Skin Health Research Articles

Dermatological Health in the Light of Skin Microbiome Evolution.

The complex ecosystem of the skin microbiome is essential for skin health by acting as a primary defense against infections, regulating immune responses, and maintaining barrier integrity. This literature review aims to consolidate existing information on the skin microbiome, focusing on its composition, functionality, importance, and its impact on skin aging. An exhaustive exploration of scholarly literature was performed utilizing electronic databases including PubMed, Google Scholar, and ResearchGate, focusing on studies published between 2011 and 2024. Keywords included "skin microbiome," "skin microbiota," and "aging skin." Studies involving human subjects that focused on the skin microbiome's relationship with skin health were included. Out of 100 initially identified studies, 70 met the inclusion criteria and were reviewed. Studies showed that aging is associated with a reduction in the variety of microorganisms of the skin microbiome, leading to an increased susceptibility to skin conditions. Consequently, this underlines the interest in bacteriotherapy, mainly topical probiotics, to reinforce the skin microbiome in older adults, suggesting improvements in skin health and a reduction in age-related skin conditions. Further exploration is needed into the microbiome's role in skin health and the development of innovative, microbe-based skincare products. Biotherapeutic approaches, including the use of phages, endolysins, probiotics, prebiotics, postbiotics, and microbiome transplantation, can restore balance and enhance skin health. This article also addresses regulatory standards in the EU and the USA that ensure the safety and effectiveness of microbial skincare products. This review underscores the need to advance research on the skin microbiome's role in cosmetic enhancements and tailored skincare solutions, highlighting a great interest in leveraging microbial communities for dermatological benefits.

Novel biophysical skin biomarkers discriminate topical anti‐inflammatory treatments based on their potential for local adverse effects

AbstractBackgroundTopical corticosteroids (TCS) are efficacious treatments for inflammatory skin conditions, however, there is a risk of adverse effects; understanding how best to use these treatments is an unmet research priority shared by patients and healthcare professionals.ObjectivesTo develop non‐invasive biomarkers of local adverse effects to facilitate the optimisation of topical therapy.MethodsAn observer‐blind randomised within‐subject controlled trial in atopic dermatitis patients was undertaken (NCT04194814) comparing betamethasone valerate 0.1% cream (BMV) to a non‐steroidal anti‐inflammatory treatment, crisaborole 2% ointment (CRB). Participants underwent 4 weeks twice‐daily treatment with CRB on one forearm and BMV on the other (left/right randomised). Skin properties were assessed on days 1, 15, 29 of treatment and again on day 57, including imaging of skin microstructure using Optical Coherence Tomography (OCT) and Attenuated Total Reflectance (ATR)‐Fourier Transform Infrared (FTIR) spectroscopic assessment of stratum corneum molecular structure. The primary outcome was the difference in the change in epidermal thickness from days 1 to 29.ResultsThirty‐seven participants received the first dose, of which 32 completed the study (all 37 were included in the analysis). Pathologic epidermal thinning at day 29 was significantly greater (p < 0.0001) at sites treated with BMV (−31.66; 95% confidence interval: −35.31, −28.01 µm) compared to CRB (−13.76; −17.42, −10.10 µm). From a panel of exploratory biomarkers, superficial plexus depth and stratum corneum carboxyl group levels had the greatest ability to discriminate the effects of the TCS treatment (p < 0.0001).ConclusionsBMV induced 2.3x more pathologic epidermal thinning than CRB after 4 weeks of treatment, suggesting that CRB may be more appropriate for longer‐term, proactive‐based, treatment strategies where the risks of adverse effects are greatest. By monitoring treatment effects using OCT and ATR‐FTIR spectroscopy, two new non‐invasive biomarkers of skin health have been identified with the potential to help optimise future safe treatment strategies.

