Skin Care Products Research Articles

Optimization of enzymatic production of anti-skin aging biopeptides from white sorghum [Sorghum bicolor (L) Moench] grain

Recently, kafirins from white sorghum [Sorghum bicolor (L) Moench] grain have shown promise as a source of biopeptides with anti-skin aging effects (anti-inflammatory, antioxidant, and inhibition of photoaging-associated enzymes). This study employed response surface methodology (RSM) to optimize the extraction and enzymatic hydrolysis of kafirins (KAF) for the production of peptides with anti-skin aging properties. The optimization of conditions (reaction time and enzyme/substrate ratio) for liquefaction with α-amylase and hydrolysis of KAF with alcalase was performed using 32 complete factorial designs. Subsequently, ultrafiltered peptide extracts were obtained with molecular weights of 1–3 kDa (KAF-UF3) and lower than 1 kDa (KAF-UF1), which mainly contain hydrophobic amino acids (proline, leucine, isoleucine, phenylalanine, and valine) and peptide fractions with molecular weights of 0.69, 1.14, and 1.87 kDa. Consequently, the peptide extracts protected immortalized human keratinocytes (HaCaT cells) from ultraviolet B radiation (UVB)-induced damage by preventing the decrease and/or restoring the activity of antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px)]. Furthermore, KAF-UF3 and KAF-UF1 inhibited (20–29%) elastase and collagenase overactivity in UVB-exposed murine fibroblasts (3T3 cells). Thus, KAF-UF3 and KAF-UF1 exhibited behavior similar to that observed with glutathione (GSH), suggesting their potential as functional peptide ingredients in skincare products.

Physicochemical Characterization of Moroccan Honey Varieties from the Fez-Meknes Region and Their Antioxidant and Antibacterial Properties.

Honey, with its varied and extensive characteristics, is a complex and diverse biological substance that has been used since ancient times. The aim of this study is to thoroughly characterize the physicochemical, phytochemical, and biological properties of four floral honey varieties from the Fez-Meknes region in Morocco, with the goal of promoting the valorization of Moroccan honey in skincare and cosmetic products. The analyses of their physicochemical characteristics encompass various parameters such as pH, acidity, density, water content, Brix index, conductivity, ash content, hydroxymethylfurfural (HMF) content, and color. The levels of polyphenols range from 22.1 ± 0.4 to 69.3 ± 0.17 mg GAE/100 g of honey, measured using the Folin-Ciocalteu method for polyphenol quantification. Additionally, the estimation of flavonoid quantities in 100 g of honey, conducted using the aluminum trichloride method, reveals values ranging from 3.6 ± 0.2 to 7.2 ± 0.6 mg QE. Furthermore, it is noteworthy that honey exhibits high levels of glucose and relatively low concentrations of proteins. The quantitative evaluation of antioxidant effects, carried out through the 2,2-diphenyl-1-picrylhydrazyl free-radical-scavenging method and the ferric-reducing antioxidant power (FRAP) method, highlights the strong antioxidant capacity of multifloral honey, characterized by low inhibitory concentration values (IC50 = 30.43 mg/mL and EC50 = 16.06 mg/mL). Moreover, all honey varieties demonstrate antibacterial and antifungal properties, with multifloral honey standing out for its particularly pronounced antimicrobial activity. The correlation analyses between phytochemical composition and antioxidant and antibacterial activities reveal an inverse relationship between polyphenols and IC50 (DPPH) and EC50 (FRAP) concentrations of honey. The correlation coefficients are established at R2 = -0.97 and R2 = -0.99, respectively. Additionally, a significant negative correlation is observed between polyphenols, flavonoids, and antifungal power (R2 = -0.95 and R2 = -0.96). In parallel, a marked positive correlation is highlighted between antifungal efficacy, DPPH antioxidant activity (R2 = 0.95), and FRAP (R2 = 0.92). These results underscore the crucial importance of phytochemical components in the beneficial properties of honey, meeting international quality standards. Consequently, honey could serve as a natural alternative to synthetic additives.

