A person is constantly under the influence of the environment, which determines the state of his health. Animal testing is used to determine the danger of certain chemical agents of inanimate nature. To extrapolate the experimental result to a person, the body of patients with a dystrophic form of epidermolysis bullosa (DVBE), which has a low threshold of resistance to aggressive stimuli, is preferred. Goal - to study the effect of anthropogenic physico-chemical factors on the skin of white mice, as well as environmental ecology on the population of patients with a dystrophic form of congenital epidermolysis bullosa. Materials and methods. Five groups of white mice were exposed to plant protection products. The chronic experiment lasted 6 months, and the daily dose of the chemical compound was 1/50 of LD50. The influence of ecology on 35 patients with DBE was also studied. Results. In the experiment, it was found that the seed with agrochemicals causes skin eczema, periorbital dermatitis, finger mutation and contracture, claw deformity and chronic itching in white mice. We have established the possibility and criteria for extrapolating the results of the experiment to patients suffering from DVBE. Such criteria include itching of the skin, mutation and pseudosyndactyly of the fingers, deformation of the nails The impact on the body of patients with DVBE toxic agents was carried out by the living environment. As a result of observation of these patients, we found that in order to achieve the positive effect of complex therapy, in addition to highly qualified medical care, they need an environmentally safe living environment. They need to organize trips and accommodation in conditions that do not pose an environmental hazard to humans, which will help reduce the severity of the disease and improve their quality of life. Conclusions. The ecology of the living environment determines the effectiveness of therapy in patients with VBI, as well as the timing of manifestation and the severity of the course of the disease. A prosperous ecology contributes to the epithelization of ulcerative elements and the disappearance of itching.