Integrated analysis of facial microbiome and skin physio-optical properties unveils cutotype-dependent aging effects

BackgroundOur facial skin hosts millions of microorganisms, primarily bacteria, crucial for skin health by maintaining the physical barrier, modulating immune response, and metabolizing bioactive materials. Aging significantly influences the composition and function of the facial microbiome, impacting skin immunity, hydration, and inflammation, highlighting potential avenues for interventions targeting aging-related facial microbes amidst changes in skin physiological properties.ResultsWe conducted a multi-center and deep sequencing survey to investigate the intricate interplay of aging, skin physio-optical conditions, and facial microbiome. Leveraging a newly-generated dataset of 2737 species-level metagenome-assembled genomes (MAGs), our integrative analysis highlighted aging as the primary driver, influencing both facial microbiome composition and key skin characteristics, including moisture, sebum production, gloss, pH, elasticity, and sensitivity. Further mediation analysis revealed that skin characteristics significantly impacted the microbiome, mostly as a mediator of aging. Utilizing this dataset, we uncovered two consistent cutotypes across sampling cities and identified aging-related microbial MAGs. Additionally, a Facial Aging Index (FAI) was formulated based on the microbiome, uncovering the cutotype-dependent effects of unhealthy lifestyles on skin aging. Finally, we distinguished aging related microbial pathways influenced by lifestyles with cutotype-dependent effect.ConclusionsTogether, our findings emphasize aging’s central role in facial microbiome dynamics, and support personalized skin microbiome interventions by targeting lifestyle, skin properties, and aging-related microbial factors.8-x6JkQezK-S195ofXGtyGVideo

Characteristics of Malassezia furfur at various pH and effects of Malassezia lipids on skin cells

Malassezia species are commensal and opportunistic fungi found in human skin. All Malassezia species lack fatty acid synthesis genes and survive by utilizing several lipases to degrade and absorb fatty acids from external lipid sources, but little research has been done on their optimal active pH and temperature. Our skin protects itself from external stimuli and maintains homeostasis, involving bacteria and fungi such as Malassezia species that inhabit our skin. Hence, dysbiosis in the skin microbiome can lead to various skin diseases. The skin’s pH is slightly acidic compared to neutral, and changes in pH can affect the metabolism of Malassezia species. We used keratinocyte cell lines to determine the effect of lipids bio-converted by Malassezia furfur, Malassezia japonica, and Malassezia yamatoensis under pH conditions similar to those of healthy skin. Lipids bio-converted from Malassezia species were associated with the regulation of transcripts related to inflammation, moisturizing, and promoting elasticity. Therefore, to determine the effect of pH on lipid metabolism in M. furfur, which is associated with seborrheic dermatitis, changes in biomass, lipid content, and fatty acid composition were determined. The results showed that pH 7 resulted in low growth and reduced lipid content, which had a negative impact on skin health. Given that bio-converted Malassezia-derived lipids show positive effects at the slightly acidic pH typical of healthy skin, it is important to study their effects on skin cells under various pH conditions.Key points• pH 6, Malassezia spp. bio-converted lipid have a positive effect on skin cells• Malassezia spp. have different lipid, fatty acid, and growth depending on pH• Malassezia spp. can play a beneficial role by secreting lipids to the outside

Pengaruh Brand Ambassador dan Kualitas Produk Terhadap Niat Beli Produk Scarlett di Shopee

In the modern era, human needs for health and beauty continue to rise rapidly, driving fierce market competition in the beauty industry. Marketers must also innovate and deliver creative and exciting products to compete with local and foreign products. The first step in caring for the skin's health and appearance is to use skin care products. Scarlett Whitening has become a popular choice among consumers with its good reputation. This research and data on the number of customers of Scarlett whitening at Shopee suggests that brand ambassadors play a crucial role in increasing product sales and consumer confidence. In addition, the brand embassy positively affects consumer interest in purchasing Scarlett products at Shopee. Beauty product sellers preferably apply this strategy to increase sales and their market share.

Ectoin attenuates cortisone-induced skin issues by suppression GR signaling and the UVB-induced overexpression of 11β-HSD1.

Accelerated pace of modern work and lifestyles subject individuals to various external and psychological stressors, which, in turn, can trigger additional stress through visible signs of fatigue, hair loss, and obesity. As the primary stress hormone affecting skin health, cortisol connects to the glucocorticoid receptor (GR) to aggravate skin issues induced by stress. This activation depends on the expression of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in skin cells, which locally converts cortisone-produced by the central and peripheral hypothalamic-pituitary-adrenal axis-into its active form. Our study delves deeper into stress's adverse effects on the skin, including the disruption of keratinocyte structural proteins, the loss of basement membrane proteins, and the degradation of collagen. Remarkably, we discovered that Ectoin, an amino acid derivative obtained from halophilic bacteria, is capable of mitigating the inhibitory impacts of cortisone on the expression of cutaneous functional proteins, including involucrin, loricrin, laminin-5, and claudin-1. Moreover, Ectoin reduces the suppressive effect of stress on collagen and hyaluronic acid synthesis by impeding GR signal transduction. Additionally, Ectoin counterbalances the UVB-induced overexpression of 11β-HSD1, thereby diminishing the concentration of endogenous glucocorticoids. Our findings illuminate the significant potential of Ectoin as a preventative agent against stress-induced skin maladies.