Plant Collections of Bogor Botanical Gardens: Potential for Cosmetics (Skincare) and Their Conservation Status

The trend in the cosmetics industry in Indonesia has been upward since 2019. There is currently a problem with consumer knowledge of cosmetics made with natural ingredients. Through bioprospecting studies, the Bogor Botanical Gardens is a key player in identifying Indonesia's potential plants, one of which is a source of raw materials for cosmetics. With a focus on skincare, this study aims to inform readers about the plant collections in the Bogor Botanical Gardens that have potential cosmetic applications. The Bogor Botanical Gardens' plant collections were directly observed for this study's secondary data, which were gathered through literature reviews. The study identified 26 plant species from 20 families – primarily Zingiberaceae, Arecaceae, and Fabaceae – as having potential uses in cosmetics, especially skincare products. These plants are mostly trees, at least 50% of them. The most frequently used plant parts were leaves (30.77%), followed by fruits (11.54%), rhizomes (11.54%), seeds (11.54%), leaf sheaths (7.69%), and other parts (3.85%). The conservation status of 13 out of the 26 species is known; of these, nine are considered to be of least concern, four have insufficient data, and one is on the verge of extinction.

A Comprehensive View on Narrative Aspects of Cosmeceutical Agents Intended for Skin Care

Abstract: Cosmetics may have "pharmaceutical therapeutic benefits" but not always "biological therapeutic rewards.,” Products for skin care that combine cosmetics and pharmaceuticals are known as Cosmeceuticals. Cosmeceuticals are applied topically like cosmetics, but they also contain substances that affect the biological functions of the skin. Cosmetics make people seem better, but they do so by giving their skin the nutrition it needs to stay healthy. Cosmeceutical skincare has specific ingredients to correct particular skin concerns or conditions. For example, they have high percentages of salicylic acid and niacinamide to correct oily to acne-prone skin. A skincare expert has access to pharmaceutical-grade items that can be utilized to customize each client's at-home or face regimen. This study aims toprovide an up-to-dateanalysis of cutting-edge natural bio-actives that not only improve skin health but also shield it from a range of dangerous agents, such as UV radiation and free radicals.

Lemon Oil Anti-Microbial And Anti Comedogenic Effects In Skin Care Products

Lemon oil, derived from the peels of citrus fruits, has garnered significant attention due to its antibacterial qualities and potential applications in skincare products. This review paper examines the antibacterial characteristics of limonene, citral, alpha-terpinene, beta-pinene, gamma-terpinene, and geranial, all of which are constituents of lemon oil. These components have demonstrated antimicrobial action against a diverse range of bacteria and fungi. The antibacterial qualities of lemon oil are believed to stem from its ability to impede cellular functions, damage the cell membranes of germs, and hinder the enzymatic processes of microbes. Furthermore, lemon oil has demonstrated potential anti-comedogenic effects, primarily by regulating sebum production and reducing pore size. The antibacterial and anti-comedogenic characteristics of lemon oil mostly stem from its constituents, namely limonene and citral. Lemon oil is commonly used to commercial skincare products due to its potential advantages in promoting clear and healthy skin. The antibacterial and anti-comedogenic qualities of lemon oil make it a valuable ingredient in skincare products. However, further research is needed to understand the mechanisms and effectiveness of lemon oil. Gaining insight into the potential of lemon oil can facilitate the creation of innovative, organic, and efficient skincare solutions.

Analysis of Shift in Translation on The Usage Instruction of Skincare Products

This research examines the translation of instructions for using skin care products from English into Indonesian, focusing on translation shifts as defined by Catford (1965). These shifts include level shifts and category shifts (structure, class, unit and intra-system shifts). This research analyzes how these shifts occur and adapt to the Indonesian linguistic and cultural context. Data from brands including Wardah, Avoskin, and Garnier were collected and analyzed using a qualitative descriptive method. The findings highlight common shifts, like structural changes due to syntactic differences and word class shifts to maintain meaning. Understanding these shifts can improve translation strategies, ensuring that bilingual packaging is clear, accurate, and culturally appropriate, thus increasing consumer understanding and satisfaction.

Moving-bed biofilm reactor (MBBR) alleviates the negative effect of methylisothiazolinone on the nitrification-denitrification process

