Incidence Of Skin Diseases Research Articles

Preliminary Studies about Valorization of Acmella oleracea Bioactive Content in Modern Dermato-Cosmetic Applications to Combat Skin Oxidative Stress.

The development of products with skin-protective effects has been driven by the increasing incidence of skin diseases that are exacerbated by increasing pollution, urbanization, poor living, working, fatigue, dietary habits, and general treatment. The ability of antioxidants to protect the skin from oxidative stress and its effects makes them one of the most important ingredients in today's cosmetics. This article aims first to characterize the plant extracts obtained from Acmella oleracea (A. oleracea) and then to evaluate the preliminary criteria for a new marketed product: the stability, antioxidant activity, and in vitro behavior of certain serums based on A. oleracea plant extract and hyaluronic acid. The extracts were obtained by liquid-solid extraction methods (maceration (M), ultrasound-assisted extraction (UEA), and a combined method between these two (UEA + M) using an aqueous solution of ethyl alcohol as the extraction solvent. The determination of the amounts of compounds with antioxidant activity highlighted the fact that the extract obtained from the whole plant of A. oleracea using maceration in conditions of S/L = 1:30, 20 days, and an extraction solvent percentage of 50% led to obtaining the highest amount of polyphenols (30.42 μg GAE/g), while using the combined UAE + M method under conditions of S/L = 1:30, 6 min + 20 days, and 50% extraction solvent led to obtaining the highest amount of flavonoids (32.88 mg QE/g). The tests performed on dermato-cosmetic serums based on the plant extract and multimolecular hyaluronic acid (HA) (1 HA with HMW-1.0 mDa-1.6 mDa; HA with LMW-10 kDa-200 kDa; and HA OLIGO, MW < 10 kDa) led to the conclusion that they exhibit structural stability, good shear behavior revealing a satisfactory texture, and high physical stability during storage. These results encourage the transition to in-depth testing, both microbiological and dermatological, as a final step in the consideration of a new commercial product.

Effects of a skin type diversity seminar on undergraduate medical students’ self-assessed competence in managing skin diseases in patients with skin of color

BackgroundSkin diseases in patients with skin of colour (Fitzpatrick skin types IV to VI) are underrepresented in dermatology training, which may lead to lower quality of care for these patients. To address this underrepresentation in medical education, a newly developed seminar on skin type diversity using an interactive teaching method was implemented in an undergraduate medical curriculum. This study examined the effects of a seminar on the self-assessed competence of medical students in managing skin conditions in patients with skin of colour.MethodsA questionnaire survey was conducted among fourth-year undergraduate medical students at the University of Hamburg (Germany) between October 2023 and February 2024. Students’ self-assessed competence was compared before and after the obligatory seminar (pre- and post-design).ResultsIn total, 158 students participated in the survey. After the seminar, knowledge of the presentation of skin diseases in patients with skin of colour and the associated psychological burden, differences in the incidence of skin diseases in different skin types, and the ability to diagnose skin diseases in darker skin types increased. Most participants stated that they wanted to attend more courses on this topic.DiscussionAppropriate courses for medical students can improve their competence in managing different skin diseases in patients with skin of colour. In the future, more attention should be paid to teaching the diversity of skin types in dermatology education.

Prevalence of skin diseases among hostellers attending the tertiary care hospital

Background: Skin diseases are more common but are mostly non-fatal and chronic. Dermatological conditions account for a significant proportion of the global burden of diseases. Aims and Objectives: The study aimed to determine the prevalence of skin diseases among hostellers, determine the causative factors, and describe the prevention. Materials and Methods: This cross-sectional study was conducted for 2 months in the outpatient Department of Dermatology, Government Medical College, Pudukottai, on 507 hostellers. The study subjects were examined and diagnosed by the dermatologist. Questions such as exposure to sunlight, usage of sunscreen, frequency of head baths, and junk food consumption were asked and recorded in a case study form by the principal investigator. Results: Pityriasis capitis was the most prevalent skin disease among 507 participants, followed by acne vulgaris (54.83%) and pediculosis capitis (25.64%). Pityriasis capitis is more common in men (56.17%), with higher chances in those with head baths (&lt;3 times/week) and exposure to sunlight (28.08%). Acne vulgaris affects both males and females equally; face washing &lt;3 times daily is associated with oil and sebum retention, while lack of sunscreen and junk food intake are linked. Periorbital melanosis is more prevalent in females (54.62%) and is linked to stress (66.39%). Sleep duration is also a factor, with 69.23% of girls having a history of cosmetic usage. Conclusion: Pityriasis capitis, acne vulgaris, pediculosis capitis, dermatophytosis, and periorbital melanosis are common skin diseases caused by sharing, sleep deprivation, stress, and poor hygiene. Proper hygiene, sleep patterns, and self-care can reduce skin disease incidence.

