsLGAp1 is predicted to hydrolyze ATP or AMP and is, thereby, suggested to have an immune dampening function. In a knockdown study targeting LsLGSP1, a significant increase in IL-8 and MMP13 at the skin infestation site was seen under LsLGSP1 knockdown salmon louse compared to the control, suggesting that LsLGSP1 may have an anti-inflammatory effect. Moreover, most of the identified labial gland proteins are expressed in mature copepodids prior to host settlement, are not regulated by starvation, and are expressed at similar or higher levels in lice infesting the salmon louse-resistant pink salmon (Oncorhynchus gorbuscha). This study, thereby, emphasizes the importance of labial gland proteins for host settlement and their immune dampening function. This work can further contribute to anti-salmon louse treatment such as vaccine development, functional feed, or gene-edited salmon louse-resistant Atlantic salmon.

Awareness and knowledge of scabies and ringworm among parents of school-age children in Calabar, Cross River State, Nigeria: Implications for prevention of superficial skin infestations.

Risk factors for the persistence of superficial skin infestations are prevalent in humid tropical environments, which are favorable for breeding of the causative vector mite Sarcoptes scabiei (ectoparasite) and dermatophyte fungi. This study aimed at assessing the awareness and knowledge of childhood scabies and ringworm infestations among parents in Calabar, a highly humid rainforest tropical environment. Cross-sectional study design and systematic random sampling were used to recruit school-age children in selected primary schools in Calabar. Researcher-driven administration of a structured questionnaire was conducted to obtain quantitative data from parents of recruited children. : Chi-square was used to assess factors associated with ever hearing or seeing scabies and ringworm infestations. Statistical significance was set at P < 0.05. One hundred and eighty-two (56.7%) and 218 (67.9%) of the respondents had heard of or seen scabies and ringworm infestation. Among respondents that were aware of scabies, 53.3% knew of the cause, 50.5% were aware of the risk factors while 68.1% and 78.0% knew their treatment and prevention, respectively; 98.6%, 60.6%, 76.6%, and 80.7% of respondents knew the cause, risk factors, treatment, and prevention of ringworm infestation, respectively. Fathers with at least secondary school literacy level and sharing beds were significantly associated with awareness of scabies. There is a suboptimal level of awareness and knowledge of two of the most common superficial skin infestations among parents of primary school children in the study setting. There is a need to redouble our effort at sensitization of parents toward improved awareness of these common infestations.

Extraction and analysis of moxidectin in wombat plasma and faeces

Sarcoptic mange in wombats results from a skin infestation by Sarcoptes mites and if untreated, results in a slow and painful death. Moxidectin is a pesticide used to treat internal and external parasites in cattle, but has shown to effectively treat other animals, including wombats. Two methods were developed to analyse wombat plasma, and methods were also developed to analyse faeces and fur. Moxidectin-D3 was used as an internal standard and behaved almost identically to moxidectin, resulting in recoveries of 95–105 % across the three matrices, even when matrix interferences caused signal suppression as high 20 %, or when moxidectin loss was high. This was presumably due to the high binding efficiency of plasma for MOX and MOX-D3. Moxidectin limits of detection were 0.01 ng/mL in plasma, 0.3 ng/g dry weight equivalent for faeces and 0.5 ng/g for fur. This study also developed a method to isolate plasma macromolecules, allowing the extraction of bound moxidectin for quantitative purposes, with an LoQ of 0.05 ng/mL. This method was subsequently used to determine that moxidectin was 97–99.4 % bound to lipoproteins in wombat plasma and 98–99 % bound in sheep, cow and horse plasma. The method reported for plasma was quick, cheap, and conducive to large sample batches, while providing high sensitivity. While faecal samples required additional cleanup steps to reduce the matrix effect, co-extracted matrix components such as undigested chlorophyll continued to result in ionisation suppression in the MS/MS. The methods reported here were used to monitor moxidectin in wombats treated with a single pour-on treatment, and confirmed that the moxidectin concentration in wombat plasma had decreased by more than 90 % by 28 days after application, while providing protection against sarcoptic mites over the majority of their life cycle. Clearance of moxidectin occurred via faecal elimination over the four week period and while moxidectin accumulated on fur due to application as a pour-on, concentrations declined rapidly by the four week period as fur fell out and was replaced by fresh fur that did not contain moxidectin.

Principles for effective management of scabies outbreaks

Background: The contagious skin infestation scabies, is caused by the mite &lt;i&gt;Sarcoptes scabiei&lt;/i&gt; var. &lt;i&gt;hominis&lt;/i&gt;. These microscopic organisms navigate under the skin surface to lay eggs, creating burrows that cause notable discomfort and itching and enable the maturation and subsequent proliferation of the mites. Spread to other hosts can occur through direct, often prolonged, skin-to-skin contact or indirectly through shared items such as clothing, bedding, or towels.Current Concepts: Management of a scabies outbreak encompasses several pivotal steps: accurate diagnosis, comprehensive treatment with topical scabicides to kill the mites, rigorous environmental control (including washing all possibly infested materials in hot water), meticulous contact tracing of all close contacts, administration of symptomatic relief through antihistamines and corticosteroids, and meticulous follow-up to verify successful treatment outcomes.Discussion and Conclusion: The prevention of further infestation and recurrent outbreaks is crucial, necessitating a holistic, integrative public health management approach. This approach involves consistent communication and public education about preventive measures and prompt treatment strategies to curtail widespread infestation, thereby safeguarding community health.

Scabbia: presentazione clinica e trattamento

Scabies is a skin infestation caused by the mite Sarcoptes scabiei variant hominis, an obligate human parasite. The infestation, whose incidence is often underestimated, is widespread with a higher prevalence within the paediatric age, particularly in children under the age of 2. In young children diagnosis can be challenging because of the differences in appearance and location of skin lesions, especially in the neonatal forms. Neonatal scabies has no treatment approved by European guidelines, and the most widely used drug in infants such as permethrin is off-label under 2 months of age. This article describes a case of neonatal scabies. The patient presented with vesicle-crusted erythematous elongated lesions on the trunk and papular lesions in the axillary region, with minor involvement of the upper limbs. Clinical suspect was then confirmed through dermatoscopy. 5% permethrin cream was applied for three consecutive days with a 3-hour exposure time. The treatment was repeated one week after the latest application for two consecutive days and was extended to all family members.