Methylisothiazolinone (MIT) is an emerging contaminant used as a biocide in housecleaning and skin care products. Therefore, MIT can reach civil wastewater treatment plants due to domestic usage, thus potentially inhibiting the biological process. This study aims to investigate, for the first time, the effect of MIT on the nitrification-denitrification process in a moving-bed biofilm reactor (MBBR). After a preliminary study performed in a fed-batch reactor, two MBBRs were simultaneously operated in semi-continuous mode for 136 days evaluating a concentration of MIT in the influent of 0.1 and 1.0 mg/L. A parallel study was also conducted under anaerobic conditions to evaluate the effect of MIT on methane production and volatile fatty acid accumulation. At a concentration of 0.1 mg MIT/L, the nitrification process experienced an initial complete inhibition. Subsequently, nitrifying bacteria gradually recovered, reaching approximately 49 % oxidation of ammonia nitrogen, a removal improved up to 64 % at 1.0 mg MIT/L. Although denitrification dealt with a temporary inhibition, the process ultimately achieved a 100 % decrease in nitrite and nitrate concentrations when the MIT concentration was increased from 0.1 to 1.0 mg/L. The cumulative methane yield reached approximately 134 mL CH4/g VS for the control group and was similar to the methane production obtained in the presence of MIT. A MIT removal of 100 % was achieved under aerobic, anoxic, and anaerobic conditions.

The Anteceding Role of Past Experience, Electronic Word-of-Mouth, and Emotional Intelligence on the Determinants of Purchase Intention of Green Skincare Products

The researchers analyzed the factors influencing Filipino millennials' intention to purchase green skincare products based on data from 454 respondents (n=454) residing or working in the National Capital Region. The Theory of Planned Behavior mainly guides the analysis to elucidate positive and significant correlation among Past Experience, Electronic Word-of-Mouth, and Emotional Intelligence on the determinants of intention to purchase green skincare products: Attitude, Subjective Norm, and Self-Efficacy. The results show that Past Experience and Emotional Intelligence have a moderate impact, whereas Electronic Word-of-Mouth has a lesser effect on the key determinants of purchase intention. The current study proposes increased information sharing through marketing campaign strategies such as brand partnerships, the creation of social care groups, fear appeal marketing (FAM), social listening, customer surveys, sales promotions, and verbal persuasion. Future research on the subject may consider various demographics, such as Generation X and Z, and the male market. Finally, to extend the study on green skincare products considering the relationship between antecedent variables.

The Effect of Celebrity Attraction on Consumer Loyalty through Trust in Skincare Products among Generation Z Women

The Effect of Celebrity Attraction on Consumer Loyalty through Trust in Skincare Products among Generation Z Women

The Effect of Digital Promotion and Brand Awareness on Purchasing Decisions on Scarlett Whitening Skincare Products (Study on TikTok Shop User Students ar FEB UNM)

The Effect of Digital Promotion and Brand Awareness on Purchasing Decisions on Scarlett Whitening Skincare Products (Study on TikTok Shop User Students ar FEB UNM)

Cell membrane-penetrating capacity of hPP10-Cu, Zn-SOD fusion protein and its antioxidant and anti-inflammatory activity

To investigate the cell membrane-penetrating capacity of human cell-penetrating peptide hPP10 carrying human antioxidant protein Cu-Zn superoxide dismutase (Cu, Zn-SOD) and assess the antioxidant and anti-inflammatory activity of these fusion proteins. The fusion protein hPP10-Cu, Zn-SOD was obtained by genetic engineering and identified by Western blotting. The membrane-penetrating ability of the fusion protein was evaluated by immunofluorescence assay, fluorescence colocalization assay and Western blotting, its SOD enzyme activity was detected using a commercial kit, and its effect on cell viability was assessed with MTT assay. In a HEK293 cell model of H2O2-induced oxidative stress, the effect of hPP10-Cu, Zn-SOD on cell apoptosis was analyzed with flow cytometry and RT-qPCR, and its antioxidant effect was assessed using reactive oxygen species (ROS) assay; its anti-inflammatory effect was evaluated in mouse model of TPA-induced ear inflammation by detecting expression of the inflammatory factors using RT-qPCR, Western blotting and immunohistochemistry. The fusion protein hPP10-Cu, Zn-SOD was successfully obtained. Immunofluorescence assay confirmed obvious membrane penetration of this fusion protein in HEK293 cells, localized both in the cell membrane and the cell nuclei after cell entry. hPP10-Cu, Zn-SOD at the concentration of 5 μmol/L exhibited strong antioxidant activity with minimal impact on cell viability at the concentration up to 10 μmol/L. The fusion protein obviously inhibited apoptosis and decreased intracellular ROS level in the oxidative stress cell model and significantly reduced mRNA and protein expression of the inflammatory factors in the mouse model of ear inflammation. The fusion protein hPP10-Cu, Zn-SOD capable of penetrating the cell membrane possesses strong antioxidant and anti-inflammatory activities with only minimal cytotoxicity, demonstrating the value of hPP10 as an efficient drug delivery vector and the potential of hPP10-Cu, Zn-SOD in the development of skincare products.