ASSESSMENT OF TWAKAROGA THROUGH THE AYURVEDA

The skin is the largest organ and reflects the Chhaya (aura) and Prabha (luster) of the body. Skin complexity and homeostasis have been influenced by numerous environmental changes. Skin is the demarcation between the internal and external environment. Many factors affect skin health like the status of diet, hygiene, habitat, sedentary lifestyle etc. In this era, skin disease incidence is increasing in tropical and developing areas. The Ayurvedic lexicon contains several references to skin conditions. The description of Twaka roga (skin disease) has mentioned on the basis of Doshik dominance. Kushtha roga appears due to Dosh-Dushya Sammurchhana (Amalgamation of Dosh-Dushya) including tri-Dosha, Twaka (skin), Rakta (blood), Mams (muscular part) Dhatu (tissue) and Lasika (fluid). Registered patients were selected for diagnosis of skin disease. Diseases were diagnosed by signs and symptoms on the basis of color, hardness, spreading, secretion, pain, elevation, burning sensation and itching. The affected part was assessed on the basis of compendia described with contemporary science and a photo was taken. On the basis of ancient knowledge different Twaka roga identified with the basic principle of Ayurveda. The Kushtha roga are Mandal Kushtha, Dadru, Shwitra, Pama, vicharchika, vipadika, charmdala, charmakushtha, kunakha, sheetpitta, yuvanpidika and vyanga these are categorized into dosha character in the lesion.

Effect of Girisindura Malahara on Padadari - Case Study

Ayurveda is considered to be the oldest healing science. In Sanskrit, Ayurveda means “The Science of Life”. The incidence of skin disease is gradually increasing and Padadari is one of the most common diseases which is seen now a days. It is also called as Vidari, Dari, Cracked Fissure. Feet are the most often neglected and affected part of the body even though they are most important part of our body. Cracks or fissures on foot have no age limit and can affect anyone. Most of the time cracks are occupational like for farmers and for those who stand for longer duration. Excessive walking, walking bare foot, back open shoes, obesity, diabetic, psoriasis, unhygienic conditions, exposure to dust, dirt and microbes are some of the common causes for Padadari. In Ayurvedic classics there are various herbs mentioned as Vrunaropaka. Here in this study Girisindura Malahara has been used in the case of Padadari. The obtained results and outcomes are being shown. Hereby presenting the case of Padadari which was treated successfully.

Dermatological disease prediction and diagnosis system using deep learning.

The prevalence of skin illnesses is higher than that of other diseases. Fungal infection, bacteria, allergies, viruses, genetic factors, and environmental factors are among important causative factors that have continuously escalated the degree and incidence of skin diseases. Medical technology based on lasers and photonics has made it possible to identify skin illnesses considerably more rapidly and correctly. However, the cost of such a diagnosis is currently limited and prohibitively high and restricted to developed areas. The present paper develops a holistic, critical, and important skin disease prediction system that utilizes machine learning and deep learning algorithms to accurately identify up to 20 different skin diseases with a high F1 score and efficiency. Deep learning algorithms like Xception, Inception-v3, Resnet50, DenseNet121, and Inception-ResNet-v2 were employed to accurately classify diseases based on the images. The training and testing have been performed on an enlarged dataset, and classification was performed for 20 diseases. The algorithm developed was free from any inherent bias and treated all classes equally. The present model, which was trained using the Xception algorithm, is highly efficient and accurate for 20 different skin conditions, with a dataset of over 10,000 photos. The developed system was able to classify 20 different dermatological diseases with high accuracy and precision.