Novel trends of frequency, demographics and clinical presentation of skin disorders in only public hospital in south of Lahore: A Descriptive observational study over 1 year.

Objective: To study the pattern of skin diseases in our population with respect to different age groups, gender and seasonal variations. Study Design: Observational Retrospective study. Setting: Department of Dermatology, Lahore General Hospital, a tertiary care referral hospital situated in second big city of Pakistan i.e Lahore. Period: July 2021 to June 2022. Methods: A total of 65284 patients presenting to skin OPD were studied. Demographic details were noted and diagnosis was made after detailed history, examination and appropriate investigations like scraping or smears. Data was analyzed for various age groups, gender distribution and effect of variables on diagnosis. Results: Out of 65284 patients, 38 %were male & 62% were female. Most of the patients (43%) were in age group of 21-40 years. Scabies was the most prevalent dermatosis and affected 27% of study population. Three most common dermatosis were tinea, scabies and acne. The maximum number of dermatosis was seen in the months of summer. Conclusion: Infectious diseases pose a major burden to skin health of most of the population suffering from dermatological problem. Fungal infections and scabies are treatable but very common diseases contributing in burden of dermatological disorder in population presenting to hospitals.

An overlooked risk for skin health: Less availability and higher cost of sunscreen for people with melanated skin

BackgroundSunscreen with a skin protection factor (SPF) of 30 or greater is recommended to reduce the risk of skin cancer and improve skin health for all people regardless of skin tone. Traditional sunscreen that creates a white cast on the skin is incompatible with melanated skin. MethodsThe number of products on the shelf, SPF level, application, coloration, and cost were recorded at three beauty supply chain stores and three pharmacy, health, and wellness stores in or near Harlem in New York City in the Spring of 2023. The number of skin tones for tinted sunscreen was visually matched to the Fitzpatrick Skin Phototypes scale. ResultsA total of 385 sunscreen products were identified; 78.7 % were traditional white sunscreen, followed by sheer (15.3 %) and tinted (6.0 %) products. Beauty supply stores offered more tinted sunscreen options than did pharmacy, health, and wellness stores (n = 17,15.3 % vs. n = 6, 2.2 %, p < 0.001). Of the tinted sunscreen products, 19 brands offered only a single tone. Tinted sunscreen was significantly more expensive with an average cost of $24.59 [SD $14.71] per ounce vs. $6.85 [SD 8.66] for traditional, and $9.38 [SD 8.92] for sheer suncreen. ConclusionsSunscreen that is tinted or sheer and compatible with melanated skin is less available and more costly than traditional white sunscreen in beauty and pharmacy chain stores in NYC. Availability and affordability of sunscreen matching the spectrum of skin tones are essential for optimal sun protection and skin health.

Regulation of dermal circadian pathways by a novel topical formulation.

Skin health is impacted by a wide range of intrinsic and extrinsic factors (J Dermatol Sci, 2017, 85, 152), including those that impact circadian rhythm, such as sleep disruption (Textbook of Aging Skin, 2016), UV (Biomed Aging Pathol, 2013, 3, 161) and blue light (Int J Cosmet Sci, 2019, 41, 558). Disruption of the skin's endogenous circadian balance, even by a consistently late bedtime, has deleterious effects on multiple measurements of skin health, including hydration, skin barrier protection, microbiome counts and skin regeneration, among others (Clin Cosmet Investig Dermatol, 2022, 15, 1051). Skin repair processes occur at night and help to maintain important aspects of skin health (FEBS Lett, 2021, 595, 2413). Interest is increasing in the development of topical products that help restore proper circadian function. This study demonstrates that a proprietary topical formulation regulates new and established gene and protein biomarkers of circadian entrainment and circadian rhythm, demonstrating the product's potential to maintain appropriate dermal diurnal balance.