Mineral Water as a Sustainable Raw Material for Skincare Products and Protective Natural Antioxidant from Solar Irradiation: Stability of Vitamin C and In Vitro Antioxidant Assessments

Oxygen is crucial for life, but its reactive species, like free radicals, can damage health and accelerate aging. Antioxidants from natural and synthetic sources mitigate these effects. Kanjiža Spa’s mineral-rich thermal water is renowned for its therapeutic benefits and potential in eco-friendly pharmaceuticals and cosmetics. Hence, the utilization of mineral water in pharmaceutical and cosmetic applications when exposed to artificially generated free radicals under simulated solar irradiation and different experimental conditions (pH values and mineral concentrations in the thermal water) was researched. Three different dermocosmetic products designed with raw minerals and water from Kanjiža Spa were tested. Our findings confirmed the protective effect of mineral water, as evidenced by the higher stability of vitamin C in thermal water. The degradation of vitamin C was significantly reduced in the presence of mineral water, with the least degradation occurring at pH = 7, which closely matches human skin pH. These results were further validated using 2,2-diphenyl-1-picrylhydrazyl and ABTS tests. Overall, the obtained results underscore the therapeutic and commercial potential of Kanjiža Spa’s mineral water, suggesting that it could be a valuable ingredient in next-generation skincare and pharmaceutical products.

Changes in the Skin Microbiome Following Dermatological Procedures: A Scoping Review

The skin microbiome consists of bacteria, fungi, viruses, and mites, which play a crucial role in maintaining skin health and immune function. Imbalances in this microbial community, known as dysbiosis, are implicated in various dermatological conditions. While skincare products are known to influence the skin microbiome, the effects of dermatological procedures have not been extensively studied. Here, we perform a scoping review to outline the studies investigating the impacts of dermatological interventions on the skin microbiome. Phototherapy emerged as the most studied intervention, encompassing UV phototherapy, light therapy, laser therapy, and photodynamic therapy. Chemical interventions, such as chemical peels, micropigmentation, and debridement, have comparatively limited studies describing their impacts on the skin microbiome. To date, no studies have been done on a wide variety of common dermatological procedures such as cryotherapy, skin grafts, and dermabrasion, which may have stronger likelihoods of affecting the skin microbiome. This underscores the need for further research on the influences of dermatological procedures, especially chemical and physical interventions, on the skin microbiome. More comprehensive pre-clinical and clinical studies are essential not only for understanding the long-term consequences of these procedures, but also for optimizing patient outcomes in dermatological care.

NURS-02. THE DEVELOPMENT AND IMPLEMENTATION OF SKINCARE TREATMENT PLANS AND PRODUCT KITS FOR PEDIATRIC PATIENTS RECEIVING TARGETED THERAPIES THAT CAUSE SKIN TOXICITY

Abstract BACKGROUND Mitogen-activated protein kinase (MAPK) pathway inhibitors are incorporated into the treatment regimens for several pediatric cancers. However, they commonly trigger dermatologic side effects, which can be challenging to manage and may have a significant impact on the quality of life. METHODS We previously performed a prospective study looking at the satisfaction and utilization of skincare kits and patient education regarding basic skincare practices. Based on these data, we developed revised skincare product kits and treatment plans that can be individualized for patients who are at risk of developing dermatologic side effects from targeted therapies. RESULTS Based on our prior study, 77% of patients thought the skincare kits and instructions were helpful. Seventy-seven percent of patients also recommended that they be distributed at the initiation of therapy. Through this study, we discovered that the patient reported medical history questions were inconsistent when compared with medical chart reviews. The most common discrepancies included information regarding patient’s diagnosis, prescribed medications, skin-related problems, and past medical history. From this data, we have developed a new skincare product kit and patient skincare plans which we distribute to every patient prior to starting their targeted therapy. The skincare kits consist of a cleanser, emollient, oral care products, sunscreen, pyrithione zinc containing shampoo, and facial moisturizers for adolescent patients. Our patient skincare plans consist of patient-specific information including diagnosis, medications, and their targeted agent. The plan provides details on how and when to use each product, application time, and order in which to apply products and topical medications. CONCLUSION Our project has highlighted the importance of patient education regarding dermatologic side effects in those starting targeted therapies. We have successfully implemented this by providing our patients with both skincare products and patient-specific care plans.