Epidemiology of Dermatologic Conditions Among Elderly Patients at the Ambulatory Care Service of a Tertiary Hospital in Metro Manila from 2014 to 2018: A Five-year Review

Introduction: Ageing is a progressive degenerative process that leads to decline in the physiological function and reserve capacity of the whole body system, including the skin. As the Filipino geriatric population escalates, the incidence of skin diseases becomes more widely acknowledged. Presently, there are only a few studies that have been reported locally describing the nature of geriatric dermatoses. Objectives: To describe the epidemiology of dermatologic conditions among Filipino elderly patients that prompted a consult at the ambulatory care service of a tertiary hospital between the years 2014 and 2018. Methodology: All Filipino elderly patients with dermatological conditions seen at the dermatology ambulatory care service from 2014 to 2018 was studied through a single-center, retrospective, descriptive study. Results: Elderly patients comprised 16.76% of the total patients who sought dermatological consultation at the ambulatory care service of the hospital. Majority of the patients were females. Xerosis/xerotic eczema (10.02%) was the most frequently encountered skin disease. The top 10 diseases were irritant contact dermatitis (7.00%), lichen simplex chronicus (6.67%), psoriasis (5.56%), seborrheic dermatitis (5.24%), allergic contact dermatitis (4.37%), tinea pedis (3.51%), herpes zoster (3.49%), seborrheic keratosis (3.23%), and milia (2.54%). Based on the nature of disease, inflammatory condition was the most commonly seen. Conclusion: Dermatological disorders are ubiquitous in older people with a significant impact on the quality of life. Inflammatory dermatoses comprise a wide array of skin diseases as evidenced in this study, which account for most of the cutaneous problems in the elderly. Similar to other epidemiological studies, xerosis/xerotic eczema still comprises majority of the cases prompting elderly patients to seek a dermatological consultation. Keywords: elderly, geriatric, dermatologic diseases, ambulatory, epidemiology

BI08 Defining the burden of mucocutaneous disease in organ transplant recipients living with HIV: the Mucocutaneous disorders in Organ Transplant recipients living with HIV study

Abstract Organ transplant recipients (OTRs) have a high incidence of skin disease. People living with HIV (PLWH) are also at increased risk of skin disease, despite highly active antiretroviral therapy. Dual immunosuppressive states would be expected to increase substantially the risk of mucocutaneous disease, including skin infections and malignancy, but this is not well documented. The aim of the MOTH (Mucocutaneous disorders in Organ Transplant recipients living with HIV) study is to assess the burden of skin disease in PLWH who are also OTRs. The first phase of the MOTH study was a single-centre observational study of PLWH who had received a solid organ transplant at our centre, following their HIV diagnosis. We identified eligible patients through our OTR database. Demographic data and details of previous/current skin disease were collected. Patients with a documented full skin examination (FSE), including anogenital skin assessment within the previous 3–6 months, were not recalled for clinical review. Those not reviewed within the prior 6 months or those without a documented anogenital skin examination (even if they had a FSE within the past 6 months) were invited for clinical review. Thirty OTRs living with HIV were identified. Twenty-five were clinically assessed in person and case notes reviewed for five. Fourteen patients were men and 16 were women; mean age was 55 years (range 31–70). Most (n = 25; 83%) were Black African; the remainder were Black Caribbean (n = 3), White (n = 1) and mixed race (n = 1). Only two patients identified as men who have sex with men (MSM). Human papillomavirus (HPV)-associated disorders were the most common mucocutaneous conditions identified with 31 separate diagnoses in 19 (63%) patients: non-anogenital cutaneous warts (n = 9); low-risk HPV-related anogenital disease (n = 14); premalignant HPV-related anogenital disease (n = 6) and HPV-associated malignant disease (n = 2; vulval squamous cell carcinoma in situ and oral mucosal carcinoma). One patient (White, MSM) had been HPV vaccinated pretransplant. Other diagnoses included cutaneous/nail fungal infections (n = 10), HSV infection (n = 10), pruritus associated with renal replacement therapy (n = 7), bacterial skin infection (n = 4), steroid-induced folliculitis (n = 3), Kaposi sarcoma (n = 3), lichen sclerosus (n = 1), acquired erythro­dysplasia verruciformis (n = 1), erythema multiforme (n = 1), lichen simplex chronicus (n = 1) and cytomegalovirus-associated perioral ulceration (n = 1). These findings confirm a high burden of skin disease in OTRs living with HIV. HPV-related mucocutaneous disease was particularly common, supporting the need for routine HPV-related anogenital surveillance and guidance on pretransplant HPV vaccination. Further prospective research is required to define the mucocutaneous health-related needs of this cohort, and an international multicentre extension of the MOTH study is currently underway.