51605 The role of a community-based skin health program in medical student dermatologic education

51605 The role of a community-based skin health program in medical student dermatologic education

Changes and expectations of the digitally underprivileged in artificial intelligence: a systematic review focusing on skin health for the welfare of the elderly

Changes and expectations of the digitally underprivileged in artificial intelligence: a systematic review focusing on skin health for the welfare of the elderly

Unlocking the psycho-social-dermal axis: A double blinded randomized placebo controlled study unveiling the influence of a novel topical formulation on skin quality, attractiveness, quality of life, and sexual satisfaction.

Improved skin appearance is closely linked to higher self-esteem, favorable first impressions, and enhanced quality of life, with skincare products often being formulated with biostimulatory and regenerative ingredients to both enhance skin health and provide psychological benefits. Certain components, such as phospholipids and botanicals, may not only improve skin quality, but also impact mood, romantic bonding, and sexual attraction. To assess whether a novel topical skin care product formulated with a proprietary combination of proteins, lipids, and botanical derivatives, can potentially result in a robust psycho-social-dermatological benefit via modulation epidermal oxytocin and pheromonal pathways. In this single-center prospective, randomized, controlled, double-blinded study, 40 female subjects were randomly assigned to use of either active novel skincare products, or placebos, for 4-8 weeks. Skin assessments, standardized photography, first impression ratings, and questionnaires on confidence and sexual satisfaction were conducted. Thirty-nine subjects completed the study and demonstrated a statistically significant improvement in skin quality following 4 and 8 weeks of use, with improvements of greater magnitude demonstrated with a longer duration of use. Product users projected a better first impression and appeared on average 3 years younger than their actual age, with 86% of subjects reporting increased confidence. Product users found random people of the opposite sex to be more attractive 88% of the time and reported improvement in sexual satisfaction in 90% of the categories. The use of this novel topical product culminated in statistically significant improvements in skin quality, confidence, sexual relationship satisfaction, perceived attractiveness, and youthfulness, highlighting its potential in anti-aging and mood enhancement.

The Skin Histopathology of Pro- and Parabiotics in a Mouse Model of Atopic Dermatitis.

As it has been revealed that the activation of human immune cells through the activity of intestinal microorganisms such as pro- and prebiotics plays a vital role, controlling the proliferation of beneficial bacteria and suppressing harmful bacteria in the intestine has become essential. The importance of probiotics, especially for skin health and the immune system, has led to the emergence of products in various forms, including probiotics, prebiotics, and parabiotics. In particular, atopic dermatitis (AD) produces hypersensitive immunosuppressive substances by promoting the differentiation and activity of immune regulatory T cells. As a result, it has been in the Th1 and Th2 immune balance through a mechanism that suppresses skin inflammation or allergic immune responses caused by bacteria. Furthermore, an immune mechanism has recently emerged that simultaneously controls the expression of IL-17 produced by Th17. Therefore, the anti-atopic effect was investigated by administering doses of anti-atopic candidate substances (Lactobacilus sakei CVL-001, Lactobacilus casei MCL, and Lactobacilus sakei CVL-001 Lactobacilus casei MCL mixed at a ratio of 4:3) in an atopy model using 2,4-dinitrochlorobenzene and observing symptom changes for 2 weeks to confirm the effect of pro-, para-, and mixed biotics on AD. First, the body weight and feed intake of the experimental animals were investigated, and total IgG and IgM were confirmed through blood biochemical tests. Afterward, histopathological staining was performed using H&E staining, Toluidine blue staining, Filaggrin staining, and CD8 antibody staining. In the treatment group, the hyperproliferation of the epidermal layer, the inflammatory cell infiltration of the dermal layer, the expression of CD8, the expression of filaggrin, and the secretion of mast cells were confirmed to be significantly reduced. Lastly, small intestine villi were observed through a scanning microscope, and scoring evaluation was performed through skin damage. Through these results, it was confirmed that AD was reduced when treated with pro-, para-, and mixed biotics containing probiotics and parabiotics.