Potensi Spirulina Platensis Sebagai Sumber Kosmetik

Spirulina Platensis, a type of blue-green algae, has attracted the attention of the cosmetics industry due to its extraordinary nutritional and antioxidant properties. This microalgae is rich in vitamins, minerals, and amino acids, making it an attractive ingredient for skin care products. Methods used. The qualitative literature review research method is an approach used to collect, evaluate, and synthesize existing studies in the relevant scientific literature. with a specific topic. Based on research results, Spirulina platensis has great potential as a cosmetic ingredient that can provide benefits in caring for and protecting the skin. However, consult a medical professional or esthetician before using products containing Spirulina platensis.

Anti-aging trends in Australia.

Anti-aging trends in Australia have changed considerably since the country emerged from the lockdowns associated with the SARS-Cov2 pandemic. People now rely on social media influencers for skin care advice and skin care products, including professional skin care treatments that can be purchased on Internet platforms. The quest for the perfect 'zoom face' led to a 300% rise in cosmetic procedures across Australia in the year to April 2021. People now want to use less products on their skin, while looking healthy and natural (termed 'skin minimalism'). The popularity of retinoid derivatives for preventing wrinkles has been superseded by non-irritating actives like hyaluronic acid (HA) and niacinamide that provide skin barrier protection, skin hydration, plumping and anti-inflammatory effects. Botulinum toxin injections remain the most popular non-surgical cosmetic procedure, followed by HA fillers, and biostimulators that promote the synthesis of collagen and give longer lasting but more gradual results than HA fillers. Laser resurfacing is widely used for epidermal resurfacing and skin tightening, as well as non-ablative lasers, intense pulsed light and radiofrequency or ultrasound skin tightening devices. Superficial chemical peels are still popular because they are relatively gentle, inexpensive, and require no downtime, whereas medium-to-deep chemical peels have largely been superseded by laser technology. However, the most efficient approach to prevent skin aging is adopting a healthy lifestyle and taking action against all factors of the skin aging exposome.

Consumer behaviour towards Ayurvedic products in India

Ayurveda is a traditional Indian system of medicine that focuses on holistic health and balance through natural remedies, diet, and lifestyle practices. Many skin and hair care products are available in the Indian markets. Yet, consumers are confused with brand authenticity, 100% natural or not? Reliability of the quality in the absence of proper third-party verification. This study examines this intriguing domain by probing consumer perceptions, experiences, and their ability to discern authentic natural products from those containing synthetic chemicals. The study is based on both primary and secondary data. Primary data is collected through structured questionnaires from a cross-section of 260 households in year 2022, and secondary data is collected from the Amazon ratings. The results of the primary survey show that 58% of respondents said they were unsure whether the ayurvedic or herbal hair and skin care products they use contain chemical ingredients. Results of the secondary survey show that purchasing decisions are not made solely based on a product's chemical-free ingredients; other considerations also play a role. Overall, higher share of five-star rating for ayurvedic products, indicates consumers are happy about the products, however, the market concentration for the ayurvedic products is high, and there is a good scope for new entrants into the market.

International expert consensus recommendations for the use of dermocosmetics in acne.

A wide variety of dermocosmetics (products with both active skincare and cosmetic activity) are available for the management of acne vulgaris. These products are important because they may be the first line of approach for patients desiring to self-treat and they can also have beneficial effects-reducing lesion counts and improving global acne severity. When used in conjunction with medical therapy, dermocosmetics can improve tolerability and enhance results. We reviewed available evidence and combined it with our clinical experience to help guide clinicians in selecting skincare products with acne-targeting ingredients. An international panel of dermatologists with an interest and expertise in managing acne performed a literature review, formulated clinical questions related to the role of dermocosmetics in the acne setting, used a modified GRADE approach to evaluate available evidence and then utilized an online iterative Delphi process to create consensus recommendations. It should be noted that due to the limited number of available studies, the category of dermocosmetics was evaluated rather than specific ingredients. The quality of evidence was found to be low to moderate. Key recommendations were made based on available evidence for the use of dermocosmetics in acne to improve acne global assessment, reduce acne lesion counts, reduce superficial skin oiliness and serve as maintenance therapy after medical treatment, while providing a good tolerability. Recommendations were also made for using dermocosmetics as adjuncts to medical treatment. While there is a need for better quality evidence, dermocosmetics have demonstrated some benefit for acne both when used alone in its milder clinical presentations or in maintenance post acne medication and as adjunct to acne treatments.