Characterizing Occupational Skin Disease Incidence, 2017-2021.

Dermatitis®Ahead of Print LettersCharacterizing Occupational Skin Disease Incidence, 2017–2021Aneesh Agarwal and Nicholas GulatiAneesh Agarwalhttps://orcid.org/0000-0002-6614-3763Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.Search for more papers by this author and Nicholas GulatiDepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Search for more papers by this authorEmail the corresponding author at nicholas.gulati@mssm.eduPublished Online:19 Jun 2023https://doi.org/10.1089/derm.2023.0090AboutSectionsView articleView Full TextPDF/EPUB Permissions & CitationsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail View articleFiguresReferencesRelatedDetails Volume 0Issue 0 Information© 2023 American Contact Dermatitis Society. All Rights Reserved.To cite this article:Aneesh Agarwal and Nicholas Gulati.Characterizing Occupational Skin Disease Incidence, 2017–2021.Dermatitis®.ahead of printhttp://doi.org/10.1089/derm.2023.0090Online Ahead of Print:June 19, 2023PDF download

A scientific review on Dadrukushta with special reference to Dermatophytosis and its management through Ayurveda

Skin is the largest organ of the body and skin diseases has a high prevalence throughout the world and fungal infection of skin is one of them. In the high populated countries like India and China the incidence of skin diseases is considerably increased in recent years due to predisposing factors like warm, humid climate, crowded living conditions, hygiene and poor nutrition. In Ayurveda all the skin related diseases are explained under main heading of Kushta and skin fungal infections termed as Dadrukushta (Dermatophytosis). Ayurveda has a versatile approach towards skin disorders depending on the requirement of the patient. The present article is aimed at understanding the disease Dadrukushta with special reference to Dermatophytosis and its management through Ayurveda.

Personal Hygiene with the Incidence of Skin Diseases

Skin disease is a disease that attacks the surface of the body and is caused by various diseases. Skin diseases can also be caused by fungi, germs, viruses and parasites. The purpose of this study was to determine the relationship between personal hygiene and the incidence of skin diseases. This type of research uses an analytic observational method with a cross sectional research design. The population in this study were 149 residents, samples taken from the entire population were 149 respondents. The sampling technique uses total sampling. Collecting data using questionnaires and observation. The data analysis used was univariate analysis and bivariate analysis, using the chi-square test (α&lt;0.05). The results of the study show an overview of the incidence of skin disease from 149 respondents who suffer from skin disease (67.1%). The description of personal hygiene (skin cleanliness, hand hygiene, clothing cleanliness, and use of towels) from 149 respondents (89.3%) was not good. The results of personal hygiene research obtained p-value = (0.000). The conclusion is that there is a relationship between personal hygiene and the incidence of skin diseases. For Community Health Centers to increase efforts to prevent and control skin diseases by increasing the socialization of clean and healthy living behaviors to support public health.