The Influence of Product Quality and Marketing Strategy Management on Consumer Satisfaction and Customer Loyalty with the Use of Wardah Skincare Products in Jambi City

Beauty care has become a crucial necessity in modern society, not only for enhancing appearance but also for skin health. The inundation of the market with beauty products and advertisements creates a strong urge for individuals, especially women, to consume beauty products and services for desired appearances. In efforts to attract consumers, beauty business owners strive to provide the best services to fulfill consumer satisfaction. Consumer satisfaction becomes the primary focus for consumer- oriented companies, with consumer loyalty formed from a combination of satisfaction and complaint handling. Consumers, as key players in the business ecosystem, play a significant role in determining product acceptance in the market. Product quality is a crucial factor in creating customer loyalty, with perceived quality by customers playing a crucial role in enhancing satisfaction and ultimately strengthening customer loyalty. Therefore, a deep understanding of consumer needs and preferences, along with efforts to maintain high product quality, is key to successfully building long-term customer loyalty.

Formulation and evaluation of herbal wet wipes using non-woven fabrics

Herbal wet wipes are a viable substitute for conventional wipes, tackling worries regarding chemical composition and ecological effects while offering advantages for skin health. This research uses non-woven fabric as the substrate and focuses on the formulation and assessment of herbal wet wipes. Selected plant extracts or essential oils with antibacterial and skin-soothing qualities are incorporated into the recipe. Testing the herbal wet wipes' antimicrobial activity against common skin bacteria and fungus allows for an evaluation of their effectiveness. Testing for skin sensitivity is done to determine safety and suitability for different skin types. To guarantee product integrity under various storage circumstances, stability testing is carried out by incorporating extracts of Azadirachta indica (Neem), Aloe barbadensis, Tulsi, and Clove Extract. Thus, the final cloth will include qualities like softness, antimicrobial, and anti-allergy for adults and infants. The intended application of the fabric material is to improve skin health through the use of wet wipes.

Skin health of Aboriginal children living in urban communities.

Skin concerns are frequent among urban-living Aboriginal children, yet specialist dermatology consultations are limited with studies highlighting the need for improved cultural security. Through newly established paediatric dermatology clinics at two urban Aboriginal Community Controlled Health Organisations (ACCHOs), we aimed to describe clinic and patient data, including disease frequencies and associations, to inform dermatology service provision and advocacy. A prospective cohort study of Aboriginal children and young people (CYP, 0-18 years) attending Aboriginal Health Practitioner (AHP) co-ordinated paediatric dermatology clinics at two urban ACCHOs. Data were collected from 32 clinics over 19 months, with 335 episodes of care and a mean attendance rate of 74%. From 78 new patients, 72 (92%) were recruited into the study, only one of whom had previously received dermatologist assessment. Eczema, tinea or acne accounted for 47% (34/72) of referrals, and 60% of patients received their first appointment within 4 weeks of referral. In 47/72 (65%) consultations, the GP referral and dermatologist diagnosis concurred. The most frequent diagnoses (primary or secondary) at first consultation were atopic dermatitis (26%, 19/72), dermatophyte infections (25%, 18/72), acne (21%, 15/72), bacterial skin infections (18%, 13/72) and post-inflammatory dyspigmentation (18%, 13/72). Three categories of the 2022 Australasian College of Dermatologists curriculum (infections, eczema/dermatitis, pigmentary disorders) accounted for 59% of all diagnoses. This study highlights the specialist dermatology needs of urban-living Aboriginal CYP. ACCHO-embedded dermatology clinics co-ordinated by AHPs demonstrated benefits for Aboriginal CYP in accessing care. Opportunities to embed dermatology practice within ACCHOs should be prioritised.

Bioactives in Nutricosmetics: A Focus on Caffeine from Tea to Coffee

Known for its stimulating effects on the nervous and cardiovascular systems, caffeine has proven remarkable versatile properties. It can be used in a wide range of different products, from anti-aging cosmetics to the pharmaceutical treatment of hair loss. Caffeine is known for its antioxidant properties and is commonly found in moisturising creams recommended as anti-aging or anti-cellulite and also for the treatment of different skin disorders, including androgenic alopecia. This bioactive is also described to be able to enhance the sunscreen scattering effect of well-known ultraviolet (UV) blockers. One of the major challenges remains its penetration capacity into deeper skin layers, which may be achieved by the use of nanosized delivery systems, yet without the risk of transdermal delivery. In this review, we discuss the nutraceutical value of caffeine in cosmetic products, so-called nutricosmetics, which grants this bioactive several advantages in several formulations, in comparison to other potential bioactives of nutricosmetic value. Furthermore, the disclosed effects of bioactives commonly found in coffee, tea, and their by-products are reviewed and discussed. The discussion concludes by highlighting the significant benefits of caffeine in the treatment of skin disorders and its potential to enhance and promote skin health.

