BackgroundUltimate aim of learning pharmacology for undergraduate medical students is to be able to select and prescribe drugs rationally. It is necessary to evaluate the effectiveness of curriculum in achieving this aim.ObjectivesTo evaluate the effectiveness of revised pharmacology curriculum through perceptions of interns regarding confidence in rational prescribing and clinical skills related to it.Materials and MethodsA questionnaire-based study was carried out with interns in November 2011. The questionnaire contained questions pertaining to interns’ perception about relevance of pharmacology learning experiences and their confidence in prescribing and related skills.ResultsOf the 135 interns, 113 responded (83.3%), M/F ratio being 2.7:1. Thirty interns (26.5%) had rotated through major clinical postings. As many as 92% agreed that pharmacology curriculum was relevant to make them rational prescribers. In response to confidence in prescribing for common illnesses, more than 90% were confident for malaria, for acute diarrhoeal illness and for upper respiratory tract infection (URTI), whereas the results were low for depression (13%), primary dysmenorrhoea (30%) and transient insomnia (31%). Majority of interns were confident in withdrawing required quantity of drug in syringe (74%) and giving intravenous injection (65%), whereas the results were low for calculating dose based on body weight and body surface area (BSA), 27% and 16%, respectively. Interns who completed paediatrics posting were more confident in calculating dose by body weight and BSA than those who had not (<italic>P</italic><0.001, <italic>P</italic><0.02).Curriculum for skill development in pharmacology is effective to a great extent. However, some weak areas need greater emphasis during training.