A Case Study on the Ayurvedic Management of Childhood Atopic Dermatitis

Atopic Dermatitis (AD) is a chronic inflammatory skin condition with impaired cell-mediated immune function and compromised skin barrier. It is characterized by erythema, oedema, vesicles, oozing in the acute stage, and thickening and hyperpigmentation (lichenification) in the chronic stage. The incidence of skin diseases is increasing day by day. Other medical systems provide temporary relief but not a complete cure. Ayurveda can contribute remarkably in the management of skin problems. Atopic dermatitis comes under Twak vikaras which can be correlated with Charmadala described in Kashyapa samhitha. This is the case report of a nine-year-old girl with dry, itchy and scaly skin associated with blackish excoriated lesions and oozing. She visited the outpatient department of Government Ayurveda Hospital. Ayurveda medications were administered along with dietary advice for a period of three weeks, followed by inpatient treatment with internal medications along with Snehapana (intake of ghee) followed by Vamana (emesis) and external procedures like Dhara (pouring of medicated liquids) with Kushtahara (alleviates itching) and Kandughna (anti-pruritic) Dravyas along with dietary advice for a period of one month. Encouraging results were observed in the form of a reduction in itching, dryness, and excoriation. The efficacy of the treatment was assessed using SCORAD (scoring atopic dermatitis scale), where the pre-value is 54.7 and the post-value is 17. On POEM (patient-oriented eczema measure) scale evaluation the condition changed from severe eczema to clear or almost clear. Dietary restrictions and internal medication must be continued to prevent the recurrence of the condition.

Analisis Hubungan Faktor Lingkungan Terhadap Kejadian Penyakit Kulit Pada Masyarakat yang Tinggal di Aliran Sungai Indragiri di Desa Sukaping Kecamatan Pangean

Skin disease is a disease relate to environment and human behavior. Environmental factors are closely relate to skin diseases such as clean water facilities, accupancy density, economic factors, and sosial factors. This reasearch method used in Analytical survey method with a cross-sectional research design. The sample in this study was 87 people. The sampling technique used Simple Random Sampling. The analysis method used is univariate analysis, bivariate analysis with the chi square test using the SPSS program and multivariate analysis. The results of multivariate analysis found that there were 3 risk factors with the gratest influence of contribution to the incidence of skin diseases, namely clean water facilities OR (0,508), the habit of washing hand with the soap OR (0,204), and economic factors OR (0,203)

Assessment of Cutaneous Parameters and Sympathetic Skin Response as a Non-Invasive Complementary Diagnostic Tool in Psoriasis: An Exploratory Study.

Various diagnostic tools are used to assess cutaneous psoriasis, but most of it were subjective. Sympathetic skin response (SSR), skin PH and temperature objectively measure the skin barrier functions that could aid clinicians to evaluate accurately and predict skin disease incidence even before the onset of clinical symptoms. The study's objective was to assess the utility of cutaneous parameters (skin temperature and pH) and SSRs influencing psoriatic patients' diagnosis management and treatment compared to controls. A total of 40 healthy participants and 40 psoriasis patients aged 18 to 65 years were recruited for this study. SSR, skin temperature and pH were assessed. The psoriasis disability index (PDI) was recorded from all the patients. Data analysis was carried out using SPSS version 20.0. The results shows significantly increased skin temperature, prolonged SSR latency (bilaterally) and decreased SSR amplitude (bilaterally) among patients affected with psoriasis compared to control subjects. There is a positive correlation between SSR latency with PDI and a negative correlation between SSR amplitude and PDI in psoriasis patients. SSR reveals sympathetic sudomotor dysfunction and increased skin temperature in psoriasis. Furthermore, there is a link between increased SSR latency and PDI, which shows that local nervous system impairment significantly contributes to the inflammatory process in psoriasis. Thus, SSR can be used as a complementary tool for the early identification and assessment of epidermal barrier integrity in psoriasis patients, along with the clinician's standard protocols.

Dermatocosmetic Emulsions Based on Resveratrol, Ferulic Acid and Saffron (Crocus sativus) Extract to Combat Skin Oxidative Stress-Trigger Factor of Some Potential Malignant Effects: Stability Studies and Rheological Properties.