Impact of Krill Meal on Enhancing Skin Mucosal Health and Reducing Sea Lice in Atlantic Salmon

The salmon industry’s challenges with skin health and sea lice emphasize the necessity for fish-sensitive measures like functional nutrition to boost skin health and fish welfare. The present study investigated the efficacy of krill meal (KM) for skin mucosal health and sea lice in Atlantic salmon (170 g). Following an 8-week feeding period, in duplicate tanks, on test diets (8% KM, 12% KM, and the control group), fish underwent a 2-week sea lice challenge, reaching 350 g. The 8% KM diet group had thicker skin epithelium (72.3 µ) compared to the 12% KM (51.3 µ) and the control groups (43.8 µ) after 8 weeks. Additionally, skin mucosal health parameters—cell size (208 µ2), cell density (25.2%), and defense activity (1.19)—were significantly enhanced with 8% KM compared to the 12% KM (cell size: 162.3 µ2, cell density: 17%, defense activity: 1.04) and the control group (cell size: 173.5 µ2, cell density: 16.4%, defense activity: 0.93). Furthermore, fish fed with 8% KM significantly showed the lowest sea lice, along with reduced cell size while maintaining a high abundance of skin mucous cells, suggesting efficient turnover of the skin mucosal layer to remove sea lice effectively. This study highlights the potential of KM as part of a functional nutrition strategy to enhance skin mucosal health and mitigate sea lice challenges.

The Role of Brand Awareness Mediation on the Influence of Media Richness and Information Quality on Purchase Intention on MS Glow Cosmetic Products

The era of globalization has brought many changes, one of which is the use of social media as a communication medium used by local brands in carrying out their marketing activities. MS Glow took advantage of this opportunity to increase the use of social media to promote skin health to the public and succeeded in achieving first position in the ranking of the best-selling skincare brands in e-commerce. This achievement is not in line with the results of the pre-survey which found that the public has a minimal level of purchase intention. This research aims to analyze the influence of brand awareness in mediating media richness and information quality on purchase intention. The research design was a quantitative associative study carried out in Denpasar City which has quite high purchasing power and health awareness. There were 70 respondents who acted as samples in the research and the research instrument was distributed via the Google Form platform. Validity tests, reliability tests, and confirmatory factor analysis were carried out on the research instruments, and path and Sobel analyzes were carried out to test the research hypotheses. The results of this research are: 1) media richness has a positive and significant effect on brand awareness, 2) information quality has a positive and significant effect on brand awareness, 3) media richness has a positive and significant effect on purchase intention, 4) information quality has an effect positively and significantly on purchase intention, 5) brand awareness has a positive and significant effect on purchase intention 6) brand awareness plays a role in mediating the influence of media richness on purchase intention, and 7) brand awareness has a positive and significant influence in mediating the influence of information quality on purchase intention

Co-Delivery of Valsartan and Metformin from a Thermosensitive Hydrogel-Nanoparticle System Promotes Collagen Production in Proliferating and Senescent Primary Human Dermal Fibroblasts.

Aging negatively impacts skin health, notably through the senescent cell phenotype, which reduces collagen production and leads to thinner, more fragile skin prone to injuries and chronic wounds. We designed a drug delivery system that addresses these age-related issues using a hybrid hydrogel-nanoparticle system that utilizes a poly(δ-valerolactone-co-lactide)-b-poly(ethylene-glycol)-b-poly(δ-valerolactone-co-lactide) (PVLA-PEG-PVLA) hydrogel. This hydrogel allows for the local, extended release of therapeutics targeting both proliferating and senescent cells. The PVLA-PEG-PVLA hydrogel entrapped valsartan, and metformin-loaded liposomes functionalized with a fibronectin-mimetic peptide, PR_b. Metformin acts as a senomorphic, reversing aspects of cellular senescence, and valsartan, an angiotensin receptor blocker, promotes collagen production. This combination treatment partially reversed the senescent phenotype and improved collagen production in senescent dermal fibroblasts from both young and old adults. Our codelivery hydrogel-nanoparticle system offers a promising treatment for improving age-related dermal pathologies.