γ-Mangosteen, an autophagy enhancer, prevents skin-aging via activating KEAP1/NRF2 signaling and downregulating MAPKs/AP-1/NF-κB-mediated MMPs

BackgroundMangosteens, a naturally occurring xanthones, found abundantly in mangosteen fruits. The anti-skin aging potential of γ-mangosteen (GM) remains unexplored; therefore, we investigated the UVB-induced anti-skin aging of GM via activation of autophagy. HypothesisWe hypothesized that GM exerts antioxidant and anti-aging capabilities both in vitro and in vivo through activation of autophagy as well as control of KEAP1/NRF2 signaling and MAPKs/AP-1/NF-κB-mediated MMPs pathways. MethodsThe anti-skin aging effects of GM were studied using HDF cells and a mice model. Various assays, such as DPPH, ABTS, CUPRAC, FRAP, and ROS generation, assessed antioxidant activities. Kits measured antioxidant enzymes, SA-β-gal staining, collagen, MDA content, si-RNA experiments, and promoter assays. Western blotting evaluated protein levels of c-Jun, c-Fos, p-IκBα/β, p-NF-κB, MAPK, MMPs, collagenase, elastin, KEAP1, NRF2, HO-1, and autophagy-related proteins. ResultsGM exhibited strong antioxidant, collagenase and elastase enzyme inhibition activity surpassing α- and β-mangosteen. GM competitively inhibited elastase with a Ki value of 29.04 µM. GM orchestrated the KEAP1-NRF2 pathway, enhancing HO-1 expression, and suppressed UVB-induced ROS in HDF cells. NRF2 knockdown compromised GM's antioxidant efficacy, leading to uncontrolled ROS post-UVB. GM bolstered endogenous antioxidants, curbing lipid peroxidation in UVB-exposed HDF cells and BALB/c mice. GM effectively halted UVB-induced cell senescence, and reduced MMP-1/-9, while elevated TIMP-1 levels, augmented COL1A1, ELN, and HAS-2 expression in vitro and in vivo. Additionally, it suppressed UVB-induced MAPKs, AP-1, NF-κB phosphorylation. Pharmacological inhibitors synergistically enhanced GM's anti-skin aging potential. Moreover, GM inhibited UVB-induced mTOR activation, upregulated LC3-II, Atg5, Beclin 1, and reduced p62 in both UVB induced HDF cells and BALB/c mice, while blocking of autophagy successfully halt the GM effects against the UVB-induced increase of cell senescence, degradation of collagen through upregulation of MMP-1, underscoring GM's substantial anti-skin aging impact via autophagy induction in vitro and in vivo. ConclusionTogether, GM has potent antioxidant and anti-skin aging ingredients that can be used to formulate skin care products for both the nutraceutical and cosmeceutical industries.

Pengaruh Influencer dan Ulasan Pengguna Terhadap Keputusan Pembelian KOnsumen Pada Brand Skincare Avoskin di Media Sosial

This research focuses on the influence of influencers and customer reviews on Avoskin skincare purchases on social media, especially in digital marketing. The goal is to understand their role in consumer behavior, and explore effective marketing strategies to increase sales and loyalty. It aims to provide insight into the importance of influencers and customer reviews in Avoskin's digital marketing success. The research focused on Avoskin Skincare users, by collecting field data through questionnaires to 107 respondents who met the criteria. A quantitative descriptive approach was used to analyze the influence of beauty influencers on purchasing decisions. An online survey was used to explore respondents' opinions about influencers, interest in products, reviews, and purchase factors. Data analysis was conducted descriptively with a table of survey results.This study tested three hypotheses about the influence of influencers and user reviews on purchasing decisions. The first and second hypotheses are supported by previous research, showing the significant influence of influencers and user reviews. The results of the third hypothesis show that both jointly influence purchasing decisions with strong statistical significance. This confirms the important role of influencers and user reviews in shaping consumer purchasing decisions. The results of the study using IBM SPSS 29 confirmed that influencers and customer reviews have a positive and significant impact on purchasing decisions, encouraging consumers to purchase Avoskin skincare products in accordance with the hypothesis. However, this study has limitations in population and references, and only considers three variables. It is recommended that similar studies expand the population and consider additional variables for a more comprehensive analysis.