The increasing incidence of skin diseases, against the background of increased pollution, urbanism, poor habits in lifestyle, work, rest, diet and general medication, led to the development of products with a protective effect. These new types of dermatocosmetic preparations ensure maximum benefits with minimal formulation. Antioxidants are, nowadays, ingredients that stand out with a proven role in skin protection from oxidative stress and its effects. Thus, research has shown that light-textured formulas, quickly absorbed into the skin, with optimum hydration and protection against excessive free radicals, uphold the skin integrity and appearance. This article aims to evaluate essential criteria for a newly marketed product: stability, rheological properties and microbiological characteristics of oil-in-water emulsions based on a mixture of 3% resveratrol 0.5% ferulic acid and 1mL alcoholic extract of Saffron. The tests led to the conclusion that O / W dermatocosmetic emulsions, based on 3% resveratrol and 0.5% ferulic acid, or also 1mL alcoholic extract of Saffron, show resistance to microbiological contamination, good rheological properties (viscoelastic behavior, structural stability, acceptable shearing behavior) that reveal satisfactory texture and high physical stability during storage. These results encourage the transition to dermatological testing as the final stage in considering a new commercial product.

Gambaran Sanitasi Lingkungan dan Hygiene Perseorangan dengan Kejadian Penyakit Kulit di Lapas Anak Kota Kupang

Skin disease is a disorder of the skin caused by fungi, germs, parasites, viruses, and infections that can attack everyone regardless of age. Skin diseases can attack the entire human body or certain parts of the body. Skin diseases can occur due to lack of personal hygiene such as using shared clothes, using toiletries such as soap and towels at the same time. The purpose of this study was to determine environmental sanitation and personal hygiene with the incidence of acute diseases at the Special Guidance Institute for Class 1 Children in Kupang City. This type of research is descriptive and conducted by means of a survey. This research was conducted in Kupang City with a sample of 30 prisoners. The data analysis used is univariate analysis which only looks at the description of the frequency distribution of each variable studied. Thus, it can be concluded that all the independent variables of this study consisted of: skin hygiene, hand and nail hygiene, bed and bed linen cleanliness, towels cleanliness and clothing cleanliness with the incidence of skin diseases in special child prisoners in Kupang City. Prisoners need to carry out clean and healthy living behavior (PHBS) well as things are known. The Kupang City Health Office is expected to increase health education efforts through various media, especially counseling/socialization about clean and healthy living behavior (PHBS).

Skin Lesion Classification on Imbalanced Data Using Deep Learning with Soft Attention.

Today, the rapid development of industrial zones leads to an increased incidence of skin diseases because of polluted air. According to a report by the American Cancer Society, it is estimated that in 2022 there will be about 100,000 people suffering from skin cancer and more than 7600 of these people will not survive. In the context that doctors at provincial hospitals and health facilities are overloaded, doctors at lower levels lack experience, and having a tool to support doctors in the process of diagnosing skin diseases quickly and accurately is essential. Along with the strong development of artificial intelligence technologies, many solutions to support the diagnosis of skin diseases have been researched and developed. In this paper, a combination of one Deep Learning model (DenseNet, InceptionNet, ResNet, etc) with Soft-Attention, which unsupervisedly extract a heat map of main skin lesions. Furthermore, personal information including age and gender are also used. It is worth noting that a new loss function that takes into account the data imbalance is also proposed. Experimental results on data set HAM10000 show that using InceptionResNetV2 with Soft-Attention and the new loss function gives 90 percent accuracy, mean of precision, F1-score, recall, and AUC of 0.81, 0.81, 0.82, and 0.99, respectively. Besides, using MobileNetV3Large combined with Soft-Attention and the new loss function, even though the number of parameters is 11 times less and the number of hidden layers is 4 times less, it achieves an accuracy of 0.86 and 30 times faster diagnosis than InceptionResNetV2.

Incidence of skin diseases in healthcare workers before and during the COVID-19 pandemic at Trieste hospitals (northeastern Italy).

