BackgroundResearch investigating lifeguards’ performance of Basic Life Support (BLS) with Automated External Defibrillator (AED) is limited. AimAssessing simulated BLS/AED performance in Flemish lifeguards and identifying factors affecting this performance. MethodsSix hundred and sixteen (217 female and 399 male) certified Flemish lifeguards (aged 16–71 years) performed BLS with an AED on a Laerdal ResusciAnne manikin simulating an adult victim of drowning. Stepwise multiple linear regression analysis was conducted with BLS/AED performance as outcome variable and demographic data as explanatory variables. ResultsMean BLS/AED performance for all lifeguards was 66.5%. Compression rate and depth adhered closely to ERC 2010 guidelines. Ventilation volume and flow rate exceeded the guidelines. A significant regression model, F(6, 415)=25.61, p<.001, ES=.38, explained 27% of the variance in BLS performance (R2=.27). Significant predictors were age (beta=−.31, p<.001), years of certification (beta=−.41, p<.001), time on duty per year (beta=−.25, p<.001), practising BLS skills (beta=.11, p=.011), and being a professional lifeguard (beta=−.13, p=.029). 71% of lifeguards reported not practising BLS/AED. DiscussionBeing young, recently certified, few days of employment per year, practising BLS skills and not being a professional lifeguard are factors associated with higher BLS/AED performance. ConclusionMeasures should be taken to prevent BLS/AED performances from decaying with age and longer certification. Refresher courses could include a formal skills test and lifeguards should be encouraged to practise their BLS/AED skills.