BackgroundOccupational skin diseases (OSDs) are common in healthcare workers (HCWs).ObjectivesTo investigate and compare the incidence and clinical features of OSDs among HCWs before and during the COVID‐19 pandemic.Materials and MethodsIncident cases of OSDs were investigated in the cohort of HCWs at Trieste Hospitals from 1 July 2018 (3340 workers) to 31 October 2021 (137 532 person‐months).ResultsThe monthly incidence was ranging from 0 to 11.90 cases per 10 000 person‐months in pre‐COVID‐19 period (cumulative incidence 4.22; 95% confidence interval [CI]: 2.9–6.0) and from 0 to 13.61 cases per 10 000 person‐months in COVID‐19 period (cumulative incidence 5.06; 95% CI: 3.6–6.9). The incidence rate ratio (IRR) between COVID‐19 and pre‐COVID‐19 period was 1.22 (95% CI: 0.73–1.98). The incidence of OSDs in the COVID‐19 period was 6.1 (4.2–8.6) and 2.7 (95% CI: 1.1–5.6) cases × 10 000 person‐months for women and men, respectively, with an IRR of 2.25 (95% CI: 0.98–5.9). Incidence in nurses in the COVID‐19 period was 6.7 (95% CI: 4.2–10.2) cases × 10 000 person‐months.ConclusionsIncidence of OSDs was a little bit higher during the COVID‐19 pandemic compared to the previous period but fluctuation of numbers were mainly related to calendar period, with higher incidence in winter and spring. Incidence data were higher than that observed in 2004–2013 in the same cohort. Face dermatitis cases doubled after the start of COVID‐19 pandemic. Overall data demonstrated a non‐significant increase of OSDs in HCWs during the pandemic, probably due to the preventive strategies set up in our cohort over the years.

Potential of propolis antifungal activity for clinical applications.

The high incidence of skin diseases of microbial origin along with the widespread increase of microbial resistance demand for therapeutic alternatives. Research on natural compounds has been opening new perspectives for the development of new therapies with health-positive impacts. Propolis, a resinous mixture produced by honeybees from plant exudates, is widely used as a natural medicine since ancient times, mainly due to its antimicrobial properties. More recently, antioxidant, anti-tumour, anti-inflammatory, hepatoprotective and immunomodulatory activities were also reported for this natural product, highlighting its high potential pharmacological interest. In the present work, an extensive review of the main fungi causing skin diseases as well as the effects of natural compounds, particularly propolis, against such disease-causing micro-organisms was organized and compiled in concise handy tables. This information allows to conclude that propolis is a highly effective antimicrobial agent suggesting that it could be used as an alternative skin treatment against pathogenic micro-organisms and also as a cosmeceutical component or as a source of bioactive ingredients.

Exploration of Potential Biomarkers for Type 2 Diabetes by UPLC-QTOF-MS and WGCNA of Skin Surface Lipids.

BackgroundDiabetes has become popular and has become one of the most important global health care challenges. Patients with diabetes have a high incidence of skin diseases. Cell and animal models are often used to study the skin conditions of people with diabetes.MethodsIn this study, a volunteer questionnaire survey, skin lipomics analysis based on ultra-high performance liquid chromatography-quadrupole tandem time-of-flight mass spectrometry (UPLC-QTOF-MS), and weighted gene co-expression network analysis (WGCNA) were used to study the differences in skin conditions and skin lipids of participants with type 2 diabetes mellitus (Group D) versus healthy individuals (Group H) and the correlation between these groups. The questionnaire was used to investigate personal basic, diabetes, and facial skin status information of 77 female volunteers aged 55–65 years old from the Peking University Shougang Hospital. The facial skin lipids of all volunteers were analysed by UPLC-QTOF-MS technique; the differential lipids between groups D and H were analysed by partial least-squared discriminant and univariate analysis.ResultsIn total, 23 kinds of differential lipids were identified, all of which belonged to sphingolipids. The use of WGCNA combined clinical information with lipid analysis to study the relationship between glycosylated haemoglobin, skin pigmentation/non-pigmentation, and skin lipids. Two types of lipids were identified to distinguish between hub lipids of high and low glycosylated haemoglobin; 12 types of lipids were identified that could distinguish between the hub lipids of pigmented and non-pigmented participants (PLS-DA).ConclusionThe experimental results not only provide a reference for the diagnosis and classification of diabetes via analysing the skin lipids of patients, but also provides a theoretical basis for further study on the effects of diabetes on the skin of patients.